Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung

PLoS Genetics

Volumn 9, Issue 2, 2013, Pages

  Calvi, Carla ^a   Podowski, Megan ^a   Lopez Mercado, Armando ^a   Metzger, Shana ^a   Misono, Kaori ^a   Malinina, Alla ^a   Dikeman, Dustin ^a   Poonyagariyon, Hataya ^a   Ynalvez, Leslie ^a   Derakhshandeh, Roshanak ^a   Le, Anne ^a   Merchant, Mark ^b   Schwall, Ralph ^b   Neptune, Enid R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; PROTEIN KINASE B; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; STAT3 PROTEIN; STAUROSPORINE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GAIN OF FUNCTION MUTATION; HOMEOSTASIS; LOSS OF FUNCTION MUTATION; LUNG; LUNG ALVEOLUS EPITHELIUM; LUNG BLOOD VESSEL; LUNG EMPHYSEMA; MORPHOGENESIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; EPITHELIAL CELLS; HEPATOCYTE GROWTH FACTOR; HOMEOSTASIS; MICE; MORPHOGENESIS; PROTO-ONCOGENE PROTEINS C-MET; PULMONARY ALVEOLI; PULMONARY EMPHYSEMA; SIGNAL TRANSDUCTION; TISSUE SURVIVAL;

EID: 84874786848     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003228     Document Type: Article

References (48)

1. Burri PH, (2006) Structural aspects of postnatal lung development- alveolar formation and growth. Biol Neonate 89: 313-322.
2. Mechanisms and limits of induced postnatal lung growth. Am J Respir Crit Care Med 170: 319-343.
3. Ware LB, Matthay MA, (2002) Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Am J Physiol Lung Cell Mol Physiol 282: L924-940.
4. Stoker M, Gherardi E, Perryman M, Gray J, (1987) Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327: 239-242.
5. Mason RJ, (2002) Hepatocyte growth factor: the key to alveolar septation? Am J Respir Cell Mol Biol 26: 517-520.
6. Zhang YW, Vande Woude GF, (2003) HGF/SF-met signaling in the control of branching morphogenesis and invasion. J Cell Biochem 88: 408-417.
7. Sakamaki Y, Matsumoto K, Mizuno S, Miyoshi S, Matsuda H, et al. (2002) Hepatocyte growth factor stimulates proliferation of respiratory epithelial cells during postpneumonectomy compensatory lung growth in mice. Am J Respir Cell Mol Biol 26: 525-533.
8. Ohmichi H, Matsumoto K, Nakamura T, (1996) In vivo mitogenic action of HGF on lung epithelial cells: pulmotrophic role in lung regeneration. Am J Physiol 270: L1031-1039.
9. Gazdhar A, Fachinger P, van Leer C, Pierog J, Gugger M, et al. (2007) Gene transfer of hepatocyte growth factor by electroporation reduces bleomycin-induced lung fibrosis. Am J Physiol Lung Cell Mol Physiol 292: L529-536.
10. Yamamoto H, Yun EJ, Gerber HP, Ferrara N, Whitsett JA, et al. (2007) Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol 308: 44-53.
11. Perl AK, Tichelaar JW, Whitsett JA, (2002) Conditional gene expression in the respiratory epithelium of the mouse. Transgenic Res 11: 21-29.
12. Huh CG, Factor VM, Sanchez A, Uchida K, Conner EA, et al. (2004) Hepatocyte growth factor/Met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A 101: 4477-4482.
13. Borowiak M, Garratt AN, Wustefeld T, Strehle M, Trautwein C, et al. (2004) Met provides essential signals for liver regeneration. Proc Natl Acad Sci U S A 101: 10608-10613.
14. Crepaldi T, Gautreau A, Comoglio PM, Louvard D, Arpin M, (1997) Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells. J Cell Biol 138: 423-434.
15. Ridley AJ, Comoglio PM, Hall A, (1995) Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol Cell Biol 15: 1110-1122.
16. Mason RJ, Leslie CC, McCormick-Shannon K, Deterding RR, Nakamura T, et al. (1994) Hepatocyte growth factor is a growth factor for rat alveolar type II cells. Am J Respir Cell Mol Biol 11: 561-567.
17. Shiratori M, Michalopoulos G, Shinozuka H, Singh G, Ogasawara H, et al. (1995) Hepatocyte growth factor stimulates DNA synthesis in alveolar epithelial type II cells in vitro. Am J Respir Cell Mol Biol 12: 171-180.
18. Martorana PA, van Even P, Gardi C, Lungarella G, (1989) A 16-month study of the development of genetic emphysema in tight-skin mice. Am Rev Respir Dis 139: 226-232.
19. Podowski M, Calvi CL, Cheadle C, Tuder RM, Biswals S, et al. (2009) Complex integration of matrix, oxidative stress, and apoptosis in genetic emphysema. Am J Pathol 175: 84-96.
20. Trusolino L, Bertotti A, Comoglio PM, (2010) MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol 11: 834-848.
21. Liu Y, (2004) Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action. Am J Physiol Renal Physiol 287: F7-16.
22. Kim WH, Matsumoto K, Bessho K, Nakamura T, (2005) Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol 166: 1017-1028.
23. Hojo S, Fujita J, Yoshinouchi T, Yamanouchi H, Kamei T, et al. (1997) Hepatocyte growth factor and neutrophil elastase in idiopathic pulmonary fibrosis. Respir Med 91: 511-516.
24. Dohi M, Hasegawa T, Yamamoto K, Marshall BC, (2000) Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis. Am J Respir Crit Care Med 162: 2302-2307.
25. Liu Y, (2002) Hepatocyte growth factor and the kidney. Curr Opin Nephrol Hypertens 11: 23-30.
26. Yaekashiwa M, Nakayama S, Ohnuma K, Sakai T, Abe T, et al. (1997) Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study. Am J Respir Crit Care Med 156: 1937-1944.
27. Panos RJ, Rubin JS, Csaky KG, Aaronson SA, Mason RJ, (1993) Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium. J Clin Invest 92: 969-977.
28. Sakon M, Kita Y, Yoshida T, Umeshita K, Gotoh M, et al. (1996) Plasma hepatocyte growth factor levels are increased in systemic inflammatory response syndrome. Surg Today 26: 236-241.
29. Sekine K, Fujishima S, Aikawa N, (2004) Plasma hepatocyte growth factor is increased in early-phase sepsis. J Infect Chemother 10: 110-114.
30. Plantier L, Marchand-Adam S, Marchal-Somme J, Leseche G, Fournier M, et al. (2005) Defect of hepatocyte growth factor production by fibroblasts in human pulmonary emphysema. Am J Physiol Lung Cell Mol Physiol 288: L641-647.
31. Bonay M, Boutten A, Lecon-Malas V, Marchal J, Soler P, et al. (2005) Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema. BMC Pulm Med 5: 13.
32. Jaffre S, Dehoux M, Paugam C, Grenier A, Chollet-Martin S, et al. (2002) Hepatocyte growth factor is produced by blood and alveolar neutrophils in acute respiratory failure. Am J Physiol Lung Cell Mol Physiol 282: L310-315.
33. Lassus P, Heikkila P, Andersson LC, von Boguslawski K, Andersson S, (2003) Lower concentration of pulmonary hepatocyte growth factor is associated with more severe lung disease in preterm infants. J Pediatr 143: 199-202.
34. Miettinen PJ, Warburton D, Bu D, Zhao JS, Berger JE, et al. (1997) Impaired lung branching morphogenesis in the absence of functional EGF receptor. Dev Biol 186: 224-236.
35. Bostrom H, Gritli-Linde A, Betsholtz C, (2002) PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev Dyn 223: 155-162.
36. Min H, Danilenko DM, Scully SA, Bolon B, Ring BD, et al. (1998) Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev 12: 3156-3161.
37. Ingram JL, Bonner JC, (2006) EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseases. Curr Mol Med 6: 409-421.
38. Papaioannou AI, Kostikas K, Kollia P, Gourgoulianis KI, (2006) Clinical implications for vascular endothelial growth factor in the lung: friend or foe? Respir Res 7: 128.
39. Yi ES, Williams ST, Lee H, Malicki DM, Chin EM, et al. (1996) Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. Am J Pathol 149: 1963-1970.
40. Simonet WS, DeRose ML, Bucay N, Nguyen HQ, Wert SE, et al. (1995) Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung. Proc Natl Acad Sci U S A 92: 12461-12465.
41. Ray P, (2005) Protection of epithelial cells by keratinocyte growth factor signaling. Proc Am Thorac Soc 2: 221-225.
42. Cramer A, Kleiner S, Westermann M, Meissner A, Lange A, et al. (2005) Activation of the Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3. J Cell Biochem 95: 805-816.
43. Hokuto I, Ikegami M, Yoshida M, Takeda K, Akira S, et al. (2004) Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest 113: 28-37.
44. Lian X, Qin Y, Hossain SA, Yang L, White A, et al. (2005) Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury. J Immunol 174: 7250-7256.
45. Lu Y, Parkyn L, Otterbein LE, Kureishi Y, Walsh K, et al. (2001) Activated Akt protects the lung from oxidant-induced injury and delays death of mice. J Exp Med 193: 545-549.
46. Alphonse RS, Vadivel A, Coltan L, Eaton F, Barr AJ, et al. Activation of Akt protects alveoli from neonatal oxygen-induced lung injury. Am J Respir Cell Mol Biol 44: 146-154.
47. Togo S, Sugiura H, Nelson A, Kobayashi T, Wang X, et al. Hepatic growth factor (HGF) inhibits cigarette smoke extract induced apoptosis in human bronchial epithelial cells. Exp Cell Res 316: 3501-3511.
48. Denton CP, Zheng B, Shiwen X, Zhang Z, Bou-Gharios G, et al. (2001) Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice. Arthritis Rheum 44: 712-722.