Vitamin D deficiency is associated with atherosclerosis-promoting risk factor clustering but not vascular damage in children

Medical Science Monitor

Volumn 18, Issue 12, 2012, Pages

  Cheraghi, Nikoo ^a   Dai, Hongying ^b   Raghuveer, Geetha ^b  

^a UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN S MERCY HOSPITAL   (United States)

Author keywords

Cardiovascular; Children; Lipids; Obesity; Vitamin D

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL; VITAMIN D;

ADOLESCENT; ARTERIAL WALL THICKNESS; ARTERY COMPLIANCE; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOMETABOLIC RISK; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; HEART DILATATION; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; TOBACCO SMOKE; VEIN COMPLIANCE; VITAMIN D DEFICIENCY;

ADOLESCENT; ATHEROSCLEROSIS; CAROTID ARTERIES; CAROTID INTIMA-MEDIA THICKNESS; CHILD; DEMOGRAPHY; FEMALE; HUMANS; MALE; MISSOURI; RISK FACTORS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84874784315     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.883593     Document Type: Article

References (38)

1. Ross AC, Taylor CL, Yaktine AL, Del Valle H (eds.): Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Institute of Medicine. Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academies Press, 2010
2. National Center for Health Statistics: National Health and Nutrition Examination Survey, 2001-2006. Available at: http://www.cdc.gov/nchs/ nhanes/nhanes_questionnaires.htm. Accessed June 9, 2011
3. Kenrick J, Targher G, Smits G, Chonchol M: 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis, 2009; 205: 255-60
4. Wang TJ, Pencina MJ, Booth SL et al: Vitamin D deficiency and risk of cardiovascular disease. Circulation, 2008; 117(4): 503-11
5. Giovannucci E, Liu Y, Hollis BW, Rimm EB: 25-hydroxyvitamin D and risk of myocardial infarction in med. Arch Intern Med, 2008; 168(11): 1174-80
6. Hu P, Hu B, Wang J et al: Modulation of vitamin D signaling is a potential therapeutic target to lower cardiovascular risk in chronic kidney disease. Med Sci Monit, 2011; 17(6): HY14-20
7. Melamed ML, Michos ED, Post W, Astor B: 25-hydroxyvitamin D levels and risk of mortality in general population. Arch Intern Med, 2008; 168(15): 1629-37
8. Wang L, Manson JE, Song Y, Sesso HD: Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events. Ann Intern Med, 2010; 152(5): 315-23
9. Chiu KC, Chu A, Go VL, Saad MF: Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr, 2004; 79: 820-25
10. Cigolini M, Iagulli MP, Miconi V et al: Serum 25-Hydroxyvitamin D3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients. Clin Endocrinol, 2006; 65: 593-97
11. Targher G, Bertolini L, Padovani R et al: Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol, 2006; 65: 593-97
12. Zittermann A, Schleithoff SS, Tenderich G et al: Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol, 2003; 41: 105-12
13. de Boer IH, Ioannou GN, Kestenbaum B et al: 25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III). Am J Kidney Dis, 2007; 50: 69-77
14. Chonchol M, Scragg R: 25-Hydroxyvitamin D, insulin resistance, and kidney function in Third National Health and Nutrition Examination Survey. Kidney Int, 2007; 71: 134-39
15. Kumar J, Muntner P, Kaskel FJ et al: Prevalence and Associations of 25-Hydroxyvitamin D deficiency in US children: NHANES 2001-2004. Pediatrics, 2009; 124(3): e362-70
16. Reis J, von Muhlen D, Miller E et al: Vitamin D Status and Cardiometabolic Risk Factors in the United States Adolescent Population. Pediatrics, 2009; 124(3): e371-79
17. Sacheck J, Goodman E, Chui K et al: Vitamin D deficiency, adiposity, and cardiometabolic risk in urban schoolchildren. J Pediatr, 2011; 159(6): 945-50
18. London GM, Guérin AP, Verbeke FH et al: Mineral metabolism and arterial functions in end-stage renal disease: potential role of 25-hydroxyvitamin D deficiency. J Am Soc Nephrol, 2007; 18(2): 613-20
19. Sugden JA, Davies JI, Witham MD et al: Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabet Med Mar, 2008; 25(3): 320-25
20. Choi AI, Lo JC, Mulligan K et al: Association of Vitamin D Insufficiency with Carotid Intima-Media Thickness in HIV-Infected Persons. Clin Infect Dis, 2011; 52(7): 941-44
21. Pacifico L, Anania C, Osborn JF et al: Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents. Eur J Endocrinol, 2011; 165(4): 603-11
22. Shroff R, Egerton M, Bridel M et al: A bimodal association of vitamin D levels and vascular disease in children on dialysis. J Am Soc Nephrol, 2008; 19(6): 1239-46
23. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics, 2004; 114: 555-76
24. Le J, Zhang D, Menees S et al: "Vascular age" is advanced in children with atherosclerosis-promoting risk factors. Circ Cardiovasc Imaging, 2010; 3(1): 8-14
25. Menees S, Zhang D, Le J et al: Variations in carotid artery intima-media thickness during the cardiac cycle in children. J Am Soc Echocardiogr, 2010; 23(1): 58-63
26. Juonala M, Jarvisalo M, Maki-Torkko N et al: Risk Factors Identified in Childhood and Decreased Carotid Artery Elasticity in Adulthood: The cardiovascular risk in young Finns study. Circulation, 2005; 112(10): 1486-93
27. Wagner C, Greer F, and the Section on Breastfeeding and Committee on Nutrition: Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics, 2008; 122: 142-52
28. Auwerx J, Boullon R, Kesteloot H: Relation between 25-hydroxyvitamin D3, apolipoprotein A-1, and high density lipoprotein cholesterol. Arterioscler Thromb, 1992; 12(6): 671-74
29. Carbone LD, Rosenberg EW, Tolley EA et al: 25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation. Metabolism, 2008; 57(6): 741-48
30. Querfeld U, Hoffmann MM, Klaus G et al: Antagonistic effects of vitamin D and parathyroid hormone on lipoprotein lipase in cultured adipocytes. J Am Soc Nephrol, 1999; 10(10): 2158-64
31. Li YC, Qiao G, Uskokovic M et al: Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. J Steroid Biochem Mol Biol, 2004; 89-90(1-5): 387-92
32. Li YC, Kong J, Wei M et al: 1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest, 2002; 110: 229-38
33. Tai K, Need AG, Horowitz M, Chapman IM: Vitamin D, glucose, insulin, and insulin sensitivity. Nutrition, 2008; 24(3): 279-85
34. Alemzadeh R, Kichler J, Babar G, Calhoun M: Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism, 2008; 57(2): 183-91
35. Wortsman J, Matsuoka LY, Chen TC et al: Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr, 2000; 72(3): 690-93
36. Rajakumar K, Fernstrom JD, Holick MF et al: Vitamin D status and response to vitamin D(3) in obese vs non-obese African American children. Obesity (Silver Spring), 2008; 16(1): 90-95
37. Chen TC, Chimeh F, Lu Z et al: Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Arch Biochem Biophys, 2007; 460(2): 213-17
38. Clemens TL, Adams JS, Henderson SL, Holick MF: Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet, 1982; 1(8263): 74-76