-
1
-
-
61749086821
-
Transforming growth factor-beta1 increases cell migration and beta1 integrin up-regulation in human lung cancer cells
-
Fong, Y.C. et al. (2009) Transforming growth factor-beta1 increases cell migration and beta1 integrin up-regulation in human lung cancer cells. Lung Cancer, 64, 13-21.
-
(2009)
Lung Cancer
, vol.64
, pp. 13-21
-
-
Fong, Y.C.1
-
2
-
-
77955876787
-
Lung cancer progression and metastasis from the prognostic point of view
-
Inamura, K. et al. (2010) Lung cancer progression and metastasis from the prognostic point of view. Clin. Exp. Metastasis, 27, 389-397.
-
(2010)
Clin. Exp. Metastasis
, vol.27
, pp. 389-397
-
-
Inamura, K.1
-
3
-
-
41349099104
-
Cancer statistics, 2008
-
Jemal, A. et al. (2008) Cancer statistics, 2008. CA. Cancer J. Clin., 58, 71-96.
-
(2008)
CA. Cancer J. Clin.
, vol.58
, pp. 71-96
-
-
Jemal, A.1
-
4
-
-
67649399255
-
Management and prognosis in synchronous solitary resected brain metastasis from non-small-cell lung cancer
-
Louie, A.V. et al. (2009) Management and prognosis in synchronous solitary resected brain metastasis from non-small-cell lung cancer. Clin. Lung Cancer, 10, 174-179.
-
(2009)
Clin. Lung Cancer
, vol.10
, pp. 174-179
-
-
Louie, A.V.1
-
5
-
-
34247614402
-
Stage IA non-small cell lung cancer: vessel invasion is a poor prognostic factor and a new target of adjuvant chemotherapy
-
Tsuchiya, T. et al. (2007) Stage IA non-small cell lung cancer: vessel invasion is a poor prognostic factor and a new target of adjuvant chemotherapy. Lung Cancer, 56, 341-348.
-
(2007)
Lung Cancer
, vol.56
, pp. 341-348
-
-
Tsuchiya, T.1
-
6
-
-
80051543457
-
The number of lymph node metastases as a prognostic factor in patients with N1 non-small cell lung cancer
-
Jonnalagadda, S. et al. (2011) The number of lymph node metastases as a prognostic factor in patients with N1 non-small cell lung cancer. Chest, 140, 433-440.
-
(2011)
Chest
, vol.140
, pp. 433-440
-
-
Jonnalagadda, S.1
-
7
-
-
0033791318
-
Cyclooxygenases: structural, cellular, and molecular biology
-
Smith, W.L. et al. (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu. Rev. Biochem., 69, 145-182.
-
(2000)
Annu. Rev. Biochem.
, vol.69
, pp. 145-182
-
-
Smith, W.L.1
-
8
-
-
76149142776
-
Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance
-
Lim, B.J. et al. (2010) Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance. Mol. Med. Report., 3, 43-49.
-
(2010)
Mol. Med. Report.
, vol.3
, pp. 43-49
-
-
Lim, B.J.1
-
9
-
-
34247111804
-
Significance of cyclooxygenase-2 in prognosis, targeted therapy and chemoprevention of NSCLC
-
Lee, J.M. et al. (2007) Significance of cyclooxygenase-2 in prognosis, targeted therapy and chemoprevention of NSCLC. Future Oncol., 3, 149-153.
-
(2007)
Future Oncol
, vol.3
, pp. 149-153
-
-
Lee, J.M.1
-
10
-
-
74549155020
-
Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers
-
Jang, T.J. et al. (2009) Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers. Yonsei Med. J., 50, 818-824.
-
(2009)
Yonsei Med. J.
, vol.50
, pp. 818-824
-
-
Jang, T.J.1
-
11
-
-
70349165716
-
Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic
-
Voulgari, A. et al. (2009) Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim. Biophys. Acta, 1796, 75-90.
-
(2009)
Biochim. Biophys. Acta
, vol.1796
, pp. 75-90
-
-
Voulgari, A.1
-
12
-
-
82355185942
-
Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways
-
Ogunwobi, O.O. et al. (2011) Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways. Clin. Exp. Metastasis, 28, 721-731.
-
(2011)
Clin. Exp. Metastasis
, vol.28
, pp. 721-731
-
-
Ogunwobi, O.O.1
-
13
-
-
56049089380
-
Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms
-
Neil, J.R. et al. (2008) Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms. Carcinogenesis, 29, 2227-2235.
-
(2008)
Carcinogenesis
, vol.29
, pp. 2227-2235
-
-
Neil, J.R.1
-
14
-
-
34247882824
-
Phase II study of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory non-small cell lung cancer (NSCLC)
-
Gadgeel, S.M. et al. (2007) Phase II study of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory non-small cell lung cancer (NSCLC). J. Thorac. Oncol., 2, 299-305.
-
(2007)
J. Thorac. Oncol.
, vol.2
, pp. 299-305
-
-
Gadgeel, S.M.1
-
15
-
-
41749124798
-
Gefitinib plus celecoxib in chemotherapy-naïve patients with stage IIIB/IV non-small cell lung cancer: a phase II study from the Hoosier Oncology Group
-
Agarwala, A. et al. (2008) Gefitinib plus celecoxib in chemotherapy-naïve patients with stage IIIB/IV non-small cell lung cancer: a phase II study from the Hoosier Oncology Group. J. Thorac. Oncol., 3, 374-379.
-
(2008)
J. Thorac. Oncol.
, vol.3
, pp. 374-379
-
-
Agarwala, A.1
-
16
-
-
79958788120
-
Effect of celecoxib on survival in patients with advanced non-small cell lung cancer: a double blind randomised clinical phase III trial (CYCLUS study) by the Swedish Lung Cancer Study Group
-
Swedish Lung Cancer Study Group
-
Koch, A. et al.; Swedish Lung Cancer Study Group. (2011) Effect of celecoxib on survival in patients with advanced non-small cell lung cancer: a double blind randomised clinical phase III trial (CYCLUS study) by the Swedish Lung Cancer Study Group. Eur. J. Cancer, 47, 1546-1555.
-
(2011)
Eur. J. Cancer
, vol.47
, pp. 1546-1555
-
-
Koch, A.1
-
17
-
-
81855166106
-
The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma
-
Ai, J. et al. (2011) The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma. J. Natl. Cancer Inst., 103, 1696-1712.
-
(2011)
J. Natl. Cancer Inst.
, vol.103
, pp. 1696-1712
-
-
Ai, J.1
-
18
-
-
26244458018
-
TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
-
Kasai, H. et al. (2005) TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir. Res., 6, 56.
-
(2005)
Respir. Res.
, vol.6
, pp. 56
-
-
Kasai, H.1
-
19
-
-
77950931419
-
Matrix metalloproteinases: regulators of the tumor microenvironment
-
Kessenbrock, K. et al. (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell, 141, 52-67.
-
(2010)
Cell
, vol.141
, pp. 52-67
-
-
Kessenbrock, K.1
-
20
-
-
79951996444
-
Celecoxib antagonizes the cytotoxicity of cisplatin in human esophageal squamous cell carcinoma cells by reducing intracellular cisplatin accumulation
-
Yu, L. et al. (2011) Celecoxib antagonizes the cytotoxicity of cisplatin in human esophageal squamous cell carcinoma cells by reducing intracellular cisplatin accumulation. Mol. Pharmacol., 79, 608-617.
-
(2011)
Mol. Pharmacol.
, vol.79
, pp. 608-617
-
-
Yu, L.1
-
21
-
-
39049146231
-
Cyclooxygenase-2 expression during immortalization and breast cancer progression
-
Zhao, X. et al. (2008) Cyclooxygenase-2 expression during immortalization and breast cancer progression. Cancer Res., 68, 467-475.
-
(2008)
Cancer Res
, vol.68
, pp. 467-475
-
-
Zhao, X.1
-
22
-
-
0036857487
-
Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines
-
Noda, M. et al. (2002) Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines. J. Gastroenterol., 37, 896-904.
-
(2002)
J. Gastroenterol.
, vol.37
, pp. 896-904
-
-
Noda, M.1
-
23
-
-
38649142798
-
Etodolac, a selective cyclooxygenase-2 inhibitor, induces upregulation of E-cadherin and has antitumor effect on human bladder cancer cells in vitro and in vivo
-
Okamoto, A. et al. (2008) Etodolac, a selective cyclooxygenase-2 inhibitor, induces upregulation of E-cadherin and has antitumor effect on human bladder cancer cells in vitro and in vivo. Urology, 71, 156-160.
-
(2008)
Urology
, vol.71
, pp. 156-160
-
-
Okamoto, A.1
-
24
-
-
80255125999
-
Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition-independent effect
-
Kato, T. et al. (2011) Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition-independent effect. Biochem. Pharmacol., 82, 1781-1791.
-
(2011)
Biochem. Pharmacol.
, vol.82
, pp. 1781-1791
-
-
Kato, T.1
-
25
-
-
42249111036
-
The potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced non-small cell lung cancer patients treated with erlotinib and celecoxib
-
Fidler, M.J. et al. (2008) The potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced non-small cell lung cancer patients treated with erlotinib and celecoxib. Clin. Cancer Res., 14, 2088-2094.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 2088-2094
-
-
Fidler, M.J.1
-
26
-
-
44849110459
-
Impact of celecoxib on capecitabine tolerability and activity in pretreated metastatic breast cancer: results of a phase II study with biomarker evaluation
-
Fabi, A. et al. (2008) Impact of celecoxib on capecitabine tolerability and activity in pretreated metastatic breast cancer: results of a phase II study with biomarker evaluation. Cancer Chemother. Pharmacol., 62, 717-725.
-
(2008)
Cancer Chemother. Pharmacol.
, vol.62
, pp. 717-725
-
-
Fabi, A.1
-
27
-
-
31544455868
-
Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma
-
Rini, B.I. et al. (2006) Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma. Cancer, 106, 566-575.
-
(2006)
Cancer
, vol.106
, pp. 566-575
-
-
Rini, B.I.1
-
28
-
-
39749149266
-
Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy-Cancer and Leukemia Group B Trial 30203
-
Edelman, M.J. et al. (2008) Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy-Cancer and Leukemia Group B Trial 30203. J. Clin. Oncol., 26, 848-855.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 848-855
-
-
Edelman, M.J.1
-
29
-
-
77956419985
-
Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines
-
Park, S.W. et al. (2010) Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines. Anticancer. Drugs, 21, 823-830.
-
(2010)
Anticancer. Drugs
, vol.21
, pp. 823-830
-
-
Park, S.W.1
-
30
-
-
80053345756
-
Celecoxib promotes c-FLIP degradation through Aktindependent inhibition of GSK3
-
Chen, S. et al. (2011) Celecoxib promotes c-FLIP degradation through Aktindependent inhibition of GSK3. Cancer Res., 71, 6270-6281.
-
(2011)
Cancer Res
, vol.71
, pp. 6270-6281
-
-
Chen, S.1
-
31
-
-
70449574594
-
Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention
-
Guruswamy, S. et al. (2009) Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention. Int. J. Oncol., 35, 1037-1043.
-
(2009)
Int. J. Oncol.
, vol.35
, pp. 1037-1043
-
-
Guruswamy, S.1
-
32
-
-
77954931806
-
Activated PI3K/Akt/COX-2 pathway induces resistance to radiation in human cervical cancer HeLa cells
-
Xia, S. et al. (2010) Activated PI3K/Akt/COX-2 pathway induces resistance to radiation in human cervical cancer HeLa cells. Cancer Biother. Radiopharm., 25, 317-323.
-
(2010)
Cancer Biother. Radiopharm.
, vol.25
, pp. 317-323
-
-
Xia, S.1
-
33
-
-
0035403764
-
Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB
-
Niederberger, E. et al. (2001) Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB. FASEB J., 15, 1622-1624.
-
(2001)
FASEB J
, vol.15
, pp. 1622-1624
-
-
Niederberger, E.1
-
34
-
-
79958026380
-
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
-
Mendoza, M.C. et al. (2011) The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends Biochem. Sci., 36, 320-328.
-
(2011)
Trends Biochem. Sci.
, vol.36
, pp. 320-328
-
-
Mendoza, M.C.1
-
35
-
-
0037205479
-
ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase
-
Yu, C.F. et al. (2002) ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase. J. Biol. Chem., 277, 19382-19388.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 19382-19388
-
-
Yu, C.F.1
-
36
-
-
70349513280
-
Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells
-
Yoon, Y.K. et al. (2009) Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells. Mol. Cancer Ther., 8, 2526-2536.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2526-2536
-
-
Yoon, Y.K.1
-
37
-
-
77951658161
-
KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach
-
Yoon, Y.K. et al. (2010) KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach. Mol. Carcinog., 49, 353-362.
-
(2010)
Mol. Carcinog.
, vol.49
, pp. 353-362
-
-
Yoon, Y.K.1
-
38
-
-
0037163050
-
Regulation of Raf-Akt Cross-talk
-
Moelling, K. et al. (2002) Regulation of Raf-Akt Cross-talk. J. Biol. Chem., 277, 31099-31106.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 31099-31106
-
-
Moelling, K.1
|