Virus Neutralisation: New Insights from Kinetic Neutralisation Curves

PLoS Computational Biology

Volumn 9, Issue 2, 2013, Pages

  Magnus, Carsten ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

KINETICS; STOICHIOMETRY; VIRUSES;

ANTIBODY BINDING; BINDING KINETICS; CHEMICAL BINDING; CONCEPTUAL APPROACHES; HUMAN IMMUNODEFICIENCY VIRUS; MULTI-HIT; NEUTRALISATION; VIRUS NEUTRALIZATION;

ANTIBODIES;

VIRUS ANTIBODY; VIRUS PROTEIN;

ANALYTICAL PARAMETERS; ANTIGEN ANTIBODY REACTION; ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS; INFLUENZA VIRUS A; MICROBIAL KINETICS; NONHUMAN; SPECIES DIFFERENTIATION; STATISTICAL ANALYSIS; STOICHIOMETRY; VIRION; VIROLOGY; VIRUS NEUTRALIZATION;

EID: 84874764264     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002900     Document Type: Article

References (36)

1. Dulbecco R, Vogt M, (1954) Plaque formation and isolation of pure lines with poliomyelitis viruses. J Exp Med 99: 167-182.
2. Dulbecco R, Vogt M, Strickland A, (1956) A Study of the Basic Aspects of Neutralization of 2 Animal Viruses, Western Equine Encephalitis Virus and Poliomyelitis Virus. Virology 2: 162-205.
3. Della-Porta AJ, Westaway EG, (1977) A multi-hit model for the neutralization of animal viruses. Journal of General Virology 38: 1-19.
4. Dimmock N, (1984) Mechanisms of neutralization of animal viruses. J Gen Virol 65: 1015-1022.
5. McLain L, Dimmock N, (1994) Single-hit and multi-hit kinetics of immunoglobulin-g neutralization of human-immunodeficiency-virus type-1 by monoclonal-antibodies. Journal of general virology 75: 1457-1460.
6. Klasse PJ, Sattentau QJ, (2002) Occupancy and mechanism in antibody-mediated neutralization of animal viruses. Journal of General Virology 83: 2091-108.
7. Sougrat R, Bartesaghi A, Lifson JD, Bennett AE, Bess JW, et al. (2007) Electron tomography of the contact between T Cells and SIV/HIV-1: Implications for viral entry. PLoS Pathogens 3: 1-11.
8. Robey W, Safai B, Oroszlan S, Arthur L, Gonda M, et al. (1985) Characterization of envelope and core structural gene-products of HTLV-III with sera from AIDS patients. Science 228: 593-595.
9. Veronese F, Devico A, Copeland T, Oroszlan S, Gallo R, et al. (1985) Characterization of gp41 as the transmembrane protein coded by the HTLV-III/LAV envelope gene. Science 229: 1402-1405.
10. Wyatt R, Sodroski J, (1998) The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens. Science 280: 1884-1888.
11. Klatzmann D, Champagne E, Chamaret S, Gruest J, Guetard D, et al. (1984) T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 312: 767-768.
12. Sattentau Q, Moore J, (1991) Conformational-changes induced in the human-immunodeficiency-virus envelope glycoprotein by soluble cd4 binding. Journal of experimental medicine 174: 407-415.
13. Earp L, Delos S, Park H, White J, (2004) The many mechanisms of viral membrane fusion proteins. Curr Top Microbiol 285: 25-66.
14. Burton DR, Desrosiers RC, Doms RW, Koff WC, Kwong PD, et al. (2004) HIV vaccine design and the neutralizing antibody problem. Nat Immunol 5: 233-236.
15. Hedestam GBK, Fouchier RAM, Phogat S, Burton DR, Sodroski J, et al. (2008) The challenges of eliciting neutralizing antibodies to HIV-1 and to inuenza virus. Nature Reviews Microbiology 6: 143-155.
16. Schonning K, Lund O, Lund OS, Hansen JES, (1999) Stoichiometry of monoclonal antibody neutralization of T-cell line-adapted human immunodeficiency virus type 1. Journal of Virology pp. 8364-8370.
17. Yang X, Kurteva S, Lee S, Sodroski J, (2005) Stoichiometry of antibody neutralization of Human Immunodeficiency Virus type 1. Journal of Virology 79: 3500-8.
18. Yang X, Kurteva S, Ren X, Lee S, Sodroski J, (2005) Stoichiometry of envelope glycoprotein trimers in the entry of Human Immunodeficiency Virus type 1. Journal of Virology 79: 12132-47.
19. Klasse PJ, (2007) Modeling how many envelope glycoprotein trimers per virion participate in human immunodeficiency virus infectivity and its neutralization by antibody. Virology 369: 245-262.
20. Magnus C, Rusert P, Bonhoeffer S, Trkola A, Regoes RR, (2009) Estimating the stoichiometry of human immunodeficiency virus entry. Journal of Virology 83: 1523-1531.
21. Magnus C, Regoes RR, (2010) Estimating the stoichiometry of HIV neutralization. PLoS Comput Biol 6: e1000713.
22. Magnus C, Regoes R, (2011) Restricted occupancy models for neutralization of HIV virions and populations. Journal of Theoretical Biology 283: 192-202.
23. Klein JS, Gnanapragasam PNP, Galimidi RP, Foglesong CP, West AP, et al. (2009) Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10. Proceedings Of The National Academy Of Sciences Of The United States Of America 106: 7385.
24. Klein JS, Bjorkman PJ, (2010) Few and far between: how HIV may be evading antibody avidity. PLoS Pathogens 6: e1000908.
25. Atkins P, de Paula J, (2006) Atkins' Physical Chemistry. Eighth Edition. Oxford University Press.
26. Zhu P, Liu J, Bess J Jr, Chertova E, Lifson JD, et al. (2006) Distribution and three-dimensional structure of AIDS virus envelope spikes. Nature 441: 847-52.
27. R Development Core Team (2011) R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing. Available: http://www.R-project.org/. ISBN 3-900051-07-0.
28. Mason D, Williams A, (1980) The kinetics of antibody binding to membrane antigens in solution and at the cell surface. Biochemical Journal 187: 1-20.
29. Thorley JA, McKeating JA, Rappoport JZ, (2010) Mechanisms of viral entry: sneaking in the front door. Protoplasma 244: 15-24.
30. Yamaguchi M, Danev R, Nishiyama K, Sugawara K, Nagayama K, (2008) Zernike phase contrast electron microscopy of ice-embedded inuenza A virus. Journal Of Structural Biology 162: 271-276.
31. Bizebard T, Gigant B, Rigolet P, Rasmussen B, Diat O, et al. (1995) Structure of inuenza-virus hemagglutinin complexed with a neutralizing antibody. Nature 376: 92-94.
32. Skehel JJ, Wiley DC, (2000) Receptor binding and membrane fusion in virus entry: the inuenza hemagglutinin. Annual Review of Biochemistry 69: 531-569.
33. Deleersnyder V, Pillez A, Wychowski C, Blight K, Xu J, et al. (1997) Formation of native hepatitis c virus glycoprotein complexes. Journal of Virology 71: 697-704.
34. OpDeBeeck A, Voisset C, Bartosch B, Ciczora Y, Cocquerel L, et al. (2004) Characterization of functional hepatitis c virus envelope glycoproteins. Journal of Virology 78: 2994-3002.
35. Ruprecht CR, Krarup A, Reynell L, Mann AM, Brandenberg OF, et al. (2011) MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1. Journal Of Experimental Medicine 208: 439-454.
36. Little SJ, Mclean AR, Spina CA, Richman DD, Havlir DV, (1999) Viral dynamics of acute HIV-1 infection. J Exp Med 190: 841-850.