Multiparametric MRI and CT models of infarct Core and favorable penumbral imaging patterns in acute ischemic stroke

Stroke

Volumn 44, Issue 1, 2013, Pages 73-79

  Kidwell, Chelsea S ^a   Wintermark, Max ^b   De Silva, Deidre A ^c   Schaewe, Timothy J ^d   Jahan, Reza ^e   Starkman, Sidney ^e   Jovin, Tudor ^f   Hom, Jason ^g   Jumaa, Mouhammad ^f   Schreier, Jeffrie ^a   Gornbein, Jeffrey ^e   Liebeskind, David S ^d   Alger, Jeffry R ^d   Saver, Jeffrey L ^d  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

computed tomography; diffusion weighted MRI; embolectomy; infarction; magnetic resonance imaging; perfusion weighted MRI; stroke

Indexed keywords

AGED; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC ACCURACY; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RECANALIZATION;

AGED; BRAIN ISCHEMIA; CEREBRAL INFARCTION; COHORT STUDIES; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING; REPRODUCIBILITY OF RESULTS; STROKE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84872093608     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.112.670034     Document Type: Article

References (37)

1. NINDS rt-PA Stroke Group. Tissue plasminogen activator for acute ischemic stroke. New England Journal of Medicine. 1995;333:1581-1587
2. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, et al. Thrombolysis with alteplase 3 to 4. 5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317-1329
3. Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, et al. Association of outcome with early stroke treatment: Pooled analysis of atlantis, ecass, and ninds rt-pa stroke trials. Lancet. 2004;363:768-774
4. Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet. 2010;375:1695-1703.
5. NINDS t-PA Stroke Study Group. Intracerebral hemorrhage after intravenous t-pa for ischemic stroke. Stroke. 1997;28:2109-2118
6. Wahlgren N, Ahmed N, Eriksson N, Aichner F, Bluhmki E, Dávalos A, et al. Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST). Stroke. 2008;39:3316-3322.
7. Fisher M. Characterizing the target of acute stroke therapy. Stroke. 1997;28:866-872.
8. Albers GW. Expanding the window for thrombolytic therapy in acute stroke. The potential role of acute MRI for patient selection. Stroke. 1999;30:2230-2237.
9. Kidwell CS, Alger JR, Saver JL. Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging. Stroke. 2003;34:2729-2735.
10. Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, et al. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol. 2006;60:508-517.
11. Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, et al. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol. 2008;7:299-309.
12. Marchal G, Benali K, Iglesias S, Viader F, Derlon JM, Baron JC. Voxel-based mapping of irreversible ischaemic damage with PET in acute stroke. Brain. 1999;122 (Pt 12):2387-2400.
13. Fisher M, Albers GW. Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke. Neurology. 1999;52:1750-1756.
14. Wintermark M, Flanders AE, Velthuis B, Meuli R, van Leeuwen M, Goldsher D, et al. Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke. 2006;37:979-985.
15. Jovin TG, Yonas H, Gebel JM, Kanal E, Chang YF, Grahovac SZ, et al. The cortical ischemic core and not the consistently present penumbra is a determinant of clinical outcome in acute middle cerebral artery occlusion. Stroke. 2003;34:2426-2433.
16. Lev MH, Segal AZ, Farkas J, Hossain ST, Putman C, Hunter GJ, et al. Utility of perfusion-weighted CT imaging in acute middle cerebral artery stroke treated with intra-arterial thrombolysis: prediction of final infarct volume and clinical outcome. Stroke. 2001;32:2021-2028.
17. Gasparotti R, Grassi M, Mardighian D, Frigerio M, Pavia M, Liserre R, et al. Perfusion CT in patients with acute ischemic stroke treated with intra-arterial thrombolysis: predictive value of infarct core size on clinical outcome. AJNR Am J Neuroradiol. 2009;30:722-727.
18. Nighoghossian N, Hermier M, Adeleine P, Derex L, Dugor JF, Philippeau F, et al. Baseline magnetic resonance imaging parameters and stroke outcome in patients treated by intravenous tissue plasminogen activator. Stroke. 2003;34:458-463.
19. Yoo AJ, Verduzco LA, Schaefer PW, Hirsch JA, Rabinov JD, González RG. MRI-based selection for intra-arterial stroke therapy: value of pretreatment diffusion-weighted imaging lesion volume in selecting patients with acute stroke who will benefit from early recanalization. Stroke. 2009;40:2046-2054.
20. Sobesky J, Zaro Weber O, Lehnhardt FG, Hesselmann V, Neveling M, Jacobs A, et al. Does the mismatch match the penumbra? Magnetic resonance imaging and positron emission tomography in early ischemic stroke. Stroke. 2005;36:980-985.
21. Kakuda W, Lansberg MG, Thijs VN, Kemp SM, Bammer R, Wechsler LR, et al. Optimal definition for PWI/DWI mismatch in acute ischemic stroke patients. J Cereb Blood Flow Metab. 2008;28:887-891.
22. Takasawa M, Jones PS, Guadagno JV, Christensen S, Fryer TD, Harding S, et al. How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET. Stroke. 2008;39:870-877.
23. Shih LC, Saver JL, Alger JR, Starkman S, Leary MC, Vinuela F, Duckwiler G, et al. Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue. Stroke. 2003;34:1425-1430.
24. Guadagno JV, Warburton EA, Jones PS, Fryer TD, Day DJ, Gillard JH, et al. The diffusion-weighted lesion in acute stroke: heterogeneous patterns of flow/metabolism uncoupling as assessed by quantitative positron emission tomography. Cerebrovasc Dis. 2005;19:239-246.
25. Dani KA, Thomas RG, Chappell FM, Shuler K, MacLeod MJ, Muir KW, et al. Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds. Ann Neurol. 2011;70:384-401.
26. Murphy BD, Fox AJ, Lee DH, Sahlas DJ, Black SE, Hogan MJ, et al. Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements. Stroke. 2006;37:1771-1777.
27. Wu O, Koroshetz WJ, Ostergaard L, Buonanno FS, Copen WA, Gonzalez RG, et al. Predicting tissue outcome in acute human cerebral ischemia using combined diffusion-and perfusion-weighted MR imaging. Stroke. 2001;32:933-942.
28. Jacobs MA, Mitsias P, Soltanian-Zadeh H, Santhakumar S, Ghanei A, Hammond R, et al. Multiparametric MRI tissue characterization in clinical stroke with correlation to clinical outcome: part 2. Stroke. 2001;32:950-957.
29. Kidwell CS, Jahan R, Alger JR, Schaewe TJ, Guzy J, Starkman S, et al. Design and rationale of the mechanical retrieval and recanalization of stroke clots using embolectomy (MR RESCUE) trial Int J Stroke. In Press
30. The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings. Timi study group. New England Journal of Medicine. 1985;312:932-936
31. Baird AE, Benfield A, Schlaug G, Siewert B, Lövblad KO, Edelman RR, et al. Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol. 1997;41:581-589.
32. Kidwell CS, Saver JL, Mattiello J, Starkman S, Vinuela F, Duckwiler G, et al. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol. 2000;47:462-469.
33. Chalela JA, Ezzeddine MA, Calabrese TM, Latour LL, Baird AE, Luby ML, et al. Diffusion and perfsuion changes two hours after intravenous RT-PA therapy: a prelminary report. Stroke. 2002;33:356-357
34. Schlaug G, Benfield A, Baird AE, Siewert B, Lövblad KO, Parker RA, et al. The ischemic penumbra: operationally defined by diffusion and perfusion MRI. Neurology. 1999;53:1528-1537.
35. Jacobs MA, Zhang ZG, Knight RA, Soltanian-Zadeh H, Goussev AV, Peck DJ, et al. A model for multiparametric mri tissue characterization in experimental cerebral ischemia with histological validation in rat: part 1. Stroke. 2001;32:943-949.
36. Murphy BD, Fox AJ, Lee DH, Sahlas DJ, Black SE, Hogan MJ, et al. White matter thresholds for ischemic penumbra and infarct core in patients with acute stroke: CT perfusion study. Radiology. 2008;247:818-825.
37. Hacke W, Furlan AJ, Al-Rawi Y, Davalos A, Fiebach JB, Gruber F, et al. Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol. 2009;8:141-150.