Pharmacokinetic interactions between contraceptives and antiepileptic drugs

Seizure

Volumn 17, Issue 2, 2008, Pages 141-144

  Sabers, Anne ^a  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Drug interactions; Epilepsy; Oral contraceptives; Pharmacokinetics

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CYTOCHROME P450; ESTROGEN; ETHINYLESTRADIOL; ETIRACETAM; FELBAMATE; GABAPENTIN; GESTAGEN; GLUCURONOSYLTRANSFERASE; LAMOTRIGINE; LEVONORGESTREL; LIVER ENZYME; MEDROXYPROGESTERONE ACETATE; ORAL CONTRACEPTIVE AGENT; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PROGESTERONE; TIAGABINE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

ARTICLE; DRUG DOSE TITRATION; DRUG EFFECT; DRUG ELIMINATION; DRUG MONITORING; DRUG USE; ENVIRONMENTAL FACTOR; ENZYME BLOOD LEVEL; EPILEPSY; GLUCURONIDATION; HEREDITY; HUMAN; MONOTHERAPY; PRIORITY JOURNAL; RISK; SEIZURE; UNPLANNED PREGNANCY;

ANIMALS; ANTICONVULSANTS; CONTRACEPTIVE AGENTS; DRUG INTERACTIONS; HUMANS;

EID: 38949189278     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seizure.2007.11.012     Document Type: Article

References (28)

1. Shorvon S.D., Tallis R.C., and Wallace H.K. Antiepileptic drugs: coprescription of proconvulsant drugs and oral contraceptives: a national study of antiepileptic drug prescribing practice. J Neurol Neurosurg Psychiatry 72 1 (2002) 114-115
2. Long L., and Montouris G. Knowledge of women's issues and epilepsy (KNOWIE-II): a survey of health care professionals. Epilepsy Behav 6 (2005) 90-93
3. Bell G.S., Nashef L., Kendall S., Solomon J., Poole K., Johnson A.L., et al. Information recalled by women taking antiepileptic drugs for epilepsy: a questionnaire study. Epilepsy Res 52 (2002) 139-146
4. Crawford P., Chadwick D.J., Martin C., Tjia J., Back D.J., and Orme M. The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids. Br J Clin Pharmacol 30 6 (1990) 892-896
5. Saano V., Glue P., Banfield C.R., Reidenberg P., Colucci R.D., Meehan J.W., et al. Effects of felbamate on the pharmacokinetics of low-dose combination oral contraceptive. Clin Pharmacol Ther 58 (1995) 523-531
6. Fattore C., Cipolla G., Gatti G., Limido G.L., Sturm Y., Bernasconi C., et al. Induction of ethinylestradiol and levonorgestrel metabolism by oxcarbazepine in healthy women. Epilepsia 40 6 (1999) 783-787
7. Back D.J., and Orme M.L. Pharmacokinetic drug interactions with oral contraceptives. Clin Pharmacokinet 18 6 (1990) 472-484
8. Rosenfeld W.E., Doose D.R., Walker S.A., and Nayak R.K. Effect of topiramate on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in patients with epilepsy. Epilepsia 38 3 (1997) 317-323
9. Doose D.R., Wang S.-S., Padmanabhan M., Schwarbe S., Jacobs D., and Bialer M. Effect of topiramate or carbamazepine on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in healthy obese and nonobese female subjects. Epilepsia 44 4 (2003) 540-554
10. Tomson T., Svensson J., and Hilton-Brown P. Relationship of intraindividual dose to plasma concentration of carbamazepine: indication of dose-dependent induction of metabolism. Ther Drug Monitor 11 5 (1989) 533-539
11. Eldon M.A., Underwood B.A., Randinitis E.J., and Sedman A.J. Gabapentin does not interact with a contraceptive regiment of norethindrone acetate and ethinyl estradiol. Neurology 50 4 (1998) 1146-1148
12. Rangueneau-Majlessi I., Levy R.H., and Janik F. Levetiracetam does not alter the pharmacokinetics of an oral contraceptive in healthy women. Epilepsia 43 7 (2002) 697-702
13. Mengel H.B., Houston A., and Back D.J. An evaluation of the interaction between tiagabine and oral contraceptives in female volunteers. J Pharmacol Med 4 (1994) 141-150
14. Bartoli A., Gatti G., Cipolla G., Barzaghi N., Veliz G., Fattore C., et al. A double-blind placebo-controlled study on the effect of vigabatrin on in vivo parameters of hepatic microsomal enzyme induction and on the kinetics of steroid oral contraceptives in healthy female volunteers. Epilepsia 36 (1997) 702-707
15. Griffith S.G., and Dai Y. Effect of zonisamide on the pharmacokinetics and pharmacodynamics of combination ethinyl estradiol-norethindrone oral contraceptive in healthy women. Clin Ther 26 12 (2004) 2056-2065
16. Sidhu J., Job S., Singh S., and Philipson R. The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects. Br J Clin Pharmacol 61 2 (2006) 191-199
17. Holdich T., Whiteman P., Orme M., Back D., and Ward S. Effect of lamotrigine on the pharmacology of the combined oral contraceptive pill. Epilepsia 32 Suppl.1 (1991) 96
18. Reimers A., Helde G., and Brodtkorb E. Ethinyl estradiol, not progestogens, reduces lamotrigine serum concentrations. Epilepsia 46 9 (2005) 342-348
19. Sabers A., Ohman I., Christensen J., and Tomson T. Oral contraceptives reduce lamotrigine plasma levels. Neurology 61 4 (2003) 570-571
20. Christensen J., Petrenaite V., Atterman J., Sidenius P., Ohman I., Tomson T., et al. Oral contraceptives induce lamotrigine metabolism: evidence from a double-blind, placebo-controlled trial. Epilepsia 48 3 (2007) 484-489
21. Sabers A., Buchholt J.M., Uldall P., and Hansen E.L. Lamotrigine plasma levels reduced by oral contraceptives. Epilepsy Res 47 1-2 (2001) 151-154
22. Tomson T., Luef G., Sabers A., Pittschieler S., and Öhman I. Valproate effects of kinetics of lamotrigine in pregnancy and treatment with oral contraceptives. Neurology 67 7 (2006) 1297-1299
23. Contin M., Albani F., Ambrosetto G., Avoni P., Bisulli F., Riva R., et al. Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy. Epilepsia 47 9 (2006) 1573-1575
24. Herzog A.G., Farina E.L., and Blum A.S. Serum valproate levels with oral contraceptive use. Epilepsia 46 6 (2005) 970-971
25. Galimberti C.A., Mazzucchelli I., Arbazino C., Canevini M.P., Fattore C., and Perucca E. Increased apparent oral clearance of valproate acid during intake of combined contraceptive steroids in women with epilepsy. Epilepsia 47 9 (2006) 1569-1572
26. Haukkamaa M. Contraception by norplant subdermal capsules is not reliable in epileptic patients on anticonvulsant treatment. Contraception 33 6 (1986) 559-565
27. O'Brien M.D., and Gilmour-White S.K. Management of epilepsy in women. Postgrad Med J 81 (2005) 278-285
28. Bounds W., and Guillebaud J. Observational series on women using the contraceptive mirena concurrently with antiepileptic and other enzyme-inducing drugs. J Fam Plann Reprod Health Care 28 (2002) 78-80