Are plasma biomarkers of immune activation predictive of HIV progression: A longitudinal comparison and analyses in HIV-1 and HIV-2 infections?

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Nyamweya, Samuel ^a   Townend, John ^a   Zaman, Akram ^a,d   Steele, Sarah Jane ^b   Jeffries, David ^a   Rowland Jones, Sarah ^c   Whittle, Hilton ^a   Flanagan, Katie L ^a   Jaye, Assan ^a  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CD4 ANTIGEN; NEOPTERIN; SOLUBLE UROKINASE TYPE PLASMINOGEN ACTIVATOR RECEPTOR; UNCLASSIFIED DRUG; UROKINASE RECEPTOR;

ADULT; ARTICLE; COHORT ANALYSIS; COMPARATIVE STUDY; DISEASE COURSE; FEMALE; FOLLOW UP; GAMBIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS 2 INFECTION; IMMUNITY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MORTALITY; RECEIVER OPERATING CHARACTERISTIC; REGRESSION ANALYSIS; RETROSPECTIVE STUDY; VIRUS LOAD; BLOOD; CD4 LYMPHOCYTE COUNT; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; ISOLATION AND PURIFICATION; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

ADULT; BETA 2-MICROGLOBULIN; BIOLOGICAL MARKERS; CD4 LYMPHOCYTE COUNT; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIV INFECTIONS; HIV-1; HIV-2; HUMANS; LONGITUDINAL STUDIES; MALE; NEOPTERIN; VIRAL LOAD;

EID: 84874732518     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044411     Document Type: Article

References (38)

1. Papagno L, Spina CA, Marchant A, Salio M, Rufer N, et al. (2004) Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol 2: E20.
2. Hazenberg MD, Otto SA, van Benthem BH, Roos MT, Coutinho RA, et al. (2003) Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS 17: 1881-1888.
3. Sousa AE, Carneiro J, Meier-Schellersheim M, Grossman Z, Victorino RM (2002) CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load. J Immunol 169: 3400-3406.
4. Giorgi JV, Hausner MA, Hultin LE (1999) Detailed immunophenotype of CD8+ memory cytotoxic T-lymphocytes (CTL) against HIV-1 with respect to expression of CD45RA/RO, CD62L and CD28 antigens. Immunol Lett 66: 105-110.
5. Giorgi JV, Lyles RH, Matud JL, Yamashita TE, Mellors JW, et al. (2002) Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection. J Acquir Immune Defic Syndr 29: 346-355.
6. Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, et al. (2006) Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 12: 1365-1371.
7. Douek DC, Roederer M, Koup RA (2009) Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med 60: 471-484.
8. Michel P, Balde AT, Roussilhon C, Aribot G, Sarthou JL, et al. (2000) Reduced immune activation and T cell apoptosis in human immunodeficiency virus type 2 compared with type 1: correlation of T cell apoptosis with beta2 microglobulin concentration and disease evolution. J Infect Dis 181: 64-75.
9. Silvestri G, Sodora DL, Koup RA, Paiardini M, O'Neil SP, et al. (2003) Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity 18: 441-452.
10. Hunt PW, Brenchley J, Sinclair E, McCune JM, Roland M, et al. (2008) Relationship between T cell activation and CD4+ T cell count in HIVseropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis 197: 126-133.
11. Kiepiela P, Smith AN, Rosenberg E (2005) Laboratory markers associated with progression of HIV infection. Best Pract Res Clin Obstet Gynaecol 19: 243-254.
12. Piwowar EM, Tugume SB, Grant RM, Lutalo T, Pattishall K, et al. (1995) beta- 2 Microglobulin values among human immunodeficiency virus (HIV)-negative, HIV-positive asymptomatic, and HIV-positive symptomatic Ugandans. Clin Diagn Lab Immunol 2: 236-237.
13. French MA, King MS, Tschampa JM, da Silva BA, Landay AL (2009) Serum immune activation markers are persistently increased in patients with HIV infection after 6 years of antiretroviral therapy despite suppression of viral replication and reconstitution of CD4+ T cells. J Infect Dis 200: 1212-1215.
14. Amirayan-Chevillard N, Tissot-Dupont H, Obadia Y, Gallais H, Mege JL, et al. (2000) Highly active antiretroviral therapy (HAART) and circulating markers of immune activation: specific effect of HAART on neopterin. Clin Diagn Lab Immunol 7: 832-834.
15. Anderson RE, Lang W, Shiboski S, Royce R, Jewell N, et al. (1990) Use of beta 2-microglobulin level and CD4 lymphocyte count to predict development of acquired immunodeficiency syndrome in persons with human immunodeficiency virus infection. Arch Intern Med 150: 73-77.
16. Halota W, Jaruga B, Pawlowska M (2002) [Serum neopterin and beta2- microglobulin concentration as "prognostic markers" of AIDS]. Pol Merkur Lekarski 13: 126-128.
17. Sidenius N, Sier CF, Ullum H, Pedersen BK, Lepri AC, et al. (2000) Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection. Blood 96: 4091-4095.
18. Mildvan D, Spritzler J, Grossberg SE, Fahey JL, Johnston DM, et al. (2005) Serum neopterin, an immune activation marker, independently predicts disease progression in advanced HIV-1 infection. Clin Infect Dis 40: 853-858.
19. Plesner T, Behrendt N, Ploug M (1997) Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR. Stem Cells 15: 398-408.
20. Yilmaz A, Price RW, Spudich S, Fuchs D, Hagberg L, et al. (2008) Persistent intrathecal immune activation in HIV-1-infected individuals on antiretroviral therapy. J Acquir Immune Defic Syndr 47: 168-173.
21. Ostrowski SR, Piironen T, Hoyer-Hansen G, Gerstoft J, Pedersen BK, et al. (2005) High plasma levels of intact and cleaved soluble urokinase receptor reflect immune activation and are independent predictors of mortality in HIV-1- infected patients. J Acquir Immune Defic Syndr 39: 23-31.
22. Chaudhary M, Kashyap B, Gautam H, Saini S, Bhalla P (2008) Use of surrogate markers to predict the HIV disease stage and time to initiate antiretroviral therapy in developing countries. J Int Assoc Physicians AIDS Care (Chic) 7: 259-264.
23. Jaffar S, Van der Loeff MS, Eugen-Olsen J, Vincent T, Sarje-Njie R, et al. (2005) Immunological predictors of survival in HIV type 2-infected rural villagers in Guinea-Bissau. AIDS Res Hum Retroviruses 21: 560-564.
24. Whittle H, Egboga A, Todd J, Corrah T, Wilkins A, et al. (1992) Clinical and laboratory predictors of survival in Gambian patients with symptomatic HIV-1 or HIV-2 infection. AIDS 6: 685-689.
25. Manasa J, Musabaike H, Masimirembwa C, Burke E, Luthy R, et al. (2007) Evaluation of the Partec flow cytometer against the BD FACSCalibur system for monitoring immune responses of human immunodeficiency virus-infected patients in Zimbabwe. Clin Vaccine Immunol 14: 293-298.
26. Mandy FF, Nicholson JK, McDougal JS (2003) Guidelines for performing singleplatform absolute CD4+ T-cell determinations with CD45 gating for persons infected with human immunodeficiency virus. Centers for Disease Control and Prevention. MMWR Recomm Rep 52: 1-13.
27. Hansmann A, Schim van der Loeff MF, Kaye S, Awasana AA, Sarge-Njie R, et al. (2005) Baseline plasma viral load and CD4 cell percentage predict survival in HIV-1- and HIV-2-infected women in a community-based cohort in The Gambia. J Acquir Immune Defic Syndr 38: 335-341.
28. Hightower M, Kallas EG (2003) Diagnosis, antiretroviral therapy, and emergence of resistance to antiretroviral agents in HIV-2 infection: a review. Braz J Infect Dis 7: 7-15.
29. Berry N, Ariyoshi K, Jaffar S, Sabally S, Corrah T, et al. (1998) Low peripheral blood viral HIV-2 RNA in individuals with high CD4 percentage differentiates HIV-2 from HIV-1 infection. J Hum Virol 1: 457-468.
30. Chaudhary M, Kashyap B, Gautam H, Saini S, Bhalla P (2008) Use of surrogate markers to predict the HIV disease stage and time to initiate antiretroviral therapy in developing countries. J Int Assoc Physicians AIDS Care (Chic Ill) 7: 259-264.
31. Nowroozalizadeh S, Mansson F, da Silva Z, Repits J, Dabo B, et al. (2010) Microbial translocation correlates with the severity of both HIV-1 and HIV-2 infections. The Journal of infectious diseases 201: 1150-1154.
32. Leligdowicz A, Feldmann J, Jaye A, Cotten M, Dong T, et al. (2010) Direct relationship between virus load and systemic immune activation in HIV-2 infection. The Journal of infectious diseases 201: 114-122.
33. van der Loeff MF, Larke N, Kaye S, Berry N, Ariyoshi K, et al. (2010) Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village. Retrovirology 7: 46.
34. Ariyoshi K, Jaffar S, Alabi AS, Berry N, Schim van der Loeff M, et al. (2000) Plasma RNA viral load predicts the rate of CD4 T cell decline and death in HIV-2-infected patients in West Africa. AIDS 14: 339-344.
35. Hanson A, Sarr AD, Shea A, Jones N, Mboup S, et al. (2005) Distinct profile of T cell activation in HIV type 2 compared to HIV type 1 infection: differential mechanism for immunoprotection. AIDS Res Hum Retroviruses 21: 791-798.
36. Leligdowicz A, Yindom LM, Onyango C, Sarge-Njie R, Alabi A, et al. (2007) Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection. J Clin Invest 117: 3067-3074.
37. Hodges-Mameletzis I, De Bree GJ, Rowland-Jones SL (2011) An underestimated lentivirus model: what can HIV-2 research contribute to the development of an effective HIV-1 vaccine? Expert Rev Anti Infect Ther 9: 195-206.
38. Zolopa A, Andersen J, Powderly W, Sanchez A, Sanne I, et al. (2009) Early antiretroviral therapy reduces AIDS progression/death in individuals with acute opportunistic infections: a multicenter randomized strategy trial. PLoS One 4: e5575.