Reduced immune activation and T cell apoptosis in human immunodeficiency virus type 2 compared with type 1: Correlation of T cell apoptosis with β2 microglobulin concentration and disease evolution

Journal of Infectious Diseases

Volumn 181, Issue 1, 2000, Pages 64-75

  Michel, Philippe ^a,c   Balde, Aïssatou Toure ^a   Roussilhon, Christian ^a,b   Aribot, Georgette ^a   Sarthou, Jean Louis ^a,d   Gougeon, Marie Lise ^b  

^a INSTITUT PASTEUR DE DAKAR   (Senegal)

^b INSTITUT PASTEUR   (France)

^c CENTRE DE RECHERCHES   (France)

^d INSTITUT PASTEUR DE LA GUYANE   (French Guiana)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; HLA DR ANTIGEN; IMMUNOGLOBULIN G;

ADULT; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNE SYSTEM; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADULT; APOPTOSIS; BETA 2-MICROGLOBULIN; COHORT STUDIES; FEMALE; HIV INFECTIONS; HIV-1; HIV-2; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; SENEGAL; T-LYMPHOCYTES;

EID: 0033972359     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315170     Document Type: Article

References (43)

1. 1. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:123-7.
2. 2. Finkel TH. Tudor-Williams G. Banda, NK, et al. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV-and SIV-infected lymph nodes. Nat Med 1994;2:129-34.
3. ion lymphocytes undergoing apoptosis and activated macrophages in lymph nodes of HIV-1 patients. Am J Pathol 1995;146:1542-55.
4. 4. Muro-Cacho CA. Pantaleo G, Fauci A. Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with the stage of disease or viral burden. J Immunol 1995;154:5555-66.
5. 5. Amendola A, Gougeon ML, Poccia F, Bondurand A, Fesus L. Piacentini M. Induction of tissue transglutaminase in HIV-pathogenesis: evidence for high rate of apoptosis on CD4+ T lymphocytes and accessory cells in lymphoid tissues. Proc Natl Acad Sci USA 1996;93:11057-62.
6. 6. Nagata S. Apoptosis by death factor. Cell 1997;88:355-65.
7. 7. Ameisen JC, Capron A. Cell dysfunction and depletion in AIDS: the program cell death hypothesis. Immunol Today 1991;12:102-5.
8. 8. Gougeon ML, Montagnier L. Apoptosis in AIDS. Science 1993;260:1269-70.
9. 9. Gougeon ML. Does apoptosis contribute to CD4 T cell depletion in HIV infection? Cell Death Differ 1995;2:1-8.
10. 10. Gougeon ML, Olivier R, Garcia S, et al. Demonstration of an engagement process towards cell death by apoptosis in lymphocytes of HIV infected patients. C R Acad Sci III 1991;312:529-37.
11. 11. Meyaard L, Otto SA. Jonker RR, Mijnster MJ, Keet RP. Miedema F. Programmed death of T cells in HIV-1 infection. Science 1992;257:217-9.
12. 12. Gougeon ML, Garcia S. Heeney J. et al. Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res Hum Retroviruses 1993;9: 553-63.
13. 13. Groux H, Torpier G, Monté D. Mouton Y. Capron A, Ameisen JC. Activation-induced death by apoptosis from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 1992;175:331-40.
14. 14. Gougeon ML, Lecoeur H. Dulioust A, et al. PCD in peripheral lymphocytes from HIV-infected persons. The increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. J Immunol 1996;156:3509-20.
15. 15. Heeney J, Jonker J, Koornstra W, et al. The resistance of HIV-infected chimpanzees to progression to AIDS correlates with absence of HIV-related dysfunction. J Med Primatol 1993;22:194-200.
16. 16. Gougeon ML, Lecoeur H. Boudet F, et al. Lack of chronic immune activation in HIV-infected chimpanzees correlates with the resistance of T cells to Fas/Apo-1 (CD95)-induced apoptosis and preservation of a Th1 phenotype. J Immunol 1997;158:2964-76.
17. 17. Boudet F, Lecoeur H, Gougeon ML. Apoptosis associated with ex vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8+ T lymphocytes during HIV infection. J Immunol 1996;156:2282-93.
18. 18. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA. Herzenberg LA. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 1995;181: 2029-30.
19. 19. Bäumler CB. Böhler T. Herr I, Benner A, Krammer PH, Debatin K-M. Activation in the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children. Blood 1996;88:1741-6.
20. 20. Badley AD, McElhinny JA, Leibson PJ, Lynch DH, Alderson MR, Paya CV. Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes. J Virol 1996;70:199-206.
21. 21. Sloand EM, Young NS, Kumar P, Weichold FF, Sato T, Maciejewski JP. Role of Fas ligand and receptor in the mechanism of T-cell depletion in AIDS: effect on CD4+ lymphocyte depletion and HIV replication. Blood 1997;89:1357-63.
22. 22. Ledru E, Lecoeur H. Garcia S, Roué R, Gougeon ML. Differential susceptibility to activation-induced apoptosis among peripheral Th1 subsets. Correlation with Bcl-2 expression and consequences for AIDS pathogenesis. J Immunol 1998;160:3194-206.
23. 23. Poulsen AG, Kvinesdal B, Aaby P, et al. Prevalence of and mortality from human immunodeficiency virus type 2 in Bissau, West Africa. Lancet 1989;1:827-31.
24. 24. Le Guenno BM, Barabe P, Griffet PA. et al. HIV-2 and HIV-1 AIDS cases in Senegal: clinical patterns and immunological perturbations. J Acquir Immune Defic Syndr 1991;4:421-7.
25. 25. Marlink R, Kanki P, Thiour I, et al. Reduced rate of disease development after HIV-2 infection as compared to HIV-1. Science 1994;265:1587-90.
26. 26. Whittle HC, Ariyoshi K, Rowland-Jones S. HIV-2 and T cell recognition. Curr Opin Immunol 1998;10:382-7.
27. 27. Jaleco AC, Covas MJ, Victorino RM. Analysis of lymphocyte cell death and apoptosis in HIV-2 infected patients. Clin Exp Immunol 1994;98:185-9.
28. 28. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Morb Mortal Wkly Rep 1993;41:1-19.
29. 29. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991;139:271-9.
30. 30. Lecoeur H, Gougeon ML. Comparative analysis of flow cytometric methods for apoptosis quantitation in thymocytes and human peripheral blood lymphocytes of controls and HIV+ persons. Evidence for interferences of granulocytes and erythrocytes. J Immunol Methods 1996;198:87-99.
31. 31. Schmid I, Krall WJ, Uittenbogaart CH, Braun J, Giorgi JV. Dead cell discrimination with 7-amino-actinomycin D in combination with dual color immunofluorescence in single laser flow cytometry. Cytometry 1992;132: 204-8.
32. 32. Lecoeur H, Ledru E, Prevost MC, Gougeon ML. Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, Annexin-V and 7-AAD cytofluorimetric staining methods. J Immunol Methods 1997;209:111-23.
33. 33. Zangerle R, Steinhuber S, Sarcletti M, et al. Serum HIV-1 RNA levels compared to soluble markers of immune activation to predict disease progression in HIV-1 infected individuals. Int Arch Allergy Immunol 1998; 116:228-39.
34. 34. Clavel F, Guetard D. Brun-Vezinet F, et al. Isolation of a new human retrovirus from West African patients with AIDS. Science 1986;233:343-6.
35. 35. Whittle H, Agboga A, Todd J, et al. Clinical and laboratory predictors of survival in Gambian patients with symptomatic HIV-1 or HIV-2 infection. AIDS 1992;6:685-9.
36. 36. Phillips AN, Sabin CA, Elford J, et al. Serum beta-2 microglobulin at HIV-1 seroconversion as a predictor of severe immunodeficiency during 10 years follow-up. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13: 262-6.
37. 37. Ashton LJ, Carr A, Cunningham PH, et al. Predictors of disease progression in long-term nonprogressors. Australian long-term nonprogressor study group. AIDS Res Hum Retroviruses 1998;14:117-29.
38. 38. Giorgi JV, Detels R. T-cell subsets alterations in HIV-infected homosexual men: NIAID multicenter AIDS cohort study. Clin Immunol Immunopathol 1989;52:10-8.
39. 39. Estaquier J, Idziorek T, De Bels F, et al. Programmed cell death and AIDS: significance of T cell apoptosis in pathogenic and nonpathogenic primate lentiviral infections. Proc Natl Acad Sci USA 1994;91:9431-5.
40. 40. Dittmer U, Petry H, Stahl-Hennig C, et al. T cell apoptosis in HIV-2 and SIV infected macaques. J Gen Virol 1996;77:2433-6.
41. 41. Westendorp MO, Frank R, Oschsenbauer C, et al. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 1995;375: 497-501.
42. + T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4. Nature 1998;395:189-94.
43. 43. Heeney JL. AIDS: a disease of impaired Th-cell renewal. Immunol Today 1995;16:515-20.