Interleukin-6 and high-sensitivity c-reactive protein for the prediction of outcomes in non-ST-segment elevation acute coronary syndromes;Interleucina 6 y proteína C reactiva ultrasensible para la predicción de la evolución clínica en síndromes coronarios agudos sin elevación del segmento ST

Revista Espanola de Cardiologia

Volumn 66, Issue 3, 2013, Pages 185-192

  López Cuenca, Ángel ^a   Manzano Fernández, Sergio ^a,b   Lip, Gregory Y H ^c   Casas, Teresa ^a   Sánchez Martínez, Marianela ^a   Mateo Martínez, Alicia ^a   Pérez Berbel, Patricio ^d   Martínez, Javier ^d   Hernández Romero, Diana ^a   Romero Aniorte, Ana I ^a   Valdés, Mariano ^a,b   Marín, Francisco ^a,b  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

^c UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^d HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

Author keywords

High sensitivity C reactive protein; Interleukin 6; Non ST segment acute coronary syndrome

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6;

ACUTE HEART FAILURE; ADVERSE OUTCOME; ARTICLE; BLOOD ANALYSIS; CAUSE OF DEATH; CLINICAL TRIAL; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; NON ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME; PREDICTOR VARIABLE; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; ACUTE CORONARY SYNDROME; AGED; BLOOD; COMPARATIVE STUDY; FEMALE; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PROGNOSIS; PROSPECTIVE STUDY;

ACUTE CORONARY SYNDROME; AGED; C-REACTIVE PROTEIN; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RISK ASSESSMENT;

EID: 84874723670     PISSN: 03008932     EISSN: 15792242     Source Type: Journal    
DOI: 10.1016/j.recesp.2012.07.027     Document Type: Article

References (40)

1. H. Koukkunen, K. Penttila, A. Kemppainen, M. Halinen, I. Penttila, and T. Rantanen C-reactive protein, fibrinogen, interleukin-6 and tumour necrosis factor-alpha in the prognostic classification of unstable angina pectoris Ann Med 33 2001 37 47
2. E. Lindmark, E. Diderholm, L. Wallentin, and A. Siegbahn Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy JAMA 286 2001 2107 2113
3. C. Mueller, H.J. Buettner, J.M. Hodgson, S. Marsch, A.P. Perruchoud, and H. Roskamm Inflammation and long-term mortality after non-ST elevation acute coronary syndrome treated with a very early invasive strategy in 1042 consecutive patients Circulation 105 2002 1412 1415
4. J. Tan, Q. Hua, J. Gao, and Z.X. Fan Clinical implications of elevated serum interleukin-6, soluble CD40 ligand, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in patients with acute ST-segment elevation myocardial infarction Clin Cardiol 31 2008 413 418
5. H. Toss, B. Lindahl, A. Siegbahn, and L. Wallentin Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease. FRISC Study Group. Fragmin during Instability in Coronary Artery Disease Circulation 96 1997 4204 4210
6. M.N. Zairis, E.N. Adamopoulou, S.J. Manousakis, A.G. Lyras, G.P. Bibis, and O.S. Ampartzidou The impact of hs C-reactive protein and other inflammatory biomarkers on long-term cardiovascular mortality in patients with acute coronary syndromes Atherosclerosis 194 2007 397 402
7. E.R. Ferreiros, C.P. Boissonnet, R. Pizarro, P.F. Merletti, G. Corrado, and A. Cagide Independent prognostic value of elevated C-reactive protein in unstable angina Circulation 100 1999 1958 1963
8. M. Hartford, O. Wiklund, H.L. Mattsson, A. Persson, T. Karlsson, and J. Herlitz C-reactive protein, interleukin-6, secretory phospholipase A2 group IIA and intercellular adhesion molecule-1 in the prediction of late outcome events after acute coronary syndromes J Intern Med 262 2007 526 536
9. M. Kosuge, T. Ebina, K. Hibi, T. Ishikawa, M. Endo, and T. Mitsuhashi Value of serial C-reactive protein measurements in non ST-segment elevation acute coronary syndromes Clin Cardiol 31 2008 437 442
10. K.W. Lee, G.Y. Lip, M. Tayebjee, W. Foster, and A.D. Blann Circulating endothelial cells, von Willebrand factor, interleukin-6, and prognosis in patients with acute coronary syndromes Blood 105 2005 526 532
11. K.W. Lee, A.D. Blann, and G.Y. Lip Plasma markers of endothelial damage/dysfunction, inflammation and thrombogenesis in relation to TIMI risk stratification in acute coronary syndromes Thromb Haemost 94 2005 1077 1083
12. F. Passoni, B. Morelli, G. Seveso, L. Lazzati, G. Beria, and R.G. Del Comparative short-term prognostic value of hemostatic and inflammatory markers in patients with nonST elevation acute coronary syndromes Ital Heart J 3 2002 28 33
13. L.S. Rallidis, M.G. Zolindaki, P.C. Pentzeridis, K.P. Poulopoulos, A.H. Velissaridou, and T.S. Apostolou Raised concentrations of macrophage colony stimulating factor in severe unstable angina beyond the acute phase are strongly predictive of long term outcome Heart 90 2004 25 29
14. L.M. Biasucci, G. Liuzzo, G. Fantuzzi, G. Caligiuri, A.G. Rebuzzi, and F. Ginnetti Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events Circulation 99 1999 2079 2084
15. J.P. Bassand, C.W. Hamm, D. Ardissino, E. Boersma, A. Budaj, and F. Fernandez-Aviles Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes Eur Heart J 28 2007 1598 1660
16. M.E. Bertrand, M.L. Simoons, K.A. Fox, L.C. Wallentin, C.W. Hamm, and E. McFadden Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation Eur Heart J 23 2002 1809 1840
17. C.P. Cannon, A. Battler, R.G. Brindis, J.L. Cox, S.G. Ellis, and N.R. Every American College of Cardiology key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes. A report of the American College of Cardiology Task Force on Clinical Data Standards (Acute Coronary Syndromes Writing Committee) J Am Coll Cardiol 38 2001 2114 2130
18. K. Thygesen, J.S. Alpert, H.D. White, A.S. Jaffe, F.S. Apple, and M. Galvani Universal definition of myocardial infarction Circulation 116 2007 2634 2653
19. M.S. Nieminen, M. Bohm, M.R. Cowie, H. Drexler, G.S. Filippatos, and G. Jondeau Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology Eur Heart J 26 2005 384 416
20. M.J. Pencina, R.B. D'Agostino Sr., R.B. D'Agostino Jr., and R.S. Vasan Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond Stat Med 27 2008 157 172
21. F. Beygui, J. Silvain, A. Pena, A. Bellemain-Appaix, J.P. Collet, and H. Drexler Usefulness of biomarker strategy to improve GRACE score's prediction performance in patients with non-ST-segment elevation acute coronary syndrome and low event rates Am J Cardiol 106 2010 650 658
22. P.A. Kavsak, D.T. Ko, A.M. Newman, G.E. Palomaki, V. Lustig, and A.R. MacRae Risk stratification for heart failure and death in an acute coronary syndrome population using inflammatory cytokines and N-terminal pro-brain natriuretic peptide Clin Chem 53 2007 2112 2118
23. J.C. Kaski, and A.L. Arrebola-Moreno Inflamación y trombosis en la fibrilación auricular Rev Esp Cardiol 64 2011 551 553
24. B. Schieffer, E. Schieffer, D. Hilfiker-Kleiner, A. Hilfiker, P.T. Kovanen, and M. Kaartinen Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability Circulation 101 2000 1372 1378
25. F.C. Heres-Álvarez, and A. Peix-González La proteína C reactiva como blanco terapéutico en la prevención cardiovascular: ¿ficción o realidad? Rev Esp Cardiol 11 Supl E 2011 30 35
26. N. Ozer, B. Tangurek, F. Firat, S. Ozer, Z. Tartan, and R. Ozturk Effects of drug-eluting stents on systemic inflammatory response in patients with unstable angina pectoris undergoing percutaneous coronary intervention Heart Vessels 23 2008 75 82
27. L.M. Biasucci, G. Liuzzo, R.L. Grillo, G. Caligiuri, A.G. Rebuzzi, and A. Buffon Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability Circulation 99 1999 855 860
28. J.C. Kaski, J.M. Cruz-Fernández, D. Fernández- Bergés, X. García-Moll, L. Martín Jadraque, and J. Mostaza Marcadores de inflamación y estratificación de riesgo en pacientes con síndrome coronario agudo: diseño del estudio SIESTA (Systemic Inflammation Evaluation in patients with non-ST segment elevation Acute coronary syndromes) Rev Esp Cardiol 56 2003 389 395
29. J.C. Kaski, D.J. Fernández-Bergés, L. Consuegra- Sánchez, J.M. Fernández, X. García-Moll, and J.M. Mostaza A comparative study of biomarkers for risk prediction in acute coronary syndrome-Results of the SIESTA (Systemic Inflammation Evaluation in non-ST-elevation Acute coronary syndrome) study Atherosclerosis 212 2010 636 643
30. J.C. Kaski, L. Consuegra-Sanchez, D.J. Fernandez-Berges, J.M. Cruz-Fernandez, X. Garcia-Moll, and J. Marrugat Elevated serum neopterin levels and adverse cardiac events at 6 months follow-up in Mediterranean patients with non-ST-segment elevation acute coronary syndrome Atherosclerosis 201 2008 176 183
31. S.G. Wannamethee, P.H. Whincup, A.G. Shaper, A. Rumley, L. Lennon, and G.D. Lowe Circulating inflammatory and hemostatic biomarkers are associated with risk of myocardial infarction and coronary death, but not angina pectoris, in older men J Thromb Haemost 7 2009 1605 1611
32. A. Segev, S. Kassam, C.E. Buller, H.K. Lau, J.D. Sparkes, and P.W. Connelly Pre-procedural plasma levels of C-reactive protein and interleukin-6 do not predict late coronary angiographic restenosis after elective stenting Eur Heart J 25 2004 1029 1035
33. P. Bogaty, P. Poirier, S. Simard, L. Boyer, S. Solymoss, and G.R. Dagenais Biological profiles in subjects with recurrent acute coronary events compared with subjects with long-standing stable angina Circulation 103 2001 3062 3068
34. B. Hudzik, J. Szkodzinski, W. Romanowski, A. Danikiewicz, K. Wilczek, and A. Lekston Serum interleukin-6 concentration reflects the extent of asymptomatic left ventricular dysfunction and predicts progression to heart failure in patients with stable coronary artery disease Cytokine 54 2011 266 271
35. S.P. Janssen, G. Gayan-Ramirez, A. Van den Bergh, P. Herijgers, K. Maes, and E. Verbeken Interleukin-6 causes myocardial failure and skeletal muscle atrophy in rats Circulation 111 2005 996 1005
36. B. Lindahl, H. Toss, A. Siegbahn, P. Venge, and L. Wallentin Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group. Fragmin during Instability in Coronary Artery Disease N Engl J Med 343 2000 1139 1147
37. D.A. Morrow, N. Rifai, E.M. Antman, D.L. Weiner, C.H. McCabe, and C.P. Cannon C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a TIMI 11A substudy. Thrombolysis in Myocardial Infarction J Am Coll Cardiol 31 1998 1460 1465
38. T.J. Wang, P. Gona, M.G. Larson, G.H. Tofler, D. Levy, and C. Newton-Cheh Multiple biomarkers for the prediction of first major cardiovascular events and death N Engl J Med 355 2006 2631 2639
39. I. Ikonomidis, F. Andreotti, E. Economou, C. Stefanadis, P. Toutouzas, and P. Nihoyannopoulos Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin Circulation 100 1999 793 798
40. R.B. Sothern, B. Roitman-Johnson, E.L. Kanabrocki, J.G. Yager, J.A. Roodell, and M.M. Weatherbee Circadian characteristics of circulating interleukin-6 in men J Allergy Clin Immunol 95 1995 1029 1035