Partition coefficients and thermodynamics of transfer of novel drug-like spiro-derivatives in model biological solutions

Journal of Chemical Thermodynamics

Volumn 61, Issue , 2013, Pages 11-17

  Blokhina, Svetlana V ^a   Ol'Khovich, Marina V ^a   Sharapova, Angelica V ^a   Proshin, Alexey N ^b   Perlovich, German L ^a,b  

^a INSTITUTE OF SOLUTION CHEMISTRY   (Russian Federation)

^b INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

Author keywords

Descriptors; Drug like spiro derivatives; Octanol; Partition coefficient; Thermodynamics of transfer

Indexed keywords

ALIPHATIC CHAINS; BIOLOGICAL SOLUTIONS; DESCRIPTORS; DRUG-LIKE SPIRO-DERIVATIVES; FLUORINE ATOMS; HALOGEN DERIVATIVES; ISOTHERMAL SATURATION; OCTANOL; PARTITION COEFFICIENT; PHOSPHATE BUFFERS; SOLVENT MOLECULES; SPECIFIC AND NONSPECIFIC INTERACTIONS; TEMPERATURE DEPENDENCE; TEMPERATURE RANGE; THERMODYNAMIC FUNCTIONS;

HEXANE;

THERMODYNAMICS;

EID: 84874682928     PISSN: 00219614     EISSN: 10963626     Source Type: Journal    
DOI: 10.1016/j.jct.2013.01.022     Document Type: Article

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