A nitrophenyl-based prodrug type for colorectal targeting of prednisolone, budesonide and celecoxib

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 6, 2013, Pages 1693-1698

  Marquez Ruiz, Juan F ^a   Kedziora, Kinga ^a   Pigott, Maria ^a   Keogh, Brian ^c   Windle, Henry ^b   Gavin, Jason ^a   Kelleher, Dermot P ^b   Gilmer, John F ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c ST JAMES S HOSPITAL   (Ireland)

Author keywords

Budesonide; Cancer; Celecoxib; Colon; Nitroreductase; Prednisolone; Prodrug; Targeting

Indexed keywords

BUDESONIDE; CELECOXIB; PHENYLACETIC ACID; PREDNISOLONE; PRODRUG; PROPIONIC ACID;

ARTICLE; CLOSTRIDIUM PERFRINGENS; COLON FLORA; CONTROLLED STUDY; CYCLIZATION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN;

ANTINEOPLASTIC AGENTS; BUDESONIDE; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CLOSTRIDIUM PERFRINGENS; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2 INHIBITORS; HUMANS; LACTONES; NITROBENZENES; NITROREDUCTASES; PREDNISOLONE; PRODRUGS; PYRAZOLES; SULFONAMIDES;

CLOSTRIDIUM PERFRINGENS;

EID: 84874665922     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.060     Document Type: Article

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