Quantitative assessment of spinal cord perfusion by using contrast-enhanced ultrasound in a porcine model with acute spinal cord contusion

Spinal Cord

Volumn 51, Issue 3, 2013, Pages 196-201

  Huang, L ^a   Lin, X ^b   Tang, Y ^a   Yang, R ^a   Li, A H ^b   Ye, J C ^a   Chen, K ^a   Wang, P ^a   Shen, H Y ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

animal model; contrast enhanced ultrasound; perfusion; porcine; spinal cord injury

Indexed keywords

SONOVUE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN AQUEDUCT; COLOR ULTRASOUND FLOWMETRY; CONTRAST ENHANCED ULTRASOUND; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CONTUSION; DURA MATER; ECHOGRAPHY; FEMALE; GRAY SCALE ECHOGRAPHY; HISTOPATHOLOGY; INJURY SEVERITY; MICROCIRCULATION; NEUROLOGIC EXAMINATION; NONHUMAN; ORGAN PERFUSION; PIA MATER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SPINAL CORD INJURY; SWINE;

ACUTE DISEASE; ANIMALS; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; FEMALE; MICROCIRCULATION; SPINAL CORD; SPINAL CORD INJURIES; SWINE; ULTRASONOGRAPHY, DOPPLER, COLOR;

EID: 84874665888     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sc.2012.111     Document Type: Article

References (28)

1. Weir CJ, Zivin JA, Lyden PD. Inter-relationships between spinal cord blood flow, neuronal death and neurological function in rabbit spinal cord ischemia. Brain Res 2002; 946: 43-51.
2. Ueda Y, Kawahara N, Tomita K, Kobayashi T, Murakami H, Nambu K. Influence on spinal cord blood flow and function by interruption of bilateral segmental arteries at up to three levels: experimental study in dogs. Spine 2005; 30: 2239-2243.
3. Maeda M, Inoue M, Takao S, Ikegami Y, Nakai M, Krieger AJ et al. Chemical stimulation of the nucleus tractus solitarii decreases spinal cord blood flow in anesthetized rats. Neurosci Lett 1995; 185: 111-114.
4. Westergren H, Farooque M, Olsson Y, Holtz A. Spinal cord blood flow changes following systemic hypothermia and spinal cord compression injury: an experimental study in the rat using Laser-Doppler flowmetry. Spinal Cord 2001; 39: 74-84.
5. Ishikawa M, Sekizuka E, Oshio C, Sato S, Yamaguchi N, Terao S et al. Platelet adhesion and arteriolar dilation in the photothrombosis: observation with the rat closed cranial and spinal windows. J Neurol Sci 2002; 194: 59-69.
6. Duhamel G, Callot V, Cozzone PJ, Kober F. Spinal cord blood flow measurement by arterial spin labeling. Magn Reson Med 2008; 59: 846-854.
7. Frerichs KU, Feuerstein GZ. Laser-Doppler flowmetry. A review of its application for measuring cerebral and spinal cord blood flow. Mol Chem Neuropathol 1990; 12: 55-70.
8. Weber M-A, Krix M, Delorme S. Quantitative evaluation of muscle perfusion with CEUS and with MR. Eur Radiol 2007; 17: 2663-2674.
9. Cosgrove D. Ultrasound contrast agents: an overview. Eur J Radiol 2006; 60: 324-330.
10. Weber MA, Krix M, Delorme S. Quantitative evaluation of muscle perfusion with CEUS and with MR. Eur Radiol 2007; 17: 2663-2674.
11. Bartels E, Henning S, Wellmer A, Giraldo-Velasquez M, Kermer P. Evaluation of cerebral perfusion deficit in stroke patients using new transcranial contrast imaging CPS technology-preliminary results. Ultraschall Med 2005; 26: 478-486.
12. Young W. Spinal cord contusion models. Prog Brain Res 2002; 137: 231-255.
13. Nader G, Bradley JK, David S. Tissue displacement and impact force are important contributors to outcome after spinal cord contusion injury. Exp Neurol 2005; 196: 9-17.
14. Tarlov IM. Acute spinal cord compression paralysis. J Neurosurg 1972; 36: 10-20.
15. Hamamoto Y, Ogata T, Morino T, Hino M, Yamamoto H. Real-time direct measurement of spinal cord blood flow at the site of compression: relationship between blood flow recovery and motor deficiency in spinal cord injury. Spine 2007; 32: 1955-1962.
16. Tozaki M, Isobe S, Yamaguchi M, Ogawa Y, Kohara M, Joo C et al. Optimal scanning technique to cover the whole breast using an automated breast volume scanner. Jpn J Radiol 2010; 28: 325-328.
17. Fehlings MG, Tator CH, Linden RD. The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury. J Neurosurg 1989; 71: 403-416.
18. Guha A, Tator CH, Rochon J. Spinal cord blood flow and systemic blood pressure after experimental spinal cord injury in rats. Stroke 1989; 20: 372-377.
19. Kapadia SE. Ultrastructural alterations in blood vessels of the white matter after experimental spinal cord trauma. J Neurosurg 1984; 61: 539-544.
20. Schroder ML, Muizelaar JP, Fatouros P, Kuta AJ, Choi SC. Early cerebral blood volume after severe traumatic brain injury in patients with early cerebral ischemia. Acta Neurochir Suppl 1998; 71: 127-130.
21. Tenjin H, Ueda S, Mizukawa N, Imahori Y, Hino A, Yamaki T et al. Positron emission tomographic studies on cerebral hemodynamics in patients with cerebral contusion. Neurosurgery 1990; 26: 971-979.
22. Dumont RJ, Okonkwo DO, Verma RS, Hurlbert RJ, Boulos PT, Ellegala DB et al. Acute spinal cord injury, part I: Pathophysiologic mechanisms. Clin Neuropharmacol 2001; 24: 254-264.
23. Tornheim PA, McDermott F, Shiguma M. Effect of experimental blunt head injury on acute regional cerebral blood flow and edema. Adv Neurol 1990; 52: 377-384.
24. Chen S, Pickard JD, Harris NG. Time course of cellular pathology after controlled cortical impact injury. Exp Neurol 2003; 182: 87-102.
25. Levasseur JE, Alessandri B, Reinert M, Bullock R, Kontos HA. Fluid percussion injury transiently increases then decreases brain oxygen consumption in the rat. J Neurotrauma 2000; 17: 101-112.
26. Perthen JE, Lansing AE, Liau J, Liu TT, Buxton RB. Caffeine-indcued uncoupling of cerebral blood flow and oxygen metabolism: A calibrated BOLD fMRI study. Neuroimage 2008; 40: 237-247.
27. Liu Z, Lammers T, Ehling J, Fokong S, Bornemann J, Kiessling F et al. Iron oxide nanoparticle-containing microbubble composites as contrast agents for MR and ultrasound dual-modality imaging. Biomaterials 2011; 32: 6155-6163.
28. Hu YZ, Zhu JA, Jiang YG, Hu B. Ultrasound microbubble contrast agents: application to therapy for peripheral vascular disease. Adv Ther 2009; 26: 425-434.