The clinical and molecular significance of C4d staining patterns in renal allografts

Transplantation

Volumn 95, Issue 4, 2013, Pages 580-588

  Hayde, Nicole ^a   Bao, Yi ^b   Pullman, James ^b   Ye, Bin ^b   Calder, Brent R ^b   Chung, Monica ^b   Schwartz, Daniel ^b   Alansari, Ahmed ^b   De Boccardo, Graciela ^b   Ling, Min ^b   Akalin, Enver ^b  

^a CHILDREN S HOSPITAL AT MONTEFIORE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

C4d; Donor specific anti HLA antibodies; Gene expression; Microarrays

Indexed keywords

COMPLEMENT COMPONENT C4D; GAMMA INTERFERON; HLA ANTIBODY; PARAFFIN; POLYCLONAL ANTIBODY;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; CAPILLARITIS; CYTOTOXIC T LYMPHOCYTE; FEMALE; GEL ELECTROPHORESIS; GENE ACTIVATION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GLOMERULITIS; GLOMERULUS CAPILLARY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY BIOPSY; KIDNEY INTERSTITIUM; KIDNEY TUBULE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; NEPHRITIS; PRIORITY JOURNAL; TISSUE SECTION;

ADULT; BIOLOGICAL MARKERS; BIOPSY; CAPILLARIES; CHI-SQUARE DISTRIBUTION; COMPLEMENT C4B; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GRAFT REJECTION; HISTOCOMPATIBILITY; HLA ANTIGENS; HUMANS; IMMUNOHISTOCHEMISTRY; ISOANTIBODIES; KAPLAN-MEIER ESTIMATE; KIDNEY; KIDNEY GLOMERULUS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; ODDS RATIO; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDE FRAGMENTS; RNA, MESSENGER; TREATMENT OUTCOME;

EID: 84874665838     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318277b2e2     Document Type: Article

References (27)

1. Akalin E, Watschinger B. Antibody-mediated rejection. Semin Nephrol 2007; 27: 393.
2. Solez K, Colvin RB, Racusen LC, et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 2008; 8: 753.
3. Colvin RB. Antibody-mediated renal allograft rejection: diagnosis and pathogenesis. J Am Soc Nephrol 2007; 18: 1046.
4. Nadasdy GM, Bott C, Cowden D, et al. Comparative study for the detection of peritubular capillary C4d deposition in human renal allografts using different methodologies. Hum Pathol 2005; 36: 1178.
5. Kayler LK, Kiss L, Sharma V, et al. Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d. Transplantation 2008; 85: 813.
6. Kedainis RL, Koch MJ, Brennan DC, et al. Focal C4d+ in renal allografts is associated with the presence of donor-specific antibodies and decreased allograft survival. Am J Transplant 2009; 9: 812.
7. Loupy A, Hill GS, Suberbielle C, et al. Significance of C4d Banff scores in early protocol biopsies of kidney transplant recipients with preformed donor-specific antibodies (DSA). Am J Transplant 2011; 11: 56.
8. Batal I, Girnita A, Zeevi A, et al. Clinical significance of the distribution of C4d deposits in different anatomic compartments of the allograft kidney. Mod Pathol 2008; 21: 1490.
9. Suzuki T, Horita S, Kadoya K, et al. C4d Immunohistochemistry in glomerulonephritis with different antibodies. Clin Exp Nephrol 2007; 11: 287.
10. Horita S, Nitta K, Kawashima M, et al. C4d deposition in the glomeruli and peritubular capillaries associated with transplant glomerulopathy. Clin Transplant 2003; 17: 325.
11. Sijpkens YW, Joosten SA, Wong MC, et al. Immunologic risk factors and glomerular C4d deposits in chronic transplant glomerulopathy. Kidney Int 2004; 65: 2409.
12. Haas M, Rahman MH, Racusen LC, et al. C4d and C3d staining in biopsies of ABO-and HLA-incompatible renal allografts: correlation with histologic findings. Am J Transplant 2006; 6: 1829.
13. Haas M, Segev DL, Racusen LC, et al. C4d deposition without rejection correlates with reduced early scarring in ABO-incompatible renal allografts. J AmSoc Nephrol 2009; 20: 197.
14. Setoguchi K, Ishida H, Shimmura H, et al. Analysis of renal transplant protocol biopsies in ABO-incompatible kidney transplantation. Am J Transplant 2008; 8: 86.
15. Sis B, Jhangri GS, Riopel J, et al. A new diagnostic algorithmfor antibodymediated microcirculation inflammation in kidney transplants. Am J Transplant 2012; 12: 1168.
16. Kikic Z, Regele H, Nordmeyer V, et al. Significance of peritubular capillary, glomerular, and arteriolar C4d staining patterns in paraffin sections of early kidney transplant biopsies. Transplantation 2011; 91: 440.
17. Akalin E, O'Connell PJ. Genomics of chronic allograft injury. Kidney Int Suppl 2010: S33.
18. Hotchkiss H, Chu TT, Hancock WW, et al. Differential expression of profibrotic and growth factors in chronic allograft nephropathy. Transplantation 2006; 81: 342.
19. Mueller TF, Einecke G, Reeve J, et al. Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets. Am J Transplant 2007; 7: 2712.
20. Halloran PF, de Freitas DG, Einecke G, et al. The molecular phenotype of kidney transplants. Am J Transplant 2010; 10: 2215.
21. Hidalgo LG, Sis B, Sellares J, et al. NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection. Am J Transplant 2010; 10: 1812.
22. Sis B, Jhangri GS, Bunnag S, et al. Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining. Am J Transplant 2009; 9: 2312.
23. Sis B, Mengel M, Haas M, et al. Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups. Am J Transplant 2010; 10: 464.
24. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
25. Carvalho BS, Irizarry RA. A framework for oligonucleotide microarray preprocessing. Bioinformatics 2010; 26: 2363.
26. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3: 1.
27. Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102: 15545.