Comparative study for the detection of peritubular capillary C4d deposition in human renal allografts using different methodologies

Human Pathology

Volumn 36, Issue 11, 2005, Pages 1178-1185

  Nadasdy, Gyongyi M ^a   Bott, Cherri ^a   Cowden, Daniel ^a   Pelletier, Ronald ^a   Ferguson, Ronald ^a   Nadasdy, Tibor ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

C4d; Humoral rejection; Immunofluorescence; Immunohistochemistry; Renal transplantation

Indexed keywords

ANTIBODY; COMPLEMENT COMPONENT C4D; FORMALDEHYDE; MONOCLONAL ANTIBODY; PARAFFIN; PEROXIDASE; POLYCLONAL ANTIBODY;

ANALYTIC METHOD; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FROZEN SECTION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; KIDNEY ALLOGRAFT REJECTION; KIDNEY BIOPSY; KIDNEY TUBULE;

ANTIBODIES; ANTIGENS, CD4; CAPILLARIES; GRAFT REJECTION; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY TRANSPLANTATION; KIDNEY TUBULES; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 27544507838     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2005.08.002     Document Type: Article

References (14)

1. B.A. Collins, E.E. Schneeberger, and M. Pascual Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries J Am Soc Nephrol 10 1999 2208 2214
2. S.R. Lederer, B. Kluth-Pepper, H. Schneeberger, E. Albert, W. Land, and H.E. Feucht Impact of humoral alloreactivity early after transplantation on the long-term survival of renal allografts Kidney Int 59 2001 334 341
3. M. Crespo, M. Pascual, and N. Tolkoff-Rubin Acute humoral rejection in renal allograft recipients: I. Incidence, serology and clinical characteristics Transplantation 71 2001 652 658
4. G.A. Bohmig, H. Regele, and M. Exner C4d-positive acute humoral renal allograft rejection: effective treatment by immunoadsorption J Am Soc Nephrol 12 2001 2482 2489
5. V. Nickeleit, M. Zeiler, F. Gudat, G. Theil, and M.J. Mihatsch Detection of the complement degradation product C4d in renal allografts: diagnostic and therapeutic implications J Am Soc Nephrol 13 2002 242 251
6. S. Mauiyyedi, M. Crespo, and B.A. Collins Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification J Am Soc Nephrol 13 2002 779 787
7. G.A. Bohmig, M. Exner, and A. Habicht Capillary C4d deposition in kidney allografts: a specific marker of alloantibody-dependent graft injury J Am Soc Nephrol 13 2002 1091 1099
8. A.M. Herzenberg, J.S. Gill, O. Djurdjev, and A.B. Magil C4d deposition in acute rejection: an independent long-term prognostic factor J Am Soc Nephrol 13 2002 234 241
9. H.E. Feucht Complement C4d in graft capillaries-the missing link in the recognition of humoral alloreactivity Am J Transplant 3 2003 646 652
10. A. Shah, T. Nadasdy, and L. Arend Treatment of C4d positive acute humoral rejection with plasmapheresis and rabbit polyclonal antithymocyte globulin Transplantation 77 2004 1399 1405
11. S. Onitsuka, Y. Yamaguchi, and K. Tanabe Peritubular capillary deposition of C4d complement fragment in ABO-incompatible renal transplantation with humoral rejection Clin Transplant 13 Suppl 1 1999 33 37
12. L.C. Racusen, R.B. Colvin, and K. Solez Antibody-mediated rejection criteria-an addition to the Banff 97 classification of renal allograft rejection Am J Transplant 3 2003 708 714
13. S.K. Takemoto, A. Zeevi, and S. Feng National conference to assess antibody-mediated rejection in solid organ transplantation Am J Transplant 4 2004 1033 1041
14. A.B. Magil, and K. Tinckam Monocytes and peritubular capillary C4d deposition in acute renal allograft rejection Kidney Int 63 2003 1888 1893