Lymph node ratio predicts the benefit of post-operative radiotherapy in oral cavity cancer

Radiotherapy and Oncology

Volumn 106, Issue 1, 2013, Pages 74-79

  Urban, Damien ^a,b   Gluck, Iris ^a   Pfeffer, M Raphael ^a,d   Symon, Zvi ^a   Lawrence, Yaacov R ^a,c  

^a SHEBA MEDICAL CENTER   (Israel)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

Head and neck cancer; Lymph node; Mouth neoplasms; Radiotherapy; Squamous cell carcinoma

Indexed keywords

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CANCER GRADING; CANCER RADIOTHERAPY; CANCER REGISTRY; CANCER SIZE; CANCER SPECIFIC SURVIVAL; CANCER STAGING; CANCER SURVIVAL; COHORT ANALYSIS; FEMALE; HUMAN; LYMPH NODE RATIO; MAJOR CLINICAL STUDY; MALE; MOUTH SQUAMOUS CELL CARCINOMA; NECK DISSECTION; OVERALL SURVIVAL; POSTOPERATIVE CARE; POSTOPERATIVE RADIOTHERAPY; PREDICTION; PREDICTOR VARIABLE; PRIORITY JOURNAL; RACE; REFERENCE DATABASE; TUMOR VOLUME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; FEMALE; HUMANS; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; SEER PROGRAM;

EID: 84874657482     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2012.09.022     Document Type: Article

References (40)

1. Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D. GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer; 2010. Available from: http://globocan.iarc.fr [accessed 11.09.12].
2. Piccirillo J, Costas I, Reichman M. SEER survival monograph: cancer survival among adults: U.S. SEER Program, 1988-2001, patient and tumor characteristics. Chapter 2: cancers of the head and neck. Bethesda, MD: National Cancer Institute, SEER Program; 2007.
3. K.H. Fan, H.M. Wang, and C.J. Kang Treatment results of postoperative radiotherapy on squamous cell carcinoma of the oral cavity: coexistence of multiple minor risk factors results in higher recurrence rates Int J Radiat Oncol Biol Phys 77 2010 1024 1029
4. R. Corvò Evidence-based radiation oncology in head and neck squamous cell carcinoma Radiother Oncol 85 2007 156 170 (Pubitemid 47562578)
5. J. Bernier, J.S. Cooper, and T.F. Pajak Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501) Head Neck 27 2005 843 850 (Pubitemid 41395696)
6. J. Bernier, C. Domenge, and M. Ozsahin Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer N Engl J Med 350 2004 1945 1952 (Pubitemid 38580197)
7. J.S. Cooper, T.F. Pajak, and A.A. Forastiere Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck N Engl J Med 350 2004 1937 1944
8. P. Ghadjar, M. Simcock, and F. Zimmermann Predictors of severe late radiotherapy-related toxicity after hyperfractionated radiotherapy with or without concomitant cisplatin in locally advanced head and neck cancer. Secondary retrospective analysis of a randomized phase III trial (SAKK 10/94) Radiother Oncol 104 2012 213 218
9. H.R. Mortensen, J. Overgaard, and L. Specht Prevalence and peak incidence of acute and late normal tissue morbidity in the DAHANCA 6&7 randomised trial with accelerated radiotherapy for head and neck cancer Radiother Oncol 103 2012 69 75
10. J.A. Langendijk, P. Doornaert, I.M. Verdonck-de Leeuw, C.R. Leemans, N.K. Aaronson, and B.J. Slotman Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy J Clin Oncol 26 2008 3770 3776
11. I.M. Oskam, I.M. Verdonck-de Leeuw, and N.K. Aaronson Quality of life as predictor of survival: a prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer Radiother Oncol 97 2010 258 262
12. J. Gavilan, M.P. Prim, J.I. De Diego, D. Hardisson, and A. Pozuelo Postoperative radiotherapy in patients with positive nodes after functional neck dissection Ann Otol Rhinol Laryngol 109 2000 844 848
13. W.A. Kokal, J.P. Neifeld, and D. Eisert Postoperative radiation as adjuvant treatment for carcinoma of the oral cavity, larynx, and pharynx: preliminary report of a prospective randomized trial J Surg Oncol 38 1988 71 76
14. V. Van Belle, B. Van Calster, H. Wildiers, S. Van Huffel, and P. Neven Lymph node ratio better predicts disease-free survival in node-positive breast cancer than the number of positive lymph nodes J Clin Oncol 27 2009 e150 e151 author reply e152
15. M. Voordeckers, V. Vinh-Hung, J. Van de Steene, J. Lamote, and G. Storme The lymph node ratio as prognostic factor in node-positive breast cancer Radiother Oncol 70 2004 225 230 (Pubitemid 38520153)
16. H.B. Qiu, L.Y. Zhang, Y.F. Li, Z.W. Zhou, R.P. Keshari, and R.H. Xu Ratio of metastatic to resected lymph nodes enhances to predict survival in patients with stage III colorectal cancer Ann Surg Oncol 18 2011 1568 1574
17. W. Kassouf, P.K. Agarwal, and H.W. Herr Lymph node density is superior to TNM nodal status in predicting disease-specific survival after radical cystectomy for bladder cancer: analysis of pooled data from MDACC and MSKCC J Clin Oncol 26 2008 121 126
18. A.J. Spillane, B.L. Cheung, J. Winstanley, and J.F. Thompson Lymph node ratio provides prognostic information in addition to American joint committee on cancer N stage in patients with melanoma, even if quality of surgery is standardized Ann Surg 253 2011 109 115
19. A. Ebrahimi, W.J. Zhang, K. Gao, and J.R. Clark Nodal yield and survival in oral squamous cancer: defining the standard of care Cancer 117 2011 2917 2925
20. Z. Gil, D.L. Carlson, and J.O. Boyle Lymph node density is a significant predictor of outcome in patients with oral cancer Cancer 115 2009 5700 5710
21. S.Y. Kim, S.Y. Nam, S.H. Choi, K.J. Cho, and J.L. Roh Prognostic value of lymph node density in node-positive patients with oral squamous cell carcinoma Ann Surg Oncol 18 2011 2310 2317
22. C.T. Liao, C. Hsueh, and L.Y. Lee Neck dissection field and lymph node density predict prognosis in patients with oral cavity cancer and pathological node metastases treated with adjuvant therapy Oral Oncol 48 2012 329 336
23. M.G. Shrime, G. Bachar, and J. Lea Nodal ratio as an independent predictor of survival in squamous cell carcinoma of the oral cavity Head Neck 31 2009 1482 1488
24. M.G. Shrime, C. Ma, and P.J. Gullane Impact of nodal ratio on survival in squamous cell carcinoma of the oral cavity Head Neck 31 2009 1129 1136
25. M. Friedman, J.W. Lim, and W. Dickey Quantification of lymph nodes in selective neck dissection Laryngoscope 109 1999 368 370 (Pubitemid 29128532)
26. Standards and Datasets for Reporting Cancers: datasets for histopathology reports on head and neck carcinomas and salivary neoplasms. In: Lee J, editor. London: Royal College of Pathologists; 2005.
27. W.S. Maccomb, and G.H. Fletcher Planned combination of surgery and radiation in treatment of advanced primary head and neck cancers Am J Roentgenol Radium Ther Nucl Med 77 1957 397 414
28. R.C. Mishra, D.N. Singh, and T.K. Mishra Post-operative radiotherapy in carcinoma of buccal mucosa, a prospective randomized trial Eur J Surg Oncol 22 1996 502 504 (Pubitemid 26386013)
29. S. Schmitz, J.P. Machiels, B. Weynand, V. Gregoire, and M. Hamoir Results of selective neck dissection in the primary management of head and neck squamous cell carcinoma Eur Arch Otorhinolaryngol 266 2009 437 443
30. S.K. Puri, C.Y. Fan, and E. Hanna Significance of extracapsular lymph node metastases in patients with head and neck squamous cell carcinoma Curr Opin Otolaryngol Head Neck Surg 11 2003 119 123 (Pubitemid 36363696)
31. C.C. Lee, H.C. Ho, and P. Chou Multivariate analyses to assess the effect of surgeon volume on survival rate in oral cancer: a nationwide population-based study in Taiwan Oral Oncol 46 2010 271 275
32. G.J. Chang, M.A. Rodriguez-Bigas, J.M. Skibber, and V.A. Moyer Lymph node evaluation and survival after curative resection of colon cancer: systematic review J Natl Cancer Inst 99 2007 433 441 (Pubitemid 47073566)
33. T.E. Le Voyer, E.R. Sigurdson, and A.L. Hanlon Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089 J Clin Oncol 21 2003 2912 2919 (Pubitemid 46621841)
34. R. Ricciardi, and N.N. Baxter Association versus causation versus quality improvement: setting benchmarks for lymph node evaluation in colon cancer J Natl Cancer Inst 99 2007 414 415 (Pubitemid 47078734)
35. F. Pages, J. Galon, M.C. Dieu-Nosjean, E. Tartour, C. Sautes-Fridman, and W.H. Fridman Immune infiltration in human tumors: a prognostic factor that should not be ignored Oncogene 29 2010 1093 1102
36. L. de la Cruz-Merino, E. Grande-Pulido, A. Albero-Tamarit, and M.E. Codes-Manuel de Villena Cancer and immune response: old and new evidence for future challenges Oncologist 13 2008 1246 1254
37. M. Brandwein-Gensler, R.V. Smith, and B. Wang Validation of the histologic risk model in a new cohort of patients with head and neck squamous cell carcinoma Am J Surg Pathol 34 2010 676 688
38. D. Pretscher, L.V. Distel, G.G. Grabenbauer, M. Wittlinger, M. Buettner, and G. Niedobitek Distribution of immune cells in head and neck cancer: CD8+ T-cells and CD20+ B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinoma BMC Cancer 9 2009 292
39. W.F. McGuirt, K. Greven, and D. Williams 3rd PET scanning in head and neck oncology: a review Head Neck 20 1998 208 215 (Pubitemid 28169732)
40. J.C. Wadsley, and S.M. Bentzen Investigation of relationship between change in locoregional control and change in overall survival in randomized controlled trials of modified radiotherapy in head-and-neck cancer Int J Radiat Oncol Biol Phys 60 2004 1405 1409 (Pubitemid 39601858)