The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 6, 2013, Pages 1870-1873

  Han, Xiaojun ^a   Civiello, Rita L ^a   Conway, Charles M ^a   Cook, Deborah A ^a   Davis, Carl D ^a   Degnan, Andrew P ^a   Jiang, Xiang Jun ^a   MacCi, Robert ^a   Mathias, Neil R ^a   Moench, Paul ^a   Pin, Sokhom S ^a   Schartman, Richard ^a   Signor, Laura J ^a   Thalody, George ^a   Tora, George ^a   Whiterock, Valerie ^a   Xu, Cen ^a   MacOr, John E ^a   Dubowchik, Gene M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Calcitonin gene related peptide (CGRP); CGRP receptor antagonist; CYP 3A4 inhibition; Migraine headache; Tyrosine surrogates

Indexed keywords

BENZOXAZINE DERIVATIVE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; CYTOCHROME P450 3A4; INDAZOLE DERIVATIVE; TYROSINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BLOOD FLOW; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; ENZYME METABOLISM; EX VIVO STUDY; FACE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, INTRANASAL; AMINO ACIDS; ANIMALS; BENZOXAZOLES; BIOLOGICAL AVAILABILITY; HALF-LIFE; INDAZOLES; PROTEIN BINDING; QUINAZOLINONES; RABBITS; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

ORYCTOLAGUS CUNICULUS;

EID: 84874651467     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.011     Document Type: Article

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