Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: Development of a potent and highly selective M1 PAM

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 6, 2010, Pages 1972-1975

  Bridges, Thomas M ^a,c   Phillip Kennedy, J ^b,c   Noetzel, Meredith J ^a   Breininger, Micah L ^a,c   Gentry, Patrick R ^a,c   Jeffrey Conn, P ^a,c   Lindsley, Craig W ^a,b,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Acetylcholine; mAChR; Muscarinic; PAM

Indexed keywords

CHOLINERGIC RECEPTOR AFFECTING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; POSITIVE ALLOSTERIC MODULATOR; UNCLASSIFIED DRUG; VU 0119498; VU 0238429; VU 0238441; VU 0357017; VU 0365137; VU 0366369; VU 0400265;

AGONIST; ALLOSTERISM; ARTICLE; DOSE RESPONSE; HIGH THROUGHPUT SCREENING; NONHUMAN; SYNTHESIS;

ALLOSTERIC REGULATION; CHOLINERGIC AGENTS; DRUG DESIGN; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77549085696     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.109     Document Type: Article

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