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Volumn 18, Issue 1, 2013, Pages 25-37

Emerging VEGF-receptor inhibitors for colorectal cancer

Author keywords

Aflibercept; Angiogenesis; Anti VEGF inhibitors; Colorectal cancer; Regorafenib; Targeted therapy

Indexed keywords

AFLIBERCEPT; ANTIHYPERTENSIVE AGENT; BEVACIZUMAB; BRIVANIB ALANINATE; CEDIRANIB; CETUXIMAB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; ML18147; NINTEDANIB; OXALIPLATIN; RAMUCIRUMAB; REGORAFENIB; SEMAXANIB; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR; VATALANIB;

EID: 84874625316     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.2013.749856     Document Type: Review
Times cited : (26)

References (103)
  • 2
    • 84874587739 scopus 로고    scopus 로고
    • Available from: http://globocan.iarc.fr
  • 5
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
    • Saltz LB, Cox JV, Blanke C, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 2000;343:905-14
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 7
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 8
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • DOI 10.1200/JCO.2005.06.081
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23:1011-27 (Pubitemid 46202320)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 10
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
    • Saltz LB. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 2000;343:905-14
    • (2000) Irinotecan Study Group. N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1
  • 12
    • 58249088835 scopus 로고    scopus 로고
    • Addition of bevacizumab to fluorouracil.based first-line treatment of metastatic colorectal cancer: Pooled analysis of cohorts of older patients from two randomized clinical trials
    • Kabbinavar FF, Hurwitz HI, Sarkar S, et al. Addition of bevacizumab to fluorouracil.based first-line treatment of metastatic colorectal cancer: pooled analysis of cohorts of older patients from two randomized clinical trials. J Clin Oncol 2009;27:199-205
    • (2009) J Clin Oncol , vol.27 , pp. 199-205
    • Kabbinavar, F.F.1    Hurwitz, H.I.2    Sarkar, S.3
  • 13
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 2008;26:2013-19
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3
  • 15
    • 75749096309 scopus 로고    scopus 로고
    • Phase II trial of infusional fluorouracil, irinotecan,and bevacizumab for metastatic colorectal cancer: Efficacy and circulating angiogenic biomarkers associated with therapeutic resistance
    • Kopetz S, Hoff PM, Morris JS, et al. Phase II trial of infusional fluorouracil, irinotecan,and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J Clin Oncol 2010;28:453-9
    • (2010) J Clin Oncol , vol.28 , pp. 453-459
    • Kopetz, S.1    Hoff, P.M.2    Morris, J.S.3
  • 16
    • 84856304557 scopus 로고    scopus 로고
    • First-line XELOX plus bevacizumab followed by XELOX plus bevacizumab or single-agent bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: The phase III MACRO TTD study
    • Diaz-Rubio E, Gomez A, Massuti B, et al. First-line XELOX plus bevacizumab followed by XELOX plus bevacizumab or single-agent bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: the phase III MACRO TTD study. Oncologist 2012;17:15-25
    • (2012) Oncologist , vol.17 , pp. 15-25
    • Diaz-Rubio, E.1    Gomez, A.2    Massuti, B.3
  • 18
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
    • Grothey A, Sugrue MM, Purdie DM, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol 2008;26:5326-34
    • (2008) J Clin Oncol , vol.26 , pp. 5326-5334
    • Grothey, A.1    Sugrue, M.M.2    Purdie, D.M.3
  • 19
    • 84866152751 scopus 로고    scopus 로고
    • Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus CT: Results of a randomized phase III intergroup study (TML study)
    • abstract 3503
    • Arnold D, Andre T, Bennouna J, et al. Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus CT: results of a randomized phase III intergroup study (TML study). J Clin Oncol 2012;30(Suppl):abstract 3503
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Arnold, D.1    Andre, T.2    Bennouna, J.3
  • 20
    • 84856529459 scopus 로고    scopus 로고
    • A multinational, randomized phase III study of bevacizumab (Bev) with FOLFOX4 or XELOX versus FOLFOX4 alone as adjuvant treatment for colon cancer (CC): Subgroup analyses from the AVANT trial
    • abstract
    • Andre T, Van Cutsem E, Schmoll J, et al. A multinational, randomized phase III study of bevacizumab (Bev) with FOLFOX4 or XELOX versus FOLFOX4 alone as adjuvant treatment for colon cancer (CC): Subgroup analyses from the AVANT trial. J Clin Oncol 2011;29(Suppl):abstract 3509
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. , pp. 3509
    • Andre, T.1    Van Cutsem, E.2    Schmoll, J.3
  • 21
    • 36348951548 scopus 로고    scopus 로고
    • New approaches in angiogenic targeting for colorectal cancer
    • Prat A, Casado E, Cortes J. New approaches in angiogenic targeting for colorectal cancer. World J Gastroenterol 2007;13:5857-66 (Pubitemid 350148502)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.44 , pp. 5857-5866
    • Prat, A.1    Casado, E.2    Cortes, J.3
  • 22
    • 67650996205 scopus 로고    scopus 로고
    • Phase IV study of bevacizumab in combination with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) in first-line metastatic colorectal cancer
    • Sobrero A, Ackland S, Clarke S, et al. Phase IV study of bevacizumab in combination with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) in first-line metastatic colorectal cancer. Oncology 2009;77:113-19
    • (2009) Oncology , vol.77 , pp. 113-119
    • Sobrero, A.1    Ackland, S.2    Clarke, S.3
  • 24
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • Takahashi Y, Kitadai Y, Bucana CD, et al. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 1995;55:3964-8
    • (1995) Cancer Res , vol.55 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3
  • 27
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • DOI 10.1056/NEJMra0706596
    • Kerbel RS. Tumor angiogenesis. N Engl J Med 2008;358:2039-49 (Pubitemid 351656458)
    • (2008) New England Journal of Medicine , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.S.1
  • 28
    • 33645971968 scopus 로고    scopus 로고
    • Antiangiogenesis drug design: Multiple pathways targeting tumor vasculature
    • Zhong H, Bowen JP. Antiangiogenesis drug design:multiple pathways targeting tumor vasculature. Curr Med Chem 2006;13:849-62
    • (2006) Curr Med Chem , vol.13 , pp. 849-862
    • Zhong, H.1    Bowen, J.P.2
  • 29
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • DOI 10.1038/nrc1093
    • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003;3:401-10 (Pubitemid 37328844)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 30
    • 29944445729 scopus 로고    scopus 로고
    • Anti-angiogenic treatment of gastrointestinal malignancies
    • DOI 10.1080/07357900500360024
    • Salmon JS, Lockhart AC, Berlin J. Anti-angiogenic treatment of gastrointestinal malignancies. Cancer Invest 2005;23:712-26 (Pubitemid 43041717)
    • (2005) Cancer Investigation , vol.23 , Issue.8 , pp. 712-726
    • Salmon, J.S.1    Lockhart, A.C.2    Berlin, J.3
  • 33
    • 0031570672 scopus 로고    scopus 로고
    • Molecular cloning of a novel vascular endothelial growth factor, VEGF-D
    • DOI 10.1006/geno.1997.4774
    • Yamada Y, Nezu J, Shimane M, et al. Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. Genomics 1997;42:483-8 (Pubitemid 27287391)
    • (1997) Genomics , vol.42 , Issue.3 , pp. 483-488
    • Yamada, Y.1    Nezu, J.-I.2    Shimane, M.3    Hirata, Y.4
  • 34
    • 0027751890 scopus 로고
    • The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • Park JE, Keller GA, Ferrara N. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extra-cellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell 1993;4:1317-26 (Pubitemid 24045761)
    • (1993) Molecular Biology of the Cell , vol.4 , Issue.12 , pp. 1317-1326
    • Park, J.E.1    Keller, G.-A.2    Ferrara, N.3
  • 35
    • 0026702970 scopus 로고
    • Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
    • Terman BI, Dougher-Vermazen M, Carrion ME, et al. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 1992;187:1579-86
    • (1992) Biochem Biophys Res Commun , vol.187 , pp. 1579-1586
    • Terman, B.I.1    Dougher-Vermazen, M.2    Carrion, M.E.3
  • 36
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform- specific receptor for vascular endothelial growth factor
    • DOI 10.1016/S0092-8674(00)81402-6
    • Soker S, Takashima S, Miao HQ, et al. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998;92:735-45 (Pubitemid 28155313)
    • (1998) Cell , vol.92 , Issue.6 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 39
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • DOI 10.1200/JCO.2002.10.088
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002;20:4368-80 (Pubitemid 35266299)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.21 , pp. 4368-4380
    • Dvorak, H.F.1
  • 40
    • 0035920244 scopus 로고    scopus 로고
    • Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) receptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways
    • Zeng H, Dvorak HF, Mukhopadhyay D. Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) receptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways. J Biol Chem 2001;276:26969-79
    • (2001) J Biol Chem , vol.276 , pp. 26969-26979
    • Zeng, H.1    Dvorak, H.F.2    Mukhopadhyay, D.3
  • 41
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
    • DOI 10.1016/0092-8674(93)90573-9
    • Millauer B, Wizigmann-Voos S, Schnurch H, et al. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993;72:835-46 (Pubitemid 23110226)
    • (1993) Cell , vol.72 , Issue.6 , pp. 835-846
    • Millauer, B.1    Wizigmann-Voos, S.2    Schnurch, H.3    Martinez, R.4    Moller, N.P.H.5    Risau, W.6    Ullrich, A.7
  • 42
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong GH, Rossant J, Gertsenstein M, et al. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995;376:66-70
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3
  • 43
    • 0035114105 scopus 로고    scopus 로고
    • Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis
    • Hiratsuka S, Maru Y, Okada A, et al. Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res 2001;61:1207-13 (Pubitemid 32174444)
    • (2001) Cancer Research , vol.61 , Issue.3 , pp. 1207-1213
    • Hiratsuka, S.1    Maru, Y.2    Okada, A.3    Seiki, M.4    Noda, T.5    Shibuya, M.6
  • 45
    • 0028938746 scopus 로고
    • Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development
    • Kaipainen A, Korhonen J, Mustonen T, et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci USA 1995;92:3566-70
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3566-3570
    • Kaipainen, A.1    Korhonen, J.2    Mustonen, T.3
  • 48
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • Warren RS, Yuan H, Matli MR, et al. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest 1995;95:1789-97
    • (1995) J Clin Invest , vol.95 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3
  • 49
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanism of anti-tumor activity
    • Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanism of anti-tumor activity. Nat Rev Cancer 2008;8:579-91
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 51
    • 58149175849 scopus 로고    scopus 로고
    • Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
    • Huynh H, Ngo VC, Fargnoli J, et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res 2008;14:6146-53
    • (2008) Clin Cancer Res , vol.14 , pp. 6146-6153
    • Huynh, H.1    Ngo, V.C.2    Fargnoli, J.3
  • 52
    • 78650240625 scopus 로고    scopus 로고
    • Brivanib, a novel dual VEGF-R2/bFGF-R inhibitor
    • Dempke WC, Zippel R. Brivanib, a novel dual VEGF-R2/bFGF-R inhibitor. Anticancer Res 2010;30:4477-83
    • (2010) Anticancer Res , vol.30 , pp. 4477-4483
    • Dempke, W.C.1    Zippel, R.2
  • 53
    • 80053493427 scopus 로고    scopus 로고
    • Beyond VEGF: Inhibition of the fibroblast growth factor pathway and antiangiogenesis
    • Lieu C, Heymach J, Overman M, et al. Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis. Clin Cancer Res 2011;17:6130-9
    • (2011) Clin Cancer Res , vol.17 , pp. 6130-6139
    • Lieu, C.1    Heymach, J.2    Overman, M.3
  • 54
    • 84874644619 scopus 로고    scopus 로고
    • Comparison of a dual inhibitor of vegf and fgf signaling, bms- 582664, to the activity of bevacizumab, an inhibitor exclusively of vegf signaling, in xenograft models of colon carcinoma [abstract 1618]
    • Ayers M. Comparison of a dual inhibitor of VEGF and FGF signaling, BMS- 582664, to the activity of bevacizumab, an inhibitor exclusively of VEGF signaling, in xenograft models of colon carcinoma [abstract 1618]. AACR Meeting Abstracts; 2007
    • (2007) AACR Meeting Abstracts
    • Ayers, M.1
  • 55
    • 84860878985 scopus 로고    scopus 로고
    • FGF receptor inhibitors: Role in cancer therapy
    • Daniele G, Corral J, Molife LR, et al. FGF receptor inhibitors: role in cancer therapy. Curr Oncol Rep 2012;14:111-19
    • (2012) Curr Oncol Rep , vol.14 , pp. 111-119
    • Daniele, G.1    Corral, J.2    Molife, L.R.3
  • 56
    • 79959699570 scopus 로고    scopus 로고
    • Phase i dose-escalation study to determine the safety, pharmacokinetics and pharmacodynamics of brivanib alaninate in combination with full-dose cetuximab in patients with advanced gastrointestinal malignancies who have failed prior therapy
    • Garrett CR, Siu LL, El-Khoueiry A, et al. Phase I dose-escalation study to determine the safety, pharmacokinetics and pharmacodynamics of brivanib alaninate in combination with full-dose cetuximab in patients with advanced gastrointestinal malignancies who have failed prior therapy. Br J Cancer 2011;105:44-52
    • (2011) Br J Cancer , vol.105 , pp. 44-52
    • Garrett, C.R.1    Siu, L.L.2    El-Khoueiry, A.3
  • 57
    • 84874583424 scopus 로고    scopus 로고
    • Final analysis of the phase iii randomized trial of cetuximab (cet) plus either brivanib alaninate (briv) or placebo in patients (pts) with chemotherapy refractory, k-ras wildtype (wt), metastatic colorectal carcinoma (mcrc): The ncic clinical trials group and agitg co.20 trial
    • abstract 3504
    • Siu LL, Shapiro JD, Jonker DJ, et al. Final analysis of the phase III randomized trial of cetuximab (CET) plus either brivanib alaninate (BRIV) or placebo in patients (pts) with chemotherapy refractory, K-RAS wildtype (WT), metastatic colorectal carcinoma (mCRC): the NCIC Clinical Trials Group and AGITG CO.20 trial. J Clin Oncol 2012;30(Suppl):abstract 3504
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Siu, L.L.1    Shapiro, J.D.2    Jonker, D.J.3
  • 60
    • 63149168979 scopus 로고    scopus 로고
    • Phase i study of cediranib in combinationwith oxaliplatin and infusional 5-fluorouracil in patients with advanced colorectal cancer
    • Chen E, Jonker D, Gauthier I, et al. Phase I study of cediranib in combinationwith oxaliplatin and infusional 5-fluorouracil in patients with advanced colorectal cancer. Clin Cancer Res 2009;15:1481-6
    • (2009) Clin Cancer Res , vol.15 , pp. 1481-1486
    • Chen, E.1    Jonker, D.2    Gauthier, I.3
  • 61
    • 84867115561 scopus 로고    scopus 로고
    • Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: A double-blind, randomized phase III study (HORIZON III)
    • Schmoll HJ, Cunningham D, Sobrero A, et al. Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: a double-blind, randomized phase III study (HORIZON III). J Clin Oncol 2012;29:3588-95
    • (2012) J Clin Oncol , vol.29 , pp. 3588-3595
    • Schmoll, H.J.1    Cunningham, D.2    Sobrero, A.3
  • 62
    • 61349149253 scopus 로고    scopus 로고
    • Phase III trial of FOLFOX plus bevacizumab or cediranib (AZD2171) as first-line treatment of patients with metastatic colorectal cancer: HORIZON III
    • Robertson JD, Botwood NA, Rothenberg ML, et al. Phase III trial of FOLFOX plus bevacizumab or cediranib (AZD2171) as first-line treatment of patients with metastatic colorectal cancer: HORIZON III. Clin Colorectal Cancer 2009;8:59-60
    • (2009) Clin Colorectal Cancer , vol.8 , pp. 59-60
    • Robertson, J.D.1    Botwood, N.A.2    Rothenberg, M.L.3
  • 63
    • 84867602281 scopus 로고    scopus 로고
    • Cediranib plus folfox/xelox versus placebo plus folfox/xelox in patients with previously untreated metastatic colorectal cancer: A randomized, double -blind, phase iii study (horizon ii)
    • Hoff PM, Hochhaus A, Pestalozzi B, et al. Cediranib plus FOLFOX/XELOX versus placebo plus FOLFOX/XELOX in patients with previously untreated metastatic colorectal cancer: a randomized, double -blind, phase III study (Horizon II). J Clin Oncol 2012;29:3596-603
    • (2012) J Clin Oncol , vol.29 , pp. 3596-3603
    • Hoff, P.M.1    Hochhaus, A.2    Pestalozzi, B.3
  • 66
    • 66149168686 scopus 로고    scopus 로고
    • Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors
    • Castillo-Avila W, Piulats JM, Garcia Del Muro X, et al. Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors. Clin Cancer Res 2009;15:3384-95
    • (2009) Clin Cancer Res , vol.15 , pp. 3384-3395
    • Castillo-Avila, W.1    Piulats, J.M.2    Garcia Del Muro, X.3
  • 67
    • 52149110148 scopus 로고    scopus 로고
    • Sunitinib malate (SU-11248) alone or in combination with low-dose docetaxel inhibits the growth of DU-145 prostate cancer xenografts
    • Cumashi A, Tinari N, Rossi C, et al. Sunitinib malate (SU-11248) alone or in combination with low-dose docetaxel inhibits the growth of DU-145 prostate cancer xenografts. Cancer Lett 2008;270:229-33
    • (2008) Cancer Lett , vol.270 , pp. 229-233
    • Cumashi, A.1    Tinari, N.2    Rossi, C.3
  • 72
    • 35948991213 scopus 로고    scopus 로고
    • A phase i study of sunitinib in combination with modified FOLFOX 6 (mFOLFOX6) chemotherapy [abstract 285]
    • Leong S, Eckhardt SG, Chan E, et al. A phase I study of sunitinib in combination with modified FOLFOX 6 (mFOLFOX6) chemotherapy [abstract 285]. ASCO Gastrointestinal Cancers Symposium; 2007
    • (2007) ASCO Gastrointestinal Cancers Symposium
    • Leong, S.1    Eckhardt, S.G.2    Chan, E.3
  • 73
    • 84855168247 scopus 로고    scopus 로고
    • Phase i study of sunitinib in combination with FOLFIRI in patients with untreated metastatic colorectal cancer
    • Starling N, Vazquez-Mazon F, Cunningham D, et al. Phase I study of sunitinib in combination with FOLFIRI in patients with untreated metastatic colorectal cancer. Ann Oncol 2012;23:119-27
    • (2012) Ann Oncol , vol.23 , pp. 119-127
    • Starling, N.1    Vazquez-Mazon, F.2    Cunningham, D.3
  • 74
    • 78650825835 scopus 로고    scopus 로고
    • A preliminary report of a Phase II study of folinic acid, 5-fluorouracil, irinotecan (FOLFIRI) plus sunitinib with toxicity, efficacy, pharmacokinetics, biomarker, imaging data in patients with colorectal cancer with liver metastases as 1st line treatment-A study of the CESAR central european society for anticancer drug research-EWIV
    • Mross K, Buchert M, Fasol U, et al. A preliminary report of a Phase II study of folinic acid, 5-fluorouracil, irinotecan (FOLFIRI) plus sunitinib with toxicity, efficacy, pharmacokinetics, biomarker, imaging data in patients with colorectal cancer with liver metastases as 1st line treatment-a study of the CESAR central european society for anticancer drug research-EWIV. Int J Clin Pharmacol Ther 2011;1:96-8
    • (2011) Int J Clin Pharmacol Ther , vol.1 , pp. 96-98
    • Mross, K.1    Buchert, M.2    Fasol, U.3
  • 76
    • 0037099598 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging
    • Drevs J, Muller-Driver R, Wittig C, et al. PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging. Cancer Res 2002;62:4015-22 (Pubitemid 34791068)
    • (2002) Cancer Research , vol.62 , Issue.14 , pp. 4015-4022
    • Drevs, J.1    Muller-Driver, R.2    Wittig, C.3    Fuxius, S.4    Esser, N.5    Hugenschmidt, H.6    Konerding, M.A.7    Allegrini, P.R.8    Wood, J.9    Hennig, J.10    Unger, C.11    Marme, D.12
  • 77
    • 16344389752 scopus 로고    scopus 로고
    • A phase i, dose escalating and pharmacokinetic (pk) study of the vegf-receptor inhibitor ptk787/zk222584 (ptk/zk) in patients with advanced renal cell or prostate carcinomas
    • George D, Jonasch E, Hart L, et al. A phase I, dose escalating and pharmacokinetic (PK) study of the VEGF-receptor inhibitor PTK787/ZK222584 (PTK/ZK) in patients with advanced renal cell or prostate carcinomas. Clin Cancer Res 2001;7:548a
    • (2001) Clin Cancer Res , vol.7
    • George, D.1    Jonasch, E.2    Hart, L.3
  • 79
  • 80
    • 23844548194 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase iii study in patients (pts) with metastatic a line chemotherapy with oxaliplatin/5- fluorouracil/leucovorin and ptk787/zk222584 or placebo (confirm-1)
    • abstract
    • Hecht JR, Trarbach T, Jaeger E, et al. A randomized, double-blind, placebo-controlled, phase III study in patients (Pts) with metastatic a line chemotherapy with oxaliplatin/5- fluorouracil/leucovorin and PTK787/ZK222584 or placebo (CONFIRM-1). J Clin Oncol 2005;23(Suppl):abstract 3
    • (2005) J Clin Oncol , vol.23 , Issue.SUPPL. , pp. 3
    • Hecht, J.R.1    Trarbach, T.2    Jaeger, E.3
  • 81
    • 36349019056 scopus 로고    scopus 로고
    • Final results of confirm 2: A multinational, randomized, double-blind, phase iii study in 2nd line patients (pts) with metastatic colorectal cancer (mcrc) receiving folfox4 and ptk787/zk222584 (ptk/zk) or placebo
    • abstract
    • Kohne C, Bajetta E, Lin E, et al. Final results of CONFIRM 2: a multinational, randomized, double-blind, phase III study in 2nd line patients (pts) with metastatic colorectal cancer (mCRC) receiving FOLFOX4 and PTK787/ZK222584 (PTK/ZK) or placebo. J Clin Oncol 2007; 25(Suppl):abstract 4033
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. , pp. 4033
    • Kohne, C.1    Bajetta, E.2    Lin, E.3
  • 83
    • 0036718003 scopus 로고    scopus 로고
    • Results of a phase I dose-escalating study of the antiangiogenic agent, SU5416, in patients with advanced malignancies
    • Stopeck A, Sheldon M, Vahedian M, et al. Results of a phase I dose-escalating study of the antiangiogenic agent, SU5416, in patients with advanced malignancies. Clin Cancer Res 2002;8:2798-805 (Pubitemid 35025722)
    • (2002) Clinical Cancer Research , vol.8 , Issue.9 , pp. 2798-2805
    • Stopeck, A.1    Sheldon, M.2    Vahedian, M.3    Cropp, G.4    Gosalia, R.5    Hannah, A.6
  • 84
    • 0000601929 scopus 로고    scopus 로고
    • Phase i dose-escalating trial of SU5416, a novel angiogenesis inhibitor, in patients with advanced malignancies
    • Rosen L, Mulay M, Mayers A, et al. Phase I dose-escalating trial of SU5416, a novel angiogenesis inhibitor, in patients with advanced malignancies. Proc Am Soc Clin Oncol 1999;18:618a
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Rosen, L.1    Mulay, M.2    Mayers, A.3
  • 85
    • 0003037701 scopus 로고    scopus 로고
    • A phase I/II study of SU5416 in combination with 5-FU/leucovorin in patients with metastatic colorectal cancer
    • Rosen P, Amado R, Hecht J, et al. A phase I/II study of SU5416 in combination with 5-FU/leucovorin in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 2000;18:5a
    • (2000) Proc Am Soc Clin Oncol , vol.18
    • Rosen, P.1    Amado, R.2    Hecht, J.3
  • 86
    • 84874599327 scopus 로고    scopus 로고
    • A phase i/ii open-label, randomized study of bibf 1120 plus mfolfox6 compared to bevacizumab plus mfolfox6 in patients with metastatic colorectal cancer [abstract 14lb]
    • Van Cutsem E, Prenen H, Guillen-Ponce C, et al. A phase I/II open-label, randomized study of BIBF 1120 plus mFOLFOX6 compared to bevacizumab plus mFOLFOX6 in patients with metastatic colorectal cancer [abstract 14LB]. ECCO-ESMO Congress; Stockolm; 2011
    • (2011) ECCO-ESMO Congress; Stockolm
    • Van Cutsem, E.1    Prenen, H.2    Guillen-Ponce, C.3
  • 87
    • 77954682879 scopus 로고    scopus 로고
    • Ramucirumab (IMC-1121B): A novel attack on angiogenesis
    • Spratlin JL, Mulder KE, Mackey JR. Ramucirumab (IMC-1121B): a novel attack on angiogenesis. Future Oncol 2010;6:1085-94
    • (2010) Future Oncol , vol.6 , pp. 1085-1094
    • Spratlin, J.L.1    Mulder, K.E.2    Mackey, J.R.3
  • 89
    • 77649213706 scopus 로고    scopus 로고
    • Phase i pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
    • Spratlin JL, Cohen RB, Eadens M, et al. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol 2010;28:780-7
    • (2010) J Clin Oncol , vol.28 , pp. 780-787
    • Spratlin, J.L.1    Cohen, R.B.2    Eadens, M.3
  • 91
    • 65349186800 scopus 로고    scopus 로고
    • Aflibercept (AVE0005): An alternative strategy for inhibiting tumor angiogenesis by vascular endothelial growth factors
    • Chu QS. Aflibercept (AVE0005): an alternative strategy for inhibiting tumor angiogenesis by vascular endothelial growth factors. Expert Opin Biol Ther 2009;9:263-71
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 263-271
    • Chu, Q.S.1
  • 92
    • 2542450942 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines
    • DOI 10.1158/1078-0432.CCR-03-0820
    • Fukasawa M, Korc M. Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines. Clin Cancer Res 2004;10:3327-32 (Pubitemid 38685437)
    • (2004) Clinical Cancer Research , vol.10 , Issue.10 , pp. 3327-3332
    • Fukasawa, M.1    Korc, M.2
  • 94
    • 74949119167 scopus 로고    scopus 로고
    • Phase i study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors
    • Lockhart AC, Rothenberg ML, Dupont J, et al. Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors. J Clin Oncol 2010;28:207-14
    • (2010) J Clin Oncol , vol.28 , pp. 207-214
    • Lockhart, A.C.1    Rothenberg, M.L.2    Dupont, J.3
  • 95
    • 67649262706 scopus 로고    scopus 로고
    • Phase II trial of aflibercept (VEGF Trap) in previously treated patients with metastatic colorectal cancer (MCRC): A PMH phase II consortium trial
    • abstract
    • Tang P, Cohen SJ, Bjarnason GA, et al. Phase II trial of aflibercept (VEGF Trap) in previously treated patients with metastatic colorectal cancer (MCRC): a PMH phase II consortium trial. J Clin Oncol 2008;26(Suppl):abstract 4027
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. , pp. 4027
    • Tang, P.1    Cohen, S.J.2    Bjarnason, G.A.3
  • 96
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase iii randomized trial in patients with metastatic colorectal cancer
    • Van Cutsem E, Tabernero J, Lakomy R, et al. Addition of Aflibercept to Fluorouracil, Leucovorin, and Irinotecan Improves Survival in a Phase III Randomized Trial in Patients With Metastatic Colorectal Cancer. J Clin Oncol 2012;30(28):3499-06
    • (2012) J Clin Oncol , vol.30 , Issue.28 , pp. 3499-3506
    • Van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3
  • 97
    • 84868526153 scopus 로고    scopus 로고
    • Effects of prior bevacizumab (b) use on outcomes from the velour study: A phase iii study of aflibercept (afl) and folfiri in patients (pts) with metastatic colorectal cancer (mcrc) after failure of an oxaliplatin regimen
    • abstract
    • Allegra CJ, Lakomy R, Tabernero J, et al. Effects of prior bevacizumab (B) use on outcomes from the VELOUR study: a phase III study of aflibercept (Afl) and FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin regimen. J Clin Oncol 2012;30(Suppl):abstract 3505
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. , pp. 3505
    • Allegra, C.J.1    Lakomy, R.2    Tabernero, J.3
  • 99
    • 79955816044 scopus 로고    scopus 로고
    • Phase i study of regorafenib (bay 73-4506), an inhibitor of oncogenic and angiogenic kinases, administered continuously in patients (pts) with advanced refractory non-small cell lung cancer (nsclc) [abstract]
    • abstract
    • Kies MS, Blumenschein GR Jr, Christensen O, et al. Phase I study of regorafenib (BAY 73-4506), an inhibitor of oncogenic and angiogenic kinases, administered continuously in patients (pts) with advanced refractory non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2010;28(15 Suppl):abstract 7585
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL. , pp. 7585
    • Kies, M.S.1    Blumenschein Jr., G.R.2    Christensen, O.3
  • 100
    • 77953911437 scopus 로고    scopus 로고
    • Phase i study of bay 73-4506, an inhibitor of oncogenic and angiogenic kinases, in patients with advanced refractory colorectal carcinoma (crc)
    • abstract
    • Strumberg D, Scheulen ME, Frost A, et al. Phase I study of BAY 73-4506, an inhibitor of oncogenic and angiogenic kinases, in patients with advanced refractory colorectal carcinoma (CRC). J Clin Oncol 2009;27(15 Suppl):abstract 3560
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL. , pp. 3560
    • Strumberg, D.1    Scheulen, M.E.2    Frost, A.3
  • 101
    • 84861057568 scopus 로고    scopus 로고
    • Results of a phase III randomized, double-blind, placebo-controlled, multicenter trial (CORRECT) of regorafenib plus best supportive care (BSC) versus placebo plus BSC in patients (pts) with metastatic colorectal cancer (mCRC) who have progressed after standard therapies
    • abstract
    • Grothey A, Sobrero AF, Siena S, et al. Results of a phase III randomized, double-blind, placebo-controlled, multicenter trial (CORRECT) of regorafenib plus best supportive care (BSC) versus placebo plus BSC in patients (pts) with metastatic colorectal cancer (mCRC) who have progressed after standard therapies. J Clin Oncol 2012;30(4 Suppl):abstract 385
    • (2012) J Clin Oncol , vol.30 , Issue.4 SUPPL. , pp. 385
    • Grothey, A.1    Sobrero, A.F.2    Siena, S.3
  • 102
    • 69949127786 scopus 로고    scopus 로고
    • Anti-EGFR monoclonal antibodies in cancer therapy
    • Martinelli E, De Palma R, Orditura M, et al. Anti-EGFR monoclonal antibodies in cancer therapy. J Clin Immunol 2009;158(1):1-9
    • (2009) J Clin Immunol , vol.158 , Issue.1 , pp. 1-9
    • Martinelli, E.1    De Palma, R.2    Orditura, M.3
  • 103
    • 84862301209 scopus 로고    scopus 로고
    • Beyond bevacizumab: New anti-VEGF strategies in colorectal cancer
    • Troiani T, Martinelli E, Orditura M, et al. Beyond bevacizumab: new anti-VEGF strategies in colorectal cancer. Expert Opin Investig Drugs 2012;21(7):949-59
    • (2012) Expert Opin Investig Drugs , vol.21 , Issue.7 , pp. 949-959
    • Troiani, T.1    Martinelli, E.2    Orditura, M.3


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