Low circulating protein C levels are associated with lower leg ulcers in patients with diabetes

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Whitmont, K ^a   Fulcher, G ^a   Reid, I ^a   Xue, M ^a   McKelvey, K ^a   Xie, Y ^a   Aboud, M ^a   Ward, C ^a   Smith, M M ^a   Cooper, A ^a   March, L ^a   Jackson, C J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; C REACTIVE PROTEIN; HEMOGLOBIN A1C; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; PROTEIN C;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLORIMETRY; CONTROLLED STUDY; DIABETIC FOOT; DIAGNOSTIC PROCEDURE; FEMALE; HUMAN; MALE; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; BLOOD; CLINICAL TRIAL; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; C-REACTIVE PROTEIN; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIABETIC FOOT; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; MIDDLE AGED; PROTEIN C;

EID: 84874612714     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/719570     Document Type: Article

References (22)

1. Esmon C. T., The anticoagulant and anti-inflammatory roles of the protein C anticoagulant pathway. Journal of Autoimmunity 2000 15 2 113 116 2-s2.0-0033830963 10.1006/jaut.2000.0400
2. Mosnier L. O., Zlokovic B. V., Griffin J. H., The cytoprotective protein C pathway. Blood 2007 109 8 3161 3172 2-s2.0-34147119744 10.1182/blood-2006-09- 003004 (Pubitemid 46572500)
3. Xue M., Minhas N., Chow S. O., Dervish S., Sambrook P. N., March L., Jackson C. J., Endogenous protein C is essential for the functional integrity of human endothelial cells. Cellular and Molecular Life Sciences 2010 67 9 1537 1546 2-s2.0-77952298767 10.1007/s00018-010-0269-y
4. Xue M., Chow S. O., Dervish S., Chan Y. K., Julovi S., Jackson C. J., Activated protein C enhances human keratinocyte barrier integrity via sequential activation of epidermal growth factor receptor and tie2. The Journal of Biological Chemistry 2010 286 6742 6750 10.1074/jbc.M110.181388
5. Fukudome K., Kurosawa S., Stearns-Kurosawa D. J., He X., Rezaie A. R., Esmon C. T., The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. The Journal of Biological Chemistry 1996 271 29 17491 17498 2-s2.0-0030016347 10.1074/jbc.271.29.17491 (Pubitemid 26244316)
6. Kurosawa S., Stearns-Kurosawa D. J., Hidari N., Esmon C. T., Identification of functional endothelial protein C receptor in human plasma. Journal of Clinical Investigation 1997 100 2 411 418 2-s2.0-0030742589 (Pubitemid 27349089)
7. Bernard G. R., Vincent J. L., Laterre P. F., LaRosa S. P., Dhainaut J. F., Lopez-Rodriguez A., Steingrub J. S., Garber G. E., Helterbrand J. D., Ely E. W., Fisher C. J., Efficacy and safety of recombinant human activated protein C for severe sepsis. The New England Journal of Medicine 2001 344 10 699 709 2-s2.0-0035826096 10.1056/NEJM200103083441001 (Pubitemid 32204987)
8. Whitmont K., Reid I., Tritton S., March L., Xue M., Lee M., Fulcher G., Sambrook P., Slobedman E., Cooper A., Jackson C., Treatment of chronic leg ulcers with topical activated protein C. Archives of Dermatology 2008 144 11 1479 1483 2-s2.0-47949100730 10.1001/archderm.144.11.1479
9. Jackson C., Whitmont K., Tritton S., March L., Sambrook P., Xue M., New therapeutic applications for the anticoagulant, activated protein C. Expert Opinion on Biological Therapy 2008 8 8 1109 1122 2-s2.0-47949125983 10.1517/14712598.8.8.1109
10. Zlokovic B. V., Zhang C., Liu D., Fernandez J., Griffin J. H., Chopp M., Functional recovery after embolic stroke in rodents by activated protein C. Annals of Neurology 2005 58 3 474 477 2-s2.0-24644462200 10.1002/ana.20602 (Pubitemid 41266637)
11. Isermann B., Vinnikov I. A., Madhusudhan T., Herzog S., Kashif M., Blautzik J., Corat M. A. F., Zeier M., Blessing E., Oh J., Gerlitz B., Berg D. T., Grinnell B. W., Chavakis T., Esmon C. T., Weiler H., Bierhaus A., Nawroth P. P., Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nature Medicine 2007 13 11 1349 1358 2-s2.0-35948934636 10.1038/nm1667 (Pubitemid 350073598)
12. Yasui H., Gabazza E. C., Tamaki S., Kobayashi T., Hataji O., Yuda H., Shimizu S., Suzuki K., Adachi Y., Taguchi O., Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse. American Journal of Respiratory and Critical Care Medicine 2001 163 7 1660 1668 2-s2.0-0034955797 (Pubitemid 32578773)
13. Kumral A., Yesilirmak D. C., Tugyan K., Baskin H., Tekman I., Duman N., Ozkan H., Activated protein C reduces intestinal injury in an experimental model of necrotizing enterocolitis. Journal of Pediatric Surgery 2010 45 3 483 489 2-s2.0-77649216557 10.1016/j.jpedsurg.2009.07.077
14. Jackson C. J., Xue M., Thompson P., Davey R. A., Whitmont K., Smith S., Buisson-Legendre N., Sztynda T., Furphy L. J., Cooper A., Sambrook P., March L., Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair and Regeneration 2005 13 3 284 294 2-s2.0-20544475431 10.1111/j.1067-1927.2005.00130311.x (Pubitemid 40848022)
15. Xue M., Thompson P., Kelso I., Jackson C., Activated protein C stimulates proliferation, migration and wound closure, inhibits apoptosis and upregulates MMP-2 activity in cultured human keratinocytes. Experimental Cell Research 2004 299 1 119 127 10.1016/j.yexcr.2004.05.015 (Pubitemid 39078387)
16. Xue M., Campbell D., Sambrook P. N., Fukudome K., Jackson C. J., Endothelial protein C receptor and protease-activated receptor-1 mediate induction of a wound-healing phenotype in human keratinocytes by activated protein C. Journal of Investigative Dermatology 2005 125 6 1279 1285 2-s2.0-33644825461 10.1111/j.0022-202X.2005.23952.x
17. Xue M., Campbell D., Jackson C. J., Protein C is an autocrine growth factor for human skin keratinocytes. The Journal of Biological Chemistry 2007 282 18 13610 13616 2-s2.0-34250372944 10.1074/jbc.M610740200 (Pubitemid 47100554)
18. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003 26 supplement 1 S5 S20
19. Vukovich T. C., Schernthaner G., Decreased protein C levels in patients with insulin-dependent type I diabetes mellitus. Diabetes 1986 35 5 617 619 2-s2.0-0022470867 (Pubitemid 16085338)
20. Yano Y., Gabazza E. C., Kitagawa N., Bruno N. E., Matsumoto K., Nakatani K., Araki R., Katsuki A., Adachi Y., Sumida Y., Tumor necrosis, factor- α is associated with increased protein C activation in nonobese type 2 diabetic patients. Diabetes Care 2004 27 3 844 845 2-s2.0-10744230925 10.2337/diacare.27.3.844 (Pubitemid 38280568)
21. Liu Y., Min D., Bolton T., Nube V., Twigg S. M., Yue D. K., Mclennan S. V., Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers. Diabetes Care 2009 32 1 117 119 2-s2.0-64549119604 10.2337/dc08-0763
22. Esmon C. T., Protein C pathway in sepsis. Annals of Medicine 2002 34 7-8 598 605 2-s2.0-0036957150 (Pubitemid 36113819)