Collapsin response mediator protein 3 deacetylates histone H4 to mediate nuclear condensation and neuronal death

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Hou, Sheng T ^a,b   Jiang, Susan X ^a   Aylsworth, Amy ^a   Cooke, Matthew ^a   Zhou, Lei ^a,b,c  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DPYSL4 PROTEIN, MOUSE; GLUTAMIC ACID; HISTONE; HISTONE DEACETYLASE; NERVE PROTEIN; TRANSCRIPTION FACTOR E2F1; TUBULIN;

ACETYLATION; ANIMAL; ARTICLE; CELL DEATH; CELL LINE; CELL NUCLEUS; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; METABOLISM; MOUSE; NERVE CELL; PROTEIN BINDING; PROTEIN TRANSPORT; ULTRASTRUCTURE;

ACETYLATION; ANIMALS; CELL DEATH; CELL LINE; CELL NUCLEUS; E2F1 TRANSCRIPTION FACTOR; FEMALE; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUTAMIC ACID; HISTONE DEACETYLASES; HISTONES; HUMANS; MICE; NERVE TISSUE PROTEINS; NEURONS; PROTEIN BINDING; PROTEIN TRANSPORT; TUBULIN;

EID: 84874610386     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep01350     Document Type: Article

References (45)

1. Hedgecock, E. M., Culotti, J. G., Thomson, J. N. & Perkins, L. A. Axonal guidance mutants of Caenorhabditis elegans identified by filling sensory neurons with fluorescein dyes. Dev. Biol. 111, 158-170 (1985) (Pubitemid 16246484)
2. Li, W., Herman, R. K. & Shaw, J. E. Analysis of the Caenorhabditis elegans axonal guidance and outgrowth gene unc-33. Genetics 132, 675-689 (1992)
3. Luo, Y., Raible, D. & Raper, J. A. Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell 75, 217-227 (1993) (Pubitemid 23320286)
4. Charrier, E. et al. Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders. Mol. Neurobiol. 28, 51-64 (2003)
5. Deo, R. C. et al. Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. EMBO J 23, 9-22 (2004) (Pubitemid 38165743)
6. Goshima, Y., Nakamura, F., Strittmatter, P. & Strittmatter, S. M. Collapsininduced growth cone collapse mediated by an intracellular protein related to UNC-33. Nature 376, 509-514 (1995)
7. Gu, Y. & Ihara, Y. Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules. J. Biol. Chem. 275, 17917-17920 (2000) (Pubitemid 30414732)
8. Inagaki, N. et al. CRMP-2 induces axons in cultured hippocampal neurons. Nat. Neurosci. 4, 781-782 (2001) (Pubitemid 32702507)
9. Fukata, Y. et al. CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat. Cell Biol. 4, 583-591 (2002)
10. Arimura, N. et al. Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol. Cell Biol. 25, 9973-9984 (2005) (Pubitemid 41572744)
11. Nishimura, T. et al. CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat. Cell Biol. 5, 819-826 (2003) (Pubitemid 37087170)
12. Rosslenbroich, V. et al. Collapsin response mediator protein-4 regulates F-actin bundling. Exp. Cell Res. (2005)
13. Yamashita, N. et al. Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration. J. Neurosci. 26, 13357-13362 (2006) (Pubitemid 46011646)
14. Su, K. Y. et al. Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory. J Neurosci 27, 2513-2524 (2007)
15. Quach, T. T. et al. CRMP3 is required for hippocampal CA1 dendritic organization and plasticity. FASEB J. 22, 401-409 (2008) (Pubitemid 351225576)
16. Hou, S. T., Jiang, S. X. & Smith, R. A. Permissive and repulsive cues and signalling pathways of axonal outgrowth and regeneration. Int. Rev. Cell Mol. Biol. 267, 125-181 (2008)
17. Hou, S. T. et al. Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia. J Neurosci 26, 2241-2249 (2006) (Pubitemid 44699033)
18. Jiang, S. X. et al. Calpain cleavage of collapsin response mediator proteins in ischemic mouse brain. Eur. J. Neurosci. 26, 801-809 (2007) (Pubitemid 47274611)
19. Schmidt, E. F. & Strittmatter, S. M. The CRMP family of proteins and their role in Sema3A signaling. Adv. Exp. Med. Biol. 600, 1-11 (2007)
20. Wang, L. H. & Strittmatter, S. M. A family of rat CRMP genes is differentially expressed in the nervous system. J Neurosci 16, 6197-6207 (1996) (Pubitemid 26313994)
21. Aylsworth, A., Jiang, S. X., Desbois, A. & Hou, S. T. Characterization of the role of full-length CRMP3 and its calpain-cleaved product in inhibiting microtubule polymerization and neurite outgrowth. Exp. Cell Res. 315, 2856-2868 (2009)
22. Leipe, D. D. Landsman, D. Histone deacetylases, acetoin utilization proteins and acetylpolyamine amidohydrolases are members of an ancient protein superfamily. Nucleic Acids Res. 25, 3693-3697 (1997) (Pubitemid 27390190)
23. Hou, S. T. et al. The transcription factor E2F1 modulates apoptosis of neurons. J Neurochem 75, 91-100 (2000) (Pubitemid 30418173)
24. Hou, S. T. et al. The transcription factor E2F1 promotes dopamine-evoked neuronal apoptosis by a mechanism independent of transcriptional activation. J Neurochem 78, 287-297 (2001) (Pubitemid 32664410)
25. Boutillier, A. L., Trinh, E. & Loeffler, J. P. Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. J Neurochem. 84, 814-828 (2003) (Pubitemid 36176939)
26. Boutillier, A. L., Trinh, E. & Loeffler, J. P. Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival. Ann. N. Y. Acad. Sci. 973, 438-442 (2002) (Pubitemid 36125049)
27. Bolger, T. A. &Yao, T. P. Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. J. Neurosci. 25, 9544-9553 (2005) (Pubitemid 41464769)
28. Faraco, G. et al. Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain. Mol. Pharmacol. 70, 1876-1884 (2006) (Pubitemid 44771903)
29. Pandey, U. B. et al. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447, 859-863 (2007) (Pubitemid 46920134)
30. Rivieccio, M. A. et al. HDAC6 is a target for protection and regeneration following injury in the nervous system. Proc. Natl. Acad. Sci. U. S. A. 106, 19599-19604 (2009)
31. Hou, S. T. et al. Increased expression of the transcription factor E2F1 during dopamine-evoked, caspase-3-mediated apoptosis in rat cortical neurons. Neurosci Lett 306, 153-156 (2001) (Pubitemid 32530822)
32. Hou, S. T. et al. Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis. J Biol. Chem. 277, 48764-48770 (2002) (Pubitemid 35470842)
33. Smith, R. A., Walker, T., Xie, X. & Hou, S. T. Involvement of the transcription factor E2F1/Rb in kainic acid-induced death of murine cerebellar granule cells. Brain Res. Mol. Brain Res. 116, 70-79 (2003) (Pubitemid 36993698)
34. Hou, S. T. & MacManus, J. P. Molecular mechanisms of cerebral ischemiainduced neuronal death. Int. Rev. Cytol. 221, 93-148 (2002) (Pubitemid 35429861)
35. Arimura, N., Menager, C., Fukata, Y. & Kaibuchi, K. Role of CRMP-2 in neuronal polarity. J. Neurobiol. 58, 34-47 (2004) (Pubitemid 37543336)
36. Hou, S. T. et al. CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity. J. Neurochem. 111, 870-881 (2009)
37. O'Hare, M. J. et al. Induction and modulation of cerebellar granule neuron death by E2F-1. J. Biol. Chem. 275, 25358-25364 (2000)
38. Jiang, S. X. et al. Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons. J. Biol. Chem. 285, 9908-9918 (2010)
39. Hou, S. T. et al. Sustained up-regulation of semaphorin 3A, Neuropilin1, and doublecortin expression in ischemic mouse brain during long-term recovery. Biochem. Biophys. Res. Commun. 367, 109-115 (2008)
40. Hou, S. T., Jiang, S. X., Slinn, J., O'Hare, M. & Karchewski, L. Neuropilin 2 deficiency does not affect cortical neuronal viability in response to oxygenglucose-deprivation and transientmiddle cerebral artery occlusion. Neurosci. Res. 66, 396-401 (2010)
41. Huang, D., Desbois, A., Chen, G., Fang, H. & Hou, S. T. Characterization of the Expression of Key Adenoviral Receptors CAR and Integrin beta3/beta5 Subunits on the Membrane of Human NT2 Neurons. J. Mol. Neurosci. 24, 323-328 (2004) (Pubitemid 41359160)
42. Hou, S. T. et al. The transcription factor E2F1 modulates apoptosis of neurons. J. Neurochem. 75, 91-100 (2000) (Pubitemid 30418173)
43. Jiang, S. X., Sheldrick, M., Desbois, A., Slinn, J. &Hou, S. T. Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo. Mol. Cell Biol. 27, 1696-1705 (2007)
44. North, B. J., Marshall, B. L., Borra, M. T., Denu, J. M. & Verdin, E. The human Sir2 ortholog, SIRT2, is an NAD1-dependent tubulin deacetylase. Mol. Cell 11, 437-444 (2003) (Pubitemid 36293837)
45. Hubbert, C. et al. HDAC6 is a microtubule-associated deacetylase. Nature 417, 455-458 (2002). (Pubitemid 34563539)