Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein

Virology Journal

Volumn 10, Issue , 2013, Pages

  Szalmás, Anita ^a   Gyöngyösi, Eszter ^a   Ferenczi, Annamária ^a   László, Brigitta ^a   Karosi, Tamás ^a   Csomor, Péter ^a   Gergely, Lajos ^a   Veress, György ^a   Kónya, József ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

HPV 16; Non receptor protein tyrosine kinase; Oncoprotein; Src family kinases

Indexed keywords

MESSENGER RNA; PROTEIN E6; PROTEIN E7; PROTEIN KINASE FYN; PROTEIN KINASE SRC; PROTEIN KINASE YES; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; KERATINOCYTE; NONHUMAN; PROTEIN EXPRESSION; WESTERN BLOTTING;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATION; HUMAN PAPILLOMAVIRUS 16; HUMANS; KERATINOCYTES; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRUS E7 PROTEINS; PAPILLOMAVIRUS INFECTIONS; PROTO-ONCOGENE PROTEINS C-FYN; PROTO-ONCOGENE PROTEINS C-YES; PROTO-ONCOGENE PROTEINS PP60(C-SRC); REPRESSOR PROTEINS;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16;

EID: 84874589132     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-10-79     Document Type: Article

References (40)

1. The Src, Syk, and Tec family kinases: Distinct types of molecular switches. Bradshaw JM, Cell Signal 2010 22 1175 1184 10.1016/j.cellsig.2010.03. 001 20206686
2. Integrins and signal transduction. Cabodi S, Di Stefano P, Leal MDC, Tinnirello A, Bisaro B, Morello V, Integrins and Ion Channels: Molecular Complexes and Signaling 2010 674 43 54 10.1007/978-1-4419-6066-5-5
3. Src kinases as therapeutic targets for cancer. Kim LC, Song LX, Haura EB, Nat Rev Clin Oncol 2009 6 587 595 10.1038/nrclinonc.2009.129 19787002
4. Src protein-tyrosine kinase structure and regulation. Roskoski R, Biochem Biophys Res Commun 2004 324 1155 1164 10.1016/j.bbrc.2004.09.171 15504335 (Pubitemid 40292143)
5. Src kinase regulation by phosphorylation and dephosphorylation. Roskoski R, Biochem Biophys Res Commun 2005 331 1 14 10.1016/j.bbrc.2005.03.012 15845350 (Pubitemid 40545134)
6. Src signaling in cancer invasion. Guarino M, J Cell Physiol 2010 223 14 26 20049846
7. Regulation of SRC family kinases in human cancers. Sen B, Johnson FM, J Signal Transduct 2011 201 1 865819
8. Src family kinases in tumor progression and metastasis. Summy JM, Gallick GE, Cancer Metastasis Rev 2003 22 337 358 10.1023/A:1023772912750 12884910 (Pubitemid 36791891)
9. Functional activation of Src family kinase Yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3. Hamamura K, Tsuji M, Hotta H, Ohkawa Y, Takahashi M, Shibuya H, J Biol Chem 2011 286 18526 18537 10.1074/jbc.M110.164798 21454696
10. A phase 2 trial of dasatinib in advanced melanoma. Kluger HM, Dudek AZ, McCann C, Ritacco J, Southard N, Jilaveanu LB, Cancer 2011 117 2202 2208 10.1002/cncr.25766 21523734
11. Activity of the multikinase inhibitor dasatinib against ovarian cancer cells. Konecny GE, Glas R, Dering J, Manivong K, Qi J, Finn RS, Br J Cancer 2009 101 1699 1708 10.1038/sj.bjc.6605381 19861960
12. Elevated c-Src and c-Yes expression in malignant skin cancers. Lee JH, Pyon JK, Kim DW, Lee SH, Nam HS, Kim CH, J Exp Clin Cancer Res 2010 29 116 10.1186/1756-9966-29-116 20796316
13. Inhibition of Src family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. Montero JC, Seoane S, Ocana A, Pandiella A, Clin Cancer Res 2011 17 5546 5552 10.1158/1078-0432.CCR-10-2616 21670084
14. Fyn a novel molecular target in cancer. Saito YD, Jensen AR, Salgia R, Posadas EM, Cancer 2010 116 1629 1637 10.1002/cncr.24879 20151426
15. Differential effects on cell motility, embryonic stem cell self-renewal and senescence by diverse Src kinase family inhibitors. Tamm C, Galito SP, Anneren C, Exp Cell Res 2012 318 336 349 10.1016/j.yexcr.2011.12.008 22197704
16. Down-regulation of phospho-non-receptor Src tyrosine kinases contributes to growth inhibition of cervical cancer cells. Kong L, Deng ZH, Zhao YZ, Wang YM, Sarkar FH, Zhang YX, Med Oncol 2011 28 1495 1506 10.1007/s12032-010-9583-3 20532678
17. Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173. Kong L, Deng ZH, Shen HY, Zhang YX, Mol Cell Biochem 2011 348 11 19 10.1007/s11010-010-0632-1 21052789
18. Locking Src/Abl Tyrosine Kinase Activities Regulate Cell Differentiation and Invasion of Human Cervical Cancer Cells Expressing E6/E7 Oncoproteins of High-Risk HPV. Yasmeen A, Alachkar A, Dekhil H, Gambacorti-Passerini C, Al Moustafa AE, J Oncol 2010 2010 530130 10
19. Src inhibitors are promising therapy molecules for human cervical carcinomas. Al Moustafa AE, Yasmeen A, Achkhar A, Med Hypotheses 2011 77 812 814 10.1016/j.mehy.2011.07.043 21864985
20. Oncogenic potential of human papillomavirus (HPV) and its relation with cervical cancer. Faridi R, Zahra A, Khan K, Idrees M, Virol J 2011 8 269 10.1186/1743-422X-8-269 21635792
21. Human papillomavirus immortalization and transformation functions. Munger K, Howley PM, Virus Res 2002 89 213 228 10.1016/S0168-1702(02)00190-9 12445661 (Pubitemid 35351540)
22. Productive lifecycle of human papillomaviruses that depends upon squamous epithelial differentiation. Kajitani N, Satsuka A, Kawate A, Sakai H, Front Microbiol 2012 3 152 22536200
23. Genomic instability and cancer: lessons learned from human papillomaviruses. Korzeniewski N, Spardy N, Duensing A, Duensing S, Cancer Lett 2011 305 113 122 10.1016/j.canlet.2010.10.013 21075512
24. HPV16 Oncoproteins Induce MMPs/RECK-TIMP-2 Imbalance in Primary Keratinocytes: Possible Implications in Cervical Carcinogenesis. Cardeal LBD, Boccardo E, Termini L, Rabachini T, Andreoli MA, di Loreto C, PLoS One 2012 7 33585 10.1371/journal.pone.0033585 22438955
25. Human papillomavirus oncoproteins: pathways to transformation. Moody CA, Laimins LA, Nat Rev Cancer 2010 10 550 560 10.1038/nrc2886 20592731
26. Effects of human papillomavirus (HPV) type 16 oncoproteins on the expression of involucrin in human keratinocytes. Gyongyosi E, Szalmas A, Ferenczi A, Konya J, Gergely L, Veress G, Virol J 2012 9 36 10.1186/1743-422X-9- 36 22333115
27. Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells. Sancier F, Dumont A, Sirvent A, de Plater LP, Edmonds T, David G, PLoS One 2011 6 17237 10.1371/journal.pone.0017237 21390316
28. Differentiation-dependent Up-regulation of the human papillomavirus E7 gene reactivates cellular Dna-replication in suprabasal differentiated keratinocytes. Cheng S, Schmidtgrimminger DC, Murant T, Broker TR, Chow LT, Genes Dev 1995 9 2335 2349 10.1101/gad.9.19.2335 7557386
29. Establishment of human papillomavirus infection requires cell cycle progression. Pyeon D, Pearce SM, Lank SM, Ahlquist P, Lambert PF, PLoS Pathog 2009 5 1000318 10.1371/journal.ppat.1000318 19247434
30. E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway. Contreras-Paredes A, Cruz-Hernandez E, Martinez-Ramirez I, Duenas-Gonzalez A, Lizano M, Virology 2009 383 78 85 10.1016/j.virol.2008.09.040 19007961
31. The human papillomavirus E6 protein and its contribution to malignant progression. Mantovani F, Banks L, Oncogene 2001 20 7874 7887 10.1038/sj.onc.1204869 11753670 (Pubitemid 33135314)
32. Biological activities and molecular targets of the human papillomavirus E7 oncoprotein. Munger K, Basile JR, Duensing S, Eichten A, Gonzalez SL, Grace M, Oncogene 2001 20 7888 7898 10.1038/sj.onc.1204860 11753671 (Pubitemid 33135315)
33. Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells. Baldwin A, Li WL, Grace M, Pearlberg J, Harlow E, Munger K, Proc Natl Acad Sci USA 2008 105 16478 16483 10.1073/pnas.0806195105 18948598
34. The simian virus 40 large tumor antigen activates cSrc and requires cSrc for full neoplastic transformation. Arulanandam R, Geletu M, Raptis L, Anticancer Res 2010 30 47 53 20150616
35. Assessment of EGFR and TGF-alpha expression in relationship to HPV status and KI-67 distribution in cervical intraepithelial neoplasms. Dellas A, Schultheiss E, Almendral AC, Torhorst J, Gudat F, Int J Cancer 1996 69 165 169 10.1002/(SICI)1097-0215(19960621)69:3<165::AID-IJC2>3.0.CO;2-Y 8682581 (Pubitemid 26233292)
36. Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18. McCormack SJ, Brazinski SE, Moore JL, Werness BA, Goldstein DJ, Oncogene 1997 15 265 274 10.1038/sj.onc.1201186 9233761 (Pubitemid 27370873)
37. Role of Src family tyrosine kinases in the down-regulation of epidermal growth factor signaling in PC12 cells. Kasai A, Shima T, Okada M, Genes Cells 2005 10 1175 1187 10.1111/j.1365-2443.2005.00909.x 16324154 (Pubitemid 41830076)
38. Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells. Thelemann A, Petti F, Griffin G, Iwata K, Hunt T, Settinari T, Mol Cell Proteomics 2005 4 356 376 10.1074/mcp.M400118- MCP200 15657067 (Pubitemid 40590556)
39. Unexpected role for VEGF-mediated vascular permeability in tumor cell extravasation and metastasis. Weis S, Cui JH, Cheresh D, J Histochem Cytochem 2004 52 12
40. Signal transduction by focal adhesion kinase in cancer. Zhao J, Guan JL, Cancer Metastasis Rev 2009 28 35 49 10.1007/s10555-008-9165-4 19169797