SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Chen, Pan ^a,b   Guo, Xiaofang ^b   Zhou, Houde ^b   Zhang, Wenling ^b   Zeng, Zhaoyang ^a,b   Liao, Qianjin ^b   Li, Xiayu ^b   Xiang, Bo ^a,b   Yang, Jianbo ^c   Ma, Jian ^a,b   Zhou, Ming ^a,b   Peng, Shuping ^a,b   Xiang, Juanjuan ^a,b   Li, Xiaoling ^a,b   Le, Colvin Wanshura ^c   Xiong, Wei ^a,b   McCarthy, James B ^c   Li, Guiyuan ^a,b  

^a Central South University   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LATENT MEMBRANE PROTEIN 1; MICRORNA 141; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P27; SHORT PALATE LUNG AND NASAL EPITHELIUM CLONE 1; UNCLASSIFIED DRUG; BPIFA1 PROTEIN, HUMAN; CDKN1B PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; GLYCOPROTEIN; GREEN FLUORESCENT PROTEIN; MATRIX PROTEIN; MICRORNA; MIRN141 MICRORNA, HUMAN; PHOSPHOPROTEIN; PTEN PROTEIN, HUMAN;

ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CANCER GROWTH; CANCER STAGING; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EPSTEIN BARR VIRUS INFECTION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LMP1 GENE; NASOPHARYNX CARCINOMA; NONHUMAN; PERIPHERAL LYMPHOCYTE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPLUNC1 GENE; VIRUS VIRULENCE; ANIMAL; BAGG ALBINO MOUSE; COCULTURE; GENETICS; MALE; METABOLISM; MOUSE; NASOPHARYNX TUMOR; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; COCULTURE TECHNIQUES; CYCLIN-DEPENDENT KINASE INHIBITOR P27; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; GREEN FLUORESCENT PROTEINS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICRORNAS; NASOPHARYNGEAL NEOPLASMS; PHOSPHOPROTEINS; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; VIRAL MATRIX PROTEINS;

EID: 84874587775     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056929     Document Type: Article

References (45)

1. Xiong W, Zeng ZY, Xia JH, Xia K, Shen SR, et al. (2004) A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma. Cancer Res 64: 1972-1974.
2. Zeng Z, Zhou Y, Zhang W, Li X, Xiong W, et al. (2006) Family-based association analysis validates chromosome 3p21 as a putative nasopharyngeal carcinoma susceptibility locus. Genet Med 8: 156-160.
3. Zeng X, Xiang J, Wu M, Xiong W, Tang H, et al. (2012) Circulating miR-17, miR-20a, miR-29c, and miR-223 combined as non-invasive biomarkers in nasopharyngeal carcinoma. PLoS One 7: e46367.
4. Zeng Z, Huang H, Zhang W, Xiang B, Zhou M, et al. (2011) Nasopharyngeal carcinoma: advances in genomics and molecular genetics. Sci China Life Sci 54: 966-975.
5. Zheng Y, Zhang W, Ye Q, Zhou Y, Xiong W, et al. (2012) Inhibition of Epstein-Barr virus infection by lactoferrin. J Innate Immun 4: 387-398.
6. Zhang W, Zeng Z, Zhou Y, Xiong W, Fan S, et al. (2009) Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis. Acta Biochim Biophys Sin (Shanghai) 41: 414-428.
7. Dawson CW, Rickinson AB, Young LS, (1990) Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiation. Nature 344: 777-780.
8. Fan H, Gulley ML, (2001) Epstein-Barr viral load measurement as a marker of EBV-related disease. Mol Diagn 6: 279-289.
9. LeClair EE, (2003) Four reasons to consider a novel class of innate immune molecules in the oral epithelium. J Dent Res 82: 944-950.
10. Zhang B, Nie X, Xiao B, Xiang J, Shen S, et al. (2003) Identification of tissue-specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray. Genes Chromosomes Cancer 38: 80-90.
11. Zhou HD, Li GY, Yang YX, Li XL, Sheng SR, et al. (2006) Intracellular co-localization of SPLUNC1 protein with nanobacteria in nasopharyngeal carcinoma epithelia HNE1 cells depended on the bactericidal permeability increasing protein domain. Mol Immunol 43: 1864-1871.
12. Bingle CD, Craven CJ, (2002) PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. Hum Mol Genet 11: 937-943.
13. Bingle CD, Gorr SU, (2004) Host defense in oral and airway epithelia: chromosome 20 contributes a new protein family. Int J Biochem Cell Biol 36: 2144-2152.
14. Zhou HD, Li XL, Li GY, Zhou M, Liu HY, et al. (2008) Effect of SPLUNC1 protein on the Pseudomonas aeruginosa and Epstein-Barr virus. Mol Cell Biochem 309: 191-197.
15. Garcia-Caballero A, Rasmussen JE, Gaillard E, Watson MJ, Olsen JC, et al. (2009) SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage. Proc Natl Acad Sci U S A 106: 11412-11417.
16. Rollins BM, Garcia-Caballero A, Stutts MJ, Tarran R, (2010) SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes. Channels (Austin) 4: 255-259.
17. Zhang L, Deng T, Li X, Liu H, Zhou H, et al. (2010) microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis 31: 559-566.
18. Lei Q, Jiao J, Xin L, Chang CJ, Wang S, et al. (2006) NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell 9: 367-378.
19. Walsh T, King MC, (2007) Ten genes for inherited breast cancer. Cancer Cell 11: 103-105.
20. Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, et al. (1997) Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 16: 64-67.
21. Marsh DJ, Trahair TN, Martin JL, Chee WY, Walker J, et al. (2008) Rapamycin treatment for a child with germline PTEN mutation. Nat Clin Pract Oncol 5: 357-361.
22. Schneider F, Neugebauer J, Griese J, Liefold N, Kutz H, et al. (2008) The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity. PLoS Biol 6: e8.
23. Shirakata M, Imadome KI, Okazaki K, Hirai K, (2001) Activation of TRAF5 and TRAF6 signal cascades negatively regulates the latent replication origin of Epstein-Barr virus through p38 mitogen-activated protein kinase. J Virol 75: 5059-5068.
24. Chen CC, Chen LC, Liang Y, Tsang NM, Chang YS, (2010) Epstein-Barr virus latent membrane protein 1 induces the chemotherapeutic target, thymidine phosphorylase, via NF-kappaB and p38 MAPK pathways. Cell Signal 22: 1132-1142.
25. Vaysberg M, Hatton O, Lambert SL, Snow AL, Wong B, et al. (2008) Tumor-derived variants of Epstein-Barr virus latent membrane protein 1 induce sustained Erk activation and c-Fos. J Biol Chem 283: 36573-36585.
26. Ross SH, Lindsay Y, Safrany ST, Lorenzo O, Villa F, et al. (2007) Differential redox regulation within the PTP superfamily. Cell Signal 19: 1521-1530.
27. Liu TR, Chen FJ, Zhang GP, Yang AK, (2011) Different therapeutic strategies in primary salivary gland-type nasopharyngeal carcinomas. Curr Opin Otolaryngol Head Neck Surg 19: 87-91.
28. Uhlmann S, Zhang JD, Schwager A, Mannsperger H, Riazalhosseini Y, et al. (2010) miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. Oncogene 29: 4297-4306.
29. Guo X, Zeng Y, Deng H, Liao J, Zheng Y, et al. (2010) Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China. BMC Res Notes 3: 212.
30. Ren ZF, Liu WS, Qin HD, Xu YF, Yu DD, et al. (2010) Effect of family history of cancers and environmental factors on risk of nasopharyngeal carcinoma in Guangdong, China. Cancer Epidemiol 34: 419-424.
31. Yang Y, Zhou H, Li W, Zhou M, Zeng Z, et al. (2007) Lipopolysaccharide (LPS) regulates TLR4 signal transduction in nasopharynx epithelial cell line 5-8F via NFkappaB and MAPKs signaling pathways. Mol Immunol 44: 984-992.
32. Hu LF, Qiu QH, Fu SM, Sun D, Magnusson K, et al. (2008) A genome-wide scan suggests a susceptibility locus on 5p 13 for nasopharyngeal carcinoma. Eur J Hum Genet 16: 343-349.
33. Li Y, Fu L, Wong AM, Fan YH, Li MX, et al. (2011) Identification of genes with allelic imbalance on 6p associated with nasopharyngeal carcinoma in southern Chinese. PLoS One 6: e14562.
34. Peng C, Liu HY, Zhou M, Zhang LM, Li XL, et al. (2007) BRD7 suppresses the growth of Nasopharyngeal Carcinoma cells (HNE1) through negatively regulating beta-catenin and ERK pathways. Mol Cell Biochem 303: 141-149.
35. Zheng MZ, Qin HD, Yu XJ, Zhang RH, Chen LZ, et al. (2007) Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population. J Transl Med 5: 36.
36. Bei JX, Li Y, Jia WH, Feng BJ, Zhou G, et al. (2010) A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet 42: 599-603.
37. Sugimoto M, Tahara H, Ide T, Furuichi Y, (2004) Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus. Cancer Res 64: 3361-3364.
38. Chen HC, Chen GH, Chen YH, Liao WL, Liu CY, et al. (2009) MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma. Br J Cancer 100: 1002-1011.
39. Trotman LC, Niki M, Dotan ZA, Koutcher JA, Di Cristofano A, et al. (2003) Pten dose dictates cancer progression in the prostate. PLoS Biol 1: E59.
40. Brown MD, Sacks DB, (2009) Protein scaffolds in MAP kinase signalling. Cell Signal 21: 462-469.
41. Zhou HD, Fan SQ, Zhao J, Huang DH, Zhou M, et al. (2006) Tissue distribution of the secretory protein, SPLUNC1, in the human fetus. Histochem Cell Biol 125: 315-324.
42. Tang YL, Lu JH, Cao L, Wu MH, Peng SP, et al. (2008) Genetic variations of EBV-LMP1 from nasopharyngeal carcinoma biopsies: potential loss of T cell epitopes. Braz J Med Biol Res 41: 110-116.
43. Zeng ZY, Zhou YH, Zhang WL, Xiong W, Fan SQ, et al. (2007) Gene expression profiling of nasopharyngeal carcinoma reveals the abnormally regulated Wnt signaling pathway. Hum Pathol 38: 120-133.
44. Zhang W, Zeng Z, Fan S, Wang J, Yang J, et al. (2012) Evaluation of the prognostic value of TGF-beta superfamily type I receptor and TGF-beta type II receptor expression in nasopharyngeal carcinoma using high-throughput tissue microarrays. J Mol Histol 43: 297-306.
45. Zeng Z, Zhou Y, Xiong W, Luo X, Zhang W, et al. (2007) Analysis of gene expression identifies candidate molecular markers in nasopharyngeal carcinoma using microdissection and cDNA microarray. J Cancer Res Clin Oncol 133: 71-81.