Transforming growth factor-beta1 and IL-13 response to allergen predict steroid needs in asthmatic children

Pulmonary Pharmacology and Therapeutics

Volumn 26, Issue 2, 2013, Pages 290-295

  Majak, Paweł ^a   Jurałowicz, Dorota ^a   Jerzyńska, Joanna ^a   Smejda, Katarzyna ^a   Stelmach, Włodzimierz ^a   Stelmach, Iwona ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Asthma children; Immunotherapy; Inhaled glucocorticosteroids

Indexed keywords

ALLERGEN; INTERLEUKIN 13; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; ASTHMA; CD4+ CD25+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATOPHAGOIDES; DISEASE SEVERITY; FEMALE; HUMAN; IMMUNOTHERAPY; LUNG FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PREDICTIVE VALUE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REMISSION; SCHOOL CHILD;

ANIMALS; ASTHMA; CHILD; DESENSITIZATION, IMMUNOLOGIC; FEMALE; GLUCOCORTICOIDS; HUMANS; INTERLEUKIN-13; MALE; PYROGLYPHIDAE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84874581596     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2012.12.008     Document Type: Article

References (25)

1. Akdis C.A. Allergy and hypersensitivity: mechanisms of allergic disease. Curr Opin Immunol 2006, 18(6):718-726.
2. Akdis M., Burgler S., Crameri R., Eiwegger T., Fujita H., Gomez E., et al. Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases. J Allergy Clin Immunol 2011, 127(3):701-721.
3. Yoshikawa T., Kanazawa H. Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma. Respir Med 2011 Jan, 105(1):24-30.
4. Sears M.R., Greene J.M., Willan A.R., Wiecek E.M., Taylor D.R., Flannery E.M., et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003 Oct 9, 349(15):1414-1422.
5. Blumberga G., Groes L., Dahl R. SQ-standardized house dust mite immunotherapy as an immunomodulatory treatment in patients with asthma. Allergy 2011, 66:178-185.
6. Zielen S., Kardos P., Madonini E. Steroid-sparing effects with allergen-specific immunotherapy in children with asthma: a randomized controlled trial. J Allergy Clin Immunol 2010, 126:942-949.
7. Ozdemir C., Yazi D., Gocmen I., Yesil O., Aydogan M., Semic-Jusufagic A., et al. Efficacy of long-term sublingual immunotherapy as an adjunct to pharmacotherapy in house dust mite-allergic children with asthma. Pediatr Allergy Immunol 2007, 18:508-515.
8. Stelmach I., Sobocińska A., Majak P., Smejda K., Jerzyńska J., Stelmach W. Comparison of the long-term efficacy of 3- and 5-year house dust mite allergen immunotherapy. Ann Allergy Asthma Immunol 2012, 109:274-278.
9. Akdis C.A., Akdis M. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2011 Jan, 127(1):18-27.
10. Yang Y.C., Zhang N., Van Crombruggen K., Hu G.H., Hong S.L., Bachert C. Transforming growth factor-beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling. Allergy 2012, 67:1193-1202.
11. O'Garra A., Stockinger B., Veldhoen M. Differentiation of human T(H)-17 cells does require TGF-beta!. Nat Immunol 2008, 9:588-590.
12. Ryanna K., Stratigou V., Safinia N., Hawrylowicz C. Regulatory T cells in bronchial asthma. Allergy 2009, 64:335-347.
13. Lloyd C.M., Hawrylowicz C.M. Regulatory T cells in asthma. Immunity 2009, 31:438-449.
14. Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., et al. Conversion of peripheral CD4+ CD25 naive T cells to CD4+ CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003, 198:1875-1886.
15. O'Hehir R.E., Gardner L.M., de Leon M.P., Hales B.J., Biondo M., Douglass J.A., et al. House dust mite sublingual immunotherapy: the role for transforming growth factor-beta and functional regulatory T cells. Am J Respir Crit Care Med 2009, 15(180):936-947.
16. Karlsson M.R., Rugtveit J., Brandtzaeg P. Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med 2004 Jun 21, 199(12):1679-1688.
17. Noma T., Sugawara Y., Ogawa N., Saeki T., Yamaguchi K., Kawano Y. Dermatophagoides-induced interleukin-10 production by peripheral blood lymphocytes from patients with asthma in remission. Pediatr Allergy Immunol 2004 Oct, 15(5):459-466.
18. Majak P, Jerzyńska J, Smejda K, Stelmach I, Timler D, Stelmach W. Vitamin D correlates with Foxp3 induction and steroid sparing effect of immunotherapy in asthmatic children. Ann Allergy Asthma Immunol.
19. Majak P., Rychlik B., Stelmach I. The effect of oral steroids with and without vitamin D3 on early efficacy of immunotherapy in asthmatic children. Clin Exp Allergy 2009, 39:1830-1841.
20. Majak P., Rychlik B., Pułaski L., Błauz A., Brzozowska B., Bobrowska-Korzeniowska M., et al. Montelukast treatment may alter the early efficacy of immunotherapy in children with asthma. J Allergy Clin Immunol 2010, 125:1220-1227.
21. Global strategy for asthma management and prevention. NIH Publication No. 02-3659. Updated 2004 from the 2003 document. Available from: [accessed 25.11.09]. http://www.ginasthma.org/Guidelineitem.asp?l1%31%3d%312&l2%31%3d%311&intId%31%3d%31987.
22. Riccioni G., Di Stefano F., De Benedictis M., Verna N., Cavallucci E., Paolini F., et al. Seasonal variability of nonspecific bronchial responsiveness in asthmatic patients with allergy to house dust mites. Allergy Asthma Proc 2001, 22:5-9.
23. Ingram J.L., Kraft M. IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies. J Allergy Clin Immunol 2012, 130:829-842.
24. Martinez-Nunez R.T., Louafi F., Sanchez-Elsner T. The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1). J Biol Chem 2011, 286:1786-1794.
25. Gordon E.D., Sidhu S.S., Wang Z.E., Woodruff P.G., Yuan S., Solon M.C., et al. A protective role for periostin and TGF-beta in IgE-mediated allergy and airway hyperresponsiveness. Clin Exp Allergy 2012, 42:144-155.