Simple, economical, and reproducible LC-MS method for the determination of amoxicillin in human plasma and its application to a pharmacokinetic study

Journal of Chromatographic Science

Volumn 46, Issue 10, 2008, Pages 854-861

  Khuroo, A H ^a   Monif, T ^a   Verma, P R P ^b   Gurule, S ^a  

^a RANBAXY RESEARCH LABORATORIES   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 56549086027     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/46.10.854     Document Type: Article

References (26)

1. Guidance for Industry (Draft Guidance). Food-Effect Bioavailability and Bioequivalence studies, U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER) October (1997).
2. Guidance for Industry, Bioavailability and Bioequivalence Studies for Orally Administered Drug Products - General Considerations, U.S. Department of Health and Human Services, Food and Drug Administration, Mar 2003.
3. V.P. Shah and K.K. Mehta. Analytical method validation: Bioavailability, bioequivalence and pharmacokinetic studies. J. Pharm. Sci. 81: 3 (1992).
4. Guidance for industry bioanalytical method validation, Food and Drug administration, USA, May 2001.
5. D. Bragio, R.J. Barnaby, P. Grossi, and M. Cugola. A strategy for validation of bioanalytical methods. J. Pharm. Biomed. Anal. 15: 375-388 (1995).
6. Jake J. Thiessen. Bioavailability and Bioequivalence (Chapter 8), University of Toronto Canada.
7. M. Marques, C. Raposo, M. Damasceno, M. Filho, D. Pinto, and E. Barroso. Simultaneous determination of amoxicillin and Cefalexin in human plasma by LC-MS/MS. 17 IMSC, Prague, 2006.
8. F. Bruno, R. Curini, A. Corcia, M. Nazzari, and R. Samperi. Solid-phase extraction followed by liquid chromatography-mass spectrometry for trace determination of β-Lactum antibiotics in Bovine milk. J. Agric. Food Chem. 49(7): 3463-70 (2001).
9. S. Bogialli, V. Capitolino, R. Curini, A. Corcia, M. Nazzari and M. Sergi. Simple and rapid liquid chromatography-tandem mass spectrometry confirmatory assay for determining amoxicillin and ampicillin in Bovine tissue and milk. J. Agric. Food Chem. 52(11): 3286-91 (2004).
10. G. Hoizey, D. Lamiable, C. Frances, T. Trenque, M. Kaltenbach, and H. Millart. Simultaneous determination of amoxicillin and clavulanic acid in human by HPLC with UV detection. J. Pharm. Biomed. Anal. 30: 6661-66 (2002).
11. L. Abreu and R. Ortiz. HPLC determination of amoxicillin comparative bioavailability in healthy volunteers after a single dose administration. J. Pharm. Pharmaceut. Sci. 6(2): 223-30 (2003).
12. N. Lindegardh, T. Singtoroj, A. Annerberg, and N.J. White. Development and validation of a solid phase extraction-liquid chromatographic method for determination of amoxicillin in plasma. Ther. Drug Monit. 27: 503-508 (2005).
13. B. Charles and S. Chulavatnatol. Simple analysis of amoxicillin in plasma by high performance liquid chromatography with internal standardization and ultraviolet detection. Biomed. Chromatogr. 7: 204-207 (1993).
14. P. Muth, R. Metz, W. Bolten, and H. Vergen. Improved high-performance liquid chromatographic determination of amoxicillin in human plasma by means of column switching. J. Chromatogr. A 729: 266 (1996).
15. Z. Yuan. H. Russlie, and D.M. Canafaz. Sensitive assay for measuring amoxicillin in human plasma and middle ear fluid using solid extraction and reverse-phase high- performance liquid chromatography. J. Chromatogr. B 674: 93-9 (1995).
16. W.J. Krauwinkel, N. Volkers-Kamermans, and J. Van Zijtveld. Determination of amoxicillin in human plasma by high- performance liquid chromatography and solid phase extraction. Chromatogr. 617: 334-38 (1993).
17. H. Marscher and C. Kikuta. Determination of amoxicillin in plasma by high-performance liquid chromatography with fluorescence after on-line oxidation. J. Chromatogr. A 506: 417-21 (1990).
18. F.N. Eshelman and D.A. Spyker. Pharmacokinetics of amoxicillin and ampicillin: Cross-over study of effect of food. Antimicrobial agents and Chemotherapy 14(4): 539-43 (1978)
19. R.F. Straub and R.D. Voyksner. Determination of Penicillin G, ampicillin, amoxicillin, cloxacillin and cepharipin by high performance liquid chromatography-electrospray mass spectrometry. J. Chromatogr. 647(1): 167-81 (1993).
20. Amoxicillin Rxlist Monographs, 2004.
21. J. Henion. E. Brewer, and G. Rule. Sample preparation for LC/MS/MS, analyzing biological and environmental samples. Anal Chem. 70: 650-56, (1998).
22. T. Benijts, R. Dams, W. Lambert, and A. De Leenheer. Countering matrix effects in environmental chromatography-electrospray ionization tandem mass spectrometry water analysis for endocrine disrupting chemicals. J. Chromatogr. A 12: 1029(1-2): 153-59 (2004).
23. B.K. Matuszewski, M.L. Constanzer, and C.M. Chavez-Eng. Matrix effect in quantitative LC/MS/MS analysis of biological fluids: A method for determination of Finasteride in human plasma at pictogram per milliter concentrations. Anal. Chem. 70(5): 882-89 (1998).
24. J. Schuhmacher, D. Zimmer, F. Tesche, and V. Pickard. Matrix effect during analysis of plasma samples by electrospray and atmospheric chemical ionization mass spectrometry: practical approached to their elimination. InterScience 17(17): 1950-1957 (2003).
25. M. Weng and T.D.J. Halls. Systematic trouble shooting forLCMS/MS. Pharmaceutical Technology 102-20 (2002).
26. P. Gerhards, S. Sadjadi, and R. Motyka. Evaluating extract cleanliness of SPEC, Focus, and protein precipitation via LC/MS/MS postcolumn infusion. Varian, No A02101, Aug 2004.