Quality of surgery and neoadjuvant combined therapy in the ISG-GEIS trial on soft tissue sarcomas of limbs and trunk wall

Annals of Oncology

Volumn 24, Issue 3, 2013, Pages 817-823

  Gronchi, A ^a   Verderio, P ^a   De Paoli, A ^b   Ferraro, A ^c   Tendero, O ^d   Majo J ^e   Martin, J ^d   Comandone, A ^f   Grignani, G ^g   Pizzamiglio, S ^a   Quagliuolo, V ^h   Picci, P ^c   Frustaci, S ^b   Dei Tos, A P ⁱ   Palassini, E ^a   Stacchiotti, S ^a   Ferrari, S ^c   Fiore, M ^a   Casali, P G ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^c RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^d HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f GRADENIGO HOSPITAL   (Italy)

^g CANDIOLO CANCER INSTITUTE   (Italy)

^h HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

ⁱ General Hospital of Treviso   (Italy)

Author keywords

Chemotherapy; Local recurrence; Radiation therapy; Sarcoma; Surgical margins; Survival

Indexed keywords

EPIRUBICIN; IFOSFAMIDE;

ADOLESCENT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CONTROLLED STUDY; FOLLOW UP; HIGH RISK PATIENT; HUMAN; LIMB; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PHASE 3 CLINICAL TRIAL; POSTOPERATIVE CARE; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOFT TISSUE SARCOMA; SURGERY; SURGICAL MARGIN; TRUNK; TUMOR LOCALIZATION; UNIVARIATE ANALYSIS;

EID: 84874555940     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mds501     Document Type: Article

References (31)

1. Pisters PWT, Leung DH, Woodruff J et al.. Analysis of prognostic factors in 1041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol 1996; 14: 1679-1689.
2. Stojadinovic A, Leung DH, Hoos A et al.. Analysis of the prognostic significance of microscopic margins in 2,084 localized primary adult soft tissue sarcomas. Ann Surg 2002; 235: 424-434.
3. Kawaguchi N, Ahmed AR, Matsumoto S et al.. The concept of curative margin in surgery for bone and soft tissue sarcoma. Clin Orthop 2004; 419: 165-172.
4. Gronchi A, Casali PG, Mariani L et al.. Status of surgical margins and prognosis in adult soft tissue sarcomas of the extremities: a series of patients treated at a single institution. J Clin Oncol 2005; 23: 96-104.
5. Trovik CS, Bauer HC, Alvegard TA et al. Surgical margins, local recurrence and metastasis in soft tissue sarcomas: 559 surgically-treated patients from the Scandinavian sarcoma group register. Eur J Cancer 2000; 36(6): 710-716.
6. Zagars GK, Ballo MT, Pisters PWT et al.. Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy. Cancer 2003; 97: 2530-2543.
7. Gronchi A, Lo Vullo S, Colombo C et al.. Extremity soft tissue sarcoma in a series of patients treated at a single institution: local control directly impacts survival. Ann Surg 2010; 251: 512-517.
8. Gronchi A, Miceli R, Fiore M et al.. Extremity soft tissue sarcoma: adding to the prognostic meaning of local failure. Ann Surg Oncol 2007; 14(5): 1583-1590.
9. Gronchi A, Miceli R, Colombo C et al.. Primary extremity soft tissue sarcomas: outcome improvement over time at a single institution. Ann Oncol 2011; 22(7): 1675-1681.
10. Pisters PWT, Harrison LB, Leung DH et al.. Long-term results of a prospective randomized trial of adjuvant brachytherapy on soft tissue sarcoma. J Clin Oncol 1996; 14: 859-868.
11. Yang JC, Chang AE, Baker AR et al.. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 1998; 16: 197-203.
12. Kraybill WG, Harris J, Spiro JJ et al.. Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. J Clin Oncol 2006; 24(4): 619-625.
13. O'Sullivan B, Davis AM, Turcotte R et al.. Preoperative versus postoperative radiotherapy in soft tissue sarcoma of the limbs: a randomised trial. Lancet 2002; 359: 2235-2241.
14. Pisters PWT, O'Sullivan B, Maki RG. Evidence-based recommendations for local therapy for soft tissue sarcomas. J Clin Oncol 2007; 25: 1003-1008.
15. Wunder JS, Nielsen TO, Maki RG et al.. Opportunities for improving the therapeutic ration for patients with sarcoma. Lancet Oncol 2007; 8(6): 513-524.
16. Gronchi A, Frustaci S, Mercuri M et al.. Short, full-dose adjuvant chemotherapy in highrisk adult soft tissue sarcomas: a randomized clinical trial from the Italian Sarcoma Group and the Spanish Sarcoma Group. J Clin Oncol 2012; 30(8): 850-856.
17. Therasse P, Arbuck SG, Eisenhauer EA et al.. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000; 92: 205-206.
18. Stacchiotti S, Collini P, Messina A et al.. High-grade soft-tissue sarcomas: tumor response assessment-pilot study to assess the correlation between radiologic and pathologic response by using RECIST and Choi criteria. Radiology 2009; 251: 447-456.
19. Hosmer DW, Lemeshow S. Applied Logistic Regression. New York, USA: John Wiley & Sons 1989.
20. Hollander M, Wolfe DA. Nonparametric Statistical Methods, 2nd edition. New York: John Wiley & Sons 1999.
21. Kaplan EL, Maier P. Am Stat Assoc 1958; 53: 457-481.
22. Marubini E, Valsecchi MG. Analysing Survival Data From Clinical Trials and Observational Studies. Chichester, UK: Wiley 1995.
23. Cox DR. Regression models and life tables. J R Stat Soc B 1972; 34: 187-220.
24. Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med 1989; 8: 551-561.
25. Harrell FE, Califf RM, Pryor DB et al.. Evaluating the yield of medical tests. JAMA 1982; 247: 2543-2548.
26. Stacchiotti S, Verderio P, Messina A et al.. Tumor response assessment by modified Choi criteria in localized high-risk soft tissue sarcoma treated with chemotherapy: an exploratory analysis on a Phase III trial. Cancer 2012 May 17 [epub ahead of print], doi: 10.1002/cncr.27624.
27. Le Cesne A, Van Glabbeke M, Woll PJ et al.. The end of adjuvant chemotherapy era with doxorubicin-based regimen in resected high-grade soft tissue sarcoma (STS): pooled analysis of the two STBSG-EORTC phase III clinical trials. J Clin Oncol 2008; 26(suppl): abstr 10525.
28. Pervaiz N, Colterjohn N, Farrokhiar F et al.. A systematic met-analysis of randomized controlled trials for adjuvant chemotherapy for localized resectable soft tissue sarcoma. Cancer 2008; 113(3): 573-581.
29. Gerrand CH, Wunder JS, Kandel RA et al.. Classification of positive margins after resection of soft-tissue sarcoma of the limb predicts the risk of local recurrence. J Bone Joint Surg Br 2001; 83(8): 1149-1155.
30. Dagan R, Indelicato DJ, McGee L et al.. The significance of a marginal excision after preoperative radiation therapy for soft tissue sarcoma of the extremity. Cancer 2012; 118(12): 3199-3207.
31. Al Yami A, Griffin AM, Ferguson PC et al.. Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary. Int J Radiat Oncol Biol Phys 2010; 77(4): 1191-1197.