Synthesis of 1,4-bis(indolin-1-ylmethyl)benzene derivatives and their structure-activity relationships for the interaction of human carbonic anhydrase isoforms i and II

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 6, 2013, Pages 1477-1482

  Talaz, Oktay ^a   Çavdar, Hüseyin ^b   Durdagi, Serdar ^c   Azak, Hacer ^a   Ekinci, Deniz ^d  

^a KARAMANOGLU MEHMETBEY UNIVERSITY   (Turkey)

^b DUMLUPINAR UNIVERSITY   (Turkey)

^c UNIVERSITY OF CALGARY   (Canada)

^d ONDOKUZ MAYIS UNIVERSITY   (Turkey)

Author keywords

Bisindole; Carbonic anhydrase; Docking; Glaucoma

Indexed keywords

1,4 BIS(INDOLIN 1 YLMETHYL)BENZENE DERIVATIVE; 1,4 BIS[[2,3 DIHYDRO 1H CARBAZOL 9(2H)YL]METHYL]BENZENE; 1,4 BIS[[2,3 DIHYDROCYCLOPENTA[B]INDOL 4(1H) YL]METHYL]BENZENE; 1,4 BIS[[7,8,9,10 TETRAHYDROCYCLOHEPTA[B]INDOL 5(6H)YL]METHYL]BENZENE; 1,4((1 PHENYLHYDRAZINE)METHYL)BENZENE; BENZENE DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; INDOLE; ISOENZYME; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; MOLECULAR DOCKING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN PURIFICATION; STRUCTURE ACTIVITY RELATION;

BENZENE DERIVATIVES; BINDING SITES; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CATALYTIC DOMAIN; HUMANS; INDOLES; KINETICS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874550533     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.09.027     Document Type: Article

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