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Volumn 15, Issue SUPPL. 1, 2013, Pages 6-10

Newer insulin analogs: Advances in basal insulin replacement

Author keywords

Basal insulin; Insulin degludec; Investigational; Nocturnal hypoglycaemia; PEGylated long acting basal insulin; Type 1 diabetes; Type 2 diabetes

Indexed keywords

GLUCOSE; INSULIN DEGLUDEC; INSULIN GLARGINE; INSULIN PEGLISPRO;

EID: 84874538906     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12068     Document Type: Review
Times cited : (33)

References (37)
  • 1
    • 0024361124 scopus 로고
    • The physiologic replacement of insulin. An elusive goal
    • Zinman B. The physiologic replacement of insulin. An elusive goal. N Engl J Med 1989; 321: 363-370.
    • (1989) N Engl J Med , vol.321 , pp. 363-370
    • Zinman, B.1
  • 2
    • 84874413470 scopus 로고    scopus 로고
    • Better Glycemic Control and Weight Loss With the Novel Long-Acting Basal Insulin LY2605541 Compared With Insulin Glargine in Type 1 Diabetes: A randomized, crossover study
    • Nov 27. [Epub ahead of print] DOI: 10.2337/dc12-0067.
    • Rosenstock J, Bergenstal RM, Blevins TC, etal. Better Glycemic Control and Weight Loss With the Novel Long-Acting Basal Insulin LY2605541 Compared With Insulin Glargine in Type 1 Diabetes: A randomized, crossover study. Diabetes Care. 2012. Nov 27. [Epub ahead of print] DOI: 10.2337/dc12-0067.
    • (2012) Diabetes Care
    • Rosenstock, J.1    Bergenstal, R.M.2    Blevins, T.C.3
  • 3
    • 0033928514 scopus 로고    scopus 로고
    • Controlled-release, pegylation, liposomal formulations: new mechanisms in the delivery of injectable drugs
    • Reddy KR. Controlled-release, pegylation, liposomal formulations: new mechanisms in the delivery of injectable drugs. Ann Pharmacother 2000; 34: 915-923.
    • (2000) Ann Pharmacother , vol.34 , pp. 915-923
    • Reddy, K.R.1
  • 4
    • 84874415108 scopus 로고    scopus 로고
    • LY2605541: Leveraging hydrodynamic size to develop a novel basal insulin
    • (Abstract) June 8-12, Philadelphia, PA.
    • Hansen R, Cutler GB, Vick A et al. LY2605541: Leveraging hydrodynamic size to develop a novel basal insulin (Abstract 896-P). American Diabetes Association 72nd Annual Scientific Sessions, June 8-12, 2012, Philadelphia, PA.
    • (2012) American Diabetes Association 72nd Annual Scientific Sessions , pp. 896
    • Hansen, R.1    Cutler, G.B.2    Vick, A.3
  • 5
    • 84874420438 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics (PK) and glucodynamics (GD) of the novel, long-acting basal insulin LY2605541 in healthy subjects
    • (Abstract) June 8-12, Philadelphia, PA.
    • Sinha VP, Howey DC, Soon DKW et al. Single-dose pharmacokinetics (PK) and glucodynamics (GD) of the novel, long-acting basal insulin LY2605541 in healthy subjects (Abstract 1063-P). American Diabetes Association 72nd Annual Scientific Sessions. June 8-12, 2012, Philadelphia, PA.
    • (2012) American Diabetes Association 72nd Annual Scientific Sessions , pp. 1063
    • Sinha, V.P.1    Howey, D.C.2    Soon, D.K.W.3
  • 6
    • 0016784705 scopus 로고
    • Complete amino acid sequence of human serum albumin
    • Meloun B, Moravek L, Kostka V. Complete amino acid sequence of human serum albumin. FEBS Lett 1975; 58: 134-137.
    • (1975) FEBS Lett , vol.58 , pp. 134-137
    • Meloun, B.1    Moravek, L.2    Kostka, V.3
  • 7
    • 84874513309 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics (PK) and glucodynamics (GD) of the novel, long-acting basal insulin LY2605541 dosed once-daily (QD) in patients with type 2 diabetes mellitus
    • (Abstract) June 8-12, Philadelphia, PA.
    • Heise T, Howey DC, Sinha VP, Choi SL, Mace KF. Steady-state pharmacokinetics (PK) and glucodynamics (GD) of the novel, long-acting basal insulin LY2605541 dosed once-daily (QD) in patients with type 2 diabetes mellitus (Abstract 1000-P). American Diabetes Association 72nd Annual Scientific Sessions. June 8-12, 2012; Philadelphia, PA.
    • (2012) American Diabetes Association 72nd Annual Scientific Sessions , pp. 1000
    • Heise, T.1    Howey, D.C.2    Sinha, V.P.3    Choi, S.L.4    Mace, K.F.5
  • 8
    • 84868131614 scopus 로고    scopus 로고
    • A randomized, controlled study of once-daily LY2605541, a novel long-acting basal insulin, versus insulin glargine in basal insulin-treated patients with type 2 diabetes
    • Bergenstal RM, Rosenstock J, Arakaki RF, et al. A randomized, controlled study of once-daily LY2605541, a novel long-acting basal insulin, versus insulin glargine in basal insulin-treated patients with type 2 diabetes. Diabetes Care 2012; 35: 2140-2147.
    • (2012) Diabetes Care , vol.35 , pp. 2140-2147
    • Bergenstal, R.M.1    Rosenstock, J.2    Arakaki, R.F.3
  • 9
    • 84864460325 scopus 로고    scopus 로고
    • Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin
    • Jonassen I, Havelund S, Hoeg-Jensen T, Steensgaard DB, Wahlund PO, Ribel U. Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin. Pharm Res 2012; 29: 2104-2114.
    • (2012) Pharm Res , vol.29 , pp. 2104-2114
    • Jonassen, I.1    Havelund, S.2    Hoeg-Jensen, T.3    Steensgaard, D.B.4    Wahlund, P.O.5    Ribel, U.6
  • 10
    • 84865972844 scopus 로고    scopus 로고
    • Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes
    • Heise T, Nosek L, Bottcher SG, Hastrup H, Haahr H. Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes. Diabetes Obes Metab 2012; 14: 944-950.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 944-950
    • Heise, T.1    Nosek, L.2    Bottcher, S.G.3    Hastrup, H.4    Haahr, H.5
  • 11
    • 84864375931 scopus 로고    scopus 로고
    • Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady-state conditions in type 1 diabetes
    • Heise T, Hermanski L, Nosek L, Feldman A, Rasmussen S, Haahr H. Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady-state conditions in type 1 diabetes. Diabetes Obes Metab 2012; 14: 859-864.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 859-864
    • Heise, T.1    Hermanski, L.2    Nosek, L.3    Feldman, A.4    Rasmussen, S.5    Haahr, H.6
  • 12
    • 84868523718 scopus 로고    scopus 로고
    • Insulin degludec as an ultralong-acting basal insulin once a day: a systematic review
    • Wang F, Surh J, Kaur M. Insulin degludec as an ultralong-acting basal insulin once a day: a systematic review. Diabetes Metab Syndr Obes 2012; 5: 191-204.
    • (2012) Diabetes Metab Syndr Obes , vol.5 , pp. 191-204
    • Wang, F.1    Surh, J.2    Kaur, M.3
  • 13
    • 79956110739 scopus 로고    scopus 로고
    • Insulin degludec in type 1 diabetes: a randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine
    • Birkeland KI, Home PD, Wendisch U et al. Insulin degludec in type 1 diabetes: a randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine. Diabetes Care 2011; 34: 661-665.
    • (2011) Diabetes Care , vol.34 , pp. 661-665
    • Birkeland, K.I.1    Home, P.D.2    Wendisch, U.3
  • 14
    • 79952488537 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial
    • Zinman B, Fulcher G, Rao PV et al. Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial. Lancet 2011; 377: 924-931.
    • (2011) Lancet , vol.377 , pp. 924-931
    • Zinman, B.1    Fulcher, G.2    Rao, P.V.3
  • 15
    • 0037093012 scopus 로고    scopus 로고
    • Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus
    • Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
    • Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus. JAMA 2002; 287: 2563-2569.
    • (2002) JAMA , vol.287 , pp. 2563-2569
  • 16
    • 0142087597 scopus 로고    scopus 로고
    • Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study
    • Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
    • Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA 2003; 290: 2159-2167.
    • (2003) JAMA , vol.290 , pp. 2159-2167
  • 17
    • 77958169964 scopus 로고    scopus 로고
    • Legacy effects from DCCT and UKPDS: what they mean and implications for future diabetes trials
    • Murray P, Chune GW, Raghavan VA. Legacy effects from DCCT and UKPDS: what they mean and implications for future diabetes trials. Curr Atheroscler Rep 2010; 12: 432-439.
    • (2010) Curr Atheroscler Rep , vol.12 , pp. 432-439
    • Murray, P.1    Chune, G.W.2    Raghavan, V.A.3
  • 18
    • 84859896417 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial
    • Heller S, Buse J, Fisher M et al. Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet 2012; 379: 1489-1497.
    • (2012) Lancet , vol.379 , pp. 1489-1497
    • Heller, S.1    Buse, J.2    Fisher, M.3
  • 19
    • 64649104158 scopus 로고    scopus 로고
    • Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus
    • Defronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009; 58: 773-795.
    • (2009) Diabetes , vol.58 , pp. 773-795
    • Defronzo, R.A.1
  • 20
    • 0036483958 scopus 로고    scopus 로고
    • Sulfonylurea inadequacy: efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the U.K. Prospective Diabetes Study (UKPDS 57)
    • Wright A, Burden AC, Paisey RB, Cull CA, Holman RR. Sulfonylurea inadequacy: efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the U.K. Prospective Diabetes Study (UKPDS 57). Diabetes Care 2002; 25: 330-336.
    • (2002) Diabetes Care , vol.25 , pp. 330-336
    • Wright, A.1    Burden, A.C.2    Paisey, R.B.3    Cull, C.A.4    Holman, R.R.5
  • 21
    • 77953044294 scopus 로고    scopus 로고
    • Barriers to insulin initiation: the translating research into action for diabetes insulin starts project
    • Karter AJ, Subramanian U, Saha C et al. Barriers to insulin initiation: the translating research into action for diabetes insulin starts project. Diabetes Care 2010; 33: 733-735.
    • (2010) Diabetes Care , vol.33 , pp. 733-735
    • Karter, A.J.1    Subramanian, U.2    Saha, C.3
  • 22
    • 33748578996 scopus 로고    scopus 로고
    • Frequency and risk factors of severe hypoglycaemia in insulin-treated Type 2 diabetes: a cross-sectional survey
    • Akram K, Pedersen-Bjergaard U, Carstensen B, Borch-Johnsen K, Thorsteinsson B. Frequency and risk factors of severe hypoglycaemia in insulin-treated Type 2 diabetes: a cross-sectional survey. Diabet Med 2006; 23: 750-756.
    • (2006) Diabet Med , vol.23 , pp. 750-756
    • Akram, K.1    Pedersen-Bjergaard, U.2    Carstensen, B.3    Borch-Johnsen, K.4    Thorsteinsson, B.5
  • 23
    • 70350534273 scopus 로고    scopus 로고
    • Three-year efficacy of complex insulin regimens in type 2 diabetes
    • Holman RR, Farmer AJ, Davies MJ et al. Three-year efficacy of complex insulin regimens in type 2 diabetes. N Engl J Med 2009; 361: 1736-1747.
    • (2009) N Engl J Med , vol.361 , pp. 1736-1747
    • Holman, R.R.1    Farmer, A.J.2    Davies, M.J.3
  • 24
    • 84874536111 scopus 로고    scopus 로고
    • Health-related quality of life associated with daytime and nocturnal hypoglycemic events: a time trade-off survey
    • (Oral 135) June 8-12, Philadelphia, PA.
    • Evans M, Khunti K, Mamdani M. Health-related quality of life associated with daytime and nocturnal hypoglycemic events: a time trade-off survey (Oral 135). American Diabetes Association 72nd Annual Scientific Sessions. June 8-12, 2012, Philadelphia, PA.
    • (2012) American Diabetes Association 72nd Annual Scientific Sessions
    • Evans, M.1    Khunti, K.2    Mamdani, M.3
  • 25
    • 84859921058 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial
    • Garber AJ, King AB, Del Prato S et al. Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet 2012; 379: 1498-1507.
    • (2012) Lancet , vol.379 , pp. 1498-1507
    • Garber, A.J.1    King, A.B.2    Del Prato, S.3
  • 27
    • 4444307704 scopus 로고    scopus 로고
    • Improved glycemic control without an increase in severe hypoglycemic episodes in intensively treated patients with type 1 diabetes receiving morning, evening, or split dose insulin glargine
    • Garg SK, Gottlieb PA, Hisatomi ME et al. Improved glycemic control without an increase in severe hypoglycemic episodes in intensively treated patients with type 1 diabetes receiving morning, evening, or split dose insulin glargine. Diabetes Res Clin Pract 2004; 66: 49-56.
    • (2004) Diabetes Res Clin Pract , vol.66 , pp. 49-56
    • Garg, S.K.1    Gottlieb, P.A.2    Hisatomi, M.E.3
  • 28
    • 64549093838 scopus 로고    scopus 로고
    • Comparison of once- versus twice-daily administration of insulin detemir, used with mealtime insulin aspart, in basal-bolus therapy for type 1 diabetes: assessment of detemir administration in a progressive treat-to-target trial (ADAPT)
    • Le Floch JP, Levy M, Mosnier-Pudar H et al. Comparison of once- versus twice-daily administration of insulin detemir, used with mealtime insulin aspart, in basal-bolus therapy for type 1 diabetes: assessment of detemir administration in a progressive treat-to-target trial (ADAPT). Diabetes Care 2009; 32: 32-37.
    • (2009) Diabetes Care , vol.32 , pp. 32-37
    • Le Floch, J.P.1    Levy, M.2    Mosnier-Pudar, H.3
  • 30
    • 39049105019 scopus 로고    scopus 로고
    • A randomised, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes
    • Rosenstock J, Davies M, Home PD, Larsen J, Koenen C, Schernthaner G. A randomised, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetologia 2008; 51: 408-416.
    • (2008) Diabetologia , vol.51 , pp. 408-416
    • Rosenstock, J.1    Davies, M.2    Home, P.D.3    Larsen, J.4    Koenen, C.5    Schernthaner, G.6
  • 31
    • 84871934358 scopus 로고    scopus 로고
    • Insulin degludec allows for flexible daily dosing in type 1 diabetes, providing equal glycemic control with less nocturnal hypoglycemia than insulin glargine over 52 weeks
    • (Abstract 2162) June 8-12, Philadelphia, PA.
    • Mathieu C, Hollander P, Miranda-Palma B. Insulin degludec allows for flexible daily dosing in type 1 diabetes, providing equal glycemic control with less nocturnal hypoglycemia than insulin glargine over 52 weeks (Abstract 2162). American Diabetes Association 72nd Annual Scientific Sessions. June 8-12, 2012; Philadelphia, PA.
    • (2012) American Diabetes Association 72nd Annual Scientific Sessions
    • Mathieu, C.1    Hollander, P.2    Miranda-Palma, B.3
  • 32
    • 84938268848 scopus 로고    scopus 로고
    • Insulin degludec results in consistently lower rates of nocturnal hypoglycemia despite lower FPG levels compared to insulin glargine in seven trials with T1DM or T2DM
    • (Abstract 2395), June 8-12, 2012; Philadelphia, PA.
    • Russell-Jones D, Del Prato S, Gall MA. Insulin degludec results in consistently lower rates of nocturnal hypoglycemia despite lower FPG levels compared to insulin glargine in seven trials with T1DM or T2DM (Abstract 2395). American Diabetes Association 72nd Annual Scientific Sessions. June 8-12, 2012; Philadelphia, PA.
    • (2012) American Diabetes Association 72nd Annual Scientific Sessions
    • Russell-Jones, D.1    Del Prato, S.2    Gall, M.A.3
  • 34
    • 80051986265 scopus 로고    scopus 로고
    • Globalization of diabetes: the role of diet, lifestyle, and genes
    • Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care 2011; 34: 1249-1257.
    • (2011) Diabetes Care , vol.34 , pp. 1249-1257
    • Hu, F.B.1
  • 35
    • 77957291846 scopus 로고    scopus 로고
    • US trends in glycemic control, treatment, and comorbidity burden in patients with diabetes
    • Shaya FT, Yan X, Lin PJ et al. US trends in glycemic control, treatment, and comorbidity burden in patients with diabetes. J Clin Hypertens (Greenwich). 2010; 12: 826-832.
    • (2010) J Clin Hypertens (Greenwich). , vol.12 , pp. 826-832
    • Shaya, F.T.1    Yan, X.2    Lin, P.J.3
  • 36
    • 84875410508 scopus 로고    scopus 로고
    • 200 u/ml Insulin degludec improves glycemic control similar to insulin glargine with a low risk of hypoglycemia in insulin-naïve people with type 2 diabetes
    • May 23-27, Philadelphia, PA. Abstract #207.
    • Bergenstal R, Bhargava A, Jain R, et al. 200 u/ml Insulin degludec improves glycemic control similar to insulin glargine with a low risk of hypoglycemia in insulin-naïve people with type 2 diabetes. AACE 21st Annual Scientific & Clinical Congress. May 23-27, 2012; Philadelphia, PA. Abstract #207.
    • (2012) AACE 21st Annual Scientific & Clinical Congress
    • Bergenstal, R.1    Bhargava, A.2    Jain, R.3
  • 37
    • 84865972844 scopus 로고    scopus 로고
    • Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes
    • Heise T, Nosek L, Bøttcher SG, Hastrup H, Haahr H. Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes. Diabetes Obes Metab 2012; 14: 944-950.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 944-950
    • Heise, T.1    Nosek, L.2    Bøttcher, S.G.3    Hastrup, H.4    Haahr, H.5


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