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Volumn 5, Issue , 2012, Pages 191-204

Insulin degludec as an ultralong-acting basal insulin once a day: A systematic review

Author keywords

Basal insulin analog analogue; Comparative study; Degludec; Degludec aspart; Efficacy; IDeg; IDegAsp; NN1250; Safety

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN ASPART; INSULIN ASPART PLUS INSULIN DEGLUDEC; INSULIN DEGLUDEC; INSULIN DETEMIR; INSULIN GLARGINE; ISOPHANE INSULIN; LIRAGLUTIDE; METFORMIN; PIOGLITAZONE;

EID: 84868523718     PISSN: 11787007     EISSN: None     Source Type: Journal    
DOI: 10.2147/dmso.s21979     Document Type: Review
Times cited : (46)

References (68)
  • 1
    • 25444441553 scopus 로고    scopus 로고
    • How to achieve a predictable basal insulin?
    • Kurtzhals P. How to achieve a predictable basal insulin? Diabetes Metab. 2005;31(4 Pt 2):4S25-24S33.
    • (2005) Diabetes Metab. , vol.31 , Issue.4 PT 2
    • Kurtzhals, P.1
  • 2
    • 15944382350 scopus 로고    scopus 로고
    • Reduced hypoglycemia risk with insulin glargine: A meta-analysis comparing insulin glargine with human NPH insulin in type 2diabetes
    • Rosenstock J, Dailey G, Massi-Benedetti M, Fritsche A, Lin Z, Salzman A. Reduced hypoglycemia risk with insulin glargine: a meta-analysis comparing insulin glargine with human NPH insulin in type 2diabetes. Diabetes Care. 2005;28(4):950-955.
    • (2005) Diabetes Care , vol.28 , Issue.4 , pp. 950-955
    • Rosenstock, J.1    Dailey, G.2    Massi-Benedetti, M.3    Fritsche, A.4    Lin, Z.5    Salzman, A.6
  • 3
    • 12744274870 scopus 로고    scopus 로고
    • Lower within-subject variability of fasting blood glucose and reduced weight gain with insulin detemir compared to NPH insulin in patients with type 2 diabetes
    • Haak T, Tiengo A, Draeger E, Suntum M, Waldhäusl W. Lower within-subject variability of fasting blood glucose and reduced weight gain with insulin detemir compared to NPH insulin in patients with type 2 diabetes. Diabetes Obes Metab. 2005;7(1):56-64.
    • (2005) Diabetes Obes Metab. , vol.7 , Issue.1 , pp. 56-64
    • Haak, T.1    Tiengo, A.2    Draeger, E.3    Suntum, M.4    Waldhäusl, W.5
  • 4
    • 12744274867 scopus 로고    scopus 로고
    • Insulin detemir used in basal-bolus therapy in people with type 1 diabetes is associated with a lower risk of nocturnal hypoglycaemia and less weight gain over 12 months in comparison to NPH insulin
    • De Leeuw I, Vague P, Selam JL, et al. Insulin detemir used in basal-bolus therapy in people with type 1 diabetes is associated with a lower risk of nocturnal hypoglycaemia and less weight gain over 12 months in comparison to NPH insulin. Diabetes Obes Metab. 2005;7(1):73-82.
    • (2005) Diabetes Obes Metab. , vol.7 , Issue.1 , pp. 73-82
    • de Leeuw, I.1    Vague, P.2    Selam, J.L.3
  • 5
    • 0038418746 scopus 로고    scopus 로고
    • Insulin detemir is associated with more predictable glycemic control and reduced risk of hypoglycemia than NPH insulin in patients with type 1 diabetes on a basal-bolus regimen with premeal insulin aspart
    • Vague P, Selam JL, Skeie S, et al. Insulin detemir is associated with more predictable glycemic control and reduced risk of hypoglycemia than NPH insulin in patients with type 1 diabetes on a basal-bolus regimen with premeal insulin aspart. Diabetes Care. 2003;26(3):590-596.
    • (2003) Diabetes Care , vol.26 , Issue.3 , pp. 590-596
    • Vague, P.1    Selam, J.L.2    Skeie, S.3
  • 6
    • 0034033028 scopus 로고    scopus 로고
    • Less hypoglycemia with insulin glargine in intensive insulin therapy for type 1 diabetes
    • US Study Group of Insulin Glargine in Type 1 Diabetes
    • Ratner RE, Hirsch IB, Neifing JL, Garg SK, Mecca TE, Wilson CA. Less hypoglycemia with insulin glargine in intensive insulin therapy for type 1 diabetes. US Study Group of Insulin Glargine in Type 1 Diabetes. Diabetes Care. 2000;23(5):639-643.
    • (2000) Diabetes Care , vol.23 , Issue.5 , pp. 639-643
    • Ratner, R.E.1    Hirsch, I.B.2    Neifing, J.L.3    Garg, S.K.4    Mecca, T.E.5    Wilson, C.A.6
  • 7
    • 0033867021 scopus 로고    scopus 로고
    • Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes
    • HOE 901/300s Study Group, HOE 901/3002 study group
    • Yki-Järvinen H, Dressler A, Ziemen M, HOE 901/300s Study Group. Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 study group. Diabetes Care. 2000;23(8):1130-1136.
    • (2000) Diabetes Care , vol.23 , Issue.8 , pp. 1130-1136
    • Yki-Järvinen, H.1    Dressler, A.2    Ziemen, M.3
  • 8
    • 50049096963 scopus 로고    scopus 로고
    • Reduced weight gain with insulin detemir compared to NPH insulin is not explained by a reduction in hypoglycemia
    • Davies MJ, Derezinski T, Pedersen CB, Clauson P. Reduced weight gain with insulin detemir compared to NPH insulin is not explained by a reduction in hypoglycemia. Diabetes Technol Ther. 2008;10(4):273-277.
    • (2008) Diabetes Technol Ther. , vol.10 , Issue.4 , pp. 273-277
    • Davies, M.J.1    Derezinski, T.2    Pedersen, C.B.3    Clauson, P.4
  • 9
    • 33947302393 scopus 로고    scopus 로고
    • Insulin detemir results in less weight gain than NPH insulin when used in basal-bolus therapy for type 2 diabetes mellitus, and this advantage increases with baseline body mass index
    • Raslová K, Tamer SC, Clauson P, Karl D. Insulin detemir results in less weight gain than NPH insulin when used in basal-bolus therapy for type 2 diabetes mellitus, and this advantage increases with baseline body mass index. Clin Drug Investig. 2007;27(4):279-285.
    • (2007) Clin Drug Investig , vol.27 , Issue.4 , pp. 279-285
    • Raslová, K.1    Tamer, S.C.2    Clauson, P.3    Karl, D.4
  • 10
    • 57649230070 scopus 로고    scopus 로고
    • A 52-week, multinational, open-label, parallel-group, noninferiority, treat-to-target trial comparing insulin detemir with insulin glargine in a basal-bolus regimen with mealtime insulin aspart in patients with type 2 diabetes
    • Hollander P, Cooper J, Bregnhoj J, Pederson CB. A 52-week, multinational, open-label, parallel-group, noninferiority, treat-to-target trial comparing insulin detemir with insulin glargine in a basal-bolus regimen with mealtime insulin aspart in patients with type 2 diabetes. Clin Ther. 2008;30(11):1976-1987.
    • (2008) Clin Ther. , vol.30 , Issue.11 , pp. 1976-1987
    • Hollander, P.1    Cooper, J.2    Bregnhoj, J.3    Pederson, C.B.4
  • 11
    • 39049105019 scopus 로고    scopus 로고
    • A randomized, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin naïve people with type 2 diabetes
    • Rosenstock J, Davies M, Home PD, Larsen J, Koenen C, Schernthaner G. A randomized, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin naïve people with type 2 diabetes. Diabetologia. 2008;51(3):408-416.
    • (2008) Diabetologia , vol.51 , Issue.3 , pp. 408-416
    • Rosenstock, J.1    Davies, M.2    Home, P.D.3    Larsen, J.4    Koenen, C.5    Schernthaner, G.6
  • 12
    • 70350605350 scopus 로고    scopus 로고
    • Comparison of insulin detemir and insulin glargine using a basal-bolus regimen in a randomized, controlled clinical study in patients with type 2 diabetes
    • Raskin P, Gylvin T, Weng W, Chaykin L. Comparison of insulin detemir and insulin glargine using a basal-bolus regimen in a randomized, controlled clinical study in patients with type 2 diabetes. Diabetes Metab Res Rev. 2009;25(6):542-548.
    • (2009) Diabetes Metab Res Rev. , vol.25 , Issue.6 , pp. 542-548
    • Raskin, P.1    Gylvin, T.2    Weng, W.3    Chaykin, L.4
  • 13
    • 65549131199 scopus 로고    scopus 로고
    • Patient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue: An assessment of two different fasting plasma glucose targets - the TITRATE study
    • TITRATE Study Group
    • Blonde L, Merilainen M, Karwe V, Raskin P; TITRATE Study Group. Patient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue: an assessment of two different fasting plasma glucose targets - the TITRATE study. Diabetes Obes Metab. 2009;11(6):623-631.
    • (2009) Diabetes Obes Metab. , vol.11 , Issue.6 , pp. 623-631
    • Blonde, L.1    Merilainen, M.2    Karwe, V.3    Raskin, P.4
  • 14
    • 80054084342 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of basal insulins
    • Porcellati F, Bolli GB, Fanelli CG. Pharmacokinetics and pharmacodynamics of basal insulins. Diabetes Technol Ther. 2011;13(Suppl 1):S15-S24.
    • (2011) Diabetes Technol Ther. , vol.13 , Issue.SUPPL. 1 , pp. 15-24
    • Porcellati, F.1    Bolli, G.B.2    Fanelli, C.G.3
  • 17
    • 84872336434 scopus 로고    scopus 로고
    • Insulin degludec, a new generation ultra-long acting insulin, used once daily or 3-times weekly in people with type 2 diabetes: Comparison to insulin glargine
    • Mathieu C, Fulcher G, Rao PV, et al. Insulin degludec, a new generation ultra-long acting insulin, used once daily or 3-times weekly in people with type 2 diabetes: Comparison to insulin glargine. Diabetologia. 2010;53(Suppl 1):S8.
    • (2010) Diabetologia , vol.53 , Issue.SUPPL. 1 , pp. 8
    • Mathieu, C.1    Fulcher, G.2    Rao, P.V.3
  • 22
    • 79952484368 scopus 로고    scopus 로고
    • Insulin degludec is a new generation ultra-long acting basal insulin with a unique mechanism of protraction based on multi-hexamer formation
    • Jonassen I, Havelund S, Ribel U, et al. Insulin degludec is a new generation ultra-long acting basal insulin with a unique mechanism of protraction based on multi-hexamer formation. Diabetes. 2010;59(Suppl 1):A11.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1 , pp. 11
    • Jonassen, I.1    Havelund, S.2    Ribel, U.3
  • 23
    • 82955215892 scopus 로고    scopus 로고
    • Insulin degludec: Multi-hexamer formation is the underlying basis for this new generation ultra-long acting basal insulin
    • Jonassen I, Havelund S, Ribel U, et al. Insulin degludec: Multi-hexamer formation is the underlying basis for this new generation ultra-long acting basal insulin. Diabetologia. 2010;53(Suppl 1):S388.
    • (2010) Diabetologia , vol.53 , Issue.SUPPL. 1
    • Jonassen, I.1    Havelund, S.2    Ribel, U.3
  • 24
    • 82955205736 scopus 로고    scopus 로고
    • Insulin degludec: A novel ultra-long-acting basal insulin for use in type 1 and 2 diabetes
    • Meneghini LF, Miranda-Palma B. Insulin degludec: A novel ultra-long-acting basal insulin for use in type 1 and 2 diabetes. Expert Rev Endocrinol Metab. 2012;7(1):9-14.
    • (2012) Expert Rev Endocrinol Metab. , vol.7 , Issue.1 , pp. 9-14
    • Meneghini, L.F.1    Miranda-Palma, B.2
  • 29
    • 79956110739 scopus 로고    scopus 로고
    • Insulin degludec in type 1 diabetes: A randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine
    • Birkeland KI, Home PD, Wendisch U, et al. Insulin degludec in type 1 diabetes: a randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine. Diabetes Care. 2011;34(3):661-665.
    • (2011) Diabetes Care , vol.34 , Issue.3 , pp. 661-665
    • Birkeland, K.I.1    Home, P.D.2    Wendisch, U.3
  • 30
    • 79956156301 scopus 로고    scopus 로고
    • Insulin degludec, a new generation ultra-long acting insulin, in a mealtime + basal regimen in people with type 1 diabetes: Comparison to insulin glargine
    • Meneghini LF, Home PD, Wendisch U, et al. Insulin degludec, a new generation ultra-long acting insulin, in a mealtime + basal regimen in people with type 1 diabetes: Comparison to insulin glargine. Diabetologia. 2010;53(Suppl 1):S381.
    • (2010) Diabetologia , vol.53 , Issue.SUPPL. 1 , pp. 381
    • Meneghini, L.F.1    Home, P.D.2    Wendisch, U.3
  • 31
    • 84865851355 scopus 로고    scopus 로고
    • Once-daily use of a new generation ultra-long acting basal insulin with a bolus boost in insulin-naive people with type 2 diabetes: Comparison with insulin glargine
    • Cuddihy R, Tack CJ, Heise T, et al. Once-daily use of a new generation ultra-long acting basal insulin with a bolus boost in insulin-naive people with type 2 diabetes: Comparison with insulin glargine. Diabetologia. 2010;53(Suppl 1):S389.
    • (2010) Diabetologia , vol.53 , Issue.SUPPL. 1 , pp. 389
    • Cuddihy, R.1    Tack, C.J.2    Heise, T.3
  • 34
    • 79952488537 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: A 16-week, randomised, open-label, phase 2 trial
    • Zinman B, Fulcher G, Rao PV, et al. Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial. Lancet. 2011;377(9769):924-931.
    • (2011) Lancet , vol.377 , Issue.9769 , pp. 924-931
    • Zinman, B.1    Fulcher, G.2    Rao, P.V.3
  • 35
    • 79956118439 scopus 로고    scopus 로고
    • Insulin degludec: Less pharmacodynamic variability than insulin glargine under steady state conditions
    • Heise T, Hermanski L, Nosek I, et al. Insulin degludec: Less pharmacodynamic variability than insulin glargine under steady state conditions. Diabetologia. 2010;53(Suppl 1):S387.
    • (2010) Diabetologia , vol.53 , Issue.SUPPL. 1 , pp. 387
    • Heise, T.1    Hermanski, L.2    Nosek, I.3
  • 38
    • 79956136690 scopus 로고    scopus 로고
    • A new-generation ultra-long-acting basal insulin with a bolus boost compared with insulin glargine in insulin-naive people with type 2 diabetes: A randomized, controlled trial
    • Heise T, Tack CJ, Cuddihy R, et al. A new-generation ultra-long-acting basal insulin with a bolus boost compared with insulin glargine in insulin-naive people with type 2 diabetes: a randomized, controlled trial. Diabetes Care. 2011;34(3):669-674.
    • (2011) Diabetes Care , vol.34 , Issue.3 , pp. 669-674
    • Heise, T.1    Tack, C.J.2    Cuddihy, R.3
  • 40
    • 79956152438 scopus 로고    scopus 로고
    • Ultra-long acting insulin degludec can be combined with rapid-acting insulin aspart in a soluble co-formulation
    • Jonassen I, Hoeg-Jensen T, Havelund S, Ribel U. Ultra-long acting insulin degludec can be combined with rapid-acting insulin aspart in a soluble co-formulation. J Pept Sci. 2010;16(Suppl 1):32.
    • (2010) J Pept Sci. , vol.16 , Issue.SUPPL. 1 , pp. 32
    • Jonassen, I.1    Hoeg-Jensen, T.2    Havelund, S.3    Ribel, U.4
  • 45
    • 84872310771 scopus 로고    scopus 로고
    • The pharmacokinetic properties of insulin degludec in children and adolescents compared with adults with type 1 diabetes after single-dose administration
    • Danne T, Biester T, Blaesig S, et al. The pharmacokinetic properties of insulin degludec in children and adolescents compared with adults with type 1 diabetes after single-dose administration. Pediatric Diabetes. 2011;12(Suppl 15):35-36.
    • (2011) Pediatric Diabetes , vol.12 , Issue.SUPPL. 15 , pp. 35-36
    • Danne, T.1    Biester, T.2    Blaesig, S.3
  • 47
    • 79956156301 scopus 로고    scopus 로고
    • Insulin degludec, a new generation ultra-long acting insulin, in a mealtime plus basal regimen in people with type 1 diabetes: Comparison to insulin glargine
    • Meneghini LF, Home PD, Wendisch U, et al. Insulin degludec, a new generation ultra-long acting insulin, in a mealtime plus basal regimen in people with type 1 diabetes: Comparison to insulin glargine. Diabetes. 2010;59(Suppl 1):A152.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1 , pp. 152
    • Meneghini, L.F.1    Home, P.D.2    Wendisch, U.3
  • 48
    • 84861130120 scopus 로고    scopus 로고
    • Improved health status with insulin degludec compared with insulin glargine in people with type 1 diabetes
    • doi:10.1111/j.1464-5491.2011.03547.x
    • Home PD, Meneghini L, Wendisch U, et al. Improved health status with insulin degludec compared with insulin glargine in people with type 1 diabetes. Diabet Med. 2011. doi:10.1111/j.1464-5491.2011.03547.x.
    • (2011) Diabet Med.
    • Home, P.D.1    Meneghini, L.2    Wendisch, U.3
  • 52
    • 84872293141 scopus 로고    scopus 로고
    • homepage on the Internet, HYPERLINK, Accessed January 14, 2012
    • Clinical Trials at Novo Nordisk [homepage on the Internet]. Available at: HYPERLINK http://www.novonordisk-trials.com/t_blank www.novonordisk-trials.com. Accessed January 14, 2012
    • Clinical Trials At Novo Nordisk
  • 53
    • 78549247886 scopus 로고    scopus 로고
    • Insulin and its analogs: Actions via insulin and IGF receptors
    • Vigneri R, Squatrito S, Sciacca L. Insulin and its analogs: actions via insulin and IGF receptors. Acta Diabetol. 2010;47(4):271-278.
    • (2010) Acta Diabetol. , vol.47 , Issue.4 , pp. 271-278
    • Vigneri, R.1    Squatrito, S.2    Sciacca, L.3
  • 54
    • 65549138380 scopus 로고    scopus 로고
    • Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells
    • Weinstein D, Simon M, Yehezkel E, Laron Z, Werner H. Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells. Diabetes Metab Res Rev. 2009;25(1):41-49.
    • (2009) Diabetes Metab Res Rev. , vol.25 , Issue.1 , pp. 41-49
    • Weinstein, D.1    Simon, M.2    Yehezkel, E.3    Laron, Z.4    Werner, H.5
  • 55
    • 0342657181 scopus 로고    scopus 로고
    • Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use
    • Kurtzhals P, Schäffer L, Sørensen A, et al. Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use. Diabetes. 2000;49(6):999-1005.
    • (2000) Diabetes , vol.49 , Issue.6 , pp. 999-1005
    • Kurtzhals, P.1    Schäffer, L.2    Sørensen, A.3
  • 56
    • 70949084349 scopus 로고    scopus 로고
    • No evidence of increased risk of malignancies in patients with diabetes treated with insulin detemir: A meta-analysis
    • Dejgaard A, Lynggaard H, Råstam J, Krogsgaard Thomsen M. No evidence of increased risk of malignancies in patients with diabetes treated with insulin detemir: a meta-analysis. Diabetologia. 2009;52(12):2507-2512.
    • (2009) Diabetologia , vol.52 , Issue.12 , pp. 2507-2512
    • Dejgaard, A.1    Lynggaard, H.2    Råstam, J.3    Krogsgaard, T.M.4
  • 57
    • 0035122343 scopus 로고    scopus 로고
    • Insulin analogues: Impact of cell model characteristics on results and conclusions regarding mitogenic properties
    • Kellerer M, Häring H. Insulin analogues: impact of cell model characteristics on results and conclusions regarding mitogenic properties. Exp Clinl Endocrinol Diabetes. 2001;109(1):63-64.
    • (2001) Exp Clinl Endocrinol Diabetes , vol.109 , Issue.1 , pp. 63-64
    • Kellerer, M.1    Häring, H.2
  • 58
    • 0038383535 scopus 로고    scopus 로고
    • Insulin glargine: A systematic review of a long-acting insulin analogue
    • discussion 1539-1540
    • Wang F, Carabino JM, Vergara CM. Insulin glargine: a systematic review of a long-acting insulin analogue. Clin Ther. 2003;25(6):1541-1577; discussion 1539-1540.
    • (2003) Clin Ther. , vol.25 , Issue.6 , pp. 1541-1577
    • Wang, F.1    Carabino, J.M.2    Vergara, C.M.3
  • 59
    • 78650929154 scopus 로고    scopus 로고
    • Review on the in vitro interaction of insulin glargine with the insulin/insulin-like growth factor system: Potential implications for metabolic and mitogenic activities
    • Ciaraldi TP, Sasaoka T. Review on the in vitro interaction of insulin glargine with the insulin/insulin-like growth factor system: potential implications for metabolic and mitogenic activities. Horm Metab Res. 2011;43(1):1-10.
    • (2011) Horm Metab Res. , vol.43 , Issue.1 , pp. 1-10
    • Ciaraldi, T.P.1    Sasaoka, T.2
  • 60
    • 68449104156 scopus 로고    scopus 로고
    • Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: A cohort study
    • Hemkens LG, Grouven U, Bender R, et al. Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study. Diabetologia. 2009;52(9):1732-1744.
    • (2009) Diabetologia , vol.52 , Issue.9 , pp. 1732-1744
    • Hemkens, L.G.1    Grouven, U.2    Bender, R.3
  • 61
    • 68449094354 scopus 로고    scopus 로고
    • Use of insulin glargine and cancer incidence in Scotland: A study from the Scottish Diabetes Research Network Epidemiology Group
    • SDRN Epidemiology Group
    • Colhoun HM, SDRN Epidemiology Group. Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group. Diabetologia. 2009;52(9):1755-1765.
    • (2009) Diabetologia , vol.52 , Issue.9 , pp. 1755-1765
    • Colhoun, H.M.1
  • 62
    • 68449104625 scopus 로고    scopus 로고
    • Insulin glargine use and short-term incidence of malignancies - a population-based follow-up study in Sweden
    • Jonasson JM, Ljung R, Talbäck M, Haglund B, Gudbjörnsdòttir S, Steineck G. Insulin glargine use and short-term incidence of malignancies - a population-based follow-up study in Sweden. Diabetologia. 2009;52(9):1745-1754.
    • (2009) Diabetologia , vol.52 , Issue.9 , pp. 1745-1754
    • Jonasson, J.M.1    Ljung, R.2    Talbäck, M.3    Haglund, B.4    Gudbjörnsdòttir, S.5    Steineck, G.6
  • 63
    • 77954832956 scopus 로고    scopus 로고
    • Doses of insulin and its analogues and cancer occurrence in insulin-treated type 2 diabetic patients
    • Mannucci E, Monami M, Balzi D, et al. Doses of insulin and its analogues and cancer occurrence in insulin-treated type 2 diabetic patients. Diabetes Care. 2010;33(9):1997-2003.
    • (2010) Diabetes Care , vol.33 , Issue.9 , pp. 1997-2003
    • Mannucci, E.1    Monami, M.2    Balzi, D.3
  • 65
    • 80054071230 scopus 로고    scopus 로고
    • The future of basal insulin supplementation
    • Simon AC, DeVries JH. The future of basal insulin supplementation. Diabetes Technol Ther. 2011;13(Suppl 1):S103-S108.
    • (2011) Diabetes Technol Ther. , vol.13 , Issue.SUPPL. 1 , pp. 103-108
    • Simon, A.C.1    Devries, J.H.2
  • 66
    • 82955198015 scopus 로고    scopus 로고
    • Insulin degludec: A new ultra-long, basal insulin designed to maintain full metabolic effect while minimizing mitogenic potential
    • Nishimura E, Sorensen AR, Hansen BF, et al. Insulin degludec: A new ultra-long, basal insulin designed to maintain full metabolic effect while minimizing mitogenic potential. Diabetologia. 2010;53 (Suppl 1):S388.
    • (2010) Diabetologia , vol.53 , Issue.SUPPL. 1 , pp. 388
    • Nishimura, E.1    Sorensen, A.R.2    Hansen, B.F.3
  • 67
    • 82955198015 scopus 로고    scopus 로고
    • Insulin degludec is a new generation ultra-long acting basal insulin designed to maintain full metabolic effect while minimizing mitogenic potential
    • Nishimura E, Sorensen A, Hansen BF, et al. Insulin degludec is a new generation ultra-long acting basal insulin designed to maintain full metabolic effect while minimizing mitogenic potential. Diabetes. 2010;59(Suppl 1):A375.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1 , pp. 375
    • Nishimura, E.1    Sorensen, A.2    Hansen, B.F.3
  • 68
    • 84855356092 scopus 로고    scopus 로고
    • Using albumin to improve the therapeutic properties of diabetes treatments
    • Ahrén B, Burke B. Using albumin to improve the therapeutic properties of diabetes treatments. Diabetes Obes Metab. 2012;14(2):121-129.
    • (2012) Diabetes Obes Metab. , vol.14 , Issue.2 , pp. 121-129
    • Ahrén, B.1    Burke, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.