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Volumn 54, Issue 1, 2013, Pages 141-150

High-concentration of BMP2 reduces cell proliferation and increases apoptosis via DKK1 and SOST in human primary periosteal cells

Author keywords

DKK1; High concentration BMP2; Periosteum; Proliferation; SOST; Wnt

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CASPASE; DICKKOPF 1 PROTEIN; SCLEROSTIN; SMALL INTERFERING RNA; WNT PROTEIN;

EID: 84874537755     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.01.031     Document Type: Article
Times cited : (46)

References (47)
  • 1
    • 34250019537 scopus 로고
    • Bone: formation by autoinduction
    • Urist M.R. Bone: formation by autoinduction. Science 1965, 150(698):893-899.
    • (1965) Science , vol.150 , Issue.698 , pp. 893-899
    • Urist, M.R.1
  • 2
    • 0004503871 scopus 로고
    • Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation
    • Sampath T.K., Reddi A.H. Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc Natl Acad Sci U S A 1981, 78(12):7599-7603.
    • (1981) Proc Natl Acad Sci U S A , vol.78 , Issue.12 , pp. 7599-7603
    • Sampath, T.K.1    Reddi, A.H.2
  • 3
    • 0024256133 scopus 로고
    • Novel regulators of bone formation: molecular clones and activities
    • Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., et al. Novel regulators of bone formation: molecular clones and activities. Science 1988, 242(4885):1528-1534.
    • (1988) Science , vol.242 , Issue.4885 , pp. 1528-1534
    • Wozney, J.M.1    Rosen, V.2    Celeste, A.J.3    Mitsock, L.M.4    Whitters, M.J.5    Kriz, R.W.6
  • 4
    • 0024356071 scopus 로고
    • Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation
    • Luyten F.P., Cunningham N.S., Ma S., Muthukumaran N., Hammonds R.G., Nevins W.B., et al. Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation. J Biol Chem 1989, 264(23):13377-13380.
    • (1989) J Biol Chem , vol.264 , Issue.23 , pp. 13377-13380
    • Luyten, F.P.1    Cunningham, N.S.2    Ma, S.3    Muthukumaran, N.4    Hammonds, R.G.5    Nevins, W.B.6
  • 5
    • 0026721147 scopus 로고
    • The bone morphogenetic protein family and osteogenesis
    • Wozney J.M. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev 1992, 32(2):160-167.
    • (1992) Mol Reprod Dev , vol.32 , Issue.2 , pp. 160-167
    • Wozney, J.M.1
  • 6
    • 21344467281 scopus 로고    scopus 로고
    • Application of bone morphogenetic proteins in spinal fusion
    • Gupta M.C., Khan S.N. Application of bone morphogenetic proteins in spinal fusion. Cytokine Growth Factor Rev 2005, 16(3):347-355.
    • (2005) Cytokine Growth Factor Rev , vol.16 , Issue.3 , pp. 347-355
    • Gupta, M.C.1    Khan, S.N.2
  • 7
    • 85045483986 scopus 로고    scopus 로고
    • Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review
    • Garrison K.R., Donell S., Ryder J., Shemilt I., Mugford M., Harvey I., et al. Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review. Health Technol Assess 2007, 11(30):1-168.
    • (2007) Health Technol Assess , vol.11 , Issue.30 , pp. 1-168
    • Garrison, K.R.1    Donell, S.2    Ryder, J.3    Shemilt, I.4    Mugford, M.5    Harvey, I.6
  • 8
    • 36348955551 scopus 로고    scopus 로고
    • Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion
    • White A.P., Vaccaro A.R., Hall J.A., Whang P.G., Friel B.C., McKee M.D. Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion. Int Orthop 2007, 31(6):735-741.
    • (2007) Int Orthop , vol.31 , Issue.6 , pp. 735-741
    • White, A.P.1    Vaccaro, A.R.2    Hall, J.A.3    Whang, P.G.4    Friel, B.C.5    McKee, M.D.6
  • 9
    • 84870299516 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2: adverse events reported to the Manufacturer and User Facility Device Experience database
    • Woo E.J. Recombinant human bone morphogenetic protein-2: adverse events reported to the Manufacturer and User Facility Device Experience database. Spine J 2012, 12(10):894-899.
    • (2012) Spine J , vol.12 , Issue.10 , pp. 894-899
    • Woo, E.J.1
  • 10
    • 84874532969 scopus 로고    scopus 로고
    • Adverse events after recombinant human BMP2 in nonspinal orthopaedic procedures
    • Woo EJ. Adverse events after recombinant human BMP2 in nonspinal orthopaedic procedures. Clin Orthop Relat Res in press.
    • Clin Orthop Relat Res in press.
    • Woo, E.J.1
  • 11
    • 84859105670 scopus 로고    scopus 로고
    • Adverse events reported after the use of recombinant human bone morphogenetic protein 2
    • Woo E.J. Adverse events reported after the use of recombinant human bone morphogenetic protein 2. J Oral Maxillofac Surg 2012, 70(4):765-767.
    • (2012) J Oral Maxillofac Surg , vol.70 , Issue.4 , pp. 765-767
    • Woo, E.J.1
  • 12
    • 79959950769 scopus 로고    scopus 로고
    • A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned
    • Carragee E.J., Hurwitz E.L., Weiner B.K. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J 2011, 11(6):471-491.
    • (2011) Spine J , vol.11 , Issue.6 , pp. 471-491
    • Carragee, E.J.1    Hurwitz, E.L.2    Weiner, B.K.3
  • 13
    • 79959927397 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 and spinal arthrodesis: the basic science perspective on protein interaction with the nervous system
    • Dmitriev A.E., Lehman R.A., Symes A.J. Bone morphogenetic protein-2 and spinal arthrodesis: the basic science perspective on protein interaction with the nervous system. Spine J 2011, 11(6):500-505.
    • (2011) Spine J , vol.11 , Issue.6 , pp. 500-505
    • Dmitriev, A.E.1    Lehman, R.A.2    Symes, A.J.3
  • 14
    • 80052655961 scopus 로고    scopus 로고
    • Does bone morphogenetic protein increase the incidence of perioperative complications in spinal fusion? A comparison of 55,862 cases of spinal fusion with and without bone morphogenetic protein
    • Williams B.J., Smith J.S., Fu K.M., Hamilton D.K., Polly D.W., Ames C.P., et al. Does bone morphogenetic protein increase the incidence of perioperative complications in spinal fusion? A comparison of 55,862 cases of spinal fusion with and without bone morphogenetic protein. Spine (Phila Pa 1976) 2011, 36(20):1685-1691.
    • (2011) Spine (Phila Pa 1976) , vol.36 , Issue.20 , pp. 1685-1691
    • Williams, B.J.1    Smith, J.S.2    Fu, K.M.3    Hamilton, D.K.4    Polly, D.W.5    Ames, C.P.6
  • 15
    • 77951766763 scopus 로고    scopus 로고
    • Complications related to osteobiologics use in spine surgery: a systematic review
    • Mroz T.E., Wang J.C., Hashimoto R., Norvell D.C. Complications related to osteobiologics use in spine surgery: a systematic review. Spine (Phila Pa 1976) 2010, 35(Suppl. 9):S86-S104.
    • (2010) Spine (Phila Pa 1976) , vol.35 , Issue.SUPPL. 9
    • Mroz, T.E.1    Wang, J.C.2    Hashimoto, R.3    Norvell, D.C.4
  • 16
    • 33646576536 scopus 로고    scopus 로고
    • Graft resorption with the use of bone morphogenetic protein: lessons from anterior lumbar interbody fusion using femoral ring allografts and recombinant human bone morphogenetic protein-2
    • Pradhan B.B., Bae H.W., Dawson E.G., Patel V.V., Delamarter R.B. Graft resorption with the use of bone morphogenetic protein: lessons from anterior lumbar interbody fusion using femoral ring allografts and recombinant human bone morphogenetic protein-2. Spine (Phila Pa 1976) 2006, 31(10):E277-E284.
    • (2006) Spine (Phila Pa 1976) , vol.31 , Issue.10
    • Pradhan, B.B.1    Bae, H.W.2    Dawson, E.G.3    Patel, V.V.4    Delamarter, R.B.5
  • 18
    • 67651146552 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2-induced radiculitis in elective minimally invasive transforaminal lumbar interbody fusions: a series review
    • [discussion 1485]
    • Mindea S.A., Shih P., Song J.K. Recombinant human bone morphogenetic protein-2-induced radiculitis in elective minimally invasive transforaminal lumbar interbody fusions: a series review. Spine (Phila Pa 1976) 2009, 34(14):1480-1484. [discussion 1485].
    • (2009) Spine (Phila Pa 1976) , vol.34 , Issue.14 , pp. 1480-1484
    • Mindea, S.A.1    Shih, P.2    Song, J.K.3
  • 19
    • 33645508135 scopus 로고    scopus 로고
    • Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion
    • Shields L.B., Raque G.H., Glassman S.D., Campbell M., Vitaz T., Harpring J., et al. Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine (Phila Pa 1976) 2006, 31(5):542-547.
    • (2006) Spine (Phila Pa 1976) , vol.31 , Issue.5 , pp. 542-547
    • Shields, L.B.1    Raque, G.H.2    Glassman, S.D.3    Campbell, M.4    Vitaz, T.5    Harpring, J.6
  • 20
    • 34447257902 scopus 로고    scopus 로고
    • Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion
    • Tumialan L.M., Rodts G.E. Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion. Spine J 2007, 7(4):509-510.
    • (2007) Spine J , vol.7 , Issue.4 , pp. 509-510
    • Tumialan, L.M.1    Rodts, G.E.2
  • 21
    • 70450245462 scopus 로고    scopus 로고
    • The use of RhBMP-2 in single-level transforaminal lumbar interbody fusion: a clinical and radiographic analysis
    • Rihn J.A., Makda J., Hong J., Patel R., Hilibrand A.S., Anderson D.G., et al. The use of RhBMP-2 in single-level transforaminal lumbar interbody fusion: a clinical and radiographic analysis. Eur Spine J 2009, 18(11):1629-1636.
    • (2009) Eur Spine J , vol.18 , Issue.11 , pp. 1629-1636
    • Rihn, J.A.1    Makda, J.2    Hong, J.3    Patel, R.4    Hilibrand, A.S.5    Anderson, D.G.6
  • 22
    • 39049119326 scopus 로고    scopus 로고
    • Heterotopic bone formation with the use of rhBMP2 in posterior minimal access interbody fusion: a CT analysis
    • Joseph V., Rampersaud Y.R. Heterotopic bone formation with the use of rhBMP2 in posterior minimal access interbody fusion: a CT analysis. Spine (Phila Pa 1976) 2007, 32(25):2885-2890.
    • (2007) Spine (Phila Pa 1976) , vol.32 , Issue.25 , pp. 2885-2890
    • Joseph, V.1    Rampersaud, Y.R.2
  • 23
    • 79959962169 scopus 로고    scopus 로고
    • Retrograde ejaculation after anterior lumbar interbody fusion using rhBMP-2: a cohort controlled study
    • Carragee E.J., Mitsunaga K.A., Hurwitz E.L., Scuderi G.J. Retrograde ejaculation after anterior lumbar interbody fusion using rhBMP-2: a cohort controlled study. Spine J 2011, 11(6):511-516.
    • (2011) Spine J , vol.11 , Issue.6 , pp. 511-516
    • Carragee, E.J.1    Mitsunaga, K.A.2    Hurwitz, E.L.3    Scuderi, G.J.4
  • 25
    • 33644877366 scopus 로고    scopus 로고
    • TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes
    • Wu D.T., Bitzer M., Ju W., Mundel P., Bottinger E.P. TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes. J Am Soc Nephrol 2005, 16(11):3211-3221.
    • (2005) J Am Soc Nephrol , vol.16 , Issue.11 , pp. 3211-3221
    • Wu, D.T.1    Bitzer, M.2    Ju, W.3    Mundel, P.4    Bottinger, E.P.5
  • 26
    • 0026750213 scopus 로고
    • Receptors for the TGF-beta family
    • Massague J. Receptors for the TGF-beta family. Cell 1992, 69(7):1067-1070.
    • (1992) Cell , vol.69 , Issue.7 , pp. 1067-1070
    • Massague, J.1
  • 27
    • 0036785165 scopus 로고    scopus 로고
    • Establishment of a novel chondrocytic cell line N1511 derived from p53-null mice
    • Kamiya N., Jikko A., Kimata K., Damsky C., Shimizu K., Watanabe H. Establishment of a novel chondrocytic cell line N1511 derived from p53-null mice. J Bone Miner Res 2002, 17(10):1832-1842.
    • (2002) J Bone Miner Res , vol.17 , Issue.10 , pp. 1832-1842
    • Kamiya, N.1    Jikko, A.2    Kimata, K.3    Damsky, C.4    Shimizu, K.5    Watanabe, H.6
  • 28
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25(4):402-408.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 29
    • 44349125905 scopus 로고    scopus 로고
    • Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix
    • Zhang C., Cho K., Huang Y., Lyons J.P., Zhou X., Sinha K., et al. Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A 2008, 105(19):6936-6941.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.19 , pp. 6936-6941
    • Zhang, C.1    Cho, K.2    Huang, Y.3    Lyons, J.P.4    Zhou, X.5    Sinha, K.6
  • 30
  • 31
    • 77953381255 scopus 로고    scopus 로고
    • Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the Type IA receptor (BMPRIA) in osteoblasts
    • Kamiya N., Kobayashi T., Mochida Y., Yu P.B., Yamauchi M., Kronenberg H.M., et al. Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the Type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res 2010, 25(2):200-210.
    • (2010) J Bone Miner Res , vol.25 , Issue.2 , pp. 200-210
    • Kamiya, N.1    Kobayashi, T.2    Mochida, Y.3    Yu, P.B.4    Yamauchi, M.5    Kronenberg, H.M.6
  • 32
    • 8444238558 scopus 로고    scopus 로고
    • Periosteum: biology, regulation, and response to osteoporosis therapies
    • Allen M.R., Hock J.M., Burr D.B. Periosteum: biology, regulation, and response to osteoporosis therapies. Bone 2004, 35(5):1003-1012.
    • (2004) Bone , vol.35 , Issue.5 , pp. 1003-1012
    • Allen, M.R.1    Hock, J.M.2    Burr, D.B.3
  • 33
    • 0032955419 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: an update on basic biology and clinical relevance
    • Schmitt J.M., Hwang K., Winn S.R., Hollinger J.O. Bone morphogenetic proteins: an update on basic biology and clinical relevance. J Orthop Res 1999, 17(2):269-278.
    • (1999) J Orthop Res , vol.17 , Issue.2 , pp. 269-278
    • Schmitt, J.M.1    Hwang, K.2    Winn, S.R.3    Hollinger, J.O.4
  • 35
    • 38849178302 scopus 로고    scopus 로고
    • Building bone to reverse osteoporosis and repair fractures
    • Khosla S., Westendorf J.J., Oursler M.J. Building bone to reverse osteoporosis and repair fractures. J Clin Invest 2008, 118(2):421-428.
    • (2008) J Clin Invest , vol.118 , Issue.2 , pp. 421-428
    • Khosla, S.1    Westendorf, J.J.2    Oursler, M.J.3
  • 36
    • 67449146883 scopus 로고    scopus 로고
    • Emerging role of bone morphogenetic proteins in angiogenesis
    • David L., Feige J.J., Bailly S. Emerging role of bone morphogenetic proteins in angiogenesis. Cytokine Growth Factor Rev 2009, 20(3):203-212.
    • (2009) Cytokine Growth Factor Rev , vol.20 , Issue.3 , pp. 203-212
    • David, L.1    Feige, J.J.2    Bailly, S.3
  • 38
    • 84862670335 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 use in the off-label treatment of nonunions and acute fractures: a retrospective review
    • Starman J.S., Bosse M.J., Cates C.A., Norton H.J. Recombinant human bone morphogenetic protein-2 use in the off-label treatment of nonunions and acute fractures: a retrospective review. J Traumatol Acute Care Surg 2012, 72(3):676-681.
    • (2012) J Traumatol Acute Care Surg , vol.72 , Issue.3 , pp. 676-681
    • Starman, J.S.1    Bosse, M.J.2    Cates, C.A.3    Norton, H.J.4
  • 39
    • 79959579500 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2: a randomized trial in open tibial fractures treated with reamed nail fixation
    • Aro H.T., Govender S., Patel A.D., Hernigou P., Perera de Gregorio A., Popescu G.I., et al. Recombinant human bone morphogenetic protein-2: a randomized trial in open tibial fractures treated with reamed nail fixation. J Bone Joint Surg Am 2011.
    • (2011) J Bone Joint Surg Am
    • Aro, H.T.1    Govender, S.2    Patel, A.D.3    Hernigou, P.4    Perera de Gregorio, A.5    Popescu, G.I.6
  • 40
    • 77950500089 scopus 로고    scopus 로고
    • RhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model
    • Seeherman H.J., Li X.J., Bouxsein M.L., Wozney J.M. rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model. J Bone Joint Surg Am 2010, 92(2):411-426.
    • (2010) J Bone Joint Surg Am , vol.92 , Issue.2 , pp. 411-426
    • Seeherman, H.J.1    Li, X.J.2    Bouxsein, M.L.3    Wozney, J.M.4
  • 41
    • 79955022472 scopus 로고    scopus 로고
    • High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo
    • Zara J.N., Siu R.K., Zhang X., Shen J., Ngo R., Lee M., et al. High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo. Tissue Eng Part A 2011, 17(9-10):1389-1399.
    • (2011) Tissue Eng Part A , vol.17 , Issue.9-10 , pp. 1389-1399
    • Zara, J.N.1    Siu, R.K.2    Zhang, X.3    Shen, J.4    Ngo, R.5    Lee, M.6
  • 43
    • 59149096379 scopus 로고    scopus 로고
    • BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway
    • Kamiya N., Ye L., Kobayashi T., Mochida Y., Yamauchi M., Kronenberg H.M., et al. BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development 2008, 135(22):3801-3811.
    • (2008) Development , vol.135 , Issue.22 , pp. 3801-3811
    • Kamiya, N.1    Ye, L.2    Kobayashi, T.3    Mochida, Y.4    Yamauchi, M.5    Kronenberg, H.M.6
  • 44
    • 80054843585 scopus 로고    scopus 로고
    • Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1
    • Kamiya N., Kaartinen V.M., Mishina Y. Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1. Biochem Biophys Res Commun 2011, 414(2):326-330.
    • (2011) Biochem Biophys Res Commun , vol.414 , Issue.2 , pp. 326-330
    • Kamiya, N.1    Kaartinen, V.M.2    Mishina, Y.3
  • 45
    • 84861726292 scopus 로고    scopus 로고
    • The role of BMPs in bone anabolism and their potential targets SOST and DKK1
    • Kamiya N. The role of BMPs in bone anabolism and their potential targets SOST and DKK1. Curr Mol Pharmacol 2012, 5(2):153-163.
    • (2012) Curr Mol Pharmacol , vol.5 , Issue.2 , pp. 153-163
    • Kamiya, N.1
  • 46
    • 38849119866 scopus 로고    scopus 로고
    • Wnt signaling control of bone cell apoptosis
    • Bodine P.V. Wnt signaling control of bone cell apoptosis. Cell Res 2008, 18(2):248-253.
    • (2008) Cell Res , vol.18 , Issue.2 , pp. 248-253
    • Bodine, P.V.1
  • 47
    • 12144286871 scopus 로고    scopus 로고
    • Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist
    • van Bezooijen R.L., Roelen B.A., Visser A., van der Wee-Pals L., de Wilt E., Karperien M., et al. Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med 2004, 199(6):805-814.
    • (2004) J Exp Med , vol.199 , Issue.6 , pp. 805-814
    • van Bezooijen, R.L.1    Roelen, B.A.2    Visser, A.3    van der Wee-Pals, L.4    de Wilt, E.5    Karperien, M.6


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