Association of luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1833, Issue 5, 2013, Pages 1173-1179

  Menon, Bindu ^a   Sinden, Jennifer ^a   Menon, K M J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Decapping; Luteinizing hormone receptor; MRNA binding protein; MRNA decay; P bodies

Indexed keywords

BINDING PROTEIN; LUTEINIZING HORMONE RECEPTOR; LUTEINIZING HORMONE RECEPTOR BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA DEGRADATION; RNA TRANSPORT;

EID: 84874530761     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2013.01.024     Document Type: Article

References (36)

1. Lu D.L., Menon K.M.J. 3' untranslated region-mediated regulation of luteinizing hormone/human chorionic gonadotropin receptor expression. Biochemistry 1996, 35:12347-12353.
2. LaPolt P.S., Oikawa M., Jia X.C., Dargan C., Hsueh A.J. Gonadotropin-induced up- and down-regulation of rat ovarian LH receptor message levels during follicular growth, ovulation and luteinization. Endocrinology 1990, 126:3277-3279.
3. Segaloff D.L., Wang H.Y., Richards J.S. Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization. Mol. Endocrinol. 1990, 4:1856-1865.
4. Hoffman Y.M., Peegel H., Sprock M.J., Zhang Q.Y., Menon K.M.J. Evidence that human chorionic gonadotropin/luteinizing hormone receptor down-regulation involves decreased levels of receptor messenger ribonucleic acid. Endocrinology 1991, 128:388-393.
5. Kash J.C., Menon K.M.J. Identification of a hormonally regulated luteinizing hormone/human chorionic gonadotropin receptor mRNA binding protein. Increased mRNA binding during receptor down-regulation. J. Biol. Chem. 1998, 273:10658-10664.
6. Nair A.K., Kash J.C., Peegel H., Menon K.M.J. Post-transcriptional regulation of luteinizing hormone receptor mRNA in the ovary by a novel mRNA-binding protein. J. Biol. Chem. 2002, 277:21468-21473.
7. Nair A.K., Menon K.M.J. Isolation and characterization of a novel trans-factor for luteinizing hormone receptor mRNA from ovary. J. Biol. Chem. 2004, 279:14937-14944.
8. Ikeda S., Nakamura K., Kogure K., Omori Y., Yamashita S., Kubota K., Mizutani T., Miyamoto K., Minegishi T. Effect of estrogen on the expression of luteinizing hormone-human chorionic gonadotropin receptor messenger ribonucleic acid in cultured rat granulosa cells. Endocrinology 2008, 149:1524-1533.
9. Menon B., Peegel H., Menon K.M.J. Evidence for the association of luteinizing hormone receptor mRNA-binding protein with the translating ribosomes during receptor downregulation. Biochim. Biophys. Acta 2009, 1793:1787-1794.
10. Nair A.K., Menon K.M.J. Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary. J. Biol. Chem. 2005, 280:42809-42816.
11. Kash J.C., Menon K.M.J. Sequence-specific binding of a hormonally regulated mRNA binding protein to cytidine-rich sequences in the lutropin receptor open reading frame. Biochemistry 1999, 38:16889-16897.
12. Garneau N.L., Wilusz J., Wilusz C.J. The highways and byways of mRNA decay. Nat. Rev. Mol. Cell Biol. 2007, 8:113-126.
13. Franks T.M., Lykke-Andersen J. The control of mRNA decapping and P-body formation. Mol. Cell 2008, 32:605-615.
14. Sheth U., Parker R. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 2003, 300:805-808.
15. Parker R., Sheth U. P bodies and the control of mRNA translation and degradation. Mol. Cell 2007, 25:635-646.
16. Ingelfinger D., Arndt-Jovin D.J., Luhrmann R., Achsel T. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. RNA 2002, 8:1489-1501.
17. van Dijk E., Cougot N., Meyer S., Babajko S., Wahle E., Seraphin B. Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J. 2002, 21:6915-6924.
18. Bashkirov V.I., Scherthan H., Solinger J.A., Buerstedde J.M., Heyer W.D. A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates. J. Cell Biol. 1997, 136:761-773.
19. Eulalio A., Behm-Ansmant I., Izaurralde E. P bodies: at the crossroads of post-transcriptional pathways. Nat. Rev. Mol. Cell Biol. 2007, 8:9-22.
20. Kulkarni M., Ozgur S., Stoecklin G. On track with P-bodies. Biochem. Soc. Trans. 2010, 38:242-251.
21. Wang L., Nair A.K., Menon K.M.J. Ribonucleic acid binding protein-mediated regulation of luteinizing hormone receptor expression in granulosa cells: relationship to sterol metabolism. Mol. Endocrinol. 2007, 21:2233-2241.
22. Schwartz D.C., Parker R. mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E. Mol. Cell. Biol. 2000, 20:7933-7942.
23. Weston A., Sommerville J. Xp54 and related (DDX6-like) RNA helicases: roles in messenger RNP assembly, translation regulation and RNA degradation. Nucleic Acids Res. 2006, 34:3082-3094.
24. Cheadle C., Fan J., Cho-Chung Y.S., Werner T., Ray J., Do L., Gorospe M., Becker K.G. Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics 2005, 6:75.
25. Fan J., Yang X., Wang W., Wood W.H., Becker K.G., Gorospe M. Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:10611-10616.
26. Menon K.M.J., Nair A.K., Wang L. A novel post-transcriptional mechanism of regulation of luteinizing hormone receptor expression by an RNA binding protein from the ovary. Mol. Cell. Endocrinol. 2006, 246:135-141.
27. Menon K.M.J., Nair A.K., Wang L., Peegel H. Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary. Mol. Cell. Endocrinol. 2007, 260-262:109-116.
28. Coller J., Parker R. Eukaryotic mRNA decapping. Annu. Rev. Biochem. 2004, 73:861-890.
29. Lykke-Andersen J., Wagner E. Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev. 2005, 19:351-361.
30. Kedersha N., Stoecklin G., Ayodele M., Yacono P., Lykke-Andersen J., Fritzler M.J., Scheuner D., Kaufman R.J., Golan D.E., Anderson P. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J. Cell Biol. 2005, 169:871-884.
31. Stoecklin G., Anderson P. In a tight spot: ARE-mRNAs at processing bodies. Genes Dev. 2007, 21:627-631.
32. Balzer E., Moss E.G. Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules. RNA Biol. 2007, 4:16-25.
33. Minshall N., Reiter M.H., Weil D., Standart N. CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes. J. Biol. Chem. 2007, 282:37389-37401.
34. Wang L., Gulappa T., Menon K.M.J. Identification and characterization of proteins that selectively interact with the LHR mRNA binding protein (LRBP) in rat ovaries. Biochim. Biophys. Acta 2010, 1803:591-597.
35. Menon B., Franzo-Romain M., Damanpour S., Menon K.M.J. Luteinizing hormone receptor mRNA down-regulation is mediated through ERK-dependent induction of RNA binding protein. Mol. Endocrinol. 2011, 25:282-290.
36. Peegel H., Towns R., Nair A., Menon K.M.J. A novel mechanism for the modulation of luteinizing hormone receptor mRNA expression in the rat ovary. Mol. Cell. Endocrinol. 2005, 233:65-72.