Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 6, 2013, Pages 1516-1521

  Syrjänen, Leo ^a,b   Tolvanen, Martti E E ^a   Hilvo, Mika ^c   Vullo, Daniela ^d   Carta, Fabrizio ^d   Supuran, Claudiu T ^d   Parkkila, Seppo ^a,b,e  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^d UNIVERSITY OF FLORENCE   (Italy)

^e FIMLAB LABORATORIES   (Finland)

Author keywords

Carbonic anhydrase; Drosophila melanogaster; Inhibition; Phylogenetics

Indexed keywords

ACETAZOLAMIDE; ALPHA CARBONATE DEHYDRATASE; CAH1 PROTEIN; CAH2 PROTEIN; CARBON DIOXIDE; CARBONATE DEHYDRATASE; CELL MEMBRANE PROTEIN; CYTOPLASM PROTEIN; DITHIOCARBAMIC ACID; ENZYME INHIBITOR; EYE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOINFORMATICS; CELL MEMBRANE; CYTOPLASM; DISEASE MODEL; DROSOPHILA MELANOGASTER; DRUG SCREENING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME PURIFICATION; EYE DISEASE; GENE EXPRESSION; HYDRATION; MOLECULAR WEIGHT; NONHUMAN; PHYLOGENY; PROTEIN LOCALIZATION;

ANIMALS; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; COMPUTATIONAL BIOLOGY; DROSOPHILA MELANOGASTER; KINETICS; PHYLOGENY; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; THIOCARBAMATES;

ANIMALIA; DROSOPHILA MELANOGASTER; INVERTEBRATA;

EID: 84874530205     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.046     Document Type: Article

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