Moderate physical activity from childhood contributes to metabolic health and reduces hepatic fat accumulation in adult rats

Lipids in Health and Disease

Volumn 12, Issue 1, 2013, Pages

  De Moura, Leandro Pereira ^a,b   Da Silva Sponton, Amanda Christine ^a   De Araújo, Michel Barbosa ^a   Dalia, Rodrigo Augusto ^a   Pauli, José Rodrigo ^a,b   De Mello, Maria Alice Rostom ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Hepatic fat accumulation; Metabolic health; Moderate exercise

Indexed keywords

FATTY ACID; LACTIC ACID; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID METABOLISM; LIPID STORAGE; LIPOLYSIS; LIVER METABOLISM; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; RAT; SWIMMING; WEIGHT GAIN;

ADIPOSE TISSUE; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BLOOD GLUCOSE; BODY WEIGHT; FATTY ACIDS; INSULIN; INSULIN RESISTANCE; LACTIC ACID; LIPOGENESIS; LIVER; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; SWIMMING; TRIGLYCERIDES;

RATTUS;

EID: 84874515613     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-12-29     Document Type: Article

References (55)

1. Health risks associated with overweight and obesity. Kopelman P, Obes Rev 2007 8 13 17 10.1111/j.1467-789X.2007.00311.x 17316295
2. Obesity and hepatocellular carcinoma. Caldwell SH, Gastroenterology 2004 127 97 103 10.1053/j.gastro.2004.09.021 (Pubitemid 39423375)
3. Nonalcoholic steatohepatitis: pathologic features and differential diagnosis. Brunt EM, Semin Diagn Pathol 2005 22 330 338 10.1053/j.semdp.2006.04. 002 16939061 (Pubitemid 44118640)
4. Global challenges in liver disease. Williams R, Hepatology 2006 44 521 526 10.1002/hep.21347 16941687 (Pubitemid 44433707)
5. Nonalcoholic Fatty Liver Disease. Angulo P, N Engl J Med 2002 346 1221 1231 10.1056/NEJMra011775 11961152 (Pubitemid 34984585)
6. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Ludwig J, Viggiano TR, Mcgill DB, Oh BJ, Mayo Clin Proc 1980 55 434 438 7382552 (Pubitemid 10057164)
7. Liver and diabetes. A vicious circle. Loria P, Lonardo A, Anania F, Hepatol Res 2013 43 51 64 23332087
8. Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery. Pardee PE, Lavine JE, Schwimmer JB, Semin Pediatr Surg 2009 18 144 151 10.1053/j.sempedsurg.2009.04.004 19573756
9. Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. Socha P, Horvath A, Vajro P, Dziechciarz P, Dhawan A, Szajewska H, J Pediatr Gastroenterol Nutr 2009 48 587 596 10.1097/MPG.0b013e31818e04d1 19412008
10. Childhood weight affects adult morbidity and mortality. Dietz WH, J Nutr 1998 128 2 411S 414S 9478038 (Pubitemid 28090393)
11. Predicting obesity in early adulthood from childhood and parental obesity. Magarey AM, Daniels LA, Boulton TJ, Cockington RA, Int J Obes Relat Metab Disord 2003 27 505 513 10.1038/sj.ijo.0802251 12664084 (Pubitemid 36520851)
12. Global cancer statistics. Jemal FA, Bray MM, Center J, Ferlay E, Ward D, Forman, Canc J Clin 2011 61 69 90 10.3322/caac.20107
13. Overweight, obesity, and cancer risk. Bianchini F, Kaaks R, Vainio H, Lancet Oncol 2002 3 565 574 10.1016/S1470-2045(02)00849-5 12217794 (Pubitemid 34993644)
14. Thun Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Calle EEC, Rodriguez K, Walker-Thurmond MJ, N Engl J Med 2003 348 1625 1638 10.1056/NEJMoa021423 12711737 (Pubitemid 36459468)
15. Developmental Origins of Obesity: Early Feeding Environments, Infant Growth, and the Intestinal Microbiome. Thompson AL, Am J Hum Biol 2012 24 3 350 360 10.1002/ajhb.22254 22378322
16. Effects of different physical training protocols on ventricular oxidative stress parameters in infarction-induced rats. Pinho CA, Life Sci 2012 90 13-14 553 559 22365960
17. Effect of Different Doses of Aerobic Exercise on Total White Blood Cell (WBC) and WBC Subfraction Number in Postmenopausal Women: Results from DREW. Johannsen NM, PLoS One 2012 7 2 31319 10.1371/journal.pone.0031319 22363616
18. Role of nitric oxide and prostanoids in the regulation of leg blood flow and blood pressure in humans with essential hypertension: effect of high-intensity aerobic training. Nyberg M, Jensen LG, Thaning P, Hellsten Y, Mortensen SP, J Physiol 2012 590 6 1481 1494 22271868
19. Exercise Dose and Insulin Sensitivity: Relevance for Diabetes Prevention. Dubé JJ, Fleishman K, Rousson V, Goodpaster BH, Amati F, Med Sci Sports Exerc 2011 44 5 793 799
20. Importance of specificity, amount, and intensity of locomotor training to improve ambulatory function in patients poststroke. Hornby TG, Top Stroke Rehabil 2011 18 4 293 307 10.1310/tsr1804-293 21914594
21. Aptidão cardiorrespiratória e qualidade de vida pós-infarto em diferentes intensidades de exercício. Benetti M, Araujo CLP, Santos RZ, Arq Bras Cardiol 2010 95 3 399 404 10.1590/S0066- 782X2010005000089 20640381
22. Relevance of physical fitness levels and exercise-related beliefs for self-reported and experimental pain in fibromyalgia: an explorative study. De Bruijn ST, J Clin Rheumatol 2011 17 6 295 301 10.1097/RHU.0b013e31822c5196 21869713
23. Determining the extent of intensive physical performance in patients with coronary heart disease. Tegtbur U, Machold H, Meyer H, Storp D, Busse MW, Z Kardiol 2001 90 9 637 645 10.1007/s003920170111 11677800 (Pubitemid 32900417)
24. Effect of an acute beta-adrenergic blockade on the blood glucose response during lactate minimum test. Balikian JRP, Neiva CM, Denadai BS, J Sports Sci Med 2001 4 3 257 265 10.1016/S1440-2440(01)80035-9 (Pubitemid 32970967)
25. Evaluating a test protocol for predicting maximum lactate steady state. Bacon L, Kern M, J Sport Med Physiol Fitness 1999 39 300 308 (Pubitemid 30096933)
26. The lactate minimum test for cycling: estimation of the maximal lactate steady state. McIntosh BR, Esau S, Svedahl K, Can J Appl Physiol 2002 27 3 232 249 10.1139/h02-014 12180316
27. Maximal lactate steady state in rats submitted to swimming exercise. Gobatto CA, Mello MAR, Sibuya CY, Azevedo JRM, Santos LA, Kokubun E, Comp Biochem Physiol A Mol Integr Physiol 2001 130A 21 27 (Pubitemid 32735426)
28. Protocols for hyperlactatemia induction in the lactate minimum test adapted to swimming rats. Araujo GG, Papoti M, Manchado FB, Mello MAR, Gobatto CA, Comp Biochem Physiol A Mol Integr Physiol 2007 148 888 892 10.1016/j.cbpa.2007.09.002 17964836 (Pubitemid 350101302)
29. A theory of metabolic origin of the anaerobic threshold. Mader A, Heck H, Int J Sports Med 1986 7 1 45 65 10.1055/s-2008-1025802 3744647 (Pubitemid 16098648)
30. Determination of the exercise intensity that elicits maximal fat oxidation. Achten J, Gleeson M, Jeukendrup A, Med Sci Sports Exerc 2002 34 92 97 11782653 (Pubitemid 34052381)
31. Metabolic bases of excess post-exercise oxygen consumption: a review. Gaesser GA, Brooks GA, Med Sci Sports Exerc 1984 16 1 29 31 6369064
32. Maximal fat oxidation during exercise in trained men. Achten J, Jeukendrup AE, Int J Sports Med 2003 24 603 608 14598198 (Pubitemid 37421544)
33. Effect of feeding and fasting on excess postexercise oxygen consumption. Bahr R, Sejersted OM, J Appl Physiol 1991 71 6 2088 2093 1778897
34. Exercise intensity, inflammatory signaling, and insulin resistance in obese rats. Da Silva AS, Med Sci Sports Exerc 2010 42 12 2180 2188 10.1249/MSS.0b013e3181e45d08 20473230
35. Efeito da intensidade do exercício sobre a oxidação de carboidratos e gorduras durante a recuperação pós-exercício em diabéticos tipo 2. Lima LCJ, Revista Brasileira de Ciência e Movimento 2011 19 1 32 41 20863933
36. Exercise, food intake, and body weight in normal rats and genetically obese adult mice. Mayer J, Marshall NB, Vitale JJ, Christensen JH, Mashayekhi MB, Stare FJ, Am J Physiol 1954 177 544 548 13158612
37. Minireview: weapons of lean body mass destruction - the role of ectopic lipids in the metabolic syndrome. Unger RH, Endocrinology 2003 144 12 5159 5165 10.1210/en.2003-0870 12960011 (Pubitemid 37476041)
38. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. Malhi H, Bronk SF, Werneburg NW, Gores GJ, J Biol Chem 2006 281 17 12093 12101 10.1074/jbc.M510660200 16505490 (Pubitemid 43855473)
39. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. Shimomura I, Bashmakov Y, Horton JD, J Biol Chem 1999 274 30028 30032 10.1074/jbc.274.42.30028 10514488 (Pubitemid 29483385)
40. Metabolic aspects of exercise and weight reduction. Horton ES, Med Sci Sports Exerc 1985 18 10 18
41. Fator de transcrição-SREBP e homeostase lipídica: perspectiva clínica. Ferre P, Foufelle, Horm Res 2007 68 72 82 10.1159/000100426 17344645 (Pubitemid 47026704)
42. Reversion of hepatic steatosis by exercise training in obese mice: The role of sterol regulatory element-binding protein-1c. Cintra DE, Life Sci 2012 91 395 401 10.1016/j.lfs.2012.08.002 22906631
43. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Suganami T, Nishida J, Ogawa Y, Arterioscler Thromb Vasc Biol 2005 25 10 2062 2068 10.1161/01.ATV.0000183883.72263.13 16123319 (Pubitemid 41416301)
44. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β-cell dysfunction. Boden G, Shulman GI, Eur J Clin Invest 2002 32 3 14 23 10.1046/j.1365-2362.32.s3.3.x 12028371 (Pubitemid 41704996)
45. Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Luciano E, Eur J Endocrinol 2002 147 149 157 10.1530/eje.0.1470149 12088932 (Pubitemid 34814752)
46. New mechanisms by which physical exercise improves insulin resistance in the skeletal muscle. Pauli JR, Cintra DE, Souza CT, Ropelle ER, Arq Bras Endocrinol Metabol 2009 53 4 399 408 19649376
47. Acute exercise reverses TRB3 expression in the skeletal muscle and ameliorates whole body insulin sensitivity in diabetic mice. Matos A, Acta Physiol 2010 198 1 61 69 10.1111/j.1748-1716.2009.02031.x
48. Acute exercise reverses aged-induced impairments in insulin signaling in rodent skeletal muscle. Pauli JR, Mech Ageing Dev 2010 131 323 329 10.1016/j.mad.2010.03.004 20307567
49. Physical exercise reduces circulating lipopolysaccharide and TLR4 activation and improves insulin signaling in tissues of DIO rats. Oliveira AG, Diabetes 2011 60 3 784 796 10.2337/db09-1907 21282367
50. Determination of anaerobic threshold in weanling rats by lactate minimum test. Mello MAR, 15th Annual Congress of the European College of Sport Science, 2010, Antalya Book of Abstracts 15th Annual Congress of the European College of Sport Science. 2010 171 172 Volume 15
51. Causes and elimination of erratic blanc in enzymatic metabolic assays involving the use of NAD in alkaline hydrazine buffers: improved conditions for assay of L-glutamate, L-lactate and other metabolites. Engels RC, Jones JB, Anal Biochem 1978 88 475 484 10.1016/0003-2697(78)90447-5 29519 (Pubitemid 9061508)
52. Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. Bonora E, Moghetti P, Zancanaro C, J Clin Endocrinol Metab 1989 68 2 374 378 10.1210/jcem-68-2-374 2645308 (Pubitemid 19052880)
53. Intravenous glucose tolerance as a tool in definition and diagnosis of diabetes mellitus. Lundbaek K, Br Med J 1962 3 1057 1513
54. Specific determination of free fatty acid in plasm. Regow BJM, Clin Chim Acta 1971 31 187 195 10.1016/0009-8981(71)90377-9 5544048
55. Control of glucose metabolism in isolated acini of the lactanting mammary gland of the rat: effects of oleat on glucose utilization and lipogenesis. Robinson AM, Williamson DH, J Biochem 1978 170 609 613 (Pubitemid 8290557)