Development and in-house validation of an LC-MS/MS method for the quantification of the mycotoxins deoxynivalenol, zearalenone, T-2 and HT-2 toxin, ochratoxin A and fumonisin B1 and B2 in vegetable animal feed

Food Additives and Contaminants - Part A

Volumn 30, Issue 3, 2013, Pages 541-549

  Tevell Åberg, Annica ^a,b   Solyakov, Alexey ^a   Bondesson, Ulf ^a,b  

^a NATIONAL VETERINARY INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

animal feed; in house validation; LC MS MS; method development; multi mycotoxin

Indexed keywords

ANIMALS; UNCERTAINTY ANALYSIS; VETERINARY MEDICINE;

ANIMAL FEED; IN-HOUSE VALIDATIONS; LC-MS/MS; METHOD DEVELOPMENT; MULTI-MYCOTOXIN;

CHEMICAL CONTAMINATION;

FUMONISIN B1; FUMONISIN B2; HT 2 TOXIN; MYCOTOXIN; OCHRATOXIN; T 2 TOXIN; VOMITOXIN; ZEARALENONE;

ACCURACY; ANIMAL FOOD; ARTICLE; CEREAL; CONCENTRATION (PARAMETERS); DILUTION; ELECTROSPRAY MASS SPECTROMETRY; EXTRACTION; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MAIZE; PRIORITY JOURNAL; REPRODUCIBILITY; UNCERTAINTY; WHEAT;

ANIMALIA; TRITICUM AESTIVUM; ZEA MAYS;

EID: 84874506883     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440049.2012.760208     Document Type: Article

References (28)

1. Bennett, JW and Klich, M. 2003. Mycotoxins. Clin Microbiol Rev, 16: 497-516.
2. Binder, EM. 2007. Managing the risk of mycotoxins in modern feed production. Anim Feed Sci Technol, 133: 149-166.
3. Burns, DT, Danzer, K and Townshend, A. 2002. Use of the term "recovery" and "apparent recovery" in analytical procedures (IUPAC Recommendations 2002). Pure Appl Chem, 74: 2201-2205.
4. European, Commission. 2002. Commission Decision 2002/657/EC of 12 August 2002 Implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Off J Eur Comm, L221: 8-36.
5. European, Commission. 2006a. 401/2006. Commission Regulation 401/2006 of 23 February 2006 laying down the methods of sampling and analysis for the official control of the levels of mycotoxins in foodstuffs. Off J Eur Comm, L70: 12-34.
6. European, Commission. 576/2006. 2006b. Commission Recommendation 2006/576/EC of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding. Off J Eur Comm, L2297-9.
7. European, Commission. 2006c. 1881/2006. Commission Regulation 1881/2006 EC of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Off J Eur Comm, L364: 5-24.
8. Hussein, HS and Brasel, JM. 2001. Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology, 167: 101-134.
9. Kubena, LF, Harvey, RB, Huff, WE, Corrier, DE, Phillips, TD and Rottinghaus, GE. 1989. Influence of ochratoxin A and T-2 toxin singly and in combination on broiler chickens. Poult Sci, 68: 867-872.
10. Kubena, LF, Huff, WE, Harvey, RB, Phillips, TD and Rottinghaus, GE. 1989. Individual and combined toxicity of deoxynivalenol and T-2 toxin in broiler chicks. Poult Sci, 68: 622-626.
11. Lattanzio, VM, Gatta, SD, Suman, M and Visconti, A. 2011. Development and in-house validation of a robust and sensitive solid-phase extraction liquid chromatography/tandem mass spectrometry method for the quantitative determination of aflatoxins B1, B2, G1, G2, ochratoxin A, deoxynivalenol, zearalenone, T-2 and HT-2 toxins in cereal-based foods. Rapid Commun Mass Spectrom, 25: 1869-1880.
12. Lattanzio, VM, Solfrizzo, M, Powers, S and Visconti, A. 2007. Simultaneous determination of aflatoxins, ochratoxin A and fusarium toxins in maize by liquid chromatography/tandem mass spectrometry after multitoxin immunoaffinity cleanup. Rapid Commun Mass Spectrom, 21: 3253-3261.
13. Mol, HGJ, Plaza-Bolaños, P, Zomer, P, de Rijk, TC, Stolker, AAM and Mulder, PPJ. 2008. Toward a generic extraction method for simultaneous determination of pesticides, mycotoxins, plant toxins, and veterinary drugs in feed and food matrixes. Anal Chem, 80: 9450-9459.
14. Monbaliu, S, Van Poucke, C, Detavernier, C, Dumoulin, F, Van De Velde, M, Schoeters, E, Van Dyck, S, Averkieva, O, Van Peteghem, C and De Saeger, S. 2010. Occurrence of mycotoxins in feed as analyzed by a multi-mycotoxin LC-MS/MS. J Agric Food Chem, 58: 66-71.
15. Monbaliu, S, Van Poucke, C, Van Peteghem, C, Van Poucke, K, Heungens, K and De Saeger, S. 2009. Development of a multi-mycotoxin liquid chromatography/tandem mass spectrometry method for sweet pepper analysis. Rapid Commun Mass Spectrom, 23: 3-11.
16. Nilsson A, Stensiö K-E, Lundgren B. 2000. Validering av kemiska analysmetoder [Validation of chemical analytical methods]. SWEDAC DOC 00:32, ISSN 1400-6138. [cited 2013 Jan 14]; 1-29. http://www.swedac.se/sv/Dokument/foreskrifter-och-dokument (http://www.swedac.se/sv/Dokument/foreskrifter-och-dokument)
17. Plattner, RD. 1999. HPLC/MS analysis of fusarium mycotoxins, fumonisins and deoxynivalenol. Nat Toxins, 7: 365-370.
18. Rasmussen, RR, Storm, IM, Rasmussen, PH, Smedsgaard, J and Nielsen, KF. 2010. Multi-mycotoxin analysis of maize silage by LC-MS/MS. Anal Bioanal Chem, 397: 765-776.
19. Razzazi-Fazeli, E, Rabus, B, Cecon, B and Böhm, J. 2002. Simultaneous quantification of A-trichothecene mycotoxins in grains using liquid chromatography-atmospheric pressure chemical ionisation mass spectrometry. J Chromatogr A, 968: 129-142.
20. Ren, Y, Zhang, Y, Shao, S, Cai, Z, Feng, L, Pan, H and Wang, Z. 2007. Simultaneous determination of multi-component mycotoxin contaminants in foods and feeds by ultra-performance liquid chromatography tandem mass spectrometry. J Chromatogr A, 1143: 48-64.
21. Spanjer, MC, Rensen, PM and Scholten, JM. 2008. LC-MS/MS multi-method for mycotoxins after single extraction, with validation data for peanut, pistachio, wheat, maize, cornflakes, raisins and figs. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 25: 472-489.
22. Speijers, GJA and Speijers, MHM. 2004. Combined toxic effects of mycotoxins. Toxicol Lett, 153: 91-98.
23. Sørensen, LK and Elbæk, TH. 2005. Determination of mycotoxins in bovine milk by liquid chromatography tandem mass spectrometry. J Chromatogr B, 820: 183-196.
24. Sulyok, M, Berthiller, F, Krska, R and Schuhmacher, R. 2006. Development and validation of a liquid chromatography/tandem mass spectrometric method for the determination of 39 mycotoxins in wheat and maize. Rapid Commun Mass Spectrom, 20: 2649-2659.
25. van Bennekom, EO, Brouwer, L, Laurant, EHM, Hooijerink, H and Nielen, MWF. 2002. Confirmatory analysis method for zeranol, its metabolites and related mycotoxins in urine by liquid chromatography-negative ion electrospray tandem mass spectrometry. Anal Chim Acta, 473: 151-160.
26. Varga, E, Glauner, T, Koppen, R, Mayer, K, Sulyok, M, Schuhmacher, R, Krska, R and Berthiller, F. 2012. Stable isotope dilution assay for the accurate determination of mycotoxins in maize by UHPLC-MS/MS. Anal Bioanal Chem, 402: 2675-2686.
27. Völkel, I, Schröer-Merker, E and Czerny, C-P. 2011. The carry-over of mycotoxins in products of animal origin with special regard to its implications for the European Food Safety Legislation. Food Nutr Sci, 2: 852-867.
28. Zöllner, P and Mayer-Helm, B. 2006. Trace mycotoxin analysis in complex biological and food matrices by liquid chromatography-atmospheric pressure ionisation mass spectrometry. J Chromatogr A, 1136: 123-169.