Metabolic Flux and Nodes Control Analysis of Brewer's Yeasts under Different Fermentation Temperature during Beer Brewing

Applied Biochemistry and Biotechnology

Volumn 168, Issue 7, 2012, Pages 1938-1952

  Yu, Zhimin ^a   Zhao, Haifeng ^a   Zhao, Mouming ^a   Lei, Hongjie ^a   Li, Huiping ^b  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^b Guangzhou Zhujiang Brewery Co Ltd   (China)

Author keywords

Ale yeast; Fermentation temperature; Glycolytic key enzyme; Lager yeast; Metabolic flux analysis; Nodes control analysis

Indexed keywords

ALTERNATIVE APPROACH; BREWER'S YEASTS; COMBINED ANALYSIS; CONTROL ANALYSIS; DOWN-REGULATION; FERMENTATION TEMPERATURE; FLUX CONTROL; GLYCOLYTIC ENZYME; GLYCOLYTIC FLUX; GLYCOLYTIC PATHWAYS; HEXOKINASES; KEY ENZYMES; KEY NODES; METABOLIC FLUX; METABOLIC FLUX ANALYSIS; METABOLIC STATE; PHOSPHOFRUCTOKINASE; PRODUCTION EFFICIENCY; PYRUVATE KINASE;

ENZYMES; FERMENTATION; METABOLISM; YEAST;

QUALITY CONTROL;

6 PHOSPHOFRUCTOKINASE; GLUCOSE 6 PHOSPHATE; GLYCOLYTIC ENZYME; HEXOKINASE; PENTOSE PHOSPHATE; PYRUVATE KINASE; TRICARBOXYLIC ACID;

ARTICLE; BEER; BREWING; CELL MEMBRANE; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; FERMENTATION; FUNGAL METABOLISM; FUNGAL STRAIN; FUNGUS GROWTH; GENE EXPRESSION; GLYCOLYSIS; PROTEIN PROCESSING; SACCHAROMYCES CEREVISIAE; TEMPERATURE;

BEER; FERMENTATION; GLYCOLYSIS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SACCHAROMYCES CEREVISIAE; SPECIES SPECIFICITY; TEMPERATURE;

EID: 84874499131     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-012-9909-z     Document Type: Article

References (37)

1. Vidgren, V.; Multanen, J.; Ruohonen, L.; & Londesborough, J. (2010). The temperature dependence of maltose transport in ale and lager strains of brewer's yeast. FEMS Yeast Research, 10, 402-411.
2. Lodolo, E. J.; Kock, J. L. F.; Axcell, B. C.; & Brooks, M. (2008). The yeast Saccharomyces cerevisiae - the main character in beer brewing. FEMS Yeast Research, 8, 1018-1036.
3. Kourkoutas, Y.; Bekatorou, A.; Banat, I. M.; Marchant, R.; & Koutinas, A. A. (2004). Immobilization technologies and support materials suitable in alcohol beverages production: a review. Food Microbiology, 21, 377-397. (Pubitemid 38448362)
4. Piddocke, M. P.; Kreisz, S.; Heldt-Hansen, H. P.; Nielsen, K. F.; & Olsson, L. (2009). Physiological characterization of brewer's yeast in high-gravity beer fermentations with glucose or maltose syrups as adjuncts. Applied Microbiology and Biotechnology, 84, 453-464.
5. Verduyn, C.; Postma, E.; & Scheffers, W. (1990). Physiology of Saccharomyces cerevisiae in anaerobic glucose-limited chemostat cultures. Journal of the Genetics and Microbiology, 136, 395-403. (Pubitemid 20109730)
6. Saerens, S. M. G.; Verbelen, P. J.; Vanbeneden, N.; Thevelein, J. M.; & Delvaux, F. R. (2008). Monitoring the influence of high-gravity brewing and fermentation temperature on flavour formation by analysis of gene expression levels in brewing yeast. Applied Microbiology and Biotechnology, 80, 1039-1051.
7. Chowdhury, I.; Watier, D.; Leguerinel, I.; & Hornez, J. P. (1997). Effect of Pectinatus cerevisiiphilus on Saccharomyces cerevisiae concerning its growth and alcohol production in wort medium. Food Microbiology, 14, 265-272. (Pubitemid 27284966)
8. Landaud, S.; Latrille, E.; & Corrieu, G. (2001). Top pressure and temperature control the fusel alcohol/ester ratio through yeast growth in beer fermentation. Journal of the Institute of Brewing, 107, 107-117. (Pubitemid 33397538)
9. Gibson, B. R.; Lawrence, S. J.; Leclaire, J. P. R.; Powell, C. D.; & Smart, K. A. (2007). Yeast responses to stresses associated with industrial brewery handling. FEMS Microbiology Reviews, 31, 535-569. (Pubitemid 47246179)
10. Chen, Z.; Liu, H. J.; Zhang, J. A.; & Liu, D. H. (2009). Cell physiology and metabolic flux response of Klebsiella pneumoniae to aerobic conditions. Process Biochemistry, 44, 862-868.
11. Arense, P.; Bernal, V.; Iborra, J. L.; & Cánovas, M. (2010). Metabolic adaptation of Escherichia coli to long-term exposure to salt stress. Process Biochemistry, 45, 1459-1467.
12. Reuter, R.; Naumann, M.; Bär, J.; Haferburg, D.; & Kopperschläger, G. (2000). Purification, molecular and kinetic characterization of phosphofructokinase-I from the yeast Schizosaccharomyces pombe: evidence for an unusual subunit composition. Yeast, 16, 1273-1285.
13. Susan-Resiga, D.; & Nowak, T. (2003). The proton transfer step catalyzed by yeast pyruvate kinase. Journal of Biological Chemistry, 278, 12660-12671. (Pubitemid 36800026)
14. Yu, M. A.; Wei, Y. M.; Zhao, L.; Jiang, L.; Zhu, X. B.; & Qi, W. (2007). Bioconversion of ethyl 4-chloro-3-oxobutanoate by permeabilized fresh brewer's yeast cells in the presence of allyl bromide. Journal of Industry Microbiology and Biotechnology, 34, 151-156. (Pubitemid 46147395)
15. Bernal, V.; Carinhas, N.; Yokomizo, Y. Y.; Carrondo, M. J. T.; & Alves, P. M. (2009). Cell density effect in the bauculovirus-insect cells system: a quantitative analysis of energetic metabolism. Biotechnology and Bioengineering, 104, 162-178.
16. Zhang, Q.; Teng, H.; Sun, Y.; Xiu, Z.; & Zeng, A. (2008). Metabolic flux and robustness analysis of glycerol metabolism in Klebsiella pneumoniae. Bioprocess and Biosystems Engineering, 31, 127-135.
17. ven Eunen, K.; Dool, P.; Canelas, A. B.; Kiewiet, J.; Bouwman, J.; van Gulik, W. M.; Westerhoff, H. V.; & Bakker, B. M. (2010). Time-dependent regulation of yeast glycolysis upon nitrogen starvation depends on cell history. IET Systems Biology, 4, 157-168.
18. Liu, H. J.; Li, Q.; Liu, D. H.; & Zhong, J. J. (2006). Impact of hyperosmotic condition on cell physiology and metabolic flux distribution of Candida krusei. Biochemistry Engineering Journal, 28, 92-98. (Pubitemid 41774063)
19. Rossell, S.; van der Weijden, C. C.; Lindenbergh, A.; Tuijl, A.; Francke, C.; Bakker, B. M.; & Westerhoff, H. V. (2006). Unraveling the complexity of flux regulation: a new method demonstrated for nutrient starvation in Saccharomyces cerevisiae. PNAS, 103, 2166-2171. (Pubitemid 43271641)
20. Shen, Y.; Zhao, X. Q.; Ge, X. M.; & Bai, F. W. (2009). Metabolic flux and cell cycle analysis indicating new mechanism underlying process oscillation in continuous ethanol fermentation with Saccharomyces cerevisiae under VHG conditions. Biotechnology Advances, 27, 1118-1123.
21. Çaklr, T.; Arga, K. Y.; Altmtas, M. M.; & Ülgen, K. Ö. (2004). Flux analysis of recombinant Saccharomyces cerevisiae YPB-G utilizing starch for optimal ethanol production. Process Biochemistry, 39, 2097-2108. (Pubitemid 39123604)
22. Gibson, B. R.; Boulton, C. A.; Box, W. G.; Graham, N. S.; Lawrence, S. J.; Linforth, R. S. T.; & Smart, K. A. (2008). Carbohydrate utilization and the lager yeast transcriptome during brewery fermentation. Yeast, 25, 549-562.
23. Li, J.; Jiang, M.; Chen, K. Q.; Ye, Q.; Shang, L. A.; Wei, P.; Ying, H. J.; & Chang, H. N. (2010). Effect of redox potential regulation on succinic acid production by Actinobacillus succinogenes. Bioprocess and Biosystems Engineering, 33, 911-920.
24. + availability. Journal of Biotechnology, 126, 173-185. (Pubitemid 44528777)
25. Li, J.; Yang, Y.; Chu, J.; Huang, M.; Li, L.; Zhang, X.; Wang, Y.; Zhuang, Y.; & Zhang, S. (2010). Quantitative metabolic flux analysis revealed uneconomical utilization of ATP and NADPH in Acremonium chysogenum fed with soybean oil. Bioprocess and Biosystems Engineering, 33, 1119-1129.
26. Andersen, H. W.; Solem, C.; Hammer, K.; & Jensen, P. R. (2001). Twofold reduction of phosphofructokinase activity in Lactococcus lactis results in strong decreases in growth rate and in glycolytic flux. Journal of Bacteriology, 183, 3458-3467. (Pubitemid 32448609)
27. Walsh, R. M.; & Martin, P. A. (1977). Growth of Saccharomyces cerevisiae and Saccharomyces uvarum in a temperature gradient. Journal of the Institute of Brewing, 83, 169-172.
28. Tai, S. L.; Daran-Lapujade, P.; Luttik, M. A.; Walsh, M. C.; Diderich, J. A.; Krijger, G. C.; van Gulik, W. M.; Pronk, J. T.; & Daran, J. M. (2007). Control of the glycolytic flux in Saccharomyces cerevisiae grown at low temperature. Journal of Biological Chemistry, 282, 10243-10251. (Pubitemid 47093420)
29. Verbelen, P. J.; Dekoninck, T. M. L.; Saerens, S. M. G.; van Mulders, S. E.; Thevelein, J. M.; & Delvaux, F. R. (2009). Impact of pitching rate on yeast fermentation performance and beer flavour. Applied Microbiology and Biotechnology, 82, 155-167.
30. Daran-Lapujade, P.; Rossell, S.; van Gulik, W. M.; Luttik, M. A. H.; de Groot, M. J. L.; Slijper, M.; Heck, A. J. R.; Daran, J. M.; de Winde, J. H.; Westerhoff, H. V.; Pronk, J. T.; & Bakker, B. M. (2007). The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels. PNAS, 104, 15753-15758. (Pubitemid 350035372)
31. Rautio, J. J.; Huuskonen, A.; Vuokko, H.; Vidgren, V.; & Londesborough, J. (2007). Monitoring yeast physiology during very high gravity wort fermentations by frequent analysis of gene expression. Yeast, 24, 741-760. (Pubitemid 47412455)
32. Guimarães, P. M. R.; & Londesborough, J. (2008). The adenylate energy charge and specific fermentation rate of brewer's yeasts fermenting high- and very high-gravity worts. Yeast, 25, 47-58. (Pubitemid 351181638)
33. van den Brink, J.; Canelas, A. B.; van Gulik, W. M.; Pronk, J. T.; Heijnen, J. J.; de Winde, J. H.; & Daran-Lapujade, P. (2008). Dynamics of glycolytic regulation during adaptation of Saccharomyces cerevisiae to fermentative metabolism. Applied and Environmental Microbiology, 78, 5710-5723.
34. Ramos, A.; Neves, A. R.; Ventura, R.; Maycock, C.; Lopez, P.; & Santos, H. (2004). Effect of pyruvate kinase overproduction on glucose metabolism of Lactococcus lactis. Microbiol-SGM, 150, 1103-1111. (Pubitemid 38519330)
35. Breitenbach-Schmitt, I.; Schmitt, H. D.; Heinisch, J.; & Zimmermann, F. K. (1984). Genetic and physiological evidence for the existence of a second glycolytic pathway in yeast parallel to the phosphofructokinase-aldolase reaction sequence. Molecular Genetics and Genomics, 195, 536-540. (Pubitemid 14059219)
36. Pearce, A. K.; Crimmins, K.; Groussac, E.; Hewlins, M. J.; Dickinson, J. R.; Francois, J.; Booth, I. R.; & Brown, A. J. (2001). Pyruvate kinase (Pyk1) levels influence both the rate and direction of carbon flux in yeast under fermentative conditions. Microbiology, 147, 391-401. (Pubitemid 32156815)
37. Hauf, J.; Zimmermann, F. K.; & Muller, S. (2000). Simultaneous genomic overexpression of seven glycolytic enzymes in the yeast Saccharomyces cerevisiae. Enzyme and Microbial Technology, 26, 688-498. (Pubitemid 30345535)