Crystallins Are Regulated Biomarkers for Monitoring Topical Therapy of Glaucomatous Optic Neuropathy

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Prokosch, Verena ^a   Schallenberg, Maurice ^a   Thanos, Solon ^a,b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Interdisciplinary Center for Clinical Research   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS ACTING ON THE EYE; ANTIGLAUCOMA AGENT; BETA CRYSTALLIN; BRIMONIDINE PLUS TIMOLOL; CRYSTALLIN; DORZOLAMIDE PLUS TIMOLOL; TIMOLOL; TIMOLOL PLUS TRAVOPROST; TIMOPHTAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUTERIZATION; CELL LABELING; CELL SURVIVAL; CONTROLLED STUDY; DISEASE DURATION; DRUG MONITORING; ENUCLEATION; FOLLOW UP; GLAUCOMA; INTRAOCULAR PRESSURE; IRIDECTOMY; NEUROPROTECTION; NONHUMAN; OPTIC NERVE DISEASE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; RETINA GANGLION CELL; TOPICAL TREATMENT; TREATMENT RESPONSE;

ANIMALS; BIOLOGICAL MARKERS; CRYSTALLINS; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLAUCOMA; INTRAOCULAR PRESSURE; OPHTHALMIC SOLUTIONS; OPTIC NERVE DISEASES; PROTEOME; PROTEOMICS; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RETINA; RETINAL GANGLION CELLS; SULFONAMIDES; THIOPHENES; TIMOLOL;

EID: 84874485984     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049730     Document Type: Article

References (56)

1. Quigley HA, (1996) Number of people with glaucoma worldwide. Br J Ophthalmol 80: 389-393.
2. Stone EM, Fingert JH, Alward WL, Nguyen TD, Polansky JR, et al. (1997) Identification of a gene that causes primary open angle glaucoma. Science 275: 668-670.
3. Cockburn DM, (1983) Does reduction of intraocular pressure (IOP) prevent visual field loss in glaucoma? Am J Optom Physiol Opt 60: 705-711.
4. Garcia-Valenzuela E, Shareef S, Walsh J, Sharma SC, (1995) Programmed cell death of retinal ganglion cells during experimental glaucoma. Exp Eye Res 61: 33-44.
5. Hitchings RA, (1995) Therapeutic rationale for normal-tension glaucoma. Curr Opin Ophthalmol 6: 67-70.
6. Quigley HA, Nickells RW, Kerrigan LA, Pease ME, Thibault DJ, et al. (1995) Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci 36: 774-786.
7. Dreyer EB, Zurakowski D, Schumer RA, Podos SM, Lipton SA, (1996) Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol 114: 299-305.
8. Caprioli J, Kitano S, Morgan JE, (1996) Hyperthermia and hypoxia increase tolerance of retinal ganglion cells to anoxia and excitotoxicity. Invest Ophthalmol Vis Sci 37: 2376-2381.
9. Osborne NN, Wood JP, Chidlow G, Bae JH, Melena J, et al. (1999) Ganglion cell death in glaucoma: what do we really know? Br J Ophthalmol 83: 980-986.
10. Schwartz M, Yoles E, (2000) Self-destructive and self-protective processes in the damaged optic nerve: implications for glaucoma. Invest Ophthalmol Vis Sci 41: 349-351.
11. Quigley HA, McKinnon SJ, Zack DJ, Pease ME, Kerrigan-Baumrind LA, et al. (2000) Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. Invest Ophthalmol Vis Sci 41: 3460-3466.
12. Piri N, Song M, Kwong JM, Caprioli J, (2007) Modulation of alpha and beta crystallin expression in rat retinas with ocular hypertension-induced ganglion cell degeneration. Brain Res 1141: 1-9.
13. Liedtke T, Schwamborn JC, Schröer U, Thanos S, (2007) Elongation of axons during regeneration involves retinal crystallin beta b2 (crybb2). Mol Cell Proteomics 6: 895-907.
14. Tezel G, Seigel GM, Wax MB, (1998) Autoantibodies to small heat shock proteins in glaucoma. Invest Ophthalmol Vis Sci 39: 2277-2287.
15. Salvador-Silva M, Ricard CS, Agapova OA, Yang P, Hernandez MR, (2001) Expression of small heat shock proteins and intermediate filaments in the human optic nerve head astrocytes exposed to elevated hydrostatic pressure in vitro. J Neurosci Res 66: 59-73.
16. Grus FH, (2010) Relationship between oxidatve stress and autoimmunity in glaucoma. Klin Monbl Augenheilkd 227: 114-119.
17. Joachim SC, Bruns K, Lackner KJ, Pfeiffer N, Grus FH, (2007) Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor. Curr Eye Res 32: 501-509.
18. Mittag TW, Danias J, Pohorenec G, Yuan HM, Burakgazi E, et al. (2000) Retinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model. Invest Ophthalmol Vis Sci 41: 3451-3459.
19. Naskar R, Thanos S, (2006) Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure. Mol Vis 12: 1199-210.
20. Naskar R, Wissing M, Thanos S, (2002) Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma. Invest Ophthalmol Vis Sci 43: 2962-2968.
21. Liu S, Zhang Y, Xie X, Hu W, Cai R, et al. (2007) Application of two-dimensional electrophoresis in the research of retinal proteins of diabetic rat. Cell Mol Immunol 4: 65-70.
22. Wang YD, Wu JD, Jiang ZL, Wang YB, Wang XH, et al. (2007) Comparative proteome analysis of neural retinas from type 2 diabetic rats by two-dimensional electrophoresis. Curr Eye Res 32: 891-901.
23. Saylor M, McLoon LK, Harrison AR, Lee MS, (2009) Experimental and clinical evidence for brimonidine as an optic nerve and retinal neuroprotective agent: an evidence-based review. Arch Ophthalmol 127: 402-406.
24. Wood JP, Schmidt KG, Melena J, Chidlow G, Allmeier H, et al. (2003) The beta-adrenoceptor antagonists metipranolol and timolol are retinal neuroprotectants: comparison with betaxolol. Exp Eye Res 76: 505-516.
25. Nakanishi Y, Nakamura M, Mukuno H, Kanamori A, Seigel GM, et al. (2006) Latanoprost rescues retinal neuro-glial cells from apoptosis by inhibiting caspase-3, which is mediated by p44/p42 mitogen-activated protein kinase. Exp Eye Res 83: 1108-1117.
26. Park HY, Lee NY, Kim JH, Park CK, (2008) Intraocular pressure lowering, change of antiapoptotic molecule expression, and neuroretinal changes by dorzolamide 2%/timolol 0.5% combination in a chronic ocular hypertension rat model. J Ocul Pharmacol Ther 24: 563-571.
27. Hoyng PF, van Beek LM, (2000) Pharmacological therapy for glaucoma: a review. Drugs 59: 411-434.
28. Thanos S, Naskar R, Heiduschka P, (1997) Regenerating ganglion cell axons in the adult rat establish retinofugal topography and restore visual function. Exp Brain Res 114: 483-491.
29. O'Farrell PH, (1975) High-resolution two-dimensional electrophoresis of proteins. J Biol Chem 250: 4007-4021.
30. Laemmli UK, (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
31. Moore CG, Epley D, Milne ST, Morrison JC, (1995) Long-term non-invasive measurement of intraocular pressure in the rat eye. Curr Eye Res 14: 711-717.
32. Levkovitch-Verbin H, Quigley HA, Martin KR, Valenta D, Baumrind LA, et al. (2002) Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats. Invest Ophthalmol Vis Sci 43: 402-410.
33. Chauhan BC, Pan J, Archibald ML, LeVatte TL, Kelly ME, et al. (2002) Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage. Invest Ophthalmol Vis Sci 43: 2969-2976.
34. Andley UP, Mathur S, Griest TA, Petrash JM, (1996) Cloning, expression, and chaperone-like activity of human alphaA-crystallin. J Biol Chem 271: 31973-31980.
35. Graw J, (1997) The crystallins: genes, proteins and diseases. Biol Chem 378: 1331-1348.
36. Berman ER (1994) Biochemistry of cataracts. In: Garner A, Klintworth GK (eds) Pathology of Ocular Diseases: a Dynamic Approach. Dekker, New York pp 533-590.
37. Sax CM, Piatigorsky J, (1994) Expression of the alpha-crystallin/small heat-shock protein/molecular chaperone genes in the lens and other tissues. Adv Enzymol Relat Areas Mol Biol 69: 155-201.
38. Clayton RM, Thomson I, de Pomerai DI, (1979) Relationship between crystallin mRNA expression in retina cells and their capacity to re-differentiate into lens cells. Nature 282: 628-629.
39. Vázquez-Chona F, Song BK, Geisert EE Jr, (2004) Temporal changes in gene expression after injury in the rat retina. Invest Ophthalmol Vis Sci 45: 2737-2746.
40. Iwaki T, Wisniewski T, Iwaki A, Corbin E, Tomokane N, et al. (1992) Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions. Am J Pathol 140: 345-356.
41. Head MW, Corbin E, Goldman JE, (1993) Overexpression and abnormal modification of the stress proteins alpha B-crystallin and HSP27 in Alexander disease. Am J Pathol 143: 1743-1753.
42. Renkawek K, de Jong WW, Merck KB, Frenken CW, van Workum FP, et al. (1992) Alpha B-crystallin is present in reactive glia in Creutzfeldt-Jakob disease. Acta Neuropathol 83: 324-327.
43. Yoshimura N, Kikuchi T, Kuroiwa S, Gaun S, (2003) Differential temporal and spatial expression of immediate early genes in retinal neurons after ischemia-reperfusion injury. Invest Ophthalmol Vis Sci 44: 2211-2220.
44. Sakaguchi H, Miyagi M, Darrow RM, Crabb JS, Hollyfield JG, et al. (2003) Intense light exposure changes the crystallin content in retina. Exp Eye Res 76: 131-133.
45. Kumar PA, Haseeb A, Suryanarayana P, Ehtesham NZ, Reddy GB, (2005) Elevated expression of alphaA- and alphaB-crystallins in streptozotocin-induced diabetic rat. Arch Biochem Biophys 444: 77-83.
46. Furuyoshi N, Furuyoshi M, May CA, Hayreh SS, Alm A, et al. (2000) Vascular and glial changes in the retrolaminar optic nerve in glaucomatous monkey eyes. Ophthalmologica 214: 24-32.
47. Tezel G, Yang J, Wax MB, (2004) Heat shock proteins, immunity and glaucoma. Brain Res Bull 62: 473-480.
48. Young DB, (1990) Stress proteins and the immune response. Antonie Van Leeuwenhoek 58: 203-208.
49. Young RA, Elliott TJ, (1989) Stress proteins, infection, and immune surveillance. Cell 59: 5-8.
50. Zimmerman TJ, (1993) Topical ophthalmic beta blockers: a comparative review. J Ocul Pharmacol 9: 373-384.
51. Melena J, Wood JP, Osborne NN, (1999) Betaxolol, a beta1-adrenoceptor antagonist, has an affinity for L-type Ca2+ channels. Eur J Pharmacol 378: 317-322.
52. Chidlow G, Melena J, Osborne NN, (2000) Betaxolol, a beta(1)-adrenoceptor antagonist, reduces Na(+) influx into cortical synaptosomes by direct interaction with Na(+) channels: Comparison with other beta-adrenoceptor antagonists. Br J Pharmacol 130: 759-766.
53. Donello JE, Padillo EU, Webster ML, Wheeler LA, Gil DW, (2001) Alpha(2)-adrenoceptor agonists inhibit vitreal lutamate and aspartate accumulation and preserve retinal function after transient ischemia. J Pharmacol Exp Ther 296: 216-223.
54. Lai RK, Chun T, Hasson D, Lee S, Mehrbod F, et al. (2002) Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat. Vis Neurosci 19: 175-185.
55. Davis TL, Sharif NA, (1999) Quantitative autoradiographic visualization and pharmacology of FP-prostaglandin receptors in human eyes using the novel phosphor-imaging technology. J Ocul Pharmacol Ther 15: 323-336.
56. Martínez A, Sánchez-Salorio M, (2009) A comparison of the long-term effects of dorzolamide 2% and brinzolamide 1%, each added to timolol 0.5%, on retrobulbar hemodynamics and intraocular pressure in open-angle glaucoma patients. J Ocul Pharmacol Ther 25: 239-248.