The morphology of spray dried mannitol particles - The vital importance of droplet size

Powder Technology

Volumn 239, Issue , 2013, Pages 162-174

  Littringer, E M ^a   Paus, R ^b   Mescher, A ^b   Schroettner, H ^c   Walzel, P ^b   Urbanetz, N A ^a  

^a RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH   (Austria)

^b TU DORTMUND UNIVERSITY   (Germany)

^c GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Mannitol; Morphology; Roughness; Scale up; Spray drying; Surface modification

Indexed keywords

CARRIER PARTICLES; DIFFERENT SIZES; DILUTED SOLUTIONS; DROPLET SIZES; FEED TEMPERATURE; LOW TEMPERATURES; MANNITOL; OUTLET TEMPERATURE; PARTICLE FORMATION MECHANISM; PARTICLE MORPHOLOGIES; PILOT SCALE; PULMONARY DRUG DELIVERY; ROUGH PARTICLES; SCALE-UP; SMALL DROPLETS; SPRAY DRIED; SPRAY DRYERS; VISCOUS LIQUIDS;

DRUG PRODUCTS; DRYERS (EQUIPMENT); MORPHOLOGY; SPRAY DRYING; SURFACE ROUGHNESS; SURFACE TREATMENT;

DROP FORMATION;

MANNITOL;

AIR TEMPERATURE; AIRFLOW; ARTICLE; CONCENTRATION (PARAMETERS); CRYSTALLIZATION; PARTICLE SIZE; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; STRUCTURE ANALYSIS; SURFACE PROPERTY; TEMPERATURE MEASUREMENT; TEMPERATURE SENSITIVITY;

EID: 84874444632     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2013.01.065     Document Type: Article

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