Spray drying of Mannitol as a drug carrier—the impact of process parameters on product properties

Drying Technology

Volumn 30, Issue 1, 2012, Pages 114-124

  Littringer, Eva Maria ^a   Mescher, Axel ^b   Eckhard, Susanna ^c   Schröttner, Hartmuth ^d   Langes, Christoph ^e   Fries, Manfred ^c   Griesser, Ulrich ^e   Walzel, Peter ^b   Urbanetz, Nora Anne ^a  

^a RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH   (Austria)

^b TU DORTMUND UNIVERSITY   (Germany)

^c FRAUNHOFER INSTITUTE FOR CERAMIC TECHNOLOGIES AND SYSTEMS   (Germany)

^d GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^e UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Breaking strength; Carrier particles; Crystallization; Design of experiments; Dry powder inhaler; Mannitol; Particle size; Spray drying; Surface roughness

Indexed keywords

ATOMIZERS; CRYSTALLIZATION; DESIGN OF EXPERIMENTS; DRUG PRODUCTS; GAS HEATING; GASES; PARTICLE SIZE; POLYOLS; POWDERS; SHAFTS (MACHINE COMPONENTS); SPRAY DRYING; SURFACE ROUGHNESS; SURFACE TOPOGRAPHY;

ATOMIZER ROTATION SPEED; BREAKING STRENGTH; CARRIER PARTICLES; CRYSTAL MODIFICATIONS; DRY POWDER INHALER; FULL FACTORIAL DESIGN; MANNITOL; SOLUTION CONCENTRATION;

DRYING;

CRYSTALLIZATION; EXPERIMENTATION; PARTICLE SIZE; SPRAY DRYING;

EID: 84856401341     PISSN: 07373937     EISSN: 15322300     Source Type: Journal    
DOI: 10.1080/07373937.2011.620726     Document Type: Article

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