Arsenic induced neuronal apoptosis in guinea pigs is Ca2+ dependent and abrogated by chelation therapy: Role of voltage gated calcium channels

NeuroToxicology

Volumn 35, Issue 1, 2013, Pages 137-145

  Pachauri, Vidhu ^a   Mehta, Ashish ^a   Mishra, Deepshikha ^a   Flora, Swaran J S ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Arsenic; Chelation therapy; DMSA monoesters; Reactive oxygen species; Voltage gated calcium channels

Indexed keywords

ACETYLCHOLINESTERASE; AMINE OXIDASE (FLAVIN CONTAINING); ARSENIC; CALCIUM CHANNEL L TYPE; CALCIUM ION; CASPASE 3; CHELATING AGENT; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; MCHDMSA; NITRIC OXIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUCCIMER; SUCCIMER DERIVATIVE; SUCCIMER MONOISOAMYL; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARSENIC POISONING; ARTICLE; BAX GENE; BRAIN LEVEL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHELATION THERAPY; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; GENE; GENE EXPRESSION; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LONG TERM EXPOSURE; MALE; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOTHERAPY; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTO ONCOGENE; TOXICOKINETICS;

ANIMALS; APOPTOSIS; ARSENIC POISONING; ARSENITES; BCL-2-ASSOCIATED X PROTEIN; CALCIUM; CALCIUM CHANNELS, L-TYPE; CASPASE 3; CHELATING AGENTS; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; GUINEA PIGS; KINETICS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SODIUM COMPOUNDS; SUCCIMER;

EID: 84874428826     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2013.01.006     Document Type: Article

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