The venom of the fishing spider Dolomedes sulfurous contains various neurotoxins acting on voltage-activated ion channels in rat dorsal root ganglion neurons

Toxicon

Volumn 65, Issue , 2013, Pages 68-75

  Wang, Hengyun ^a   Zhang, Fan ^a   Li, Dan ^a   Xu, Shiyan ^a   He, Juan ^a   Yu, Hai ^a   Li, Jiayan ^a   Liu, Zhonghua ^a   Liang, Songping ^a  

^a HUNAN NORMAL UNIVERSITY   (China)

Author keywords

Dolomedes sulfurous; MALDI TOF MS; RP HPLC; Spider venom; Venom landscape; Voltage activated ion channels

Indexed keywords

CALCIUM CHANNEL T TYPE; ION CHANNEL; NEUROTOXIN; SPIDER VENOM; SPIDER VENOM PEPTIDE; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE ACTIVATED CALCIUM ION CHANNEL; VOLTAGE ACTIVATED ION CHANNEL; VOLTAGE ACTIVATED POTASSIUM ION CHANNEL; VOLTAGE ACTIVATED SODIUM ION CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DEATH; DOLOMEDES SULFUROUS; FEMALE; LD 50; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NERVE CELL INHIBITION; NEUROTOXICITY; NONHUMAN; PARALYSIS; PREDATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPIDER; SPINAL GANGLION; ZEBRA FISH;

ANIMALS; CALCIUM CHANNELS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GANGLIA, SPINAL; LETHAL DOSE 50; NEUROTOXINS; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPIDER VENOMS; VOLTAGE-GATED SODIUM CHANNELS; ZEBRAFISH;

EID: 84874395348     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2013.01.014     Document Type: Article

References (26)

1. + channels in pain Pathways. Trends Pharmacol. Sci. 2001, 22:27-31.
2. Bosmans F., Swartz K.J. Targeting sodium channel voltage sensors with spider toxins. Trends Pharmacol. Sci. 2010, 31:175-182.
3. Cao Y.Q. Voltage-gated calcium channels and pain. Pain 2006, 126:5-9.
4. Catterall W.A. From ionic currents to molecular mechanisms: the structure and function of voltage gated sodium channels. Neuron 2000, 26:13-25.
5. Corzo G., Escoubas P. Pharmacologically active spider peptide toxins. Cell. Mol. Life Sci. 2003, 60:2409-2426.
6. Diego-García E., Peigneur S., Waelkens E., Debaveye S., Tytgat J. Venom components from Citharischius crawshayi spider (Family Theraphosidae): exploring transcriptome, venomics, and function. Cell. Mol. Life Sci. 2010, 67:2799-2813.
7. Dos Santos L.D., Dias N.B., Roberto J., Pinto A.S., Palma M.S. Brown recluse spider venom: proteomic analysis and proposal of a putative mechanism of action. Protein Pept. Lett. 2009, 16:933-943.
8. Escoubas P., King G.F. Venomics as a drug discovery platform. Expert Rev. Proteomics 2009, 6:221-224.
9. Escoubas P., Diochot S., Corzo G. Structure and pharmacology of spider venom neurotoxins. Biochimie 2000, 82:893-907.
10. Escoubas P., Sollod B., King G.F. Venom landscapes: mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach. Toxicon 2006, 47:650-663.
11. Family: Pisauridae (Nursery Web or Fishing Spiders), 2012. Biodiversity Explorer. Online at: . http://www.biodiversityexplorer.org/arachnids/spiders/pisauridae/index.htm.
12. Harriott A.M., Gold M.S. Contribution of primary afferent channels to neuropathic pain. Curr. Pain Headache Rep. 2009, 13:197-207.
13. Ho C., O'Leary M.E. Single-cell analysis of sodium channel expression in dorsal root ganglion neurons. Mol. Cell. Neurosci. 2011, 46:159-166.
14. v1.2) potassium channels. Mol. Pain 2012, 8:2.
15. Lefebvre K.A., Dowel S.L., Silver M.W. Tissue distribution and neurotoxic effects of domoic acid in a prominent vector species, the northern anchovy Engraulis mordax. Mar. Biol. 2001, 138:693-700.
16. Liang S. Proteome and peptidome profiling of spider venoms. Expert Rev. Protemoics 2008, 5:731-746.
17. Liao Z., Cao J., Li S., Yan X., Hu W., He Q., Chen J., Tang J., Xie J., Liang S. Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics 2007, 7:1892-1907.
18. Nelson M.T., Todorovic S.M., Perez-Reyes E. The role of T-type calcium channels in epilepsy and pain. Curr. Pharm. Des. 2006, 12:2189-2197.
19. Patrick H.T., Waxman S.G. Inactivation properties of sodium channel Nav1.8 maintain action potential amplitude in small DRG neurons in the context of depolarization. Mol. Pain 2007, 3:12.
20. Platnick N.I. The World Spider Catalog, Version 13.0 2012, American Museum of Natural History, Online at:. http://research.amnh.org/iz/spiders/catalog, 10.5531/db.iz.0001.
21. + currents in physiological concentration of sodium in rat visceral afferents. Int. J. Biol. Sci. 2009, 5:293-297.
22. Tang X., Zhang Y., Hu W., Xu D., Yang X., Li Y., Jiang L., Liang S. Molecular diversification of peptide toxins from the tarantula Haplopelma (Ornithoctonus hainana) venom based on transcriptomic, peptidomic, and genomic analyses. J. Proteome Res. 2010, 9:2550-2564.
23. Wang X.C., Duan Z.G., Yang J., Yan X.J., Zhou H., He X.Z., Liang S.P. Physiological and biochemical analysis of L. tredecimguttatus venom collected by electrical stimulation. J. Physiol. Biochem. 2007, 63:221-230.
24. Xiao Y.C., Liang S.P. Inhibition of sodium channels in rat dorsal root ganglion neurons by hainantoxin-IV, a novel spider toxin. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2003, 35:82-85.
25. Yaksh T.L. Calcium channels as therapeutic targets in neuropathic pain. J. Pain 2006, 7:S13-S30.
26. Yuan C., Jin Q., Tang X., Hu W., Cao R., Yang S., Xiong J., Xie C., Xie J., Liang S. Proteomic and peptidomic characterization of the venom from the Chinese bird spider, Ornithoctonus huwena Wang. J. Proteome Res. 2007, 6:2792-2801.