Demyelinating lesions as incidental findings in magnetic resonance imaging: A study of 11 cases with clinico-radiological follow-up and a review of the literature;Lesiones incidentales desmielinizantes en resonancia magnética: Estudio de 11 casos con seguimiento clinicorradiológico y revisión de la bibliografía

Revista de Neurologia

Volumn 51, Issue 3, 2010, Pages 129-134

  Sierra Marcos, Alba ^a   Mitjana, Raquel ^b   Castilló, Joaquín ^a   Edo, Mari Carmen ^a   Horga Hernández, Alejandro ^a   Tintoré, Mar ^a   Río Izquierdo, Jordi ^a   Auger Acosta, Cristina ^b   Rovira, Àlex ^b   Montalban, Xavier ^a  

^a Centre d Esclerosi Múltiple de Catalunya Cemcat   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Demyelinating diseases; Incidental lesions; Isolated neurological syndrome; Magnetic resonance imaging; Multiple sclerosis

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; DISEASE COURSE; EPILEPSY; FEMALE; HUMAN; INCIDENCE; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PROLACTINOMA; RADICULAR PAIN; SYNCOPE; BRAIN; DEMYELINATING DISEASE; INCIDENTAL FINDING; LONGITUDINAL STUDY; MIDDLE AGED; PATHOLOGY; PROCEDURES;

ADULT; BRAIN; DEMYELINATING DISEASES; DISEASE PROGRESSION; FEMALE; HUMANS; INCIDENTAL FINDINGS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS;

EID: 77955623790     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.5103.2010259     Document Type: Article

References (24)

1. Brex PA, Ciccarelli O, O'Riordan JI, Sailer M, Thompson AJ, Miller DH. A longitudinal study of abnormalities on MRI and disability from multiple sclerosis. N Engl J Med 2002; 346: 158-64.
2. Barkhof F, Filippi M, Miller DH, Scheltens P, Campi A, Polman CH, et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 1997; 120: 2059-69.
3. Tintoré M, Rovira A, Martínez MJ, Río J, Díaz-Villoslada P, Brieva L, et al. Isolated demyelinating syndromes: comparison of different MR imaging criteria to predict conversion to clinically definite multiple sclerosis. AJNR Am J Neuroradiol 2000; 21: 702-6.
4. Gilbert J. Unsuspected multiple sclerosis. Arch Neurol 1983; 40: 533-6.
5. Engell T. A clinical patho-anatomical study of clinically silent multiple sclerosis. Acta Neurol Scand 1989; 79: 428-30.
6. Brinar V. Diagnostic and therapeutic dilemmas. Clin Neurol Neurosurg 2004; 106: 180-6.
7. De Stefano N, Cocco E, Lai M, Battaglini M, Spissu A, Marchi P, et al. Imaging brain damage in first-degree relatives of sporadic and familial multiple sclerosis. Ann Neurol 2006; 59: 634-9.
8. Lynch SG, Rose JW, Smoker W, Petajan JH. MRI in familial multiple sclerosis. Neurology 1990; 40: 900-3.
9. Barakat-Shrem O, Fernández-Pérez MJ, Benavente- Fernández A, García-Moreno JM, Ruiz-Peña JL, Fajardo-Galvez J, et al. Estudio de pacientes asintomáticos de esclerosis múltiple familiar mediante resonancia magnética. Rev Neurol 2003; 37: 811-4.
10. Tienari PJ, Salonen O, Wikström J, Valanne L, Palo J. Familial multiple sclerosis: MRI findings in clinically affected and un affected siblings. J Neurol Neurosurg Psychiatry 1992; 55: 883-6.
11. Lebrun C, Bensa C, Debouverie M, De Seze J, Wiertlievski S, Brochet B, et al. Unexpected multiple sclerosis: follow-up of 30 patients with magnetic resonance imaging and clinical conversion profile. J Neurol Neurosurg Psychiatry 2008; 79: 195-8.
12. Okuda DT, Mowry EM, Beheshtian A, Waubant E, Baranzini SE, Goodin DS, et al. Incidental MRI anomalies suggestive of multiple sclerosis. The radiologically isolated syndrome. Neurology 2009; 72: 800-5.
13. Siva A, Saip S, Altintas A, Jacob A, Keegan BM, Kantarci OH. Multiple sclerosis risk in radiologically uncovered asymptomatic possible inflammatory-demyelinating disease. Mult Scler 2009; 15: 918-27.
14. Lebrun C, Bensa C, Debouverie M, Wiertlevski S, Brassat D, De Seze J, et al. Association between clinical conversion to multiple sclerosis in radiologically isolated syndrome and magnetic resonance imaging, cerebrospinal fluid, and visual evoked potential. Arch Neurol 2009; 66: 841-6.
15. Sempere AP, López-Celada S, Berenguer-Ruiz L, Giner-Bernabeu JC, Hernández-Rubio L. Síndrome radiológico aislado. Rev Neurol 2009; 49: 599-600.
16. Korteweg T, Tintoré M, Uitdehaaq B, Rovira A, Frederiksen J, Miller D, et al. MRI criteria for dissemination in space in patients with clinically isolated syndromes: a multicenter follow-up study. Lancet Neurol 2006; 5: 221-7.
17. Amato MP, Ponziani G, Siracusa G, Sorbi S. Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years. Arch Neurol 2001; 58: 1602-6.
18. Glanz B, Holland C, Gauthier S. Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Mult Scler 2007; 13: 1004-10.
19. Rovaris M, Comi G, Filippi M. MRI markers of destructive pathology in multiple sclerosis-related cognitive dysfunction. J Neurol Sci 2006; 245: 111-6.
20. Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM, Murray TJ, et al. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study Group. N Engl J Med 2000; 343: 898-904.
21. Kappos L, Polman CH, Freedman MS, Edan G, Hartung HP, Miller DH, et al. Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes. Neurology 2006; 67: 1242-9.
22. Motamed MR, Najimi N, Fereshtehnejad SM. The effect on interferon-beta1a on relapses and progression of disability in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis. Clin Neurol Neurosurg 2007; 109: 344-9.
23. Tintoré M. New options for early treatment of multiple sclerosis. J Neurol Sci 2009; 277 (Suppl 1): S9-11.
24. Hernández-Pérez MA, en representación del grupo de investigadores del estudio PARALEN. Seguridad y tolerabilidad en la fase inicial del tratamiento con interferón beta-1a 44 microgramos en pauta lenta frente a pauta rápida en pacientes con esclerosis múltiple (estudio PARALEN). Rev Neurol 2009; 48: 505-8.