메뉴 건너뛰기




Volumn 47, Issue , 1996, Pages 333-353

The geneticist's approach to complex disease

Author keywords

Complex disease; Genotypes; Linkage analysis; Linkage disequilibrium; Phenotypes

Indexed keywords

DATA ANALYSIS; DATA BASE; GENE MAPPING; GENERAL ASPECTS OF DISEASE; GENETIC LINKAGE; GENETICS; GENOTYPE; HUMAN; METHODOLOGY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; REVIEW; RODENT; STATISTICAL ANALYSIS;

EID: 0029875956     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.47.1.333     Document Type: Review
Times cited : (58)

References (104)
  • 1
    • 0024423668 scopus 로고
    • Identification of the cystic fibrosis gene: Genetic analysis
    • Kerem B-S, Rommens JM, Buchanan JA, et al. 1989. Identification of the cystic fibrosis gene: genetic analysis. Science 245: 1073-80
    • (1989) Science , vol.245 , pp. 1073-1080
    • Kerem, B.-S.1    Rommens, J.M.2    Buchanan, J.A.3
  • 2
    • 0029057336 scopus 로고
    • A single ataxia telangiectasia gene with a product similar to PI-3 kinase
    • Savitsky K, Bar-Shira A, Gilad S, et al. 1995. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 248:1749-53
    • (1995) Science , vol.248 , pp. 1749-1753
    • Savitsky, K.1    Bar-Shira, A.2    Gilad, S.3
  • 3
    • 0026849567 scopus 로고
    • Positional cloning: Let's not call it reverse anymore
    • Collins FS. 1992. Positional cloning: let's not call it reverse anymore. Nat. Genet. 1:3-6
    • (1992) Nat. Genet. , vol.1 , pp. 3-6
    • Collins, F.S.1
  • 4
    • 0028907339 scopus 로고
    • Positional cloning moves from perditional to traditional
    • Collins FS. 1995. Positional cloning moves from perditional to traditional. Nat. Genet. 9:347-50
    • (1995) Nat. Genet. , vol.9 , pp. 347-350
    • Collins, F.S.1
  • 5
    • 0028910076 scopus 로고
    • The cystic fibrosis transmembrane conductance regulator gene
    • Tsui L. 1995. The cystic fibrosis transmembrane conductance regulator gene. Am. J. Respir. Crit. Care. Med. 151: S47-53
    • (1995) Am. J. Respir. Crit. Care. Med. , vol.151
    • Tsui, L.1
  • 7
    • 0024851989 scopus 로고
    • Disease associations, chance artifacts or susceptibility genes?
    • Cox NJ, Bell GI. 1989. Disease associations, chance artifacts or susceptibility genes? Diabetes 38:947-50
    • (1989) Diabetes , vol.38 , pp. 947-950
    • Cox, N.J.1    Bell, G.I.2
  • 8
    • 0027992091 scopus 로고
    • Comparison of statistics for candidate-gene association studies using cases and parents
    • Schaid DJ, Sommer SS. 1994. Comparison of statistics for candidate-gene association studies using cases and parents. Am. J. Hum. Genet. 55: 402-9
    • (1994) Am. J. Hum. Genet. , vol.55 , pp. 402-409
    • Schaid, D.J.1    Sommer, S.S.2
  • 9
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
    • Spielman RC, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52:506-16
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 506-516
    • Spielman, R.C.1    McGinnis, R.E.2    Ewens, W.J.3
  • 10
    • 0026494911 scopus 로고
    • A haplotype-based 'haplotype relative risk' approach to detecting allelic associations
    • Terwilliger JD, Ott J. 1992. A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. Hum. Hered. 42:337-46
    • (1992) Hum. Hered. , vol.42 , pp. 337-346
    • Terwilliger, J.D.1    Ott, J.2
  • 11
    • 0027521860 scopus 로고
    • The haplotype-relative-risk method for analysis of association in nuclear families
    • Knapp M, Seuchter SA, Baur MP. 1993. The haplotype-relative-risk method for analysis of association in nuclear families. Am. J. Hum. Genet. 52:1085-93
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 1085-1093
    • Knapp, M.1    Seuchter, S.A.2    Baur, M.P.3
  • 13
    • 0019732410 scopus 로고
    • Measuring the strength of associations between HLA antigens and diseases
    • Bengtsson BO, Thomson G. 1981. Measuring the strength of associations between HLA antigens and diseases. Tissue Antigens 18:356-63
    • (1981) Tissue Antigens , vol.18 , pp. 356-363
    • Bengtsson, B.O.1    Thomson, G.2
  • 14
    • 0025613812 scopus 로고
    • Linkage of early-onset familial breast cancer to chromosome 17q21
    • Hall JM, Lee MK, Newman B, et al. 1990. Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250: 1684-89
    • (1990) Science , vol.250 , pp. 1684-1689
    • Hall, J.M.1    Lee, M.K.2    Newman, B.3
  • 15
    • 0025735884 scopus 로고
    • Linkage studies in familial Alzheimer's disease: Evidence for chromosome 19 linkage
    • Pericak-Vance MA, Bebout JL, Gaskell PC, et al. 1991. Linkage studies in familial Alzheimer's disease: evidence for chromosome 19 linkage. Am. J. Hum. Genet. 48: 1034-50
    • (1991) Am. J. Hum. Genet. , vol.48 , pp. 1034-1050
    • Pericak-Vance, M.A.1    Bebout, J.L.2    Gaskell, P.C.3
  • 16
    • 0029124823 scopus 로고
    • Aternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues
    • Xu L, Sterner C, Maheshwar M, et al. 1995. Aternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues. Genomics 27:475-80
    • (1995) Genomics , vol.27 , pp. 475-480
    • Xu, L.1    Sterner, C.2    Maheshwar, M.3
  • 17
    • 0028041363 scopus 로고
    • A combined test of linkage heterogeneity
    • Goldstein D. 1994. A combined test of linkage heterogeneity. Am. J. Hum. Genet. 55: 841-48
    • (1994) Am. J. Hum. Genet. , vol.55 , pp. 841-848
    • Goldstein, D.1
  • 18
    • 0029022716 scopus 로고
    • Multiple trait analysis of genetic mapping for quantitative trait loci
    • Jiang C, Zeng Z. 1995. Multiple trait analysis of genetic mapping for quantitative trait loci. Genetics 140:1111-27
    • (1995) Genetics , vol.140 , pp. 1111-1127
    • Jiang, C.1    Zeng, Z.2
  • 19
    • 0029355769 scopus 로고
    • Expanded CAG repeats in schizophrenia and bipolar disorder
    • O'Donovan MC, Guy C, Craddock N, et al. 1995. Expanded CAG repeats in schizophrenia and bipolar disorder. Nat. Genet. 10:380-81
    • (1995) Nat. Genet. , vol.10 , pp. 380-381
    • O'Donovan, M.C.1    Guy, C.2    Craddock, N.3
  • 20
    • 0028567918 scopus 로고
    • Parental origin of diabetes-associated HLA types in sibling pairs with type 1 diabetes
    • Bain SC, Rowe BR, Barnett AH, et al. 1994. Parental origin of diabetes-associated HLA types in sibling pairs with type 1 diabetes. Diabetes 43:1462-68
    • (1994) Diabetes , vol.43 , pp. 1462-1468
    • Bain, S.C.1    Rowe, B.R.2    Barnett, A.H.3
  • 21
    • 0026906885 scopus 로고
    • Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness
    • Van den Ouweland JMW, Lemkes HHPJ, Ruitenbeek W, et al. 1992. Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nat. Genet. 1:11-16
    • (1992) Nat. Genet. , vol.1 , pp. 11-16
    • Van Den Ouweland, J.M.W.1    Lemkes, H.H.P.J.2    Ruitenbeek, W.3
  • 22
    • 0026906885 scopus 로고
    • Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion
    • Ballinger SW, Schoffner JM, Hedaya EV, et al. 1992. Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion. Nat. Genet. 1: 368-71
    • (1992) Nat. Genet. , vol.1 , pp. 368-371
    • Ballinger, S.W.1    Schoffner, J.M.2    Hedaya, E.V.3
  • 24
    • 0025019555 scopus 로고
    • Linkage strategies for genetically complex traits. I. Multilocus models
    • Risch N. 1990. Linkage strategies for genetically complex traits. I. Multilocus models. Am. J. Hum. Genet. 46:222-28
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 222-228
    • Risch, N.1
  • 25
    • 0026641354 scopus 로고
    • Concordance for type 1 (insulin-dependent) and type 2 (non-insulin dependent) diabetes mellitus in a population-based cohort of twins in Finland
    • Kaprio J, Tuomilehto J, Koskenvuo M, et al. 1992. Concordance for type 1 (insulin-dependent) and type 2 (non-insulin dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 35:1060-67
    • (1992) Diabetologia , vol.35 , pp. 1060-1067
    • Kaprio, J.1    Tuomilehto, J.2    Koskenvuo, M.3
  • 26
    • 0019870959 scopus 로고
    • Diabetes in identical twins. A study of 200 pairs
    • Barnett AH, Eff C, Leslie RDG, et al. 1981. Diabetes in identical twins. A study of 200 pairs. Diabetologia 20:87-93
    • (1981) Diabetologia , vol.20 , pp. 87-93
    • Barnett, A.H.1    Eff, C.2    Leslie, R.D.G.3
  • 27
    • 0023201498 scopus 로고
    • Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins
    • Newman B, Selby JV, King M-C, et al. 1987. Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins. Diabetologia 30:763-68
    • (1987) Diabetologia , vol.30 , pp. 763-768
    • Newman, B.1    Selby, J.V.2    King, M.-C.3
  • 29
    • 0023829194 scopus 로고
    • Can familial aggregation of disease be explained by familial aggregation of environmental risk factors?
    • Khoury MJ, Beaty TH, Liang K-Y. 1988. Can familial aggregation of disease be explained by familial aggregation of environmental risk factors? Am J. Epidem. 127: 674-83
    • (1988) Am J. Epidem. , vol.127 , pp. 674-683
    • Khoury, M.J.1    Beaty, T.H.2    Liang, K.-Y.3
  • 30
    • 0022728801 scopus 로고
    • Effects of misspecifying genetic parameters in lod score analysis
    • Clerget-Darpoux F, Bonaiti-Pellie C, Hochez J. 1986. Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42:393-99
    • (1986) Biometrics , vol.42 , pp. 393-399
    • Clerget-Darpoux, F.1    Bonaiti-Pellie, C.2    Hochez, J.3
  • 31
    • 0018150112 scopus 로고
    • The generalized sib pair IBD distribution: Its use in the detection of linkage
    • Suarez BK, Rice J, Reich T. 1978. The generalized sib pair IBD distribution: its use in the detection of linkage. Ann. Hum. Genet. 42:87-94
    • (1978) Ann. Hum. Genet. , vol.42 , pp. 87-94
    • Suarez, B.K.1    Rice, J.2    Reich, T.3
  • 32
    • 0027529253 scopus 로고
    • Asymptotic properties of affected-sib-pair linkage analysis
    • Holmans P. 1993. Asymptotic properties of affected-sib-pair linkage analysis. Am. J. Hum. Genet. 52:362-74
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 362-374
    • Holmans, P.1
  • 33
    • 0027171992 scopus 로고
    • Improved sib-pair linkage test for disease susceptibility loci
    • Faraway JJ. 1993. Improved sib-pair linkage test for disease susceptibility loci. Genet. Epidemiol. 10:225-33
    • (1993) Genet. Epidemiol. , vol.10 , pp. 225-233
    • Faraway, J.J.1
  • 34
    • 0028040135 scopus 로고
    • Linkage analysis in nuclear families: Optimality criteria for affected sib-pair tests
    • Knapp M, Seuchter SA, Bauer MP. 1994. Linkage analysis in nuclear families: optimality criteria for affected sib-pair tests. Hum. Hered. 44:37-43
    • (1994) Hum. Hered. , vol.44 , pp. 37-43
    • Knapp, M.1    Seuchter, S.A.2    Bauer, M.P.3
  • 35
    • 0025020461 scopus 로고
    • Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs
    • Risch N. 1990. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am. J. Hum. Genet. 46:242-53
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 242-253
    • Risch, N.1
  • 36
    • 0023894935 scopus 로고
    • The affected-pedigree-member method of linkage analysis
    • Weeks DE, Lange K. 1988. The affected-pedigree-member method of linkage analysis. Am. J. Hum. Genet. 42:315-26
    • (1988) Am. J. Hum. Genet. , vol.42 , pp. 315-326
    • Weeks, D.E.1    Lange, K.2
  • 37
    • 0026510552 scopus 로고
    • A multilocus extension of the affected-pedigree-member method of linkage analysis
    • Weeks DE, Lange K. 1992. A multilocus extension of the affected-pedigree-member method of linkage analysis. Am. J. Hum. Genet. 50:859-68
    • (1992) Am. J. Hum. Genet. , vol.50 , pp. 859-868
    • Weeks, D.E.1    Lange, K.2
  • 38
    • 0025008677 scopus 로고
    • Linkage strategies for genetically complex traits. II. The power of affected relative pairs
    • Risch N. 1990. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am. J. Hum. Genet. 46:229-41
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 229-241
    • Risch, N.1
  • 39
    • 0342499587 scopus 로고
    • Strategies for multilocus linkage analysis in humans
    • Lathrop GM, Lalouel JM, et al. 1984. Strategies for multilocus linkage analysis in humans. Proc. Natl. Acad. Sci. USA 81: 3443-46
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 3443-3446
    • Lathrop, G.M.1    Lalouel, J.M.2
  • 40
    • 0025245437 scopus 로고
    • Multipoint analysis of human quantitative genetic variation
    • Goldgar DE. 1990. Multipoint analysis of human quantitative genetic variation. Am. J. Hum. Genet. 47:957-67
    • (1990) Am. J. Hum. Genet. , vol.47 , pp. 957-967
    • Goldgar, D.E.1
  • 41
    • 0028947057 scopus 로고
    • Multipoint interval mapping of quantitative trait loci, using sib pairs
    • Fulker DW, Cherny SS, Cardon LR. 1995. Multipoint interval mapping of quantitative trait loci, using sib pairs. Am. J. Hum. Genet. 56:1224-33
    • (1995) Am. J. Hum. Genet. , vol.56 , pp. 1224-1233
    • Fulker, D.W.1    Cherny, S.S.2    Cardon, L.R.3
  • 42
    • 0029046177 scopus 로고
    • Complete multipoint sib-pair analysis of qualitative and quantitative traits
    • Kruglyak L, Lander E. 1995. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am. J. Hum. Genet. 57:439-54
    • (1995) Am. J. Hum. Genet. , vol.57 , pp. 439-454
    • Kruglyak, L.1    Lander, E.2
  • 43
    • 0024508964 scopus 로고
    • Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps
    • Lander ES, Botstein D, 1989. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-99
    • (1989) Genetics , vol.121 , pp. 185-199
    • Lander, E.S.1    Botstein, D.2
  • 44
    • 33646942472 scopus 로고
    • A simple regression method for mapping quantitative trait loci in line crosses using flanking markers
    • Haley CS, Knott SA. 1992. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69:315-24
    • (1992) Heredity , vol.69 , pp. 315-324
    • Haley, C.S.1    Knott, S.A.2
  • 45
    • 0028224156 scopus 로고
    • Precision mapping of quantitative trait loci
    • Zeng Z-B. 1994. Precision mapping of quantitative trait loci. Genetics 136: 1457-68
    • (1994) Genetics , vol.136 , pp. 1457-1468
    • Zeng, Z.-B.1
  • 46
    • 0027363428 scopus 로고
    • Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci
    • Zeng Z-B. 1993. Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci. Proc. Natl. Acad. Sci. USA 90:10972-76
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10972-10976
    • Zeng, Z.-B.1
  • 47
    • 0027487931 scopus 로고
    • Gaussian models for genetic linkage analysis using complete high-resolution maps of identity-by-descent
    • Feingold E, Brown PO, Siegmund D. 1993. Gaussian models for genetic linkage analysis using complete high-resolution maps of identity-by-descent. Am. J. Hum. Genet. 53:234-51
    • (1993) Am. J. Hum. Genet. , vol.53 , pp. 234-251
    • Feingold, E.1    Brown, P.O.2    Siegmund, D.3
  • 48
    • 21344487467 scopus 로고
    • Markov processes for modelling and analyzing a new genetic mapping method
    • Feingold E. 1993. Markov processes for modelling and analyzing a new genetic mapping method. J. Appl. Probab. 30: 766-79
    • (1993) J. Appl. Probab. , vol.30 , pp. 766-779
    • Feingold, E.1
  • 49
    • 0028090414 scopus 로고
    • Genetic dissection of complex traits
    • Lander ES, Schork NJ. 1994. Genetic dissection of complex traits. Science 265: 2037-48
    • (1994) Science , vol.265 , pp. 2037-2048
    • Lander, E.S.1    Schork, N.J.2
  • 50
    • 0028067197 scopus 로고
    • Identifying complex disease genes: Progress and paradigms
    • Thomson G. 1994. Identifying complex disease genes: progress and paradigms. Nat. Genet. 8:108-10
    • (1994) Nat. Genet. , vol.8 , pp. 108-110
    • Thomson, G.1
  • 51
    • 0026949420 scopus 로고
    • Linkage disequilibrium mapping in isolated founder populations: Diastrophic dysplasia in Finland
    • Hastbacka J, Chapelle A, Kaitila I, et al. 1992. Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland. Nat. Genet. 2:204-11
    • (1992) Nat. Genet. , vol.2 , pp. 204-211
    • Hastbacka, J.1    Chapelle, A.2    Kaitila, I.3
  • 52
    • 0027978110 scopus 로고
    • The diastrophic dysplasia gene encodes a novel sulfate transporter: Positional cloning by fine-structure linkage disequilibrium mapping
    • Hastbacka J, de la Chapelle A, Mahtani MM, et al. 1994. The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell 78:1073-78
    • (1994) Cell , vol.78 , pp. 1073-1078
    • Hastbacka, J.1    De La Chapelle, A.2    Mahtani, M.M.3
  • 53
    • 0027430716 scopus 로고
    • Two-trait-locus linkage analysis: A powerful strategy for mapping complex genetic traits
    • Schork NJ, Boehnke M, Terwilliger JD, Ott J. 1993. Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am. J. Hum. Genet. 53:1127-36
    • (1993) Am. J. Hum. Genet. , vol.53 , pp. 1127-1136
    • Schork, N.J.1    Boehnke, M.2    Terwilliger, J.D.3    Ott, J.4
  • 54
    • 0028030120 scopus 로고
    • Two-locus disease models with two marker loci: The power of affected-sib-pair tests
    • Knapp M, Seuchter SA, Baur MP. 1994. Two-locus disease models with two marker loci: the power of affected-sib-pair tests. Am. J. Hum. Genet. 55:1030-34
    • (1994) Am. J. Hum. Genet. , vol.55 , pp. 1030-1034
    • Knapp, M.1    Seuchter, S.A.2    Baur, M.P.3
  • 55
    • 0029061838 scopus 로고
    • Statistical methods for linkage analysis of complex traits from high resolution maps of identity-by-descent
    • Dupuis J, Brown PO, Siegmund D. 1995. Statistical methods for linkage analysis of complex traits from high resolution maps of identity-by-descent. Genetics 140: 843-56
    • (1995) Genetics , vol.140 , pp. 843-856
    • Dupuis, J.1    Brown, P.O.2    Siegmund, D.3
  • 56
    • 0029000346 scopus 로고
    • Genetics of bipolar affective disorder: Time for another reinvention?
    • Gelernter J. 1995. Genetics of bipolar affective disorder: time for another reinvention? Am. J. Hum. Genet. 56:1262-66
    • (1995) Am. J. Hum. Genet. , vol.56 , pp. 1262-1266
    • Gelernter, J.1
  • 58
    • 0026562918 scopus 로고
    • Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
    • Vionnet N, Stoffel M, Takeda J, et al. 1992. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature 356:721-22
    • (1992) Nature , vol.356 , pp. 721-722
    • Vionnet, N.1    Stoffel, M.2    Takeda, J.3
  • 59
    • 0026032055 scopus 로고
    • Gene for non-insulin diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q
    • Bell GI, Xiang K-S, Newman MV, et al. 1991. Gene for non-insulin diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc. Natl. Acad. Sci. USA 88:1484-88
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1484-1488
    • Bell, G.I.1    Xiang, K.-S.2    Newman, M.V.3
  • 60
    • 0028907342 scopus 로고
    • A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q
    • Vaxillaire M, Boccio V, Philippi A, et al. 1995. A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Nat. Genet. 9:418-23
    • (1995) Nat. Genet. , vol.9 , pp. 418-423
    • Vaxillaire, M.1    Boccio, V.2    Philippi, A.3
  • 61
    • 0028113345 scopus 로고
    • A strong candidate for breast and ovarian cancer susceptibility gene BRCA1
    • Mike Y, Swensen J, Shattuck-Eidens PA, et al. 1994. A strong candidate for breast and ovarian cancer susceptibility gene BRCA1. Science 266:66-71
    • (1994) Science , vol.266 , pp. 66-71
    • Mike, Y.1    Swensen, J.2    Shattuck-Eidens, P.A.3
  • 62
    • 0028859671 scopus 로고
    • Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
    • Liu B, Nicolaides NC, Markowitz S, et al. 1995. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat. Genet. 9:48-55
    • (1995) Nat. Genet. , vol.9 , pp. 48-55
    • Liu, B.1    Nicolaides, N.C.2    Markowitz, S.3
  • 63
    • 0027263363 scopus 로고
    • Genetic mapping of a locus predisposing to human colorectal cancer
    • Peltomaki P, Aaltonen LA, Sistonen P, et al. 1993. Genetic mapping of a locus predisposing to human colorectal cancer. Science 260:810-12
    • (1993) Science , vol.260 , pp. 810-812
    • Peltomaki, P.1    Aaltonen, L.A.2    Sistonen, P.3
  • 64
    • 0027137935 scopus 로고
    • Hypermutability and mismatch repair deficiency in RER+ tumor cells
    • Parsons R, Li G, Longley MJ, et al. 1993. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 75: 1227-36
    • (1993) Cell , vol.75 , pp. 1227-1236
    • Parsons, R.1    Li, G.2    Longley, M.J.3
  • 65
    • 0027145633 scopus 로고
    • Mutations of mutS homolog in hereditary nonpolyposis colorectal cancer
    • Leach FS, Nicolaides NC, Papadopoulos N, et al. 1993. Mutations of mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75:1215-25
    • (1993) Cell , vol.75 , pp. 1215-1225
    • Leach, F.S.1    Nicolaides, N.C.2    Papadopoulos, N.3
  • 66
    • 0027158031 scopus 로고
    • Clues to the pathogenesis of familial colorectal cancer
    • Aaltonen LA, Peltomaki P, Leach FS, et al. 1993. Clues to the pathogenesis of familial colorectal cancer. Science 260:812-16
    • (1993) Science , vol.260 , pp. 812-816
    • Aaltonen, L.A.1    Peltomaki, P.2    Leach, F.S.3
  • 67
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau SN, Bren G, Schaid D. 1993. Microsatellite instability in cancer of the proximal colon. Science 260:816-19
    • (1993) Science , vol.260 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 68
    • 0028350601 scopus 로고
    • Mutation of a mutL homolog in hereditary colon cancer
    • Papadopoulous N, Nicolaides NC, Wei Y, et al. 1994. Mutation of a mutL homolog in hereditary colon cancer. Science 263: 1625-29
    • (1994) Science , vol.263 , pp. 1625-1629
    • Papadopoulous, N.1    Nicolaides, N.C.2    Wei, Y.3
  • 69
    • 0028221943 scopus 로고
    • Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
    • Bronner CE, Baker SM, Morrison PT, et al. 1994. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368:258-61
    • (1994) Nature , vol.368 , pp. 258-261
    • Bronner, C.E.1    Baker, S.M.2    Morrison, P.T.3
  • 70
    • 0028366154 scopus 로고
    • Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q
    • Tomfohrde J, Silverman A, Barnes R, et al. 1994. Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science 264:1141-45
    • (1994) Science , vol.264 , pp. 1141-1145
    • Tomfohrde, J.1    Silverman, A.2    Barnes, R.3
  • 71
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R, Rogaev EI, Liang Y, et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-60
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3
  • 72
    • 0026632256 scopus 로고
    • Major gene effect for insulin levels in familial NIDDM pedigrees
    • Schumacher MC, Hasstedt SJ, Hunt SC, et al. 1992. Major gene effect for insulin levels in familial NIDDM pedigrees. Diabetes 41:416-23
    • (1992) Diabetes , vol.41 , pp. 416-423
    • Schumacher, M.C.1    Hasstedt, S.J.2    Hunt, S.C.3
  • 73
    • 0026047218 scopus 로고
    • Linkage analysis of quantitative traits: Increased power by using selected samples
    • Carey G, Williamson J. 1991. Linkage analysis of quantitative traits: increased power by using selected samples. Am. J. Hum. Genet. 49:786-96
    • (1991) Am. J. Hum. Genet. , vol.49 , pp. 786-796
    • Carey, G.1    Williamson, J.2
  • 74
    • 0029001682 scopus 로고
    • Extreme discordant sib pairs for mapping quantitative trait loci in humans
    • Risch N, Zhang H. 1995. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268:1584-89
    • (1995) Science , vol.268 , pp. 1584-1589
    • Risch, N.1    Zhang, H.2
  • 75
    • 0028343233 scopus 로고
    • Automated construction of genetic linkage maps using an expert system (MultiMap): A human genome linkage map
    • Matise TC, Perlin M, Chakravarti A. 1994. Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map. Natl. Genet. 6: 384-90
    • (1994) Natl. Genet. , vol.6 , pp. 384-390
    • Matise, T.C.1    Perlin, M.2    Chakravarti, A.3
  • 76
    • 0028365909 scopus 로고
    • Integrated human genome-wide maps constructed using the CEPH reference panel
    • Buetow KH, Weber JL, Ludwigsen S, et al. 1994. Integrated human genome-wide maps constructed using the CEPH reference panel. Nat. Genet. 6:391-93
    • (1994) Nat. Genet. , vol.6 , pp. 391-393
    • Buetow, K.H.1    Weber, J.L.2    Ludwigsen, S.3
  • 77
    • 0028231090 scopus 로고
    • The 1993-94 Genethon human genetic linkage map
    • Gyapay G, Morissette J, Vignal A, et al. 1994. The 1993-94 Genethon human genetic linkage map. Nat. Genet. 7:246-49
    • (1994) Nat. Genet. , vol.7 , pp. 246-249
    • Gyapay, G.1    Morissette, J.2    Vignal, A.3
  • 78
    • 0027933734 scopus 로고
    • A genome-wide search for human type I diabetes susceptibility genes
    • Davies JL, Kawaguchi Y, Bennett ST. et al. 1994. A genome-wide search for human type I diabetes susceptibility genes. Nature 371:130-36
    • (1994) Nature , vol.371 , pp. 130-136
    • Davies, J.L.1    Kawaguchi, Y.2    Bennett, S.T.3
  • 79
    • 0028952250 scopus 로고
    • High-resolution genetic mapping of complex traits
    • Kruglyak L, Lander ES. 1995. High-resolution genetic mapping of complex traits. Am. J. Hum. Genet. 56:1212-23
    • (1995) Am. J. Hum. Genet. , vol.56 , pp. 1212-1223
    • Kruglyak, L.1    Lander, E.S.2
  • 80
    • 0026645062 scopus 로고
    • A genetic map of the mouse suitable for typing intraspecific crosses
    • Dietrich W, Katz H, Lincoln SE, et al. 1992. A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 131: 423-27
    • (1992) Genetics , vol.131 , pp. 423-427
    • Dietrich, W.1    Katz, H.2    Lincoln, S.E.3
  • 81
    • 0027172544 scopus 로고
    • Polygenic control of autoimmune diabetes in nonobese diabetic mice
    • Ghosh S, Palmer SM, Rodrigues N, et al. 1993. Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nat. Genet. 4:404-9
    • (1993) Nat. Genet. , vol.4 , pp. 404-409
    • Ghosh, S.1    Palmer, S.M.2    Rodrigues, N.3
  • 82
    • 0025946420 scopus 로고
    • Chromosomal mapping of two genetic loci associated with blood pressure regulation in hereditary hypertensive rats
    • Hilbert P, Lindpaintner K, Bedckmann JS, et al. 1991. Chromosomal mapping of two genetic loci associated with blood pressure regulation in hereditary hypertensive rats. Nature 353:521-28
    • (1991) Nature , vol.353 , pp. 521-528
    • Hilbert, P.1    Lindpaintner, K.2    Bedckmann, J.S.3
  • 83
    • 0025936511 scopus 로고
    • Genetic mapping of a major gene causing hypertension in the stroke-prone spontaneously hypertensive rat
    • Jacob HJ, Lindpaintner K, Lincoln S, et al. 1991. Genetic mapping of a major gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 67: 213-24
    • (1991) Cell , vol.67 , pp. 213-224
    • Jacob, H.J.1    Lindpaintner, K.2    Lincoln, S.3
  • 84
    • 0026849428 scopus 로고
    • Absence of linkage between the angiotensin converting ennzyme locus and human essential hypertension
    • Jeunemaitre X, Lifton RP, Hunt SC, et al. 1992. Absence of linkage between the angiotensin converting ennzyme locus and human essential hypertension. Nat. Genet. 1:72-75
    • (1992) Nat. Genet. , vol.1 , pp. 72-75
    • Jeunemaitre, X.1    Lifton, R.P.2    Hunt, S.C.3
  • 85
    • 0026669336 scopus 로고
    • Molecular basis of human hypertension: Role of angiotensinogen
    • Jeunemaitre X, Soubrier F, Kotelevsev YV, et al. 1992. Molecular basis of human hypertension: role of angiotensinogen. Cell 71:169-80
    • (1992) Cell , vol.71 , pp. 169-180
    • Jeunemaitre, X.1    Soubrier, F.2    Kotelevsev, Y.V.3
  • 86
    • 0028200754 scopus 로고
    • Linkage of the angiotensinogen gene to essential hypertension
    • Caulfield M, Lavender P, Farrall M, et al. 1994. Linkage of the angiotensinogen gene to essential hypertension. N. Engl. J. Med. 330:1629-33
    • (1994) N. Engl. J. Med. , vol.330 , pp. 1629-1633
    • Caulfield, M.1    Lavender, P.2    Farrall, M.3
  • 87
    • 0029153057 scopus 로고
    • Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans
    • Caulfield M, Lavender P, Newell-Price J, et al. 1995. Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans. J. Clin. Invest. 96: 687-92
    • (1995) J. Clin. Invest. , vol.96 , pp. 687-692
    • Caulfield, M.1    Lavender, P.2    Newell-Price, J.3
  • 88
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A, Chartier-Harlin MC, Mullan M, et al. 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349:704-6
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.C.2    Mullan, M.3
  • 89
    • 0026471656 scopus 로고
    • Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
    • Schellenberg GD, Bird TD, Wijsman EM, et al. 1992. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 258:668-71
    • (1992) Science , vol.258 , pp. 668-671
    • Schellenberg, G.D.1    Bird, T.D.2    Wijsman, E.M.3
  • 90
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R, Rogaev EI, Liang Y, et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-60
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3
  • 91
    • 0029150716 scopus 로고
    • A familial Alzheimer's disease locus on chromosome 1
    • Levy-Lahad E, Wijsman E, Nemens E, et al. 1995. A familial Alzheimer's disease locus on chromosome 1. Science 269: 970-73
    • (1995) Science , vol.269 , pp. 970-973
    • Levy-Lahad, E.1    Wijsman, E.2    Nemens, E.3
  • 92
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad E, Wasco W, Poorkaj P, et al. 1995. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973-77
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 93
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, et al. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261: 921-23
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 94
    • 0028305380 scopus 로고
    • Protective effect of apolipoprotein e type 2 allele for late onset Alzheimer disease
    • Corder EH, Saunders AM, Risch NJ, et al. 1994. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat. Genet. 7:180-84
    • (1994) Nat. Genet. , vol.7 , pp. 180-184
    • Corder, E.H.1    Saunders, A.M.2    Risch, N.J.3
  • 95
    • 0027944781 scopus 로고
    • Multiple DNA variant association analysis: Application to the insulin gene region in type 1 diabetes
    • Julier C, Lucassen A, Villedieu P, et al. 1994. Multiple DNA variant association analysis: application to the insulin gene region in type 1 diabetes. Am. J. Hum. Genet. 55:1247-54
    • (1994) Am. J. Hum. Genet. , vol.55 , pp. 1247-1254
    • Julier, C.1    Lucassen, A.2    Villedieu, P.3
  • 96
    • 0028871202 scopus 로고
    • Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
    • Bennett ST, Lucassen AM, Gough SCL, et al. 1995. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat. Genet. 9: 284-91
    • (1995) Nat. Genet. , vol.9 , pp. 284-291
    • Bennett, S.T.1    Lucassen, A.M.2    Gough, S.C.L.3
  • 97
    • 0028881617 scopus 로고
    • The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription
    • Kennedy GC, German MS, Rutter WJ. 1995. The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nat. Genet. 9:293-98
    • (1995) Nat. Genet. , vol.9 , pp. 293-298
    • Kennedy, G.C.1    German, M.S.2    Rutter, W.J.3
  • 98
    • 0028175491 scopus 로고
    • Linkage of the VNTR/insulin-gene and type 1 diabetes mellitus: Increased gene sharing in affected sibling pairs
    • Owerbach D, Gabbay KH. 1994. Linkage of the VNTR/insulin-gene and type 1 diabetes mellitus: increased gene sharing in affected sibling pairs. Am. J. Hum. Genet. 54:909-12
    • (1994) Am. J. Hum. Genet. , vol.54 , pp. 909-912
    • Owerbach, D.1    Gabbay, K.H.2
  • 99
    • 0027200763 scopus 로고
    • Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR
    • Lucassen AM, Julier C, Beressi J, et al. 1993. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nat. Genet. 4:305-9
    • (1993) Nat. Genet. , vol.4 , pp. 305-309
    • Lucassen, A.M.1    Julier, C.2    Beressi, J.3
  • 100
    • 0027966026 scopus 로고
    • A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus
    • Field LL, Tobias R, Magnus T. 1994. A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus. Nat. Genet. 8:189-94
    • (1994) Nat. Genet. , vol.8 , pp. 189-194
    • Field, L.L.1    Tobias, R.2    Magnus, T.3
  • 101
    • 0028070552 scopus 로고
    • Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q
    • Hashimoto L, Habita C, Beressi JP, et al. 1994. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 371: 161-64
    • (1994) Nature , vol.371 , pp. 161-164
    • Hashimoto, L.1    Habita, C.2    Beressi, J.P.3
  • 102
    • 0028843482 scopus 로고
    • Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (TDDM7) to chromosome 2q31-q33
    • Copeman JB, Cucca F, Hearne CM, et al. 1995. Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (TDDM7) to chromosome 2q31-q33. Nat. Genet. 9:80-85
    • (1995) Nat. Genet. , vol.9 , pp. 80-85
    • Copeman, J.B.1    Cucca, F.2    Hearne, C.M.3
  • 103
    • 0028840092 scopus 로고
    • The HOXD8 locus (2q31) is linked to type 1 diabetes
    • Owerbach D, Gabbay KH. 1995. The HOXD8 locus (2q31) is linked to type 1 diabetes. Diabetes 44:132-36
    • (1995) Diabetes , vol.44 , pp. 132-136
    • Owerbach, D.1    Gabbay, K.H.2
  • 104
    • 0029314872 scopus 로고
    • Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7
    • Rowe RE, Wapelhorst B, Bell GI, et al. 1995. Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7. Nat. Genet. 10:240-42
    • (1995) Nat. Genet. , vol.10 , pp. 240-242
    • Rowe, R.E.1    Wapelhorst, B.2    Bell, G.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.