Vitamin B6 and colorectal cancer: Current evidence and future directions

World Journal of Gastroenterology

Volumn 19, Issue 7, 2013, Pages 1005-1010

  Zhang, Xue Hong ^a   Ma, Jing ^a   Smith Warner, Stephanie A ^b   Lee, Jung Eun ^c   Giovannucci, Edward ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c Sookmyung Women's University   (South Korea)

Author keywords

Adenoma; Case control study; Cohort study; Colorectal cancer; Epidemiology; Incidence; Plasma pyridoxal 5' phosphate; Randomized controlled trial; Vitamin B6

Indexed keywords

ACETYLSALICYLIC ACID; CYANOCOBALAMIN; FOLIC ACID; PLACEBO; PYRIDOXAL 5 PHOSPHATE; PYRIDOXINE;

ARTICLE; CANCER RISK; CARBON METABOLISM; CARCINOGENESIS; CELL PROLIFERATION; COLORECTAL ADENOMA; COLORECTAL CANCER; DIET SUPPLEMENTATION; DIETARY INTAKE; DISEASE ASSOCIATION; DNA METHYLATION; DNA SYNTHESIS; HUMAN; INFLAMMATION; META ANALYSIS (TOPIC); OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL (TOPIC);

EID: 84874379762     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i7.1005     Document Type: Article

References (55)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBO-CAN 2008. Int J Cancer 2010; 127: 2893-2917 [PMID: 21351269 DOI: 10.1002/ijc.25516]
2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012; 62: 10-29 [PMID: 22237781 DOI: 10.3322/ caac.20138]
3. World Cancer Research Fund, American Institute for Cancer Research. Continuous Update Project Report Summary: Food, Nutrition, Physical Activity, and the Prevention of Colorectal Cancer. 2011
4. World Cancer Research Fund, American Institute for Cancer Research Expert Panel. Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective. 2007
5. Chan AT, Giovannucci EL. Primary prevention of colorectal cancer. Gastroenterology 2010; 138: 2029-2043.e10 [PMID: 20420944]
6. Schernhammer ES, Giovannuccci E, Fuchs CS, Ogino S. A prospective study of dietary folate and vitamin B and colon cancer according to microsatellite instability and KRAS mutational status. Cancer Epidemiol Biomarkers Prev 2008; 17: 2895-2898 [PMID: 18843035 DOI: 10.1158/1055-9965. EPI-08-0638]
7. Schernhammer ES, Giovannucci E, Kawasaki T, Rosner B, Fuchs CS, Ogino S. Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer. Gut 2010; 59: 794-799 [PMID: 19828464 DOI: 10.1136/gut.2009. 183707]
8. Schernhammer ES, Ogino S, Fuchs CS. Folate and vitamin B6 intake and risk of colon cancer in relation to p53 expression. Gastroenterology 2008; 135: 770-780 [PMID: 18619459 DOI: 10.1053/j.gastro.2008.06.033]
9. Eussen SJ, Vollset SE, Hustad S, Midttun Ø, Meyer K, Fredriksen A, Ueland PM, Jenab M, Slimani N, Boffetta P, Overvad K, Thorlacius-Ussing O, Tjønneland A, Olsen A, Clavel-Chapelon F, Boutron-Ruault MC, Morois S, Weikert C, Pischon T, Linseisen J, Kaaks R, Trichopoulou A, Zilis D, Katsoulis M, Palli D, Pala V, Vineis P, Tumino R, Panico S, Peeters PH, Bueno-de-Mesquita HB, van Duijnhoven FJ, Skeie G, Muñoz X, Martínez C, Dorronsoro M, Ardanaz E, Navarro C, Rodríguez L, VanGuelpen B, Palmqvist R, Manjer J, Ericson U, Bingham S, Khaw KT, Norat T, Riboli E. Plasma vitamins B2, B6, and B12, and related genetic variants as predictors of colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 2010; 19: 2549-2561 [PMID: 20813848 DOI: 10.1158/1055-9965.epi-10-0407]
10. Le Marchand L, Wang H, Selhub J, Vogt TM, Yokochi L, Decker R. Association of plasma vitamin B6 with risk of colorectal adenoma in a multiethnic case-control study. Cancer Causes Control 2011; 22: 929-936 [PMID: 21437631 DOI: 10.1007/s10552-011-9759-y]
11. Figueiredo JC, Levine AJ, Grau MV, Midttun O, Ueland PM, Ahnen DJ, Barry EL, Tsang S, Munroe D, Ali I, Haile RW, Sandler RS, Baron JA. Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation. Cancer Epidemiol Biomarkers Prev 2008; 17: 2136-2145 [PMID: 18708408 DOI: 10.1158/1055-9965.epi-07-2895]
12. Institute of Medicine. Dietary Reference Intakes: Thiamin R, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press, 1998
13. Morris MS, Picciano MF, Jacques PF, Selhub J. Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr 2008; 87: 1446-1454 [PMID: 18469270]
14. Bailey RL, Gahche JJ, Lentino CV, Dwyer JT, Engel JS, Thomas PR, Betz JM, Sempos CT, Picciano MF. Dietary supplement use in the United States, 2003-2006. J Nutr 2011; 141: 261-266 [PMID: 21178089 DOI: 10.3945/jn.110.133025]
15. Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging 2002; 6: 39-42 [PMID: 11813080]
16. Komatsu S, Watanabe H, Oka T, Tsuge H, Kat N. Dietary vitamin B6 suppresses colon tumorigenesis, 8-hydroxyguanosine, 4-hydroxynonenal, and inducible nitric oxide synthase protein in azoxymethane-treated mice. J Nutr Sci Vitaminol (Tokyo) 2002; 48: 65-68 [PMID: 12026192]
17. Matsubara K, Komatsu S, Oka T, Kato N. Vitamin B6-mediated suppression of colon tumorigenesis, cell proliferation, and angiogenesis (review). J Nutr Biochem 2003; 14: 246-250 [PMID: 12832027]
18. Matsubara K, Mori M, Matsuura Y, Kato N. Pyridoxal 5' -phosphate and pyridoxal inhibit angiogenesis in serum-free rat aortic ring assay. Int J Mol Med 2001; 8: 505-508 [PMID: 11605018]
19. Jain SK, Lim G. Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes. Free Radic Biol Med 2001; 30: 232-237 [PMID: 11165869]
20. Shen J, Lai CQ, Mattei J, Ordovas JM, Tucker KL. Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. Am J Clin Nutr 2010; 91: 337-342 [PMID: 19955400 DOI: 10.3945/ajcn.2009.28571]
21. Boland CR, Luciani MG, Gasche C, Goel A. Infection, inflammation, and gastrointestinal cancer. Gut 2005; 54: 1321-1331 [PMID: 16099799 DOI: 10.1136/gut.2004.060079]
22. Saibeni S, Cattaneo M, Vecchi M, Zighetti ML, Lecchi A, Lombardi R, Meucci G, Spina L, de Franchis R. Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants. Am J Gastroenterol 2003; 98: 112-117 [PMID: 12526945 DOI: 10.1111/j.1572-0241.2003.07160.x]
23. Chiang EP, Bagley PJ, Selhub J, Nadeau M, Roubenoff R. Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med 2003; 114: 283-287 [PMID: 12681455]
24. Roubenoff R, Roubenoff RA, Selhub J, Nadeau MR, Cannon JG, Freeman LM, Dinarello CA, Rosenberg IH. Abnormal vitamin B6 status in rheumatoid cachexia. Association with spontaneous tumor necrosis factor alpha production and markers of inflammation. Arthritis Rheum 1995; 38: 105-109 [PMID: 7818558]
25. Folsom AR, Nieto FJ, McGovern PG, Tsai MY, Malinow MR, Eckfeldt JH, Hess DL, Davis CE. Prospective study of coronary heart disease incidence in relation to fasting total ho mocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. Circulation 1998; 98: 204-210 [PMID: 9697819]
26. Robinson K, Arheart K, Refsum H, Brattström L, Boers G, Ueland P, Rubba P, Palma-Reis R, Meleady R, Daly L, Witteman J, Graham I. Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group. Circulation 1998; 97: 437-443 [PMID: 9490237]
27. Friso S, Jacques PF, Wilson PW, Rosenberg IH, Selhub J. Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels. Circulation 2001; 103: 2788-2791 [PMID: 11401933]
28. Theodoratou E, Farrington SM, Tenesa A, McNeill G, Cetnarskyj R, Barnetson RA, Porteous ME, Dunlop MG, Campbell H. Dietary vitamin B6 intake and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2008; 17: 171-182 [PMID: 18199722]
29. Larsson SC, Orsini N, Wolk A. Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies. JAMA 2010; 303: 1077-1083 [PMID: 20233826]
30. Zhang X, Lee JE, Ma J, Je Y, Wu K, Willett WC, Fuchs CS, Giovannucci EL. Prospective cohort studies of vitamin B-6 intake and colorectal cancer incidence: modification by time? Am J Clin Nutr 2012; 96: 874-881 [PMID: 22875713 DOI: 10.3945/ajcn.112.037267]
31. Wei EK, Giovannucci E, Selhub J, Fuchs CS, Hankinson SE, Ma J. Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women. J Natl Cancer Inst 2005; 97: 684-692 [PMID: 15870439 DOI: 10.1093/jnci/dji116]
32. Weinstein SJ, Albanes D, Selhub J, Graubard B, Lim U, Taylor PR, Virtamo J, Stolzenberg-Solomon R. One-carbon metabolism biomarkers and risk of colon and rectal cancers. Cancer Epidemiol Biomarkers Prev 2008; 17: 3233-3240 [PMID: 18990766 DOI: 10.1158/1055-9965.EPI-08-0459]
33. Le Marchand L, White KK, Nomura AM, Wilkens LR, Selhub JS, Tiirikainen M, Goodman MT, Murphy SP, Henderson BE, Kolonel LN. Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev 2009; 18: 2195-2201 [PMID: 19661077 DOI: 10.1158/1055-9965.EPI-09-0141]
34. Lee JE, Li H, Giovannucci E, Lee IM, Selhub J, Stampfer M, Ma J. Prospective study of plasma vitamin B6 and risk of colorectal cancer in men. Cancer Epidemiol Biomarkers Prev 2009; 18: 1197-1202 [PMID: 19336555 DOI: 10.1158/1055-9965. EPI-08-1001]
35. Bønaa KH, Njølstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, Wang H, Nordrehaug JE, Arnesen E, Rasmussen K. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 2006; 354: 1578-1588 [PMID: 16531614 DOI: 10.1056/NEJMoa055227]
36. Ebbing M, Bleie Ø, Ueland PM, Nordrehaug JE, Nilsen DW, Vollset SE, Refsum H, Pedersen EK, Nygård O. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. JAMA 2008; 300: 795-804 [PMID: 18714059 DOI: 10.1001/jama.300.7.795]
37. Ebbing M, Bønaa KH, Nygård O, Arnesen E, Ueland PM, Nordrehaug JE, Rasmussen K, Njølstad I, Refsum H, Nilsen DW, Tverdal A, Meyer K, Vollset SE. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 2009; 302: 2119-2126 [PMID: 19920236 DOI: 10.1001/ jama.2009.1622]
38. Martínez ME, Henning SM, Alberts DS. Folate and colorectal neoplasia: relation between plasma and dietary markers of folate and adenoma recurrence. Am J Clin Nutr 2004; 79: 691-697 [PMID: 15051616]
39. Brussaard JH, Löwik MR, van den Berg H, Brants HA, Bemelmans W. Dietary and other determinants of vitamin B6 parameters. Eur J Clin Nutr 1997; 51 Suppl 3: S39-S45 [PMID: 9598767]
40. Zhang SM, Moore SC, Lin J, Cook NR, Manson JE, Lee IM, Buring JE. Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women. Am J Epidemiol 2006; 163: 108-115 [PMID: 16339055 DOI: 10.1093/aje/kwj016]
41. Larsson SC, Giovannucci E, Wolk A. Vitamin B6 intake, alcohol consumption, and colorectal cancer: a longitudinal population-based cohort of women. Gastroenterology 2005; 128: 1830-1837 [PMID: 15940618]
42. Ishihara J, Otani T, Inoue M, Iwasaki M, Sasazuki S, Tsugane S. Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. J Nutr 2007; 137: 1808-1814 [PMID: 17585035]
43. Zhang X, Giovannucci E. Calcium, vitamin D and colorectal cancer chemoprevention. Best Pract Res Clin Gastroenterol 2011; 25: 485-494 [PMID: 22122765 DOI: 10.1016/j.bpg.2011.10.001]
44. Martínez ME. Primary prevention of colorectal cancer: lifestyle, nutrition, exercise. Recent Results Cancer Res 2005; 166: 177-211 [PMID: 15648191]
45. Chiang EP, Smith DE, Selhub J, Dallal G, Wang YC, Roubenoff R. Inflammation causes tissue-specific depletion of vitamin B6. Arthritis Res Ther 2005; 7: R1254-R1262 [PMID: 16277678 DOI: 10.1186/ar1821]
46. Folsom AR, Desvarieux M, Nieto FJ, Boland LL, Ballantyne CM, Chambless LE. B vitamin status and inflammatory markers. Atherosclerosis 2003; 169: 169-174 [PMID: 12860264]
47. Chan AT, Ogino S, Giovannucci EL, Fuchs CS. Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugs. Gastroenterology 2011; 140: 799-808 [PMID: 21115010]
48. Shu XO, Yang G, Jin F, Liu D, Kushi L, Wen W, Gao YT, Zheng W. Validity and reproducibility of the food frequency questionnaire used in the Shanghai Women's Health Study. Eur J Clin Nutr 2004; 58: 17-23 [PMID: 14679362 DOI: 10.1038/sj.ejcn.1601738]
49. Harnack L, Jacobs DR, Nicodemus K, Lazovich D, Anderson K, Folsom AR. Relationship of folate, vitamin B-6, vitamin B-12, and methionine intake to incidence of colorectal cancers. Nutr Cancer 2002; 43: 152-158 [PMID: 12588695]
50. Lumeng L, Li TK. Vitamin B6 metabolism in chronic alcohol abuse. Pyridoxal phosphate levels in plasma and the effects of acetaldehyde on pyridoxal phosphate synthesis and degradation in human erythrocytes. J Clin Invest 1974; 53: 693-704 [PMID: 4359937 DOI: 10.1172/JCI107607]
51. Giovannucci E. Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies. J Nutr 2004; 134: 2475S-2481S [PMID: 15333745]
52. Slattery ML, Schaffer D, Edwards SL, Ma KN, Potter JD. Are dietary factors involved in DNA methylation associated with colon cancer? Nutr Cancer 1997; 28: 52-62 [PMID: 9200151]
53. Lee JE, Willett WC, Fuchs CS, Smith-Warner SA, Wu K, Ma J, Giovannucci E. Folate intake and risk of colorectal cancer and adenoma: modification by time. Am J Clin Nutr 2011; 93: 817-825 [PMID: 21270374]
54. Barker DJ. The fetal and infant origins of adult disease. BMJ 1990; 301: 1111 [PMID: 2252919]
55. Trichopoulos D. Hypothesis: does breast cancer originate in utero? Lancet 1990; 335: 939-940 [PMID: 1970028]