Exposure of rats to extremely low-frequency electromagnetic fields (ELF-EMF) alters cytokines production

Electromagnetic Biology and Medicine

Volumn 32, Issue 1, 2013, Pages 1-8

  Salehi, Iraj ^a   Sani, Karim Ghazikhanlou ^a   Zamani, Alireza ^b,c  

^a HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cytokine; Electromagnetic fields; Interferon; Interleukin; T lymphocytes

Indexed keywords

BLOOD CULTURE; CONTROL GROUPS; CYTOKINES; DOWN-REGULATION; ELF-EMF; EXPOSED TO; EXTREMELY LOW FREQUENCIES; FLUX DENSITIES; IMMUNE RESPONSE; IN-CONTROL; IN-VITRO; INTERFERON-GAMMA; INTERLEUKIN; INTERLEUKIN-4; MALE RATS; SIGNIFICANT DIFFERENCES; T-LYMPHOCYTES; UP-REGULATION;

ANTIBIOTICS; BLOOD; ELECTROMAGNETIC FIELDS; GLYCOPROTEINS; IMMUNE SYSTEM; INTERFERONS; RATS;

T-CELLS;

CYTOKINE; PHYTOHEMAGGLUTININ; CULTURE MEDIUM;

ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; CULTURE MEDIUM; CYTOLOGY; ELECTROMAGNETIC FIELD; MALE; METABOLISM; RAT; SPLEEN; WISTAR RAT;

ANIMALS; CULTURE MEDIA, CONDITIONED; CYTOKINES; ELECTROMAGNETIC FIELDS; MALE; PHYTOHEMAGGLUTININS; RATS; RATS, WISTAR; SPLEEN;

EID: 84874373735     PISSN: 15368378     EISSN: 15368386     Source Type: Journal    
DOI: 10.3109/15368378.2012.692343     Document Type: Article

References (35)

1. Al-Akhras, M. A. (2008). Influence of 50 Hz magnetic field on sex hormones and body, uterine, and ovarian weights of adult female rats. Electromagn. Biol. Med. 27:55-163.
2. Aldinucci, C., Garcia, J. B., Palmi, M., et al. (2003). The effect of strong static magnetic field on lymphocytes. Bioelectromagnetics 24:109-117.
3. Bao, X. Q., Shi, Y. J., Zhang, Y. X. (2006). [Effects of extremely low magnetic field on acute and chronic arthritis of rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi 22:505-508 (English Abstract).
4. Blackman, C., Blank, M., Kundi, M., et al. (2007). A Rationale for a Biologically-based Public Exposure Standard for Electromagnetic Fields (ELF and RF). BioInitiative Report, 1-610
5. Boscolo, P., Bergamaschi, A., Di Sciascio, M. B., et al. (2001). Effects of low frequency electromagnetic fields on expression of lymphocyte subsets and production of cytokines of men and women employed in a museum. Sci. Total Environ. 270:13-20.
6. Cossarizza, A., Angioni, S., Petraglia, F., et al. (1993). Exposure to low frequency pulsed electromagnetic fields increases interleukin-1 and interleukin-6 production by human peripheral blood mononuclear cells. Exp. Cell Res. 204:385-387.
7. Hardell, L., Sage, C. (2008). Biological effects from electromagnetic field exposure and public exposure standards. Biomed. Pharmacother. 62:104-109.
8. Harrington, L. E., Hatton, R. D., Mangan, P. R., et al. (2005). Interleukin 17-producing CD4 + effector T cells develop via a lineage distinct from the Thelper type 1and 2 lineages. Nat. Immunol. 6:1123-1132.
9. Heikkila, K., Ebrahim, S., Lawlor, D. A. (2008). Systematic review of the association between circulating interleukin-6 (IL-6) and cancer. Eur. J. Cancer 44:937-945.
10. House, R. V., Ratajczak, H. V., Gauger, J. R., et al. (1996). Immune function and host defense in rodents exposed to 60-Hz magnetic fields. Fund. Appl. Toxicol. 34:228-239.
11. Ikeda, K., Shinmura, Y., Mizoe, H., et al. (2003). No effects of extremely low frequency magnetic fields found on cytotoxic activities and cytokine production of human peripheral blood mononuclear cells in vitro. Bioelectromagnetics 24:21-31.
12. Jonai, H., Villanueva, M. B., Yasuda, A. (1996). Cytokine profile of human peripheral blood mononuclear cells exposed to 50Hz EMF. Indiv. Health 34:359-368.
13. Kaszuba-Zwoinska, J., Ciecko-Michalska, I., Madroszkiewicz, D., et al. (2008). Magnetic field anti-inflammatory effects in Crohn's disease depends upon viability and cytokine profile of the immune competent cells. J. Physiol. Pharmacol. 59:177-187.
14. Lin, C. T., Lee, S. Y., Chen, C. Y., et al. (2008). Long-term continuous exposure to static magnetic field reduces popolysaccharide-induced cytotoxicity of fibroblasts. Int. J. Radiat. Biol. 84:219-226.
15. Lin, S. L., Chang, W. J., Lin, Y. S., et al. (2009). Static magnetic field attenuates mortality rate of mice by increasing the production of IL-1 receptor antagonist. Int. J. Radiat. Biol. 85:633-640.
16. Majewska, M., Zajac, K., Zemelka, M., et al. (2007). Influence of melatonin and its precursor L-tryptophan on Th1 dependent contact hypersensitivity. J. Physiol. Pharmacol. 58(Suppl 6):125-132.
17. Marino, A. A., Becker, R. O. (1978). High-voltage lines: hazard at a distance. Environment 20:6-15.
18. Marino, A. A., Wolcott, R. M., Chervenak, R., et al. (2000). Nonlinear response of the immune system to power-frequency magnetic fields. Amer. J. Physiol. Regul. Integr. Comp. Physiol. 279:R761-R768.
19. Mevissen, M., Haussler, M., Szamel, M., et al. (1998). Complex effects of long-term 50 Hz magnetic field exposure in vivo on immune functions in female Sprague-Dawley rats depend on duration of exposure. Bioelectromagnetics 19:259-270.
20. Morandi, M. A., Del Rio, J. A., Caren, R. P., et al. (1994). Effects of short term exposure to 60Hz electromagnetic fields on interleukin 1 and interleukin 6 production by peritoneal exudate cells. Life Sci. 54:731-738.
21. Mosmann, T. R., Cherwinski, H., Bond, M. W., et al. (1986). Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136: 2348-2357.
22. Mosmann, T. R., Coffman, R. L. (1989). TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 7:145-173.
23. Park, H., Li, Z., Yang, X. O., et al. (2005). A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6:1133-1141.
24. Roosli, M., Frei, P., Mohler, E., et al. (2010). Systematic review on the health effects of exposure to radiofrequency electromagnetic fields from mobile phone base stations. Bull. World Health Organ 88: 887-896F.
25. Saito, S., Nakashima, A., Shima, T., et al. (2010). Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Amer. J. Reprod. Immunol. 63:601-610.
26. Salerno, S., Lo Casto, A., Caccamo, N., et al. (1999). Static magnetic fields generated by a 0.5T MRI unit affects in vitro expression of activation markers and interleukin release in human peripheral blood mononuclear cells (PBMC). Int. J. Radiat. Biol. 75:457-463.
27. Shen, W. W., Zhao, J. H. (2010). Pulsed electromagnetic fields stimulation affects BMD and local factor production of rats with disuse osteoporosis. Bioelectromagnetics 31:113-119.
28. Simko, M., Mattsson, M. O. (2004). Extremely low frequency electromagnetic fields as effectors of cellular responses in vitro: possible immune cell activation. J. Cell. Biochem. 93:83-92.
29. Sommer, A. M., Lerchl, A. (2006). 50Hz magnetic fields of 1mT do not promote lymphoma development in AKR/J mice. Radiat. Res. 165:343-349.
30. Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., et al. (2008a). Therapeutic actions of melatonin in cancer: possible mechanisms. Integr. Cancer Ther. 7:189-203.
31. Srinivasan, V., Spence, D. W., Trakht, I., et al. (2008b). Immunomodulation by melatonin: its significance for seasonally occurring diseases. Neuroimmunomodulation 15:93-101.
32. Taniguchi, A., Kohsaka, H., Carson, D. A. (1994). Competitive RT-PCR ELISA: a rapid, sensitive and non-radioactive method to quantitate cytokine mRNA. J. Immunol. Meth. 169:101-109.
33. Xu, M., Mizoguchi, I., Morishima, N. (2010). Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27. Clin. Dev. Immunol. 2010:1-9.
34. Zamani, A., Vahidinia, A., Ghannad, M. S. (2009). The effect of garlic consumption on Th1/Th2 cytokines in phytohemagglutinin (PHA) activated rat spleen lymphocytes. Phytother. Res. 23:579-581.
35. Zhou, J., Li, C., Yao, G., et al. (2002). Gene expression of cytokine receptors in HL60 cells exposed to a 50Hz magnetic field. Bioelectromagnetics 23:339-346.