Foam Cell Specific LXRα Ligand

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Feldmann, Radmila ^a,b   Geikowski, Anne ^a,c   Weidner, Christopher ^a   Witzke, Annabell ^a   Kodelja, Vitam ^a   Schwarz, Thomas ^d   Gabriel, Mario ^d   Erker, Thomas ^d   Sauer, Sascha ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c BEUTH UNIVERSITY OF APPLIED SCIENCES   (Germany)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[4 (STYRYL)PHENOXY]METHYL]OXIRANE; 22 HYDROXYCHOLESTEROL; CHOLESTEROL ESTER; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; STX 4; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; FOAM CELL; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; TRANSCRIPTION REGULATION;

CELL LINE; FOAM CELLS; GENE KNOCKDOWN TECHNIQUES; HUMANS; LIGANDS; ORPHAN NUCLEAR RECEPTORS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84874357044     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057311     Document Type: Article

References (17)

1. Moore KJ, Tabas I, (2011) Macrophages in the pathogenesis of atherosclerosis. Cell 145: 341-355.
2. Tabas I, (2011) Pulling down the plug on atherosclerosis: finding the culprit in your heart. Nat Med 17: 791-793.
3. Cuchel M, Rader DJ, (2006) Macrophage reverse cholesterol transport: key to the regression of atherosclerosis? Circulation 113: 2548-2555.
4. Chinetti-Gbaguidi G, Staels B, (2009) Lipid ligand-activated transcription factors regulating lipid storage and release in human macrophages. Biochim Biophys Acta 1791: 486-493.
5. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, et al. (2002) Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A 99: 7604-7609.
6. Zanotti I, Poti F, Pedrelli M, Favari E, Moleri E, et al. (2008) The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential. J Lipid Res 49: 954-960.
7. Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, et al. (2000) Role of LXRs in control of lipogenesis. Genes Dev 14: 2831-2838.
8. Jakobsson T, Treuter E, Gustafsson JA, Steffensen KR, (2012) Liver X receptor biology and pharmacology: new pathways, challenges and opportunities. Trends Pharmacol Sci 33: 394-404.
9. Bischoff ED, Daige CL, Petrowski M, Dedman H, Pattison J, et al. (2010) Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice. J Lipid Res 51: 900-906.
10. Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, et al. (2001) Autoregulation of the human liver X receptor alpha promoter. Mol Cell Biol 21: 7558-7568.
11. Auwerx J, (1991) The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation. Experientia 47: 22-31.
12. Sauer S, Lange BM, Gobom J, Nyarsik L, Seitz H, et al. (2005) Miniaturization in functional genomics and proteomics. Nat Rev Genet 6: 465-476.
13. Saeed AI, Sharov V, White J, Li J, Liang W, et al. (2003) TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34: 374-378.
14. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102: 15545-15550.
15. Battke F, Symons S, Nieselt K, (2010) Mayday-integrative analytics for expression data. BMC Bioinformatics 11: 121.
16. Weidner C, de Groot JC, Prasad A, Freiwald A, Quedenau C, et al. (2012) Amorfrutins are potent antidiabetic dietary natural products. Proc Natl Acad Sci U S A 109: 7257-7262.
17. Fievet C, Staels B, (2009) Liver X receptor modulators: effects on lipid metabolism and potential use in the treatment of atherosclerosis. Biochem. Pharm. 77: 1316-1327.