-
1
-
-
84874291602
-
-
Alzheimer's Disease International: World Alzheimer Report 2010: The Global Economic Impact of Dementia. London, United Kingdom: Alzheimer's Disease International (ADI)
-
Wimo A, Prince M. Alzheimer's Disease International: World Alzheimer Report 2010: The Global Economic Impact of Dementia. London, United Kingdom: Alzheimer's Disease International (ADI); 2010.
-
(2010)
-
-
Wimo, A.1
Prince, M.2
-
2
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy JA, Selkoe D. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002; 19; 297(5580):353-356.
-
(2002)
Science
, vol.19
, Issue.5580
, pp. 353-356
-
-
Hardy, J.A.1
Selkoe, D.2
-
3
-
-
50149118691
-
Developing new treatments for alzheimer's disease: The who, what, when, and how of biomarker-guided therapies
-
Lyketsos CG, Szekely CA, Mielke MM, et al. Developing new treatments for alzheimer's disease: The who, what, when, and how of biomarker-guided therapies. Int Psychogeriatr. 2008; 20(5):871-889.
-
(2008)
Int Psychogeriatr
, vol.20
, Issue.5
, pp. 871-889
-
-
Lyketsos, C.G.1
Szekely, C.A.2
Mielke, M.M.3
-
4
-
-
68449087508
-
An update on treatment and prevention strategies for alzheimer's disease
-
Neugroschl J, Sano M. An update on treatment and prevention strategies for alzheimer's disease. Curr Neurol Neurosci Rep. 2009;9(5):368-376.
-
(2009)
Curr Neurol Neurosci Rep
, vol.9
, Issue.5
, pp. 368-376
-
-
Neugroschl, J.1
Sano, M.2
-
5
-
-
78751692575
-
Anti-abeta therapeutics in alzheimer's disease: The need for a paradigm shift
-
Golde TE, Schneider LS, Koo EH. Anti-abeta therapeutics in alzheimer's disease: the need for a paradigm shift. Neuron. 2011;69(2):203-213.
-
(2011)
Neuron
, vol.69
, Issue.2
, pp. 203-213
-
-
Golde, T.E.1
Schneider, L.S.2
Koo, E.H.3
-
6
-
-
78650210590
-
Immunotherapy for alzheimer's disease
-
Morgan D. Immunotherapy for alzheimer's disease. J Intern Med. 2011;269(1):54-63.
-
(2011)
J Intern Med
, vol.269
, Issue.1
, pp. 54-63
-
-
Morgan, D.1
-
7
-
-
33845388059
-
A phase II study targeting amyloid-beta with 3APS in mild-to-moderate alzheimer disease
-
Aisen PS, Saumier D, Briand R, et al. A phase II study targeting amyloid-beta with 3APS in mild-to-moderate alzheimer disease. Neurology. 2006; 67(10):1757-1763.
-
(2006)
Neurology
, vol.67
, Issue.10
, pp. 1757-1763
-
-
Aisen, P.S.1
Saumier, D.2
Briand, R.3
-
8
-
-
73349091534
-
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate alzheimer disease
-
Salloway S, Sperling R, Gilman S, et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate alzheimer disease. Neurology. 2009; 73(24):2061-2070.
-
(2009)
Neurology
, vol.73
, Issue.24
, pp. 2061-2070
-
-
Salloway, S.1
Sperling, R.2
Gilman, S.3
-
9
-
-
47149108940
-
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate alzheimer's disease: A randomised, double-blind, placebo-controlled study
-
Dimebon investigators
-
Doody RS, Gavrilova SI, Sano M, Dimebon investigators, et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate alzheimer's disease: a randomised, double-blind, placebo-controlled study. Lancet. 2008;372(9634):207-215.
-
(2008)
Lancet
, vol.372
, Issue.9634
, pp. 207-215
-
-
Doody, R.S.1
Gavrilova, S.I.2
Sano, M.3
-
10
-
-
72549105935
-
Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild alzheimer disease: A randomized controlled trial
-
Tarenflurbil Phase 3 Study Group
-
Green RC, Schneider LS, Amato DA, Tarenflurbil Phase 3 Study Group, et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild alzheimer disease: a randomized controlled trial. JAMA. 2009;302(23):2557-2564.
-
(2009)
JAMA
, vol.302
, Issue.23
, pp. 2557-2564
-
-
Green, R.C.1
Schneider, L.S.2
Amato, D.A.3
-
11
-
-
47149112621
-
Long-term effects of Abeta42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial
-
Holmes C, Boche D, Wilkinson D, et al. Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet. 2008; 372 (9634):216-223.
-
(2008)
Lancet
, vol.372
, Issue.9634
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
-
12
-
-
78049501333
-
A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
-
Laxton AW, Tang-Wai DF, McAndrews MP, et al. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Ann Neurol. 2010;68:521-534.
-
(2010)
Ann Neurol
, vol.68
, pp. 521-534
-
-
Laxton, A.W.1
Tang-Wai, D.F.2
McAndrews, M.P.3
-
13
-
-
77952496309
-
Functional alterations in memory networks in early Alzheimer's disease
-
Sperling RA, Dickerson BC, Pihlajamaki M, et al. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med. 2010;12(1):27-43.
-
(2010)
Neuromolecular Med
, vol.12
, Issue.1
, pp. 27-43
-
-
Sperling, R.A.1
Dickerson, B.C.2
Pihlajamaki, M.3
-
14
-
-
36549068174
-
Disruption of large-scale brain systems in advanced aging
-
Andrews-Hanna JR, Snyder AZ, Vincent JL, et al. Disruption of large-scale brain systems in advanced aging. Neuron. 2007;56(5):924-935.
-
(2007)
Neuron
, vol.56
, Issue.5
, pp. 924-935
-
-
Andrews-Hanna, J.R.1
Snyder, A.Z.2
Vincent, J.L.3
-
15
-
-
67650875899
-
Amyloid deposition is associated with impaired default network function in older persons without dementia
-
Sperling RA, Laviolette PS, O'Keefe K, et al. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron. 2009;63(2):178-188.
-
(2009)
Neuron
, vol.63
, Issue.2
, pp. 178-188
-
-
Sperling, R.A.1
Laviolette, P.S.2
O'Keefe, K.3
-
17
-
-
41149168614
-
Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation
-
Miller SL, Celone K, DePeau K, et al. Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation. Proc Natl Acad Sci U S A. 2008;105(6):2181-2186.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.6
, pp. 2181-2186
-
-
Miller, S.L.1
Celone, K.2
Depeau, K.3
-
18
-
-
60849136325
-
Cortical hubs revealed by intrinsic functional connectivity: Mapping, assessment of stability, and relation to alzheimer's disease
-
Buckner RL, Sepulcre J, Talukdar T, et al. Cortical hubs revealed by intrinsic functional connectivity: Mapping, assessment of stability, and relation to alzheimer's disease. J Neurosci. 2009;29(6):1860-1873.
-
(2009)
J Neurosci
, vol.29
, Issue.6
, pp. 1860-1873
-
-
Buckner, R.L.1
Sepulcre, J.2
Talukdar, T.3
-
19
-
-
64149093013
-
Neurodegenerative diseases target large-scale human brain networks
-
Seeley WW, Crawford RK, Zhou J, et al. Neurodegenerative diseases target large-scale human brain networks. Neuron. 2009;62(1):42-52.
-
(2009)
Neuron
, vol.62
, Issue.1
, pp. 42-52
-
-
Seeley, W.W.1
Crawford, R.K.2
Zhou, J.3
-
20
-
-
0026446225
-
Topography of cross-sectional and longitudinal glucose metabolic deficits in alzheimer's disease. pathophysiologic implications
-
Smith GS, de Leon MJ, George AE, et al. Topography of cross-sectional and longitudinal glucose metabolic deficits in alzheimer's disease. pathophysiologic implications. Arch Neurol. 1992;49(11):1142-1150.
-
(1992)
Arch Neurol
, vol.49
, Issue.11
, pp. 1142-1150
-
-
Smith, G.S.1
de Leon, M.J.2
George, A.E.3
-
21
-
-
0030874251
-
Metabolic reduction in the posterior cingulate cortex in very early alzheimer's disease
-
Jul
-
Minoshima S, Giordani B, Berent S, et al. Metabolic reduction in the posterior cingulate cortex in very early alzheimer's disease. Ann Neurol. 1997 Jul;42(1):85-94.
-
(1997)
Ann Neurol
, vol.42
, Issue.1
, pp. 85-94
-
-
Minoshima, S.1
Giordani, B.2
Berent, S.3
-
22
-
-
0029970342
-
Preclinical evidence of alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein
-
Reiman EM, Caselli RJ, Yun LS, et al. Preclinical evidence of alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med. 1996;334(12):752-758.
-
(1996)
E. N Engl J Med
, vol.334
, Issue.12
, pp. 752-758
-
-
Reiman, E.M.1
Caselli, R.J.2
Yun, L.S.3
-
23
-
-
70350266228
-
Amyloid imaging in aging and dementia: Testing the amyloid hypothesis in vivo
-
Rabinovici GD, Jagust WJ. Amyloid imaging in aging and dementia: Testing the amyloid hypothesis in vivo. Behaviour Neurol. 2009;21(1):117-128.
-
(2009)
Behaviour Neurol
, vol.21
, Issue.1
, pp. 117-128
-
-
Rabinovici, G.D.1
Jagust, W.J.2
-
24
-
-
23944444806
-
Molecular, structural, and functional characterization of alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory
-
Buckner RL, Snyder AZ, Shannon BJ, et al. Molecular, structural, and functional characterization of alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci. 2005;25(34):7709-7717.
-
(2005)
J Neurosci
, vol.25
, Issue.34
, pp. 7709-7717
-
-
Buckner, R.L.1
Snyder, A.Z.2
Shannon, B.J.3
-
25
-
-
66549127860
-
Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
-
Mormino EC, Kluth JT, Madison CM, et al. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain. 2009;132(Pt 5):1310-1323.
-
(2009)
Brain
, vol.132
, Issue.PART 5
, pp. 1310-1323
-
-
Mormino, E.C.1
Kluth, J.T.2
Madison, C.M.3
-
26
-
-
10744232413
-
Imaging brain amyloid in alzheimer's disease with pittsburgh compound-B
-
Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in alzheimer's disease with pittsburgh compound-B. Ann Neurol. 2004;55(3):306-319.
-
(2004)
Ann Neurol
, vol.55
, Issue.3
, pp. 306-319
-
-
Klunk, W.E.1
Engler, H.2
Nordberg, A.3
-
27
-
-
54249117138
-
Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in alzheimer's disease, mild cognitive impairment and healthy aging
-
Fripp J, Bourgeat P, Acosta O, et al. Appearance modeling of 11C PiB PET images: characterizing amyloid deposition in alzheimer's disease, mild cognitive impairment and healthy aging. Neuroimage. 2008; 43(3):430-439.
-
(2008)
Neuroimage
, vol.43
, Issue.3
, pp. 430-439
-
-
Fripp, J.1
Bourgeat, P.2
Acosta, O.3
-
28
-
-
70349446475
-
Imaging and biomarkers in early alzheimer's disease and mild cognitive impairment
-
Petersen RC, Jack CR, Jr. Imaging and biomarkers in early alzheimer's disease and mild cognitive impairment. Clin Pharmacol Ther. 2009;86(4):438-441.
-
(2009)
Clin Pharmacol Ther
, vol.86
, Issue.4
, pp. 438-441
-
-
Petersen, R.C.1
Jack Jr., C.R.2
-
29
-
-
69149094447
-
Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort
-
Alzheimer's Disease Neuroimaging Initiative (ADNI)
-
Risacher SL, Saykin AJ, West JD, Alzheimer's Disease Neuroimaging Initiative (ADNI), et al. Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort. Curr Alzheimer Res. 2009;6(4):347-361.
-
(2009)
Curr Alzheimer Res
, vol.6
, Issue.4
, pp. 347-361
-
-
Risacher, S.L.1
Saykin, A.J.2
West, J.D.3
-
30
-
-
0001659874
-
A quantitative study of the fornixmamillo-thalamic system
-
Powell, TP, Guillery, RW, Cowan WM. A quantitative study of the fornixmamillo-thalamic system. J Anat. 1957;91(4):419-437.
-
(1957)
J Anat
, vol.91
, Issue.4
, pp. 419-437
-
-
Powell, T.P.1
Guillery, R.W.2
Cowan, W.M.3
-
31
-
-
46049111205
-
A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory
-
Tsivilis D, Vann SD, Denby C, et al. A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory. Nat Neurosci. 2008;11(7):834-842.
-
(2008)
Nat Neurosci
, vol.11
, Issue.7
, pp. 834-842
-
-
Tsivilis, D.1
Vann, S.D.2
Denby, C.3
-
32
-
-
41549086538
-
Addition of fornix transection to frontal-temporal disconnection increases the impairment in object-in-place memory in macaque monkeys
-
Wilson CR, Baxter MG, Easton A, Gaffan D. Addition of fornix transection to frontal-temporal disconnection increases the impairment in object-in-place memory in macaque monkeys. Eur J Neurosci. 2008;27(7):1814-1822.
-
(2008)
Eur J Neurosci
, vol.27
, Issue.7
, pp. 1814-1822
-
-
Wilson, C.R.1
Baxter, M.G.2
Easton, A.3
Gaffan, D.4
-
33
-
-
74249111157
-
Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection
-
Browning PG, Gaffan D, Croxson PL, Baxter MG. Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection. Cereb Cortex. 2010;20(2):282-293.
-
(2010)
Cereb Cortex
, vol.20
, Issue.2
, pp. 282-293
-
-
Browning, P.G.1
Gaffan, D.2
Croxson, P.L.3
Baxter, M.G.4
-
34
-
-
84874343479
-
Fornix integrity and hippocampal volume predict memory decline and progression to AD
-
In Press
-
Mielke M, Okonkwo O, Oishi K, et al. Fornix integrity and hippocampal volume predict memory decline and progression to AD. Alz Demen. In Press.
-
Alz Demen
-
-
Mielke, M.1
Okonkwo, O.2
Oishi, K.3
-
35
-
-
62749122900
-
Regionally-specific diffusion tensor imaging in mild cognitive impairment and alzheimer's disease
-
Mielke MM, Kozauer NA, Chan KC, et al. Regionally-specific diffusion tensor imaging in mild cognitive impairment and alzheimer's disease. Neuroimage. 2009;46(1):47-55.
-
(2009)
Neuroimage
, vol.46
, Issue.1
, pp. 47-55
-
-
Mielke, M.M.1
Kozauer, N.A.2
Chan, K.C.3
-
36
-
-
79951526730
-
Deep brain stimulation for Parkinson disease: An expert consensus and review of key issues
-
Bronstein JM, Tagliati M, Alterman RL, et al. Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch Neurol. 2011;68:165.
-
(2011)
Arch Neurol
, vol.68
, pp. 165
-
-
Bronstein, J.M.1
Tagliati, M.2
Alterman, R.L.3
-
38
-
-
84859736894
-
Deep brain stimulation therapy
-
Lozano AM. Deep brain stimulation therapy. Br Med J. 2012;344:e1100
-
(2012)
Br Med J
, vol.344
-
-
Lozano, A.M.1
-
39
-
-
3843077481
-
Bilateral globus pallidus stimulation for huntington's disease
-
Moro E, Lang AE, Strafella AP, et al. Bilateral globus pallidus stimulation for huntington's disease. Ann Neurol. 2004;56(2):290-294.
-
(2004)
Ann Neurol
, vol.56
, Issue.2
, pp. 290-294
-
-
Moro, E.1
Lang, A.E.2
Strafella, A.P.3
-
40
-
-
14644402983
-
Deep brain stimulation for treatment-resistant depression
-
Mayberg HS, Lozano AM, Voon V, et al. Deep brain stimulation for treatment-resistant depression. Neuron. 2005;45(5):651-660.
-
(2005)
Neuron
, vol.45
, Issue.5
, pp. 651-660
-
-
Mayberg, H.S.1
Lozano, A.M.2
Voon, V.3
-
41
-
-
84874301437
-
-
Medtronic. Parkinson's disease, Accessed Dec 1
-
Medtronic. Parkinson's disease. http://www.medtronic.com/patients/parkinsons-disease/index.htm. Accessed Dec 1, 2012.
-
(2012)
-
-
-
42
-
-
0036626673
-
Long-term hardware-related complications of deep brain stimulation
-
Oh MY, Seong KH, Abosch A, et al. Long-term hardware-related complications of deep brain stimulation. Neurosurgery. 2002; 50:1268-1276.
-
(2002)
Neurosurgery
, vol.50
, pp. 1268-1276
-
-
Oh, M.Y.1
Seong, K.H.2
Abosch, A.3
-
43
-
-
38149116056
-
The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation
-
Toda H, Hamani C, Fawcett AP, et al. The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation. J Neurosurg. 2008;108(1):132-138.
-
(2008)
J Neurosurg
, vol.108
, Issue.1
, pp. 132-138
-
-
Toda, H.1
Hamani, C.2
Fawcett, A.P.3
-
44
-
-
80053982534
-
Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone
-
Hamani C, Stone SS, Garten A, et al. Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone. Exp Neurol. 2011; 232(1):100-104.
-
(2011)
Exp Neurol
, vol.232
, Issue.1
, pp. 100-104
-
-
Hamani, C.1
Stone, S.S.2
Garten, A.3
-
45
-
-
80052991513
-
Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory
-
Stone SS, Teixeira CM, Devito LM, et al. Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. J Neurosci. 2011;31(38):13469-13484.
-
(2011)
J Neurosci
, vol.31
, Issue.38
, pp. 13469-13484
-
-
Stone, S.S.1
Teixeira, C.M.2
Devito, L.M.3
-
46
-
-
78049501333
-
A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
-
Laxton AW, Tang-Wai DF, McAndrews MP, et al. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Ann Neurol. 2010;68(4):521-534.
-
(2010)
Ann Neurol
, vol.68
, Issue.4
, pp. 521-534
-
-
Laxton, A.W.1
Tang-Wai, D.F.2
McAndrews, M.P.3
-
47
-
-
0036235195
-
Longitudinal PET evaluation of cerebral metabolic decline in dementia: A potential outcome measure in Alzheimer's disease treatment studies
-
Alexander GE, Chen K, Pietrini P, et al. Longitudinal PET evaluation of cerebral metabolic decline in dementia: a potential outcome measure in Alzheimer's disease treatment studies. Am J Psychiatry. 2002;159(5):738-745.
-
(2002)
Am J Psychiatry
, vol.159
, Issue.5
, pp. 738-745
-
-
Alexander, G.E.1
Chen, K.2
Pietrini, P.3
-
48
-
-
1842427969
-
Default-mode network activity distinguishes alzheimer's disease from healthy aging: Evidence from functional MRI
-
Greicius MD, Srivastava G, Reiss AL, Menon V. Default-mode network activity distinguishes alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A. 2004;101(13):4637-4642.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.13
, pp. 4637-4642
-
-
Greicius, M.D.1
Srivastava, G.2
Reiss, A.L.3
Menon, V.4
-
49
-
-
41949121294
-
The brain's default network: Anatomy, function, and relevance to disease
-
Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: Anatomy, function, and relevance to disease. Ann N Y Acad Sci. 2008;1124:1-38.
-
(2008)
Ann N Y Acad Sci
, vol.1124
, pp. 1-38
-
-
Buckner, R.L.1
Andrews-Hanna, J.R.2
Schacter, D.L.3
-
50
-
-
73249121028
-
Disease progression meta-analysis model in alzheimer's disease
-
Alzheimer's Disease Working Group
-
Ito K, Ahadieh S, Corrigan B, Alzheimer's Disease Working Group, et al. Disease progression meta-analysis model in alzheimer's disease. Alzheimers Dement. 2010;6(1):39-53.
-
(2010)
Alzheimers Dement
, vol.6
, Issue.1
, pp. 39-53
-
-
Ito, K.1
Ahadieh, S.2
Corrigan, B.3
-
51
-
-
0028262405
-
A longitudinal study of alzheimer's disease: Measurement, rate, and predictors of cognitive deterioration
-
Stern RG, Mohs RC, Davidson M, et al. A longitudinal study of alzheimer's disease: measurement, rate, and predictors of cognitive deterioration. Am J Psychiatry. 1994;151(3):390-396.
-
(1994)
Am J Psychiatry
, vol.151
, Issue.3
, pp. 390-396
-
-
Stern, R.G.1
Mohs, R.C.2
Davidson, M.3
|