Control of AMP-activated protein kinase, Akt, and mTOR in EGCG-treated HT-29 colon cancer cells

Food Science and Biotechnology

Volumn 22, Issue 1, 2013, Pages 147-151

  Park, Song Yi ^b   Lee, Yun Kyoung ^c   Kim, Young Min ^b   Park, Ock Jin ^b   Shin, Jang In ^a  

^a Dankook University   (South Korea)

^b Hannam University   (South Korea)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Akt; AMP activated protein kinase; colon cancer; epigallocatechin 3 gallate; mTOR

Indexed keywords

CELLS; DISEASES; ENZYMES; MAMMALS;

AMP-ACTIVATED PROTEIN KINASE; CHEMOPREVENTIVE; COLON CANCER; COLON CANCER CELLS; EPIGALLOCATECHIN-3-GALLATE; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); MTOR; REGULATORY MECHANISM;

ANTIBIOTICS;

EID: 84874290569     PISSN: 12267708     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10068-013-0020-1     Document Type: Article

References (22)

1. Carnero A. The PKB/AKT pathway in cancer. Curr. Pharm. Design 16: 34-44 (2010).
2. Zhang YJ, Dai Q, Sun DF, Xiong H, Tian XQ, Gao FH, Xu MH, Chen GQ, Han ZG, Fang JY. mTOR Signaling pathway is a target for the treatment of colorectal cancer. Ann. Surg. Oncol. 16: 2617-2628 (2009).
3. Liu P, Cheng H, Roberts TM, Zhao JJ. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat. Rev. Drug Discov. 8: 627-644 (2009).
4. LoPiccolo J, Blumenthal GM, Bernstein WB, Dennis PA. Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations. Drug Resist. Updat. 11: 32-50 (2008).
5. Bunkholt Elstrand M, Dong HP, Odegaard E, Holth A, Elloul S, Reich R, Trope CG, Davidson B. Mammalian target of rapamycin is a biomarker of poor survival in metastatic serous ovarian carcinoma. Hum. Patho. 41: 794-804 (2010).
6. Yang SX, Costantino JP, Kim C, Mamounas EP, Nguyen D, Jeong JH, Wolmark N, Kidwell K, Paik S, Swain SM. Akt phosphorylation at ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer. J. Clin. Oncol. 28: 2974-2981 (2010).
7. Bhaskar PT, Hay N. The two TORCs and Akt. Dev. Cell. 12: 487-502 (2007).
8. Memmott RM, Dennis PA. Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell. Signal. 21: 656-664 (2009).
9. Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr. Opin. Cell Biol. 17: 596-603 (2005).
10. Motoshima H, Goldstein BJ, Igata M, Araki E. AMPK and cell proliferation - AMPK as a therapeutic target for atherosclerosis and cancer. J. Physiol. 574: 63-71 (2006).
11. Wang W, Guan KL. AMP-activated protein kinase and cancer. Acta Physiol. 196: 55-63 (2009).
12. Lee YK, Lee WS, Hwang JT, Kwon DY, Surh YJ, Park OJ. Curcumin exerts antidifferentiation effect through AMPKα-PPARγ in 3T3-L1 adipocytes and antiproliferatory effect through AMPKα-COX-2 in cancer cells. J. Agr. Food Chem. 57: 305-310 (2009).
13. Shaw RJ. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol. 196: 65-80 (2009).
14. Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell. 30: 214-226 (2008).
15. Kuhajda FP. AMP-activated protein kinase and human cancer: Cancer metabolism revisited. Int. J. Obesity 4: 36-41 (2008).
16. Luo Z, Zang M, Guo W. AMPK as a metabolic tumor suppressor: Control of metabolism and cell growth. Future Oncol. 6: 457-470 (2010).
17. Sen T, Moulik S, Dutta A, Choudhury PR, Banerji A, Das S, Roy M, Chatterjee A. Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7. Life Sci. 84: 194-204 (2009).
18. Shankar S, Ganapathy S, Srivastava RK. Green tea polyphenols: Biology and therapeutic implications in cancer. Front Biosci. 12: 4881-4899 (2007).
19. Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4: 648-657 (2002).
20. Lee YK, Park SY, Kim YM, Kim DC, Lee WS, Surh YJ, Park OJ. Suppression of mTOR via Akt dependent and independent mechanisms in selenium treated colon cancer cells: Involvement of AMPK {α} 1. Carcinogenesis 31: 1092-1099 (2010).
21. Goto M, Iwase A, Harata T, Takigawa S, Suzuki K, Manabe S, Kikkawa F. IGF1-induced AKT phosphorylation and cell proliferation are suppressed with the increase in PTEN during luteinization in human granulosa cells. Reproduction 137: 835-842 (2009).
22. Desbois-Mouthon C, Cadoret A, Blivet-van Eggelpoël MJ, Bertrand F, Cherqui G, Perret C, Capeau J. Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation. Oncogene 20: 252-259 (2001).