Practical synthesis of (20S)-10-(3-aminopropyloxy)-7-ethylcamptothecin, a water-soluble analogue of camptothecin

Chemistry - An Asian Journal

Volumn 8, Issue 3, 2013, Pages 630-638

  Watanabe, Tatsuya ^a   Tsuboi, Yasunori ^a   Nomura, Sumihiro ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

camptothecin; chiral auxiliaries; diastereoselectivity; natural products; total synthesis

Indexed keywords

CAMPTOTHECIN (CPT); CHIRAL AUXILIARIES; DIASTEREO-SELECTIVITY; NATURAL PRODUCTS; TOTAL SYNTHESIS;

ACETONE; AROMATIC COMPOUNDS; CARBOXYLIC ACIDS; CHROMATOGRAPHIC ANALYSIS; CONDENSATION REACTIONS; ESTERIFICATION; ESTERS; STEREOSELECTIVITY;

BODY FLUIDS;

(20S) 10 (3 AMINOPROPYLOXY) 7 ETHYLCAMPTOTHECIN; (20S)-10-(3-AMINOPROPYLOXY)-7-ETHYLCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DRUG DERIVATIVE; WATER;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLUBILITY; STEREOISOMERISM; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; SOLUBILITY; STEREOISOMERISM; WATER;

MLCS; MLOWN;

EID: 84874283189     PISSN: 18614728     EISSN: 1861471X     Source Type: Journal    
DOI: 10.1002/asia.201200904     Document Type: Article

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