Enantioselective synthesis of a key intermediate of 20(S)-camptothecin via an enzyme-catalyzed resolution

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 12, 1998, Pages 1878-1880

  Imura, Akihiro ^a   Itoh, Motohiro ^a   Miyadera, Akihiko ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

20(S) camptothecin; Antitumor activity; Commercially available protease; Enzyme catalyzed resolution

Indexed keywords

CAMPTOTHECIN; PLANT EXTRACT; PROTEINASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG ISOLATION; DRUG SYNTHESIS; ENANTIOMER; ENZYME MECHANISM; HYDROLYSIS; NONHUMAN; REACTION ANALYSIS;

EID: 0032431685     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.1878     Document Type: Article

References (2)

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2. Wani M. C., Nicholas A. W., Wall M. E., J. Med. Chem., 30, 2317 -2319 (1987).