A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance

Protein Engineering, Design and Selection

Volumn 26, Issue 3, 2013, Pages 187-193

  Yazaki, Paul J ^a   Lee, Brian ^a   Channappa, Divya ^a   Cheung, Chia Wei ^a   Crow, Desiree ^a   Chea, Junie ^a   Poku, Erasmus ^a   Li, Lin ^a   Andersen, Jan Terje ^b   Sandlie, Inger ^b   Orcutt, Kelly Davis ^c   Wittrup, K Dane ^c,d   Shively, John E ^a   Raubitschek, Andrew ^a   Colcher, David ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Anti carcinoembryonic antigen; bispecific antibody, pre targeted radioimmunotherapy

Indexed keywords

ANTI-TUMORS; BIODISTRIBUTIONS; BONE MARROW; CARCINOEMBRYONIC ANTIGEN; IN-VIVO; MONONUCLEAR PHAGOCYTE SYSTEMS; PHARMACOKINETIC PROPERTIES; RADIOIMMUNOTHERAPY; RADIOIODINE; RADIOLABEL; SCFV ANTIBODY FRAGMENTS; SERUM STABILITY; SUBSTANTIAL REDUCTION; THERAPEUTIC POTENTIALS; TUMOR MODELS; TUMOR TARGETING; TUMOR UPTAKE;

ANTIGENS; MONOCLONAL ANTIBODIES; RADIOTHERAPY; TUMORS;

BLOOD;

BISPECIFIC ANTIBODY; CEA ANTIBODY; DOTA ANTIBODY; FC RECEPTOR; INDIUM 111; IODINE 125; LUTETIUM 177; MONOCLONAL ANTIBODY; RADIOACTIVE IODINE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG RELEASE; DRUG TARGETING; DRUG TUMOR LEVEL; FEMALE; IN VIVO STUDY; ISOTOPE LABELING; LIVER FUNCTION; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN STABILITY; RADIOIMMUNOTHERAPY; RADIOIODINATION; SPLEEN FUNCTION; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; CARCINOEMBRYONIC ANTIGEN; FEMALE; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; IODINE RADIOISOTOPES; MICE; MICE, NUDE; NEOPLASMS; PROTEIN ENGINEERING; PROTEIN STABILITY; RADIOIMMUNOTHERAPY; SINGLE-CHAIN ANTIBODIES; TISSUE DISTRIBUTION;

EID: 84874276034     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs096     Document Type: Article

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