Inhaled corticosteroids reduce asthma-associated airway hyperperfusion through genomic and nongenomic mechanisms

Pulmonary Pharmacology and Therapeutics

Volumn 20, Issue 2, 2007, Pages 157-162

  Horvath, Gabor ^a   Vasas, Szilvia ^b   Wanner, Adam ^c  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b MAV Hospital   (Hungary)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Airway blood flow; Asthma; Bronchial circulation; Inhaled corticosteroids; Nongenomic action; Vasoconstriction

Indexed keywords

BECLOMETASONE DIPROPIONATE; CORTICOSTEROID; FLUTICASONE; MONTELUKAST;

AIRWAY; ARTICLE; ASTHMA; BLOOD FLOW; BRONCHOSPASM; DISEASE ASSOCIATION; DRUG MECHANISM; GENE ACTIVATION; GENOMICS; HUMAN; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; TRACHEOBRONCHIAL TREE;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ANIMALS; ASTHMA; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; PULMONARY CIRCULATION;

EID: 33751200363     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2006.03.009     Document Type: Article

References (56)

1. Charan N.B., Baile E.M., and Pare P.D. Bronchial vascular congestion and angiogenesis. Eur Respir J 10 5 (1997) 1173-1180
2. Horvath G., and Wanner A. Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma. Eur Respir J 27 1 (2006) 172-187
3. McFadden Jr. E.R. A century of asthma. Am J Respir Crit Care Med 170 3 (2004) 215-221
4. Adcock I.M., Ito K., and Barnes P.J. Glucocorticoid: effects on gene transcription. Proc Am Thorac Soc 1 3 (2004) 247-254
5. Hayashi R., Wada H., Ito K., and Adcock I.M. Effects of glucocorticoids on gene transcription. Eur J Pharmacol 500 1-3 (2004) 51-62
6. Karin M. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?. Cell 93 4 (1998) 487-490
7. Barnes P.J., and Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336 15 (1997) 1066-1071
8. Nguyen C., Teo J.L., Matsuda A., Eguchi M., Chi E.Y., Henderson Jr. W.R., et al. Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma. Proc Natl Acad Sci USA 100 3 (2003) 1169-1173
9. Wilusz C.J., and Wilusz J. Bringing the role of mRNA decay in the control of gene expression into focus. Trends Genet 20 10 (2004) 491-497
10. Stellato C. Post-transcriptional and nongenomic effects of glucocorticoids. Proc Am Thorac Soc 1 3 (2004) 255-263
11. Losel R., and Wehling M. Nongenomic actions of steroid hormones. Nat Rev Mol Cell Biol 4 1 (2003) 46-56
12. Norman A.W., Mizwicki M.T., and Norman D.P. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov 3 1 (2004) 27-41
13. Johnson L.R., Farb C., Morrison J.H., McEwen B.S., and Ledoux J.E. Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala. Neuroscience 136 1 (2005) 289-299
14. Horvath G., Sutto Z., Torbati A., Conner G.E., Salathe M., and Wanner A. Norepinephrine transport by the extraneuronal monoamine transporter in human bronchial arterial smooth muscle cells. Am J Physiol-Lung Cell & Mol Physiol 285 4 (2003) L829-L837
15. Tumlin J.A., Lea J.P., Swanson C.E., Smith C.L., Edge S.S., and Someren J.S. Aldosterone and dexamethasone stimulate calcineurin activity through a transcription-independent mechanism involving steroid receptor-associated heat shock proteins. J Clin Invest 99 6 (1997) 1217-1223
16. Croxtall J.D., Choudhury Q., and Flower R.J. Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol 130 2 (2000) 289-298
17. Whiting K.P., Restall C.J., and Brain P.F. Steroid hormone-induced effects on membrane fluidity and their potential roles in non-genomic mechanisms. Life Sci 67 7 (2000) 743-757
18. Long W.M., Yerger L.D., Martinez H., Codias E., Sprung C.L., Abraham W.M., et al. Modification of bronchial blood flow during allergic airway responses. J Appl Physiol 65 1 (1988) 272-282
19. Wanner A. Circulation of the airway mucosa. J Appl Physiol 67 3 (1989) 917-925
20. Kumar S.D., Emery M.J., Atkins N.D., Danta I., and Wanner A. Airway mucosal blood flow in bronchial asthma. Am J Respir Crit Care Med 158 1 (1998) 153-156
21. Kumar S.D., Brieva J.L., Danta I., and Wanner A. Transient effect of inhaled fluticasone on airway mucosal blood flow in subjects with and without asthma. Am J Respir Crit Care Med 161 3 Pt 1 (2000) 918-921
22. Brieva J.L., Danta I., and Wanner A. Effect of an inhaled glucocorticosteroid on airway mucosal blood flow in mild asthma. Am J Respir Crit Care Med 161 1 (2000) 293-296
23. Brieva J., and Wanner A. Adrenergic airway vascular smooth muscle responsiveness in healthy and asthmatic subjects. J Appl Physiol 90 2 (2001) 665-669
24. Onorato D.J., Demirozu M.C., Breitenbucher A., Atkins N.D., Chediak A.D., and Wanner A. Airway mucosal blood flow in humans. Response to adrenergic agonists. Am J Respir Crit Care Med 149 5 (1994) 1132-1137
25. Scuri M., McCaskill V., Chediak A.D., Abraham W.M., and Wanner A. Measurement of airway mucosal blood flow with dimethylether: validation with microspheres. J Appl Physiol 79 4 (1995) 1386-1390
26. Paredi P., Kharitonov S.A., and Barnes P.J. Correlation of exhaled breath temperature with bronchial blood flow in asthma. Respir Res 6 14-16 (2005) 15
27. Widdicombe J.G., and Webber S.E. Neuroregulation and pharmacology of the tracheobronchial circulation. In: Butler J. (Ed). The bronchial circulation (1992), Marcel Dekker, New York, Basel, Hong Kong 249-289
28. Wilson J. The bronchial microcirculation in asthma. Clin & Exp Allergy 30 Suppl 1 (2000) 51-53
29. Chetta A., Zanini A., Foresi A., Del Donno M., Castagnaro A., D'Ippolito R., et al. Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone. Am J Respir Crit Care Med 167 5 (2003) 751-757
30. Clarke G.W., Rafferty G.F., Ledbetter C.L., Ketchell R.I., Ratoff J.R., Greenough A., et al. The effects of inhaled spasmogens on airway mucosal blood flow in asthmatic subjects. Am J Respir Crit Care Med 169 (2004) A185
31. Mendes E.S., Pereira A., Danta I., Duncan R.C., and Wanner A. Comparative bronchial vasoconstrictive efficacy of inhaled glucocorticosteroids. Eur Respir J 21 6 (2003) 989-993
32. Wanner A., Horvath G., Brieva J.L., Kumar S.D., and Mendes E.S. Nongenomic actions of glucocorticosteroids on the airway vasculature in asthma. Proc Am Thor Soc 1 2 (2004) 235-238
33. Iversen L.L., and Salt P.J. Inhibition of catecholamine uptake-2 by steroids in the isolated rat heart. Br J Pharmacol 40 3 (1970) 528-530
34. Horvath G., Lieb T., Conner G.E., Salathe M., and Wanner A. Steroid sensitivity of norepinephrine uptake by human bronchial arterial and rabbit aortic smooth muscle cells. Am J Respir Cell Mol Biol 25 4 (2001) 500-506
35. Horvath G., Torbati A., Conner G.E., Salathe M., and Wanner A. Systemic ovalbumin sensitization downregulates norepinephrine uptake by rabbit aortic smooth muscle cells. Am J Respir Cell Mol Biol 27 6 (2002) 746-751
36. Busse W., Banks-Schlegel S., Noel P., Ortega H., Taggart V., Elias J., et al. Future research directions in asthma: an NHLBI Working Group report. Am J Respir Crit Care Med 170 6 (2004) 683-690
37. Mendes E.S., Campos M.A., Hurtado A., and Wanner A. Effect of montelukast and fluticasone propionate on airway mucosal blood flow in asthma. Am J Respir Crit Care Med 169 10 (2004) 1131-1134
38. Orsida B.E., Li X., Hickey B., Thien F., Wilson J.W., and Walters E.H. Vascularity in asthmatic airways: relation to inhaled steroid dose. Thorax 54 4 (1999) 289-295
39. Hoshino M., Takahashi M., Takai Y., Sim J., and Aoike N. Inhaled corticosteroids decrease vascularity of the bronchial mucosa in patients with asthma. Clin Exp Allergy 31 5 (2001) 722-730
40. Hammond G.L. Determinants of steroid hormone bioavailability. Biochem Soc Trans 25 2 (1997) 577-582
41. McKenzie A.W., and Stoughton R.B. Method for comparing percutaneous absorption of steroids. Arch Dermatol 86 (1962) 608-610
42. Noon J.P., Evans C.E., Haynes W.G., Webb D.J., and Walker B.R. A comparison of techniques to assess skin blanching following the topical application of glucocorticoids. Br J Dermatol 134 5 (1996) 837-842
43. Mariassy A.T., Gazeroglu H., and Wanner A. Morphometry of the subepithelial circulation in sheep airways. Effect of vascular congestion. Am Rev Respir Dis 143 1 (1991) 162-166
44. Csete M.E., Abraham W.M., and Wanner A. Vasomotion influences airflow in peripheral airways. Am Rev Respir Dis 141 6 (1990) 1409-1413
45. Wagner E.M., and Mitzner W. Effects of bronchial vascular engorgement on airway dimensions. J Appl Physiol 81 1 (1996) 293-301
46. Rodrigo G.J., Rodrigo C., and Hall J.B. Acute asthma in adults: a review. Chest 125 3 (2004) 1081-1102
47. Wanner A. Clinical perspectives: role of the airway circulation in drug therapy. J Aerosol Med 9 1 (1996) 19-23
48. Cazzola M., Santus P., Di Marco F., Carlucci P., Mondoni M., Matera M.G., et al. Onset of action of formoterol/budesonide in single inhaler vs. formoterol in patients with COPD. Pulm Pharmacol Ther 17 3 (2004) 121-125
49. + exchange activity in vascular smooth muscle cells by nongenomic and genomic mechanisms. Kidney Int 57 6 (2000) 2319-2333
50. 2+ in vascular smooth-muscle cells. Circ Res 76 6 (1995) 973-979
51. Steiner A., Locher R., Sachinidis A., and Vetter W. Cortisol-stimulated phosphoinositide metabolism in vascular smooth muscle cells: a role for glucocorticoids in blood pressure control? J Hypertens 7 6 (1989) S140-S141
52. Liu L., Wang Y.X., Zhou J., Long F., Sun H.W., Liu Y., et al. Rapid non-genomic inhibitory effects of glucocorticoids on human neutrophil degranulation. Inflamm Res 54 1 (2005) 37-41
53. Schmid D., Burmester G.R., Tripmacher R., Kuhnke A., and Buttgereit F. Bioenergetics of human peripheral blood mononuclear cell metabolism in quiescent, activated, and glucocorticoid-treated states. Biosci Rep 20 4 (2000) 289-302
54. Baccan G.C., Oliveira R.D.R., and Mantovani B. Stress and immunological phagocytosis: possible nongenomic action of corticosterone. Life Sci 75 11 (2004) 1357-1368
55. Long F., Wang Y.X., Liu L., Zhou J., Cui R.Y., and Jiang C.L. Rapid nongenomic inhibitory effects of glucocorticoids on phagocytosis and superoxide anion production by macrophages. Steroids 70 1 (2005) 55-61
56. Pitzalis C., Pipitone N., and Perretti M. Regulation of leukocyte-endothelial interactions by glucocorticoids. Ann NY Acad Sci 966 (2002) 108-118